GAL (galanin and GMAP prepropeptide)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 51083
Gene name Galanin and GMAP prepropeptide
Gene symbol GAL
Synonyms (NCBI Gene)
ETL8GAL-GMAPGALNGLNNGMAP
Chromosome 11
Chromosome location 11q13.2
Summary This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically
miRNA miRNA information provided by mirtarbase database.
21
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (21)
miRTarBase ID miRNA Experiments Reference
MIRT551980 hsa-miR-7151-5p PAR-CLIP 21572407
MIRT060523 hsa-miR-889-5p PAR-CLIP 21572407
MIRT551979 hsa-miR-885-5p PAR-CLIP 21572407
MIRT060526 hsa-miR-4671-5p PAR-CLIP 21572407
MIRT060522 hsa-miR-345-5p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (37)
GO ID Ontology Definition Evidence Reference
GO:0004966 Function Galanin receptor activity IMP 25691535
GO:0005179 Function Hormone activity IEA
GO:0005184 Function Neuropeptide hormone activity IBA
GO:0005184 Function Neuropeptide hormone activity IDA 24517231
GO:0005184 Function Neuropeptide hormone activity NAS 1722333
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
137035 4114 ENSG00000069482
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P22466
Protein name Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide (GMAP)]
Protein function Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth
PDB 7S3O , 7S3Q , 7S3R , 7WQ3 , 7WQ4 , 7XBD , 7XJJ , 7XJK , 8DHZ , 8DJ4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01296 Galanin 33 → 61 Galanin Family
PF06540 GMAP 62 → 122 Galanin message associated peptide (GMAP) Family
Sequence
Sequence length 123
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Neuroactive ligand-receptor interaction   Peptide ligand-binding receptors
G alpha (i) signalling events
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
56
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial temporal lobe epilepsy 8 Pathogenic rs1057517661 RCV000412584
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
GAL-related disorder Benign; Likely benign rs34725707, rs139127322, rs145825008 RCV003935547
RCV003945325
RCV003965407
Show/Hide Text Mining Associations (43)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Alcoholism Associate 16314872, 17083333
Alzheimer Disease Associate 10537062, 18322398, 19749437, 20237460
Anxiety Associate 16314872, 20237460, 24706871, 31881033
Bile Duct Diseases Associate 37443714, 40194702
Carcinogenesis Associate 32265844
Carcinoma Adenoid Cystic Associate 36039037
Carcinoma Hepatocellular Associate 22219594, 34147074
Cholestasis Associate 37443714
Cognition Disorders Associate 10537062
Colonic Neoplasms Associate 18413313