PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase)

Gene

• Entrez ID: 5110
• Gene name: Protein-L-isoaspartate (D-aspartate) O-methyltransferase
• Gene symbol: PCMT1
• Synonyms (NCBI Gene): PIMT
• Chromosome: 6
• Chromosome location: 6q25.1
• Summary: This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation bac

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031439	hsa-miR-16-5p	Proteomics	18668040
MIRT038565	hsa-miR-106b-3p	CLASH	23622248
MIRT037052	hsa-miR-877-3p	CLASH	23622248
MIRT037052	hsa-miR-877-3p	CLASH	23622248
MIRT555811	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT555810	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT555809	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT098833	hsa-miR-330-3p	PAR-CLIP	21572407
MIRT555808	hsa-miR-495-3p	PAR-CLIP	21572407
MIRT555807	hsa-miR-5688	PAR-CLIP	21572407
MIRT555806	hsa-miR-7-1-3p	PAR-CLIP	21572407
MIRT555805	hsa-miR-7-2-3p	PAR-CLIP	21572407
MIRT098841	hsa-miR-548ag	PAR-CLIP	21572407
MIRT098842	hsa-miR-548ai	PAR-CLIP	21572407
MIRT098847	hsa-miR-548ba	PAR-CLIP	21572407
MIRT098838	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT098839	hsa-miR-646	PAR-CLIP	21572407
MIRT555804	hsa-miR-1283	PAR-CLIP	21572407
MIRT098837	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT555803	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT098840	hsa-miR-3135a	PAR-CLIP	21572407
MIRT098843	hsa-miR-4477b	PAR-CLIP	21572407
MIRT098846	hsa-miR-7856-5p	PAR-CLIP	21572407
MIRT098827	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT098829	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT031439	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT098830	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT733731	hsa-miR-143-3p	Immunoprecipitaion (IP), In situ hybridization, Luciferase reporter assay, Microarray, qRT-PCR, Western blotting	33898446
MIRT555811	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT555810	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT555809	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT098833	hsa-miR-330-3p	PAR-CLIP	21572407
MIRT555808	hsa-miR-495-3p	PAR-CLIP	21572407
MIRT555807	hsa-miR-5688	PAR-CLIP	21572407
MIRT555806	hsa-miR-7-1-3p	PAR-CLIP	21572407
MIRT555805	hsa-miR-7-2-3p	PAR-CLIP	21572407
MIRT098841	hsa-miR-548ag	PAR-CLIP	21572407
MIRT098842	hsa-miR-548ai	PAR-CLIP	21572407
MIRT098847	hsa-miR-548ba	PAR-CLIP	21572407
MIRT098838	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT098839	hsa-miR-646	PAR-CLIP	21572407
MIRT555804	hsa-miR-1283	PAR-CLIP	21572407
MIRT098837	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT555803	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT098840	hsa-miR-3135a	PAR-CLIP	21572407
MIRT098843	hsa-miR-4477b	PAR-CLIP	21572407
MIRT098846	hsa-miR-7856-5p	PAR-CLIP	21572407
MIRT1217892	hsa-miR-105	CLIP-seq
MIRT1217893	hsa-miR-1271	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT1217897	hsa-miR-182	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217899	hsa-miR-214	CLIP-seq
MIRT1217900	hsa-miR-217	CLIP-seq
MIRT1217901	hsa-miR-299-5p	CLIP-seq
MIRT1217902	hsa-miR-3185	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217905	hsa-miR-3619-5p	CLIP-seq
MIRT1217906	hsa-miR-3622a-3p	CLIP-seq
MIRT1217907	hsa-miR-3622b-3p	CLIP-seq
MIRT1217908	hsa-miR-3659	CLIP-seq
MIRT1217909	hsa-miR-3913-3p	CLIP-seq
MIRT1217910	hsa-miR-3941	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT1217912	hsa-miR-4291	CLIP-seq
MIRT1217913	hsa-miR-4436a	CLIP-seq
MIRT1217914	hsa-miR-4470	CLIP-seq
MIRT1217915	hsa-miR-4539	CLIP-seq
MIRT1217916	hsa-miR-4658	CLIP-seq
MIRT1217917	hsa-miR-466	CLIP-seq
MIRT1217918	hsa-miR-4672	CLIP-seq
MIRT1217919	hsa-miR-4699-3p	CLIP-seq
MIRT1217920	hsa-miR-4700-3p	CLIP-seq
MIRT1217921	hsa-miR-4709-3p	CLIP-seq
MIRT1217922	hsa-miR-4722-3p	CLIP-seq
MIRT1217923	hsa-miR-4728-3p	CLIP-seq
MIRT1217924	hsa-miR-4769-3p	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT1217926	hsa-miR-499-3p	CLIP-seq
MIRT1217927	hsa-miR-499a-3p	CLIP-seq
MIRT1217928	hsa-miR-5095	CLIP-seq
MIRT1217929	hsa-miR-520d-5p	CLIP-seq
MIRT1217930	hsa-miR-524-5p	CLIP-seq
MIRT1217931	hsa-miR-545	CLIP-seq
MIRT1217932	hsa-miR-548aa	CLIP-seq
MIRT1217933	hsa-miR-574-5p	CLIP-seq
MIRT1217934	hsa-miR-584	CLIP-seq
MIRT1217935	hsa-miR-761	CLIP-seq
MIRT1217936	hsa-miR-889	CLIP-seq
MIRT1217937	hsa-miR-922	CLIP-seq
MIRT1217938	hsa-miR-96	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT2063001	hsa-miR-337-3p	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217909	hsa-miR-3913-3p	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT2063002	hsa-miR-4511	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT2291412	hsa-miR-1197	CLIP-seq
MIRT1217893	hsa-miR-1271	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT1217897	hsa-miR-182	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217899	hsa-miR-214	CLIP-seq
MIRT1217900	hsa-miR-217	CLIP-seq
MIRT2291413	hsa-miR-223	CLIP-seq
MIRT2291414	hsa-miR-224	CLIP-seq
MIRT2291415	hsa-miR-3154	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT2291416	hsa-miR-324-5p	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217905	hsa-miR-3619-5p	CLIP-seq
MIRT2291417	hsa-miR-3667-3p	CLIP-seq
MIRT2291418	hsa-miR-3675-3p	CLIP-seq
MIRT1217910	hsa-miR-3941	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT1217912	hsa-miR-4291	CLIP-seq
MIRT1217914	hsa-miR-4470	CLIP-seq
MIRT2063002	hsa-miR-4511	CLIP-seq
MIRT1217917	hsa-miR-466	CLIP-seq
MIRT1217918	hsa-miR-4672	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT1217931	hsa-miR-545	CLIP-seq
MIRT2291419	hsa-miR-548g	CLIP-seq
MIRT1217935	hsa-miR-761	CLIP-seq
MIRT1217937	hsa-miR-922	CLIP-seq
MIRT2291420	hsa-miR-935	CLIP-seq
MIRT1217938	hsa-miR-96	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217899	hsa-miR-214	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217905	hsa-miR-3619-5p	CLIP-seq
MIRT1217910	hsa-miR-3941	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT1217912	hsa-miR-4291	CLIP-seq
MIRT1217917	hsa-miR-466	CLIP-seq
MIRT1217918	hsa-miR-4672	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT1217931	hsa-miR-545	CLIP-seq
MIRT1217935	hsa-miR-761	CLIP-seq
MIRT1217937	hsa-miR-922	CLIP-seq
MIRT2442451	hsa-miR-1273f	CLIP-seq
MIRT2442452	hsa-miR-143	CLIP-seq
MIRT2442453	hsa-miR-4708-5p	CLIP-seq
MIRT2442454	hsa-miR-4770	CLIP-seq
MIRT2442455	hsa-miR-4775	CLIP-seq
MIRT2442456	hsa-miR-590-3p	CLIP-seq
MIRT1217932	hsa-miR-548aa	CLIP-seq
MIRT2588924	hsa-miR-1257	CLIP-seq
MIRT2442451	hsa-miR-1273f	CLIP-seq
MIRT2588925	hsa-miR-1276	CLIP-seq
MIRT2442452	hsa-miR-143	CLIP-seq
MIRT2588926	hsa-miR-147	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT2588927	hsa-miR-188-5p	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217899	hsa-miR-214	CLIP-seq
MIRT2291414	hsa-miR-224	CLIP-seq
MIRT2588928	hsa-miR-2278	CLIP-seq
MIRT2588929	hsa-miR-298	CLIP-seq
MIRT2588930	hsa-miR-3074-3p	CLIP-seq
MIRT2588931	hsa-miR-3140-3p	CLIP-seq
MIRT2291415	hsa-miR-3154	CLIP-seq
MIRT1217902	hsa-miR-3185	CLIP-seq
MIRT2588932	hsa-miR-3190	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT2588933	hsa-miR-323-5p	CLIP-seq
MIRT2063001	hsa-miR-337-3p	CLIP-seq
MIRT2588934	hsa-miR-3611	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217905	hsa-miR-3619-5p	CLIP-seq
MIRT2291418	hsa-miR-3675-3p	CLIP-seq
MIRT2588935	hsa-miR-3911	CLIP-seq
MIRT1217910	hsa-miR-3941	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT1217912	hsa-miR-4291	CLIP-seq
MIRT2588936	hsa-miR-4468	CLIP-seq
MIRT2063002	hsa-miR-4511	CLIP-seq
MIRT1217917	hsa-miR-466	CLIP-seq
MIRT1217918	hsa-miR-4672	CLIP-seq
MIRT2588937	hsa-miR-4694-5p	CLIP-seq
MIRT2442453	hsa-miR-4708-5p	CLIP-seq
MIRT2588938	hsa-miR-4760-3p	CLIP-seq
MIRT2442454	hsa-miR-4770	CLIP-seq
MIRT2442455	hsa-miR-4775	CLIP-seq
MIRT2588939	hsa-miR-4780	CLIP-seq
MIRT2588940	hsa-miR-4790-3p	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT1217931	hsa-miR-545	CLIP-seq
MIRT1217932	hsa-miR-548aa	CLIP-seq
MIRT2588941	hsa-miR-577	CLIP-seq
MIRT2442456	hsa-miR-590-3p	CLIP-seq
MIRT2588942	hsa-miR-623	CLIP-seq
MIRT2588943	hsa-miR-644	CLIP-seq
MIRT2588944	hsa-miR-7	CLIP-seq
MIRT1217935	hsa-miR-761	CLIP-seq
MIRT2588945	hsa-miR-876-3p	CLIP-seq
MIRT1217936	hsa-miR-889	CLIP-seq
MIRT1217937	hsa-miR-922	CLIP-seq
MIRT2588924	hsa-miR-1257	CLIP-seq
MIRT2442451	hsa-miR-1273f	CLIP-seq
MIRT2588925	hsa-miR-1276	CLIP-seq
MIRT2442452	hsa-miR-143	CLIP-seq
MIRT2588926	hsa-miR-147	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT2588927	hsa-miR-188-5p	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217899	hsa-miR-214	CLIP-seq
MIRT2291413	hsa-miR-223	CLIP-seq
MIRT2291414	hsa-miR-224	CLIP-seq
MIRT2588928	hsa-miR-2278	CLIP-seq
MIRT2588929	hsa-miR-298	CLIP-seq
MIRT2588931	hsa-miR-3140-3p	CLIP-seq
MIRT2291415	hsa-miR-3154	CLIP-seq
MIRT1217902	hsa-miR-3185	CLIP-seq
MIRT2588932	hsa-miR-3190	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT2588933	hsa-miR-323-5p	CLIP-seq
MIRT2063001	hsa-miR-337-3p	CLIP-seq
MIRT2588934	hsa-miR-3611	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217905	hsa-miR-3619-5p	CLIP-seq
MIRT2291418	hsa-miR-3675-3p	CLIP-seq
MIRT2588935	hsa-miR-3911	CLIP-seq
MIRT1217910	hsa-miR-3941	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT1217912	hsa-miR-4291	CLIP-seq
MIRT2588936	hsa-miR-4468	CLIP-seq
MIRT2063002	hsa-miR-4511	CLIP-seq
MIRT1217917	hsa-miR-466	CLIP-seq
MIRT1217918	hsa-miR-4672	CLIP-seq
MIRT2588937	hsa-miR-4694-5p	CLIP-seq
MIRT2442453	hsa-miR-4708-5p	CLIP-seq
MIRT2588938	hsa-miR-4760-3p	CLIP-seq
MIRT2442454	hsa-miR-4770	CLIP-seq
MIRT2442455	hsa-miR-4775	CLIP-seq
MIRT2588939	hsa-miR-4780	CLIP-seq
MIRT2588940	hsa-miR-4790-3p	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT1217931	hsa-miR-545	CLIP-seq
MIRT1217932	hsa-miR-548aa	CLIP-seq
MIRT2588941	hsa-miR-577	CLIP-seq
MIRT2442456	hsa-miR-590-3p	CLIP-seq
MIRT2588942	hsa-miR-623	CLIP-seq
MIRT2588943	hsa-miR-644	CLIP-seq
MIRT2588944	hsa-miR-7	CLIP-seq
MIRT1217935	hsa-miR-761	CLIP-seq
MIRT2588945	hsa-miR-876-3p	CLIP-seq
MIRT1217937	hsa-miR-922	CLIP-seq
MIRT2291420	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004719	Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IBA
GO:0004719	Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IDA	3167043
GO:0004719	Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IEA
GO:0004719	Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	TAS	8074695
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32296183, 32814053, 32838362, 33961781, 34232536
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006479	Process	Protein methylation	IDA	3167043
GO:0006479	Process	Protein methylation	TAS	3355545
GO:0008168	Function	Methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030091	Process	Protein repair	TAS	8074695
GO:0032259	Process	Methylation	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:1903561	Component	Extracellular vesicle	HDA	24769233

Other IDs

• MIM: 176851
• HGNC: 8728
• e!Ensembl: ENSG00000120265

Protein

• UniProt ID: P22061
• Protein name: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase)
• Protein function: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins
• PDB: 1I1N, 1KR5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01135	PCMT	8 → 221		Family

• Sequence:

  MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATIS
  APHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSV
  NNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLI
  LPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRWK

• Sequence length: 227

Pathways

Reactome:

Protein repair