MEMO1 (mediator of cell motility 1)

Gene

• Entrez ID: 51072
• Gene name: Mediator of cell motility 1
• Gene symbol: MEMO1
• Synonyms (NCBI Gene): C2orf4, CGI-27, MEMO, NS5ATP7
• Chromosome: 2
• Chromosome location: 2p22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT648563	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT648562	hsa-miR-4477a	HITS-CLIP	23824327
MIRT615879	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT615879	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT615879	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT615881	hsa-miR-3609	HITS-CLIP	23824327
MIRT615880	hsa-miR-548ah-5p	HITS-CLIP	23824327
MIRT615879	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT473356	hsa-miR-324-5p	PAR-CLIP	23592263
MIRT473353	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT473350	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT473349	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT473348	hsa-miR-4712-3p	PAR-CLIP	23592263
MIRT473347	hsa-miR-3687	PAR-CLIP	23592263
MIRT473346	hsa-miR-4442	PAR-CLIP	23592263
MIRT473344	hsa-miR-3665	PAR-CLIP	23592263
MIRT473343	hsa-miR-657	PAR-CLIP	23592263
MIRT473339	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT473338	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT473337	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT473335	hsa-miR-4642	PAR-CLIP	23592263
MIRT473356	hsa-miR-324-5p	PAR-CLIP	23592263
MIRT473353	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT473354	hsa-miR-3929	PAR-CLIP	23592263
MIRT473352	hsa-miR-4419b	PAR-CLIP	23592263
MIRT473351	hsa-miR-4478	PAR-CLIP	23592263
MIRT473350	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT473349	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT473348	hsa-miR-4712-3p	PAR-CLIP	23592263
MIRT473347	hsa-miR-3687	PAR-CLIP	23592263
MIRT473346	hsa-miR-4442	PAR-CLIP	23592263
MIRT473345	hsa-miR-645	PAR-CLIP	23592263
MIRT473344	hsa-miR-3665	PAR-CLIP	23592263
MIRT473343	hsa-miR-657	PAR-CLIP	23592263
MIRT473342	hsa-miR-4505	PAR-CLIP	23592263
MIRT473341	hsa-miR-5787	PAR-CLIP	23592263
MIRT473340	hsa-miR-3649	PAR-CLIP	23592263
MIRT473339	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT473338	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT473337	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT473335	hsa-miR-4642	PAR-CLIP	23592263
MIRT648563	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT648562	hsa-miR-4477a	HITS-CLIP	23824327
MIRT615879	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT615879	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT615879	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT615881	hsa-miR-3609	HITS-CLIP	23824327
MIRT615880	hsa-miR-548ah-5p	HITS-CLIP	23824327
MIRT615879	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT473356	hsa-miR-324-5p	PAR-CLIP	23592263
MIRT473353	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT473350	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT473349	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT473348	hsa-miR-4712-3p	PAR-CLIP	23592263
MIRT473347	hsa-miR-3687	PAR-CLIP	23592263
MIRT473346	hsa-miR-4442	PAR-CLIP	23592263
MIRT473344	hsa-miR-3665	PAR-CLIP	23592263
MIRT473343	hsa-miR-657	PAR-CLIP	23592263
MIRT473339	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT473338	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT473337	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT473335	hsa-miR-4642	PAR-CLIP	23592263
MIRT473356	hsa-miR-324-5p	PAR-CLIP	23592263
MIRT473353	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT473354	hsa-miR-3929	PAR-CLIP	23592263
MIRT473352	hsa-miR-4419b	PAR-CLIP	23592263
MIRT473351	hsa-miR-4478	PAR-CLIP	23592263
MIRT473350	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT473349	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT473348	hsa-miR-4712-3p	PAR-CLIP	23592263
MIRT473347	hsa-miR-3687	PAR-CLIP	23592263
MIRT473346	hsa-miR-4442	PAR-CLIP	23592263
MIRT473345	hsa-miR-645	PAR-CLIP	23592263
MIRT473344	hsa-miR-3665	PAR-CLIP	23592263
MIRT473343	hsa-miR-657	PAR-CLIP	23592263
MIRT473342	hsa-miR-4505	PAR-CLIP	23592263
MIRT473341	hsa-miR-5787	PAR-CLIP	23592263
MIRT473340	hsa-miR-3649	PAR-CLIP	23592263
MIRT473339	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT473338	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT473337	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT473335	hsa-miR-4642	PAR-CLIP	23592263
MIRT1142871	hsa-miR-130a	CLIP-seq
MIRT1142872	hsa-miR-130b	CLIP-seq
MIRT1142873	hsa-miR-19a	CLIP-seq
MIRT1142874	hsa-miR-19b	CLIP-seq
MIRT1142875	hsa-miR-2276	CLIP-seq
MIRT1142876	hsa-miR-301a	CLIP-seq
MIRT1142877	hsa-miR-301b	CLIP-seq
MIRT1142878	hsa-miR-3201	CLIP-seq
MIRT1142879	hsa-miR-3666	CLIP-seq
MIRT1142880	hsa-miR-3669	CLIP-seq
MIRT1142881	hsa-miR-4295	CLIP-seq
MIRT1142882	hsa-miR-454	CLIP-seq
MIRT1142883	hsa-miR-455-5p	CLIP-seq
MIRT1142884	hsa-miR-4766-5p	CLIP-seq
MIRT1142885	hsa-miR-4772-3p	CLIP-seq
MIRT1142886	hsa-miR-4778-5p	CLIP-seq
MIRT1142887	hsa-miR-4791	CLIP-seq
MIRT1142888	hsa-miR-518a-5p	CLIP-seq
MIRT1142889	hsa-miR-527	CLIP-seq
MIRT1142890	hsa-miR-651	CLIP-seq
MIRT1142891	hsa-miR-1267	CLIP-seq
MIRT1142892	hsa-miR-129-3p	CLIP-seq
MIRT1142871	hsa-miR-130a	CLIP-seq
MIRT1142872	hsa-miR-130b	CLIP-seq
MIRT1142893	hsa-miR-1323	CLIP-seq
MIRT1142873	hsa-miR-19a	CLIP-seq
MIRT1142874	hsa-miR-19b	CLIP-seq
MIRT1142875	hsa-miR-2276	CLIP-seq
MIRT1142876	hsa-miR-301a	CLIP-seq
MIRT1142877	hsa-miR-301b	CLIP-seq
MIRT1142894	hsa-miR-3121-3p	CLIP-seq
MIRT1142895	hsa-miR-3154	CLIP-seq
MIRT1142896	hsa-miR-3613-3p	CLIP-seq
MIRT1142897	hsa-miR-3613-5p	CLIP-seq
MIRT1142879	hsa-miR-3666	CLIP-seq
MIRT1142880	hsa-miR-3669	CLIP-seq
MIRT1142881	hsa-miR-4295	CLIP-seq
MIRT1142898	hsa-miR-450b-5p	CLIP-seq
MIRT1142882	hsa-miR-454	CLIP-seq
MIRT1142883	hsa-miR-455-5p	CLIP-seq
MIRT1142899	hsa-miR-4687-5p	CLIP-seq
MIRT1142900	hsa-miR-4766-3p	CLIP-seq
MIRT1142884	hsa-miR-4766-5p	CLIP-seq
MIRT1142885	hsa-miR-4772-3p	CLIP-seq
MIRT1142886	hsa-miR-4778-5p	CLIP-seq
MIRT1142888	hsa-miR-518a-5p	CLIP-seq
MIRT1142889	hsa-miR-527	CLIP-seq
MIRT1142901	hsa-miR-548a-3p	CLIP-seq
MIRT1142902	hsa-miR-548ae	CLIP-seq
MIRT1142903	hsa-miR-548aj	CLIP-seq
MIRT1142904	hsa-miR-548am	CLIP-seq
MIRT1142905	hsa-miR-548e	CLIP-seq
MIRT1142906	hsa-miR-548f	CLIP-seq
MIRT1142907	hsa-miR-548g	CLIP-seq
MIRT1142908	hsa-miR-548o	CLIP-seq
MIRT1142909	hsa-miR-548x	CLIP-seq
MIRT1142910	hsa-miR-607	CLIP-seq
MIRT2040674	hsa-miR-3667-3p	CLIP-seq
MIRT1142880	hsa-miR-3669	CLIP-seq
MIRT1142883	hsa-miR-455-5p	CLIP-seq
MIRT1142884	hsa-miR-4766-5p	CLIP-seq
MIRT1142891	hsa-miR-1267	CLIP-seq
MIRT2270387	hsa-miR-203	CLIP-seq
MIRT2270388	hsa-miR-219-1-3p	CLIP-seq
MIRT1142894	hsa-miR-3121-3p	CLIP-seq
MIRT2270389	hsa-miR-3132	CLIP-seq
MIRT1142895	hsa-miR-3154	CLIP-seq
MIRT1142897	hsa-miR-3613-5p	CLIP-seq
MIRT1142900	hsa-miR-4766-3p	CLIP-seq
MIRT2270390	hsa-miR-571	CLIP-seq
MIRT2270391	hsa-miR-582-3p	CLIP-seq
MIRT2040674	hsa-miR-3667-3p	CLIP-seq
MIRT2569579	hsa-miR-1202	CLIP-seq
MIRT2569580	hsa-miR-142-5p	CLIP-seq
MIRT2270387	hsa-miR-203	CLIP-seq
MIRT2270388	hsa-miR-219-1-3p	CLIP-seq
MIRT2569581	hsa-miR-3064-3p	CLIP-seq
MIRT2569582	hsa-miR-3157-3p	CLIP-seq
MIRT2569583	hsa-miR-3194-5p	CLIP-seq
MIRT2569584	hsa-miR-340	CLIP-seq
MIRT2569585	hsa-miR-3614-3p	CLIP-seq
MIRT2040674	hsa-miR-3667-3p	CLIP-seq
MIRT2569586	hsa-miR-3972	CLIP-seq
MIRT2569587	hsa-miR-4297	CLIP-seq
MIRT2569588	hsa-miR-4422	CLIP-seq
MIRT2569589	hsa-miR-4436b-5p	CLIP-seq
MIRT2569590	hsa-miR-4698	CLIP-seq
MIRT2270390	hsa-miR-571	CLIP-seq
MIRT2569579	hsa-miR-1202	CLIP-seq
MIRT2569580	hsa-miR-142-5p	CLIP-seq
MIRT2270387	hsa-miR-203	CLIP-seq
MIRT2270388	hsa-miR-219-1-3p	CLIP-seq
MIRT2569581	hsa-miR-3064-3p	CLIP-seq
MIRT2569582	hsa-miR-3157-3p	CLIP-seq
MIRT2569583	hsa-miR-3194-5p	CLIP-seq
MIRT2569584	hsa-miR-340	CLIP-seq
MIRT2569585	hsa-miR-3614-3p	CLIP-seq
MIRT2040674	hsa-miR-3667-3p	CLIP-seq
MIRT2569586	hsa-miR-3972	CLIP-seq
MIRT2569587	hsa-miR-4297	CLIP-seq
MIRT2569588	hsa-miR-4422	CLIP-seq
MIRT2569589	hsa-miR-4436b-5p	CLIP-seq
MIRT2684835	hsa-miR-4476	CLIP-seq
MIRT2684836	hsa-miR-4477b	CLIP-seq
MIRT2684837	hsa-miR-4533	CLIP-seq
MIRT2569590	hsa-miR-4698	CLIP-seq
MIRT2684838	hsa-miR-4759	CLIP-seq
MIRT2270390	hsa-miR-571	CLIP-seq
MIRT2040674	hsa-miR-3667-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21516116, 21840311, 25416956, 32296183, 33961781
GO:0005634	Component	Nucleus	HDA	16780588
GO:0005829	Component	Cytosol	HDA	16780588
GO:0005829	Component	Cytosol	TAS
GO:0032886	Process	Regulation of microtubule-based process	IMP	20937854

Other IDs

• MIM: 611786
• HGNC: 14014
• e!Ensembl: ENSG00000162959

Protein

• UniProt ID: Q9Y316
• Protein name: Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1)
• Protein function: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubul
• PDB: 3BCZ, 3BD0, 7KQ8, 7L5C, 7M8H
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01875	Memo	9 → 293	Memo-like protein	Family

• Sequence:

  MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAA
  HAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFE
  RMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADP
  SNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYH
  NTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH

• Sequence length: 297

Pathways

Reactome:

ERBB2 Regulates Cell Motility