GAL (galanin and GMAP prepropeptide)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51083
Gene name Gene Name - the full gene name approved by the HGNC.
Galanin and GMAP prepropeptide
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GAL
Synonyms (NCBI Gene) Gene synonyms aliases
ETL8, GAL-GMAP, GALN, GLNN, GMAP
Disease Acronyms (UniProt) Disease acronyms from UniProt database
ETL8
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(21)
miRTarBase ID miRNA Experiments Reference
MIRT551980 hsa-miR-7151-5p PAR-CLIP 21572407
MIRT060523 hsa-miR-889-5p PAR-CLIP 21572407
MIRT551979 hsa-miR-885-5p PAR-CLIP 21572407
MIRT060526 hsa-miR-4671-5p PAR-CLIP 21572407
MIRT060522 hsa-miR-345-5p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(33)
GO ID Ontology Definition Evidence Reference
GO:0004966 Function Galanin receptor activity IMP 25691535
GO:0005184 Function Neuropeptide hormone activity IBA 21873635
GO:0005184 Function Neuropeptide hormone activity IDA 24517231
GO:0005184 Function Neuropeptide hormone activity NAS 1722333
GO:0005515 Function Protein binding IPI 25416956, 25691535, 32296183, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
137035 4114 ENSG00000069482
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P22466
Protein name Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide (GMAP)]
Protein function Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth
PDB 7S3O , 7S3Q , 7S3R , 7WQ3 , 7WQ4 , 7XBD , 7XJJ , 7XJK , 8DHZ , 8DJ4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01296 Galanin 33 → 61 Galanin Family
PF06540 GMAP 62 → 122 Galanin message associated peptide (GMAP) Family
Sequence
Sequence length 123
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction   Peptide ligand-binding receptors
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (4)
Causal
Disease term Disease name dbSNP ID References
Epilepsy EPILEPSY, FAMILIAL TEMPORAL LOBE, 8 rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670
View all (165 more)		 25691535
Hirschsprung disease Hirschsprung Disease rs76262710, rs75996173, rs77316810, rs75076352, rs76534745, rs76764689, rs76449634, rs377767412, rs193922699, rs75030001, rs606231342, rs1553540620, rs759944122, rs1057519322, rs1057519323
View all (4 more)		 22325380
Hypertension Hypertensive disease rs13306026 10818254
Seizure Complex partial seizures rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061
View all (179 more)
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Huntington disease Huntington Disease 22325380 ClinVar
Mental depression Mental Depression, Depressive disorder, Major Depressive Disorder 24706871, 25228436, 23933912, 24782539, 25522404, 27940914 ClinVar
Show/Hide Text Mining Associations (43)
Associations from Text Mining
Disease Name Relationship Type References
Alcoholism Associate 16314872, 17083333
Alzheimer Disease Associate 10537062, 18322398, 19749437, 20237460
Anxiety Associate 16314872, 20237460, 24706871, 31881033
Bile Duct Diseases Associate 37443714, 40194702
Carcinogenesis Associate 32265844
Carcinoma Adenoid Cystic Associate 36039037
Carcinoma Hepatocellular Associate 22219594, 34147074
Cholestasis Associate 37443714
Cognition Disorders Associate 10537062
Colonic Neoplasms Associate 18413313