SERPINA10 (serpin family A member 10)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 51156
Gene name Serpin family A member 10
Gene symbol SERPINA10
Synonyms (NCBI Gene)
PZIZPI
Chromosome 14
Chromosome location 14q32.13
Summary The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations
miRNA miRNA information provided by mirtarbase database.
16
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (16)
miRTarBase ID miRNA Experiments Reference
MIRT1338580 hsa-miR-193a-5p CLIP-seq
MIRT1338581 hsa-miR-297 CLIP-seq
MIRT1338582 hsa-miR-3148 CLIP-seq
MIRT1338583 hsa-miR-3713 CLIP-seq
MIRT1338584 hsa-miR-410 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA
GO:0004867 Function Serine-type endopeptidase inhibitor activity IEA
GO:0004867 Function Serine-type endopeptidase inhibitor activity TAS 10460162
GO:0005515 Function Protein binding IPI 20427285, 33961781
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605271 15996 ENSG00000140093
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UK55
Protein name Protein Z-dependent protease inhibitor (PZ-dependent protease inhibitor) (PZI) (Serpin A10)
Protein function Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.
PDB 3F1S , 3H5C , 4AFX , 4AJU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00079 Serpin 77 → 441 Serpin (serine protease inhibitor) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
Sequence
Sequence length 444
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
LAMB2-related infantile-onset nephrotic syndrome Likely benign rs2232698 RCV001258290
Venous thrombosis, susceptibility to Uncertain significance rs61754487 RCV000005413
Show/Hide Text Mining Associations (21)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Associate 22039093
Abortion Spontaneous Associate 22039093
alpha 1 Antitrypsin Deficiency Autosomal Recessive Associate 15461625
Autistic Disorder Associate 40185380
Blood Coagulation Disorders Inhibit 24158387
Carcinoma Hepatocellular Associate 31545220
Emphysema Associate 26030696
Endometrial Neoplasms Associate 31028196
Fetal Growth Retardation Associate 35072242
Hemophilia A Associate 31423718