FAM135B (family with sequence similarity 135 member B)

Gene

• Entrez ID: 51059
• Gene name: Family with sequence similarity 135 member B
• Gene symbol: FAM135B
• Synonyms (NCBI Gene): C8ORFK32
• Chromosome: 8
• Chromosome location: 8q24.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT572561	hsa-miR-361-3p	PAR-CLIP	20371350
MIRT572559	hsa-miR-615-3p	PAR-CLIP	20371350
MIRT572558	hsa-miR-2114-3p	PAR-CLIP	20371350
MIRT572557	hsa-miR-6823-3p	PAR-CLIP	20371350
MIRT572561	hsa-miR-361-3p	PAR-CLIP	20371350
MIRT572559	hsa-miR-615-3p	PAR-CLIP	20371350
MIRT572558	hsa-miR-2114-3p	PAR-CLIP	20371350
MIRT572557	hsa-miR-6823-3p	PAR-CLIP	20371350
MIRT980542	hsa-miR-127-5p	CLIP-seq
MIRT980543	hsa-miR-1298	CLIP-seq
MIRT980544	hsa-miR-186	CLIP-seq
MIRT980545	hsa-miR-203	CLIP-seq
MIRT980546	hsa-miR-21	CLIP-seq
MIRT980547	hsa-miR-3183	CLIP-seq
MIRT980548	hsa-miR-338-5p	CLIP-seq
MIRT980549	hsa-miR-3670	CLIP-seq
MIRT980550	hsa-miR-3677-5p	CLIP-seq
MIRT980551	hsa-miR-3976	CLIP-seq
MIRT980552	hsa-miR-4300	CLIP-seq
MIRT980553	hsa-miR-4436b-5p	CLIP-seq
MIRT980554	hsa-miR-451b	CLIP-seq
MIRT980555	hsa-miR-4659a-3p	CLIP-seq
MIRT980556	hsa-miR-4659b-3p	CLIP-seq
MIRT980557	hsa-miR-4699-3p	CLIP-seq
MIRT980558	hsa-miR-4723-3p	CLIP-seq
MIRT980559	hsa-miR-4753-3p	CLIP-seq
MIRT980560	hsa-miR-4766-5p	CLIP-seq
MIRT980561	hsa-miR-522	CLIP-seq
MIRT980562	hsa-miR-590-5p	CLIP-seq
MIRT980563	hsa-miR-621	CLIP-seq
MIRT980564	hsa-miR-627	CLIP-seq
MIRT980565	hsa-miR-653	CLIP-seq
MIRT980566	hsa-miR-920	CLIP-seq
MIRT980567	hsa-miR-939	CLIP-seq
MIRT1990494	hsa-miR-3686	CLIP-seq
MIRT1990495	hsa-miR-4264	CLIP-seq
MIRT2224681	hsa-miR-3150b-3p	CLIP-seq
MIRT2224682	hsa-miR-4434	CLIP-seq
MIRT2224683	hsa-miR-4516	CLIP-seq
MIRT2224684	hsa-miR-4691-5p	CLIP-seq
MIRT2224685	hsa-miR-4784	CLIP-seq
MIRT2224686	hsa-miR-520d-5p	CLIP-seq
MIRT2224687	hsa-miR-524-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0044255	Process	Cellular lipid metabolic process	IBA	21873635

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q49AJ0
• Protein name: Protein FAM135B
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12394	DUF3657	111 → 172	Protein FAM135	Family
  PF05057	DUF676	1135 → 1331	Putative serine esterase (DUF676)	Family

• Sequence:

  MSEIQGTVEFSVELHKFYNVDLFQRGYYQIRVTLKVSSRIPHRLSASIAGQTESSSLHSA
  CVHDSTVHSRVFQILYRNEEVPINDAVVFRVHLLLGGERMEDALSEVDFQLKVDLHFTDS
  EQQLRDVAGAPMVSSRTLGLHFHPRNGLHHQVPVMFDYFHLSVISVTVHAALVALQQPLI
  SFTRPGRGSWLGKGGPDTGQEQSIISLENLVFGAGYCKPTSSEGSFYITSENCMQHAHKW
  HRDLCLLLLHAYRGLRLHFLVIMRDIPELPHTELEALAVEETLSQLCSELQMLNNPEKIA
  EQISKDLAWLTSHMMTLWTQFLDTVTLHSQVTTYLTQEHHTLRVRRFSEAFFYMEHQKLA
  VLTFQENLIQTHSQLSLDIRNSEYLTSMPPLPAECLDIDGDWNTLPVIFEDRYVDCPATG
  HNLSVYPNFDVPVTSPTIMNLKDKEDNCMVNSNLSFREDLVLSTIKPSQMDSDEEVIRCP
  EPGENVATQNHMDMCSESQVYISIGEFQNKAGVPEDECWTGQTSDAGTYPVADVDTSRRS
  PGPEDGQAPVLTYIDVKSSNKNPSRAEPLVAFNAQHESRSSRDKYGLDRTGLSKVVVGGS
  HQNAISSDKTTLHELSTLGKGIDQEGKMVLLSLKLTPSEPCDPLSSTLREPLDIRSSLKD
  SHTEEQEELSVLSGVIKRSSSIISDSGIESEPSSVAWSEARSRALELPSDREVLHPFVRR
  HALHRNSLEGGHTESNTSLPSGIQASLTSISSLPFEEDEREVALTKLTKSVSAPHISSPE
  EAAEDADTKQQDGGFAEPSDMHSKSQGSPGSCSQLCGDSGTDAGADHPLVEIVLDADNQQ
  GPGYIDIPKGKGKQFDAQGHCLPDGRTENTPGVETKGLNLKIPRVIALENPRTRSLHRAL
  EETPKGMPKDLNVGQQALSNSGISEVEGLSQHQVPELSCTSAADAINRNSTGQQSQSGSP
  CIMDDTAFNRGVNAFPEAKHKAGTVCPTVTHSVHSQVLKNQELKAGTSIMGSHLTSAETF
  TLDSLKAVEVVNLSVSCTATCLPFSSVPKETPARAGFSSKQTLFPITHQPLGSFGVVSTH
  SSTLDEEVSERMFSFYQAKEKFKKELKIEGFLYSDLTVLASDIPYFPPEEEEENLEDGIH
  LVVCVHGLDGNSADLRLVKTFIELGLPGGKLDFLMSEKNQMDTFADFDTMTDRLLDEIIQ
  HIQLYNLSISRISFIGHSLGNIIIRSVLTRPRFRYYLNKLHTFLSLSGPHLGTLYNNSTL
  VSTGLWLMQKLKKSGSLLQLTFRDNADLRKCFLYQLSQKTGLQYFKNVVLVASPQDRYVP
  FHSARIEMCKTALKDRHTGPVYAEMINNLLGPLVEAKDCTLIRHNVFHALPNTANTLIGR
  AAHIAVLDSELFLEKFFLVAGLNYFK

• Sequence length: 1406

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542	22935194

Unknown
Disease term	Disease name	Evidence	References	Source
Neuroticism	Neuroticism			GWAS
Alzheimer disease	Alzheimer disease			GWAS
Mental Depression	Mental Depression			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Autistic Disorder	Associate	24204716
Melanoma Cutaneous Malignant	Associate	32639949
Neoplasms	Associate	32639949, 35610288
Pulmonary Disease Chronic Obstructive	Associate	35610288
Small Cell Lung Carcinoma	Associate	31199602
Squamous Cell Carcinoma of Head and Neck	Associate	29927694
Substance Related Disorders	Associate	37845746