DERA (deoxyribose-phosphate aldolase)

Gene

• Entrez ID: 51071
• Gene name: Deoxyribose-phosphate aldolase
• Gene symbol: DERA
• Synonyms (NCBI Gene): CGI-26, DEOC
• Chromosome: 12
• Chromosome location: 12p12.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029949	hsa-miR-26b-5p	Microarray	19088304
MIRT046612	hsa-miR-222-3p	CLASH	23622248
MIRT933057	hsa-miR-1238	CLIP-seq
MIRT933058	hsa-miR-3120-3p	CLIP-seq
MIRT933059	hsa-miR-3140-5p	CLIP-seq
MIRT933060	hsa-miR-3143	CLIP-seq
MIRT933061	hsa-miR-33a	CLIP-seq
MIRT933062	hsa-miR-33b	CLIP-seq
MIRT933063	hsa-miR-4436b-3p	CLIP-seq
MIRT933064	hsa-miR-4684-3p	CLIP-seq
MIRT933065	hsa-miR-4737	CLIP-seq
MIRT933066	hsa-miR-4761-3p	CLIP-seq
MIRT933067	hsa-miR-503	CLIP-seq
MIRT933068	hsa-miR-543	CLIP-seq
MIRT933069	hsa-miR-561	CLIP-seq
MIRT1976240	hsa-miR-214	CLIP-seq
MIRT1976241	hsa-miR-27a	CLIP-seq
MIRT1976242	hsa-miR-27b	CLIP-seq
MIRT933058	hsa-miR-3120-3p	CLIP-seq
MIRT1976243	hsa-miR-3619-5p	CLIP-seq
MIRT933065	hsa-miR-4737	CLIP-seq
MIRT933067	hsa-miR-503	CLIP-seq
MIRT1976244	hsa-miR-5096	CLIP-seq
MIRT1976245	hsa-miR-513a-5p	CLIP-seq
MIRT1976246	hsa-miR-635	CLIP-seq
MIRT1976247	hsa-miR-761	CLIP-seq
MIRT1976248	hsa-miR-889	CLIP-seq
MIRT1976240	hsa-miR-214	CLIP-seq
MIRT1976241	hsa-miR-27a	CLIP-seq
MIRT1976242	hsa-miR-27b	CLIP-seq
MIRT1976243	hsa-miR-3619-5p	CLIP-seq
MIRT1976244	hsa-miR-5096	CLIP-seq
MIRT1976245	hsa-miR-513a-5p	CLIP-seq
MIRT1976247	hsa-miR-761	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004139	Function	Deoxyribose-phosphate aldolase activity	IBA	21873635
GO:0004139	Function	Deoxyribose-phosphate aldolase activity	IDA	9226884
GO:0004139	Function	Deoxyribose-phosphate aldolase activity	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006098	Process	Pentose-phosphate shunt	TAS
GO:0009264	Process	Deoxyribonucleotide catabolic process	IBA	21873635
GO:0016052	Process	Carbohydrate catabolic process	IBA	21873635
GO:0034774	Component	Secretory granule lumen	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0046121	Process	Deoxyribonucleoside catabolic process	IDA	9226884
GO:0046386	Process	Deoxyribose phosphate catabolic process	IEA
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 619668
• HGNC: 24269
• e!Ensembl: ENSG00000023697

Protein

• UniProt ID: Q9Y315
• Protein name: Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)
• Protein function: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in condi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01791	DeoC	49 → 298	DeoC/LacD family aldolase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Mainly expressed in liver, lung and colon. {ECO:0000269|PubMed:25229427}.
• Sequence:

  MSAHNRGTELDLSWISKIQVNHPAVLRRAEQIQARRTVKKEWQAAWLLKAVTFIDLTTLS
  GDDTSSNIQRLCYKAKYPIREDLLKALNMHDKGITTAAVCVYPARVCDAVKALKAAGCNI
  PVASVAAGFPAGQTHLKTRLEEIRLAVEDGATEIDVVINRSLVLTGQWEALYDEIRQFRK
  ACGEAHLKTILATGELGTLTNVYKASMIAMMAGSDFIKTSTGKETVNATFPVAIVMLRAI
  RDFFWKTGNKIGFKPAGGIRSAKDSLAWLSLVKEELGDEWLKPELFRIGASTLLSDIERQ
  IYHHVTGRYAAYHDLPMS

• Sequence length: 318

Pathways

KEGG:

Pentose phosphate pathway
Metabolic pathways

Reactome:

Neutrophil degranulation
Pentose phosphate pathway

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	31371054
Glaucoma	Glaucoma	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644	25027321

Unknown
Disease term	Disease name	Evidence	References	Source
Astrocytoma	Astrocytoma			GWAS