ASB3 (ankyrin repeat and SOCS box containing 3)

Gene

• Entrez ID: 51130
• Gene name: Ankyrin repeat and SOCS box containing 3
• Gene symbol: ASB3
• Synonyms (NCBI Gene): ASB-3
• Chromosome: 2
• Chromosome location: 2p16.2
• Summary: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018047	hsa-miR-335-5p	Microarray	18185580
MIRT040170	hsa-miR-615-3p	CLASH	23622248
MIRT036646	hsa-miR-935	CLASH	23622248
MIRT527249	hsa-miR-1285-5p	PAR-CLIP	22012620
MIRT527248	hsa-miR-342-3p	PAR-CLIP	22012620
MIRT728292	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT728291	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT088933	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT088936	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT088934	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT088935	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT088938	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT088933	hsa-miR-30a-5p	HITS-CLIP	27418678
MIRT088936	hsa-miR-30b-5p	HITS-CLIP	27418678
MIRT088934	hsa-miR-30c-5p	HITS-CLIP	27418678
MIRT088935	hsa-miR-30d-5p	HITS-CLIP	27418678
MIRT088938	hsa-miR-30e-5p	HITS-CLIP	27418678
MIRT527249	hsa-miR-1285-5p	PAR-CLIP	22012620
MIRT527248	hsa-miR-342-3p	PAR-CLIP	22012620
MIRT802234	hsa-miR-127-5p	CLIP-seq
MIRT802235	hsa-miR-128	CLIP-seq
MIRT802236	hsa-miR-142-5p	CLIP-seq
MIRT802237	hsa-miR-2116	CLIP-seq
MIRT802238	hsa-miR-27a	CLIP-seq
MIRT802239	hsa-miR-27b	CLIP-seq
MIRT802240	hsa-miR-30a	CLIP-seq
MIRT802241	hsa-miR-30b	CLIP-seq
MIRT802242	hsa-miR-30c	CLIP-seq
MIRT802243	hsa-miR-30d	CLIP-seq
MIRT802244	hsa-miR-30e	CLIP-seq
MIRT802245	hsa-miR-383	CLIP-seq
MIRT802246	hsa-miR-4299	CLIP-seq
MIRT802247	hsa-miR-4496	CLIP-seq
MIRT802248	hsa-miR-4659a-5p	CLIP-seq
MIRT802249	hsa-miR-4659b-5p	CLIP-seq
MIRT802250	hsa-miR-4677-5p	CLIP-seq
MIRT802251	hsa-miR-4716-5p	CLIP-seq
MIRT802252	hsa-miR-4766-3p	CLIP-seq
MIRT802253	hsa-miR-4772-5p	CLIP-seq
MIRT802254	hsa-miR-4803	CLIP-seq
MIRT802255	hsa-miR-499-3p	CLIP-seq
MIRT802256	hsa-miR-499a-3p	CLIP-seq
MIRT802257	hsa-miR-543	CLIP-seq
MIRT802258	hsa-miR-548a-5p	CLIP-seq
MIRT802259	hsa-miR-548ab	CLIP-seq
MIRT802260	hsa-miR-548ak	CLIP-seq
MIRT802261	hsa-miR-548b-5p	CLIP-seq
MIRT802262	hsa-miR-548c-5p	CLIP-seq
MIRT802263	hsa-miR-548d-5p	CLIP-seq
MIRT802264	hsa-miR-548h	CLIP-seq
MIRT802265	hsa-miR-548i	CLIP-seq
MIRT802266	hsa-miR-548j	CLIP-seq
MIRT802267	hsa-miR-548k	CLIP-seq
MIRT802268	hsa-miR-548l	CLIP-seq
MIRT802269	hsa-miR-548p	CLIP-seq
MIRT802270	hsa-miR-548w	CLIP-seq
MIRT802271	hsa-miR-548y	CLIP-seq
MIRT802272	hsa-miR-559	CLIP-seq
MIRT802273	hsa-miR-570	CLIP-seq
MIRT802274	hsa-miR-802	CLIP-seq
MIRT802248	hsa-miR-4659a-5p	CLIP-seq
MIRT802249	hsa-miR-4659b-5p	CLIP-seq
MIRT2480041	hsa-miR-3163	CLIP-seq
MIRT2480042	hsa-miR-3664-5p	CLIP-seq
MIRT2480043	hsa-miR-3919	CLIP-seq
MIRT2480044	hsa-miR-3942-3p	CLIP-seq
MIRT2480045	hsa-miR-4474-3p	CLIP-seq
MIRT2480046	hsa-miR-4668-3p	CLIP-seq
MIRT2480047	hsa-miR-4714-5p	CLIP-seq
MIRT2480048	hsa-miR-4756-3p	CLIP-seq
MIRT2480049	hsa-miR-548ac	CLIP-seq
MIRT2480050	hsa-miR-548ae	CLIP-seq
MIRT2480051	hsa-miR-548aj	CLIP-seq
MIRT2480052	hsa-miR-548am	CLIP-seq
MIRT2480053	hsa-miR-548d-3p	CLIP-seq
MIRT2480054	hsa-miR-548x	CLIP-seq
MIRT2480055	hsa-miR-548z	CLIP-seq
MIRT2480056	hsa-miR-760	CLIP-seq
MIRT2480041	hsa-miR-3163	CLIP-seq
MIRT2480042	hsa-miR-3664-5p	CLIP-seq
MIRT2480043	hsa-miR-3919	CLIP-seq
MIRT2480044	hsa-miR-3942-3p	CLIP-seq
MIRT2480045	hsa-miR-4474-3p	CLIP-seq
MIRT2480046	hsa-miR-4668-3p	CLIP-seq
MIRT2480047	hsa-miR-4714-5p	CLIP-seq
MIRT2480048	hsa-miR-4756-3p	CLIP-seq
MIRT2480049	hsa-miR-548ac	CLIP-seq
MIRT2480050	hsa-miR-548ae	CLIP-seq
MIRT2480051	hsa-miR-548aj	CLIP-seq
MIRT2480052	hsa-miR-548am	CLIP-seq
MIRT2480053	hsa-miR-548d-3p	CLIP-seq
MIRT2480054	hsa-miR-548x	CLIP-seq
MIRT2480055	hsa-miR-548z	CLIP-seq
MIRT2480056	hsa-miR-760	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25814554
GO:0005829	Component	Cytosol	TAS
GO:0016567	Process	Protein ubiquitination	IEA
GO:0030315	Component	T-tubule	IBA	21873635
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0036371	Process	Protein localization to T-tubule	IBA	21873635
GO:0043687	Process	Post-translational protein modification	TAS
GO:0055117	Process	Regulation of cardiac muscle contraction	IBA	21873635

Other IDs

• MIM: 605760
• HGNC: 16013
• e!Ensembl: ENSG00000115239

Pathways

Reactome:

Neddylation
Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28736931

Unknown
Disease term	Disease name	Evidence	References	Source
Diabetes	Diabetes			GWAS
Bulimia	Bulimia			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Anorexia	Anorexia			GWAS
Alzheimer disease	Alzheimer disease			GWAS
Insomnia	Insomnia			GWAS
Restless Legs Syndrome	Restless Legs Syndrome			GWAS
Astrocytoma	Astrocytoma			GWAS
Anxiety Disorder	Anxiety Disorder			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Asthma	Associate	36835202
Cystitis Interstitial	Associate	39399486
Drug Related Side Effects and Adverse Reactions	Associate	15899873
Systemic Inflammatory Response Syndrome	Associate	30585438