SERPINA10 (serpin family A member 10)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51156
Gene name Gene Name - the full gene name approved by the HGNC.
Serpin family A member 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SERPINA10
Synonyms (NCBI Gene) Gene synonyms aliases
PZI, ZPI
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.13
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(16)
miRTarBase ID miRNA Experiments Reference
MIRT1338580 hsa-miR-193a-5p CLIP-seq
MIRT1338581 hsa-miR-297 CLIP-seq
MIRT1338582 hsa-miR-3148 CLIP-seq
MIRT1338583 hsa-miR-3713 CLIP-seq
MIRT1338584 hsa-miR-410 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
GO ID Ontology Definition Evidence Reference
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA 21873635
GO:0005515 Function Protein binding IPI 20427285
GO:0005615 Component Extracellular space IBA 21873635
GO:0005788 Component Endoplasmic reticulum lumen TAS
GO:0007596 Process Blood coagulation IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605271 15996 ENSG00000140093
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9UK55
Protein name Protein Z-dependent protease inhibitor (PZ-dependent protease inhibitor) (PZI) (Serpin A10)
Protein function Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.
PDB 3F1S , 3H5C , 4AFX , 4AJU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00079 Serpin 77 → 441 Serpin (serine protease inhibitor) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
Sequence
Sequence length 444
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Thrombophilia Thrombophilia rs118203912, rs118203911, rs121918141, rs121918142, rs121918143, rs121918144, rs121918145, rs121918146, rs121918147, rs121918148, rs121918149, rs121918151, rs121918152, rs121918153, rs121918154
View all (56 more)		 10829076, 15461625
Show/Hide Text Mining Associations (21)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Associate 22039093
Abortion Spontaneous Associate 22039093
alpha 1 Antitrypsin Deficiency Autosomal Recessive Associate 15461625
Autistic Disorder Associate 40185380
Blood Coagulation Disorders Inhibit 24158387
Carcinoma Hepatocellular Associate 31545220
Emphysema Associate 26030696
Endometrial Neoplasms Associate 31028196
Fetal Growth Retardation Associate 35072242
Hemophilia A Associate 31423718