ST8SIA3 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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51046 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ST8SIA3 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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SIAT8C, ST8SiaIII |
Chromosome
Chromosome number
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18 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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18q21.31 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008] |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | O43173 | ||||||||||
Protein name | Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8C) (Alpha-2,8-sialyltransferase III) (Ganglioside GD3 synthase ST8SIA3) (EC 2.4.3.8) (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3) (S | ||||||||||
Protein function | Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an acceptor, such as N-linked oligosaccharides of glycoproteins and glycolipids through alpha-2, | ||||||||||
PDB | 5BO6 , 5BO7 , 5BO8 , 5BO9 , 5CXY | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Expressed in fetal and adult brain and fetal liver. {ECO:0000269|PubMed:9826427}. | ||||||||||
Sequence |
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Sequence length | 380 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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