Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5101
Gene name	Protocadherin 9
Gene symbol	PCDH9
Synonyms (NCBI Gene)	-
Chromosome	13
Chromosome location	13q21.32
Summary	This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may be involved

Show/Hide all (75)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020565	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT053695	hsa-miR-188-5p	Microarray	22942087
MIRT449552	hsa-miR-548m	PAR-CLIP	22100165
MIRT449551	hsa-miR-548ag	PAR-CLIP	22100165
MIRT449550	hsa-miR-548ai	PAR-CLIP	22100165
MIRT449549	hsa-miR-548ba	PAR-CLIP	22100165
MIRT449548	hsa-miR-570-5p	PAR-CLIP	22100165
MIRT449547	hsa-miR-18a-5p	PAR-CLIP	22100165
MIRT449546	hsa-miR-18b-5p	PAR-CLIP	22100165
MIRT449544	hsa-miR-4735-3p	PAR-CLIP	22100165
MIRT449545	hsa-miR-1264	PAR-CLIP	22100165
MIRT449542	hsa-miR-4635	PAR-CLIP	22100165
MIRT449543	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT449541	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT734654	hsa-miR-1260b	Western blottingMicroarrayqRT-PCR	32523124
MIRT449552	hsa-miR-548m	PAR-CLIP	22100165
MIRT449551	hsa-miR-548ag	PAR-CLIP	22100165
MIRT449550	hsa-miR-548ai	PAR-CLIP	22100165
MIRT449549	hsa-miR-548ba	PAR-CLIP	22100165
MIRT449548	hsa-miR-570-5p	PAR-CLIP	22100165
MIRT449547	hsa-miR-18a-5p	PAR-CLIP	22100165
MIRT449546	hsa-miR-18b-5p	PAR-CLIP	22100165
MIRT449544	hsa-miR-4735-3p	PAR-CLIP	22100165
MIRT449545	hsa-miR-1264	PAR-CLIP	22100165
MIRT449542	hsa-miR-4635	PAR-CLIP	22100165
MIRT449543	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT449541	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT1216917	hsa-miR-1303	CLIP-seq
MIRT1216918	hsa-miR-204	CLIP-seq
MIRT1216919	hsa-miR-211	CLIP-seq
MIRT1216920	hsa-miR-3065-5p	CLIP-seq
MIRT1216921	hsa-miR-583	CLIP-seq
MIRT1216922	hsa-miR-1305	CLIP-seq
MIRT1216923	hsa-miR-141	CLIP-seq
MIRT1216924	hsa-miR-200a	CLIP-seq
MIRT1216920	hsa-miR-3065-5p	CLIP-seq
MIRT1216925	hsa-miR-382	CLIP-seq
MIRT1216926	hsa-miR-421	CLIP-seq
MIRT1216927	hsa-miR-4522	CLIP-seq
MIRT1216928	hsa-miR-4727-5p	CLIP-seq
MIRT1216929	hsa-miR-4769-3p	CLIP-seq
MIRT2062608	hsa-miR-124	CLIP-seq
MIRT1216920	hsa-miR-3065-5p	CLIP-seq
MIRT2062609	hsa-miR-3146	CLIP-seq
MIRT2062610	hsa-miR-330-3p	CLIP-seq
MIRT2062611	hsa-miR-4470	CLIP-seq
MIRT2062612	hsa-miR-4493	CLIP-seq
MIRT2062613	hsa-miR-506	CLIP-seq
MIRT2062614	hsa-miR-802	CLIP-seq
MIRT2291032	hsa-miR-103b	CLIP-seq
MIRT2291033	hsa-miR-1206	CLIP-seq
MIRT2291034	hsa-miR-1256	CLIP-seq
MIRT2291035	hsa-miR-320a	CLIP-seq
MIRT2291036	hsa-miR-320b	CLIP-seq
MIRT2291037	hsa-miR-320c	CLIP-seq
MIRT2291038	hsa-miR-320d	CLIP-seq
MIRT2291039	hsa-miR-376a	CLIP-seq
MIRT2291040	hsa-miR-376b	CLIP-seq
MIRT2291041	hsa-miR-4274	CLIP-seq
MIRT2291042	hsa-miR-4427	CLIP-seq
MIRT2291043	hsa-miR-4429	CLIP-seq
MIRT2291044	hsa-miR-4645-5p	CLIP-seq
MIRT2291045	hsa-miR-4673	CLIP-seq
MIRT2291046	hsa-miR-4722-3p	CLIP-seq
MIRT2291047	hsa-miR-4755-3p	CLIP-seq
MIRT2291034	hsa-miR-1256	CLIP-seq
MIRT2588720	hsa-miR-1263	CLIP-seq
MIRT2588721	hsa-miR-138	CLIP-seq
MIRT2588722	hsa-miR-338-5p	CLIP-seq
MIRT2291044	hsa-miR-4645-5p	CLIP-seq
MIRT2291045	hsa-miR-4673	CLIP-seq
MIRT2291046	hsa-miR-4722-3p	CLIP-seq
MIRT2588723	hsa-miR-4728-3p	CLIP-seq
MIRT2291047	hsa-miR-4755-3p	CLIP-seq
MIRT2588724	hsa-miR-495	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence
GO:0005509	Function	Calcium ion binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0016020	Component	Membrane	IEA
GO:0030426	Component	Growth cone	IEA
GO:0030900	Process	Forebrain development	IEA
GO:0044291	Component	Cell-cell contact zone	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA
GO:0097060	Component	Synaptic membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
603581	8661	ENSG00000184226

Q9HC56

Protein name

Protocadherin-9

Protein function

Potential calcium-dependent cell-adhesion protein.

PDB

2EE0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08266	Cadherin_2	25 → 118	Cadherin-like	Domain
PF00028	Cadherin	147 → 243	Cadherin domain	Domain
PF00028	Cadherin	257 → 349	Cadherin domain	Domain
PF00028	Cadherin	370 → 460	Cadherin domain	Domain
PF00028	Cadherin	474 → 563	Cadherin domain	Domain
PF00028	Cadherin	577 → 666	Cadherin domain	Domain
PF00028	Cadherin	687 → 772	Cadherin domain	Domain
PF08374	Protocadherin	777 → 1000	Protocadherin	Family

Sequence

MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSA
SLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPN
DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYE
LLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQV
TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK
RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDL
RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL
LETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSE
NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF
TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD
AGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAK
VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG
NNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN
ASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRH
ASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPI
NGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKK
HHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSD
NIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLI
SHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSD
NCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGS
NEGHFNNGSHMTDIPLANLKSYKQAGGATESPKEHQL

Sequence length

1237

Interactions

View interactions

	KEGG
	Virion - Lassa virus and SFTS virus

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
PCDH9-related disorder	Uncertain significance; Likely benign	rs2502338044, rs1010987405, rs555154692, rs2502330210, rs146006048, rs775537328	RCV003393050 RCV003405827 RCV003404451 RCV003899804 RCV003934757 RCV003983639

Show/Hide Text Mining Associations (22)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Auditory Neuropathy Autosomal Dominant 1	Associate	19353688
Autism Spectrum Disorder	Associate	18252227, 36150388
Autistic Disorder	Associate	24204716, 36150388, 39766876
Blast Crisis	Associate	33557955
Breast Neoplasms	Associate	36936167, 37144994
Carcinoma Hepatocellular	Associate	25172662, 28791409
Cerebral Palsy	Associate	33557955
Dermatitis Atopic	Associate	25935106
Dystonia	Associate	33557955
Ehlers Danlos syndrome type 3	Associate	27518164
Essential Tremor	Associate	36183486
Glioblastoma	Associate	18828157
Glioma	Associate	28055966
Hemangioblastoma	Associate	28742274
Leukemia Lymphocytic Chronic B Cell	Associate	37629695
Lymphoma Mantle Cell	Associate	22150124
Motor Neuron Disease	Associate	33557955
Neoplasm Metastasis	Inhibit	25172662
Neoplasms	Inhibit	18828157, 28791409, 29267965
Neoplasms	Associate	25172662
Portal Vein Cavernous Transformation Of	Associate	25172662
Seizures	Associate	33557955

PCDH9 (protocadherin 9)