Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51085
Gene name Gene Name - the full gene name approved by the HGNC.	MLX interacting protein like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MLXIPL
Synonyms (NCBI Gene) Gene synonyms aliases	CHREBP, MIO, MLX, MONDOB, WBSCR14, WS-bHLH, bHLHd14
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q11.23
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs

Show/Hide all(301)

miRTarBase ID	miRNA	Experiments	Reference
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT629338	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT629338	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT615322	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT615321	hsa-miR-5193	HITS-CLIP	23824327
MIRT615320	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT615319	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT615318	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615317	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT615316	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT615315	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT609730	hsa-miR-8485	HITS-CLIP	23824327
MIRT609729	hsa-miR-4643	HITS-CLIP	23824327
MIRT609728	hsa-miR-1322	HITS-CLIP	23824327
MIRT609727	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT609726	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT1152666	hsa-miR-3202	CLIP-seq
MIRT1152667	hsa-miR-3692	CLIP-seq
MIRT1152668	hsa-miR-371b-3p	CLIP-seq
MIRT1152669	hsa-miR-4476	CLIP-seq
MIRT1152670	hsa-miR-4756-3p	CLIP-seq
MIRT1152671	hsa-miR-486-3p	CLIP-seq
MIRT2273054	hsa-miR-1915	CLIP-seq
MIRT2273055	hsa-miR-361-3p	CLIP-seq
MIRT2273056	hsa-miR-3922-5p	CLIP-seq
MIRT2273057	hsa-miR-4436b-3p	CLIP-seq
MIRT2273058	hsa-miR-4685-5p	CLIP-seq
MIRT2273059	hsa-miR-4686	CLIP-seq
MIRT2273060	hsa-miR-4765	CLIP-seq
MIRT2438597	hsa-miR-1291	CLIP-seq
MIRT2438598	hsa-miR-1343	CLIP-seq
MIRT2438599	hsa-miR-1976	CLIP-seq
MIRT2438600	hsa-miR-3176	CLIP-seq
MIRT2438601	hsa-miR-328	CLIP-seq
MIRT2438602	hsa-miR-3922-3p	CLIP-seq
MIRT2438603	hsa-miR-4639-3p	CLIP-seq
MIRT2438604	hsa-miR-668	CLIP-seq
MIRT2273054	hsa-miR-1915	CLIP-seq
MIRT2273055	hsa-miR-361-3p	CLIP-seq
MIRT2454218	hsa-miR-3690	CLIP-seq
MIRT2454219	hsa-miR-4725-5p	CLIP-seq
MIRT2454220	hsa-miR-504	CLIP-seq
MIRT2454221	hsa-miR-711	CLIP-seq
MIRT2438597	hsa-miR-1291	CLIP-seq
MIRT2438598	hsa-miR-1343	CLIP-seq
MIRT2438599	hsa-miR-1976	CLIP-seq
MIRT2438600	hsa-miR-3176	CLIP-seq
MIRT2438601	hsa-miR-328	CLIP-seq
MIRT2438602	hsa-miR-3922-3p	CLIP-seq
MIRT2438603	hsa-miR-4639-3p	CLIP-seq
MIRT2438604	hsa-miR-668	CLIP-seq

Show/Hide all(65)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000432	Process	Positive regulation of transcription from RNA polymerase II promoter by glucose	IEA
GO:0000785	Component	Chromatin	IDA	21084751
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001216	Function	DNA-binding transcription activator activity	IDA	21084751
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	ISS	11230181
GO:0003677	Function	DNA binding	NAS	10780788
GO:0003700	Function	DNA-binding transcription factor activity	NAS	10780788
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS	11230181
GO:0005634	Component	Nucleus	NAS	10780788
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005667	Component	Transcription regulator complex	NAS	11230181
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS	11230181
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	10780788
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	19995986
GO:0008610	Process	Lipid biosynthetic process	IDA	21084751
GO:0008610	Process	Lipid biosynthetic process	IDA	21084751
GO:0009653	Process	Anatomical structure morphogenesis	TAS	9860302
GO:0010255	Process	Glucose mediated signaling pathway	IEA
GO:0010255	Process	Glucose mediated signaling pathway	ISS
GO:0035538	Function	Carbohydrate response element binding	TAS	18591247
GO:0035774	Process	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA
GO:0042593	Process	Glucose homeostasis	IEA
GO:0042593	Process	Glucose homeostasis	ISS	11230181
GO:0042803	Function	Protein homodimerization activity	IDA	11230181
GO:0045723	Process	Positive regulation of fatty acid biosynthetic process	IEA
GO:0045723	Process	Positive regulation of fatty acid biosynthetic process	ISS	11230181
GO:0045821	Process	Positive regulation of glycolytic process	IEA
GO:0045821	Process	Positive regulation of glycolytic process	IMP	19995986
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	ISS	11230181
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	ISS	11230181
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS	11230181
GO:0046889	Process	Positive regulation of lipid biosynthetic process	IEA
GO:0046889	Process	Positive regulation of lipid biosynthetic process	IMP	19995986
GO:0046982	Function	Protein heterodimerization activity	IPI	11230181
GO:0046983	Function	Protein dimerization activity	IEA
GO:0055089	Process	Fatty acid homeostasis	ISS
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	11230181
GO:0070328	Process	Triglyceride homeostasis	NAS	19571538
GO:0090324	Process	Negative regulation of oxidative phosphorylation	IMP	19995986
GO:0097009	Process	Energy homeostasis	ISS
GO:0140297	Function	DNA-binding transcription factor binding	IDA	21084751
GO:1901797	Process	Negative regulation of signal transduction by p53 class mediator	IMP	19995986

MIM	HGNC	e!Ensembl
605678	12744	ENSG00000009950

Protein

UniProt ID

Q9NP71

Protein name

Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosom

Protein function

Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By

PDB

6MJL , 6YGJ , 8BTQ , 8BWE , 8BWH , 8C1Y

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	650 → 704	Helix-loop-helix DNA-binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in liver, heart, kidney, cerebellum and intestinal tissues.

Sequence

MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD
SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI
RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE
YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR
QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS
DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN
SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP
PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS
EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA
LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER
LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQK
RRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDE
IEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFE
SFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQAT
RAVTEGTLGKPL

Sequence length

852

Interactions

View interactions

	KEGG		Reactome
	Insulin resistance Non-alcoholic fatty liver disease		PKA-mediated phosphorylation of key metabolic factors ChREBP activates metabolic gene expression

Show/Hide Unknown Diseases (8)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Cholelithiasis	Cholelithiasis	N/A	N/A	GWAS
Diabetes	Type 2 diabetes, Triglyceride levels in non-type 2 diabetes	N/A	N/A	GWAS
Glioblastoma	Glioblastoma	N/A	N/A	GWAS
Gout	Gout	N/A	N/A	GWAS
Hyperlipidemia	Familial combined hyperlipidemia defined by Brunzell criteria, Familial combined hyperlipidemia defined by Goldstein criteria	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Williams Syndrome	williams syndrome	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (30)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	37074818
Autism Spectrum Disorder	Associate	31413120
Breast Neoplasms	Associate	24366300
Carcinoma Hepatocellular	Associate	28816938, 31407220, 33656238, 36809979
Colonic Neoplasms	Associate	32144313
Colorectal Neoplasms	Associate	32144313
Constriction Pathologic	Associate	25179879
Coronary Artery Disease	Associate	25179879
Coronary Disease	Associate	23840567, 29848931, 37074818
Coronary Stenosis	Associate	25179879
Diabetes Mellitus	Associate	32144313, 35908073
Diabetes Mellitus Type 2	Associate	19680233
Diabetes Mellitus Type 2	Inhibit	23209190
Dyslipidemias	Associate	22840581, 34270325
Fatty Liver	Stimulate	25406988, 29786745
Glucose Intolerance	Associate	23209190
Gout	Associate	29976226
Hyperglycemic Hyperosmolar Nonketotic Coma	Associate	35908073
Hypertriglyceridemia	Associate	24448738
Hypoxia	Associate	24366300
Insulin Resistance	Associate	19680233
Metabolic Diseases	Associate	32144313, 36432414
Metabolic Syndrome	Associate	38201907
Myocardial Infarction	Associate	24448738
Neoplasms	Associate	24366300, 24845031, 26725848, 36809979
Non alcoholic Fatty Liver Disease	Associate	29786745, 32144313
Obesity	Associate	21840420, 32144313
Pancreatic Intraductal Neoplasms	Associate	22355676
Prostatic Neoplasms	Associate	24845031
Williams Syndrome	Associate	31413120

MLXIPL (MLX interacting protein like)