DERA (deoxyribose-phosphate aldolase)

Gene

• Entrez ID: 51071
• Gene name: Deoxyribose-phosphate aldolase
• Gene symbol: DERA
• Synonyms (NCBI Gene): CGI-26, DEOC
• Chromosome: 12
• Chromosome location: 12p12.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029949	hsa-miR-26b-5p	Microarray	19088304
MIRT046612	hsa-miR-222-3p	CLASH	23622248
MIRT933057	hsa-miR-1238	CLIP-seq
MIRT933058	hsa-miR-3120-3p	CLIP-seq
MIRT933059	hsa-miR-3140-5p	CLIP-seq
MIRT933060	hsa-miR-3143	CLIP-seq
MIRT933061	hsa-miR-33a	CLIP-seq
MIRT933062	hsa-miR-33b	CLIP-seq
MIRT933063	hsa-miR-4436b-3p	CLIP-seq
MIRT933064	hsa-miR-4684-3p	CLIP-seq
MIRT933065	hsa-miR-4737	CLIP-seq
MIRT933066	hsa-miR-4761-3p	CLIP-seq
MIRT933067	hsa-miR-503	CLIP-seq
MIRT933068	hsa-miR-543	CLIP-seq
MIRT933069	hsa-miR-561	CLIP-seq
MIRT1976240	hsa-miR-214	CLIP-seq
MIRT1976241	hsa-miR-27a	CLIP-seq
MIRT1976242	hsa-miR-27b	CLIP-seq
MIRT933058	hsa-miR-3120-3p	CLIP-seq
MIRT1976243	hsa-miR-3619-5p	CLIP-seq
MIRT933065	hsa-miR-4737	CLIP-seq
MIRT933067	hsa-miR-503	CLIP-seq
MIRT1976244	hsa-miR-5096	CLIP-seq
MIRT1976245	hsa-miR-513a-5p	CLIP-seq
MIRT1976246	hsa-miR-635	CLIP-seq
MIRT1976247	hsa-miR-761	CLIP-seq
MIRT1976248	hsa-miR-889	CLIP-seq
MIRT1976240	hsa-miR-214	CLIP-seq
MIRT1976241	hsa-miR-27a	CLIP-seq
MIRT1976242	hsa-miR-27b	CLIP-seq
MIRT1976243	hsa-miR-3619-5p	CLIP-seq
MIRT1976244	hsa-miR-5096	CLIP-seq
MIRT1976245	hsa-miR-513a-5p	CLIP-seq
MIRT1976247	hsa-miR-761	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004139	Function	Deoxyribose-phosphate aldolase activity	IBA
GO:0004139	Function	Deoxyribose-phosphate aldolase activity	IDA	9226884
GO:0004139	Function	Deoxyribose-phosphate aldolase activity	IEA
GO:0004139	Function	Deoxyribose-phosphate aldolase activity	TAS
GO:0005515	Function	Protein binding	IPI	32296183, 33961781, 35271311
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006098	Process	Pentose-phosphate shunt	TAS
GO:0009264	Process	Deoxyribonucleotide catabolic process	IBA
GO:0009264	Process	Deoxyribonucleotide catabolic process	IEA
GO:0016052	Process	Carbohydrate catabolic process	IBA
GO:0016829	Function	Lyase activity	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0046121	Process	Deoxyribonucleoside catabolic process	IDA	9226884
GO:0046386	Process	Deoxyribose phosphate catabolic process	IEA
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 619668
• HGNC: 24269
• e!Ensembl: ENSG00000023697

Protein

• UniProt ID: Q9Y315
• Protein name: Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)
• Protein function: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in condi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01791	DeoC	49 → 298	DeoC/LacD family aldolase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Mainly expressed in liver, lung and colon. {ECO:0000269|PubMed:25229427}.
• Sequence:

  MSAHNRGTELDLSWISKIQVNHPAVLRRAEQIQARRTVKKEWQAAWLLKAVTFIDLTTLS
  GDDTSSNIQRLCYKAKYPIREDLLKALNMHDKGITTAAVCVYPARVCDAVKALKAAGCNI
  PVASVAAGFPAGQTHLKTRLEEIRLAVEDGATEIDVVINRSLVLTGQWEALYDEIRQFRK
  ACGEAHLKTILATGELGTLTNVYKASMIAMMAGSDFIKTSTGKETVNATFPVAIVMLRAI
  RDFFWKTGNKIGFKPAGGIRSAKDSLAWLSLVKEELGDEWLKPELFRIGASTLLSDIERQ
  IYHHVTGRYAAYHDLPMS

• Sequence length: 318

Pathways

KEGG:

Pentose phosphate pathway
Metabolic pathways

Reactome:

Neutrophil degranulation
Pentose phosphate pathway

<

Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Astrocytoma	Astrocytoma	N/A	N/A	GWAS
Glaucoma	Glaucoma	N/A	N/A	GWAS