DESI2 (desumoylating isopeptidase 2)

Gene

• Entrez ID: 51029
• Gene name: Desumoylating isopeptidase 2
• Gene symbol: DESI2
• Synonyms (NCBI Gene): C1orf121, CGI-146, DESI, DESI1, DeSI-2, FAM152A, PNAS-4, PPPDE1
• Chromosome: 1
• Chromosome location: 1q44

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT041187	hsa-miR-497-5p	CLASH	23622248

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Cysteine-type deubiquitinase activity	IDA	28483520
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0005515	Function	Protein binding	IPI	28483520, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008474	Function	Palmitoyl-(protein) hydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0052816	Function	Long-chain fatty acyl-CoA hydrolase activity	IDA	35427157
GO:0061578	Function	K63-linked deubiquitinase activity	IMP	28483520
GO:0098734	Process	Macromolecule depalmitoylation	IEA
GO:0101005	Function	Deubiquitinase activity	IBA
GO:1990380	Function	K48-linked deubiquitinase activity	IMP	28483520

Other IDs

• MIM: 614638
• HGNC: 24264
• e!Ensembl: ENSG00000121644

Protein

• UniProt ID: Q9BSY9
• Protein name: Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing protein 1) (Palmitoyl protein thioesterase DESI2) (EC 3.1.2.22) (Protein FAM152A) (S-depalmitoylase DESI2)
• Protein function: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520). Exhibits palmitoyl protein thioesterase (S-depal
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05903	Peptidase_C97	5 → 149	PPPDE putative peptidase domain	Domain

• Sequence:

  MGANQLVVLNVYDMYWMNEYTSSIGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNA
  SELGETFKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHKNCNHFSSALSEILC
  GKEIPRWINRLAYFSSCIPFLQSCLPKEWLTPAALQSSVSQELQDELEEAEDAAASASVA
  STAAGSRPGRHTKL

• Sequence length: 194