Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5110
Gene name Gene Name - the full gene name approved by the HGNC.	Protein-L-isoaspartate (D-aspartate) O-methyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PCMT1
Synonyms (NCBI Gene) Gene synonyms aliases	PIMT
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q25.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation bac

Show/Hide all(267)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031439	hsa-miR-16-5p	Proteomics	18668040
MIRT038565	hsa-miR-106b-3p	CLASH	23622248
MIRT037052	hsa-miR-877-3p	CLASH	23622248
MIRT037052	hsa-miR-877-3p	CLASH	23622248
MIRT555811	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT555810	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT555809	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT098833	hsa-miR-330-3p	PAR-CLIP	21572407
MIRT555808	hsa-miR-495-3p	PAR-CLIP	21572407
MIRT555807	hsa-miR-5688	PAR-CLIP	21572407
MIRT555806	hsa-miR-7-1-3p	PAR-CLIP	21572407
MIRT555805	hsa-miR-7-2-3p	PAR-CLIP	21572407
MIRT098841	hsa-miR-548ag	PAR-CLIP	21572407
MIRT098842	hsa-miR-548ai	PAR-CLIP	21572407
MIRT098847	hsa-miR-548ba	PAR-CLIP	21572407
MIRT098838	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT098839	hsa-miR-646	PAR-CLIP	21572407
MIRT555804	hsa-miR-1283	PAR-CLIP	21572407
MIRT098837	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT555803	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT098840	hsa-miR-3135a	PAR-CLIP	21572407
MIRT098843	hsa-miR-4477b	PAR-CLIP	21572407
MIRT098846	hsa-miR-7856-5p	PAR-CLIP	21572407
MIRT098827	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT098829	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT031439	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT098830	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT733731	hsa-miR-143-3p	Immunoprecipitaion (IP), In situ hybridization, Luciferase reporter assay, Microarray, qRT-PCR, Western blotting	33898446
MIRT555811	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT555810	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT555809	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT098833	hsa-miR-330-3p	PAR-CLIP	21572407
MIRT555808	hsa-miR-495-3p	PAR-CLIP	21572407
MIRT555807	hsa-miR-5688	PAR-CLIP	21572407
MIRT555806	hsa-miR-7-1-3p	PAR-CLIP	21572407
MIRT555805	hsa-miR-7-2-3p	PAR-CLIP	21572407
MIRT098841	hsa-miR-548ag	PAR-CLIP	21572407
MIRT098842	hsa-miR-548ai	PAR-CLIP	21572407
MIRT098847	hsa-miR-548ba	PAR-CLIP	21572407
MIRT098838	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT098839	hsa-miR-646	PAR-CLIP	21572407
MIRT555804	hsa-miR-1283	PAR-CLIP	21572407
MIRT098837	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT555803	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT098840	hsa-miR-3135a	PAR-CLIP	21572407
MIRT098843	hsa-miR-4477b	PAR-CLIP	21572407
MIRT098846	hsa-miR-7856-5p	PAR-CLIP	21572407
MIRT1217892	hsa-miR-105	CLIP-seq
MIRT1217893	hsa-miR-1271	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT1217897	hsa-miR-182	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217899	hsa-miR-214	CLIP-seq
MIRT1217900	hsa-miR-217	CLIP-seq
MIRT1217901	hsa-miR-299-5p	CLIP-seq
MIRT1217902	hsa-miR-3185	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217905	hsa-miR-3619-5p	CLIP-seq
MIRT1217906	hsa-miR-3622a-3p	CLIP-seq
MIRT1217907	hsa-miR-3622b-3p	CLIP-seq
MIRT1217908	hsa-miR-3659	CLIP-seq
MIRT1217909	hsa-miR-3913-3p	CLIP-seq
MIRT1217910	hsa-miR-3941	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT1217912	hsa-miR-4291	CLIP-seq
MIRT1217913	hsa-miR-4436a	CLIP-seq
MIRT1217914	hsa-miR-4470	CLIP-seq
MIRT1217915	hsa-miR-4539	CLIP-seq
MIRT1217916	hsa-miR-4658	CLIP-seq
MIRT1217917	hsa-miR-466	CLIP-seq
MIRT1217918	hsa-miR-4672	CLIP-seq
MIRT1217919	hsa-miR-4699-3p	CLIP-seq
MIRT1217920	hsa-miR-4700-3p	CLIP-seq
MIRT1217921	hsa-miR-4709-3p	CLIP-seq
MIRT1217922	hsa-miR-4722-3p	CLIP-seq
MIRT1217923	hsa-miR-4728-3p	CLIP-seq
MIRT1217924	hsa-miR-4769-3p	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT1217926	hsa-miR-499-3p	CLIP-seq
MIRT1217927	hsa-miR-499a-3p	CLIP-seq
MIRT1217928	hsa-miR-5095	CLIP-seq
MIRT1217929	hsa-miR-520d-5p	CLIP-seq
MIRT1217930	hsa-miR-524-5p	CLIP-seq
MIRT1217931	hsa-miR-545	CLIP-seq
MIRT1217932	hsa-miR-548aa	CLIP-seq
MIRT1217933	hsa-miR-574-5p	CLIP-seq
MIRT1217934	hsa-miR-584	CLIP-seq
MIRT1217935	hsa-miR-761	CLIP-seq
MIRT1217936	hsa-miR-889	CLIP-seq
MIRT1217937	hsa-miR-922	CLIP-seq
MIRT1217938	hsa-miR-96	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT2063001	hsa-miR-337-3p	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217909	hsa-miR-3913-3p	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT2063002	hsa-miR-4511	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT2291412	hsa-miR-1197	CLIP-seq
MIRT1217893	hsa-miR-1271	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT1217897	hsa-miR-182	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217899	hsa-miR-214	CLIP-seq
MIRT1217900	hsa-miR-217	CLIP-seq
MIRT2291413	hsa-miR-223	CLIP-seq
MIRT2291414	hsa-miR-224	CLIP-seq
MIRT2291415	hsa-miR-3154	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT2291416	hsa-miR-324-5p	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217905	hsa-miR-3619-5p	CLIP-seq
MIRT2291417	hsa-miR-3667-3p	CLIP-seq
MIRT2291418	hsa-miR-3675-3p	CLIP-seq
MIRT1217910	hsa-miR-3941	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT1217912	hsa-miR-4291	CLIP-seq
MIRT1217914	hsa-miR-4470	CLIP-seq
MIRT2063002	hsa-miR-4511	CLIP-seq
MIRT1217917	hsa-miR-466	CLIP-seq
MIRT1217918	hsa-miR-4672	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT1217931	hsa-miR-545	CLIP-seq
MIRT2291419	hsa-miR-548g	CLIP-seq
MIRT1217935	hsa-miR-761	CLIP-seq
MIRT1217937	hsa-miR-922	CLIP-seq
MIRT2291420	hsa-miR-935	CLIP-seq
MIRT1217938	hsa-miR-96	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217899	hsa-miR-214	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217905	hsa-miR-3619-5p	CLIP-seq
MIRT1217910	hsa-miR-3941	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT1217912	hsa-miR-4291	CLIP-seq
MIRT1217917	hsa-miR-466	CLIP-seq
MIRT1217918	hsa-miR-4672	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT1217931	hsa-miR-545	CLIP-seq
MIRT1217935	hsa-miR-761	CLIP-seq
MIRT1217937	hsa-miR-922	CLIP-seq
MIRT2442451	hsa-miR-1273f	CLIP-seq
MIRT2442452	hsa-miR-143	CLIP-seq
MIRT2442453	hsa-miR-4708-5p	CLIP-seq
MIRT2442454	hsa-miR-4770	CLIP-seq
MIRT2442455	hsa-miR-4775	CLIP-seq
MIRT2442456	hsa-miR-590-3p	CLIP-seq
MIRT1217932	hsa-miR-548aa	CLIP-seq
MIRT2588924	hsa-miR-1257	CLIP-seq
MIRT2442451	hsa-miR-1273f	CLIP-seq
MIRT2588925	hsa-miR-1276	CLIP-seq
MIRT2442452	hsa-miR-143	CLIP-seq
MIRT2588926	hsa-miR-147	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT2588927	hsa-miR-188-5p	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217899	hsa-miR-214	CLIP-seq
MIRT2291414	hsa-miR-224	CLIP-seq
MIRT2588928	hsa-miR-2278	CLIP-seq
MIRT2588929	hsa-miR-298	CLIP-seq
MIRT2588930	hsa-miR-3074-3p	CLIP-seq
MIRT2588931	hsa-miR-3140-3p	CLIP-seq
MIRT2291415	hsa-miR-3154	CLIP-seq
MIRT1217902	hsa-miR-3185	CLIP-seq
MIRT2588932	hsa-miR-3190	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT2588933	hsa-miR-323-5p	CLIP-seq
MIRT2063001	hsa-miR-337-3p	CLIP-seq
MIRT2588934	hsa-miR-3611	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217905	hsa-miR-3619-5p	CLIP-seq
MIRT2291418	hsa-miR-3675-3p	CLIP-seq
MIRT2588935	hsa-miR-3911	CLIP-seq
MIRT1217910	hsa-miR-3941	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT1217912	hsa-miR-4291	CLIP-seq
MIRT2588936	hsa-miR-4468	CLIP-seq
MIRT2063002	hsa-miR-4511	CLIP-seq
MIRT1217917	hsa-miR-466	CLIP-seq
MIRT1217918	hsa-miR-4672	CLIP-seq
MIRT2588937	hsa-miR-4694-5p	CLIP-seq
MIRT2442453	hsa-miR-4708-5p	CLIP-seq
MIRT2588938	hsa-miR-4760-3p	CLIP-seq
MIRT2442454	hsa-miR-4770	CLIP-seq
MIRT2442455	hsa-miR-4775	CLIP-seq
MIRT2588939	hsa-miR-4780	CLIP-seq
MIRT2588940	hsa-miR-4790-3p	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT1217931	hsa-miR-545	CLIP-seq
MIRT1217932	hsa-miR-548aa	CLIP-seq
MIRT2588941	hsa-miR-577	CLIP-seq
MIRT2442456	hsa-miR-590-3p	CLIP-seq
MIRT2588942	hsa-miR-623	CLIP-seq
MIRT2588943	hsa-miR-644	CLIP-seq
MIRT2588944	hsa-miR-7	CLIP-seq
MIRT1217935	hsa-miR-761	CLIP-seq
MIRT2588945	hsa-miR-876-3p	CLIP-seq
MIRT1217936	hsa-miR-889	CLIP-seq
MIRT1217937	hsa-miR-922	CLIP-seq
MIRT2588924	hsa-miR-1257	CLIP-seq
MIRT2442451	hsa-miR-1273f	CLIP-seq
MIRT2588925	hsa-miR-1276	CLIP-seq
MIRT2442452	hsa-miR-143	CLIP-seq
MIRT2588926	hsa-miR-147	CLIP-seq
MIRT1217894	hsa-miR-15a	CLIP-seq
MIRT1217895	hsa-miR-15b	CLIP-seq
MIRT1217896	hsa-miR-16	CLIP-seq
MIRT2588927	hsa-miR-188-5p	CLIP-seq
MIRT1217898	hsa-miR-195	CLIP-seq
MIRT1217899	hsa-miR-214	CLIP-seq
MIRT2291413	hsa-miR-223	CLIP-seq
MIRT2291414	hsa-miR-224	CLIP-seq
MIRT2588928	hsa-miR-2278	CLIP-seq
MIRT2588929	hsa-miR-298	CLIP-seq
MIRT2588931	hsa-miR-3140-3p	CLIP-seq
MIRT2291415	hsa-miR-3154	CLIP-seq
MIRT1217902	hsa-miR-3185	CLIP-seq
MIRT2588932	hsa-miR-3190	CLIP-seq
MIRT1217903	hsa-miR-323-3p	CLIP-seq
MIRT2588933	hsa-miR-323-5p	CLIP-seq
MIRT2063001	hsa-miR-337-3p	CLIP-seq
MIRT2588934	hsa-miR-3611	CLIP-seq
MIRT1217904	hsa-miR-361-5p	CLIP-seq
MIRT1217905	hsa-miR-3619-5p	CLIP-seq
MIRT2291418	hsa-miR-3675-3p	CLIP-seq
MIRT2588935	hsa-miR-3911	CLIP-seq
MIRT1217910	hsa-miR-3941	CLIP-seq
MIRT1217911	hsa-miR-424	CLIP-seq
MIRT1217912	hsa-miR-4291	CLIP-seq
MIRT2588936	hsa-miR-4468	CLIP-seq
MIRT2063002	hsa-miR-4511	CLIP-seq
MIRT1217917	hsa-miR-466	CLIP-seq
MIRT1217918	hsa-miR-4672	CLIP-seq
MIRT2588937	hsa-miR-4694-5p	CLIP-seq
MIRT2442453	hsa-miR-4708-5p	CLIP-seq
MIRT2588938	hsa-miR-4760-3p	CLIP-seq
MIRT2442454	hsa-miR-4770	CLIP-seq
MIRT2442455	hsa-miR-4775	CLIP-seq
MIRT2588939	hsa-miR-4780	CLIP-seq
MIRT2588940	hsa-miR-4790-3p	CLIP-seq
MIRT1217925	hsa-miR-497	CLIP-seq
MIRT1217931	hsa-miR-545	CLIP-seq
MIRT1217932	hsa-miR-548aa	CLIP-seq
MIRT2588941	hsa-miR-577	CLIP-seq
MIRT2442456	hsa-miR-590-3p	CLIP-seq
MIRT2588942	hsa-miR-623	CLIP-seq
MIRT2588943	hsa-miR-644	CLIP-seq
MIRT2588944	hsa-miR-7	CLIP-seq
MIRT1217935	hsa-miR-761	CLIP-seq
MIRT2588945	hsa-miR-876-3p	CLIP-seq
MIRT1217937	hsa-miR-922	CLIP-seq
MIRT2291420	hsa-miR-935	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004719	Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IBA
GO:0004719	Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IDA	3167043
GO:0004719	Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IEA
GO:0004719	Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	TAS	8074695
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32296183, 32814053, 32838362, 33961781, 34232536
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006479	Process	Protein methylation	IDA	3167043
GO:0006479	Process	Protein methylation	TAS	3355545
GO:0008168	Function	Methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030091	Process	Protein repair	TAS	8074695
GO:0032259	Process	Methylation	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:1903561	Component	Extracellular vesicle	HDA	24769233

MIM	HGNC	e!Ensembl
176851	8728	ENSG00000120265

Protein

UniProt ID

P22061

Protein name

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase)

Protein function

Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins

PDB

1I1N , 1KR5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01135	PCMT	8 → 221		Family

Sequence

MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATIS
APHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSV
NNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLI
LPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRWK

Sequence length

227

Interactions

View interactions

	Reactome
			Protein repair

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Lymphoblastic Leukemia	Acute lymphoblastic leukemia	Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis	35033172	CBGDA

Show/Hide Text Mining Associations (26)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	21372823
Alzheimer Disease	Inhibit	32705859
Ataxia Telangiectasia	Associate	37994408
Blood Platelet Disorders	Associate	22486984
Breast Neoplasms	Associate	34868337, 35535040, 37953789
Carcinoma Hepatocellular	Associate	25119594
Central Nervous System Infections	Associate	29856810
Conversion Disorder	Associate	28100787
Epilepsy	Inhibit	12390520
Epilepsy	Associate	12390520, 28100787, 29856810
Epilepsy Familial Mesial Temporal Lobe	Associate	12390520
Glioblastoma	Associate	34082401, 35628507
Glioma	Associate	35628507
Heredodegenerative Disorders Nervous System	Associate	29856810
Inflammation	Associate	37953789
Lupus Erythematosus Systemic	Inhibit	37994408
Lymphatic Metastasis	Associate	29517839, 37899170
Neoplasm Metastasis	Associate	29517839, 37899170
Neoplasms	Associate	25119594, 29517839, 35535040, 37899170, 37953789
Neural Tube Defects	Associate	16256389
Neurologic Manifestations	Associate	12390520, 28100787
Primary Ovarian Insufficiency	Associate	18582870
Prostatic Neoplasms	Stimulate	37899170
Spinal Dysraphism	Associate	16256389
Triple Negative Breast Neoplasms	Associate	37953789
Urinary Bladder Neoplasms	Associate	29517839

PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase)