Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51046
Gene name Gene Name - the full gene name approved by the HGNC.
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ST8SIA3
Synonyms (NCBI Gene) Gene synonyms aliases
SIAT8C, ST8SiaIII
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.31
Summary Summary of gene provided in NCBI Entrez Gene.
ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT723465 hsa-miR-4425 HITS-CLIP 19536157
MIRT723464 hsa-miR-3147 HITS-CLIP 19536157
MIRT723463 hsa-miR-5701 HITS-CLIP 19536157
MIRT723462 hsa-miR-4273 HITS-CLIP 19536157
MIRT723461 hsa-miR-7156-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0001574 Process Ganglioside biosynthetic process IDA 10766765
GO:0003828 Function Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA 21873635
GO:0003828 Function Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA 9826427, 10766765
GO:0006486 Process Protein glycosylation IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609478 14269 ENSG00000177511
Protein
UniProt ID O43173
Protein name Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8C) (Alpha-2,8-sialyltransferase III) (Ganglioside GD3 synthase ST8SIA3) (EC 2.4.3.8) (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3) (S
Protein function Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an acceptor, such as N-linked oligosaccharides of glycoproteins and glycolipids through alpha-2,
PDB 5BO6 , 5BO7 , 5BO8 , 5BO9 , 5CXY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00777 Glyco_transf_29 113 376 Glycosyltransferase family 29 (sialyltransferase) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in fetal and adult brain and fetal liver. {ECO:0000269|PubMed:9826427}.
Sequence
Sequence length 380
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Sialic acid metabolism
N-Glycan antennae elongation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Associations from Text Mining
Disease Name Relationship Type References
Endometrial Neoplasms Associate 35832124
Glioblastoma Associate 37511403