AMDHD2 (amidohydrolase domain containing 2)

Gene

• Entrez ID: 51005
• Gene name: Amidohydrolase domain containing 2
• Gene symbol: AMDHD2
• Synonyms (NCBI Gene): CGI-14
• Chromosome: 16
• Chromosome location: 16p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030119	hsa-miR-26b-5p	Microarray	19088304
MIRT641278	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT641277	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT641276	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT641275	hsa-miR-4267	HITS-CLIP	23824327
MIRT641274	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT641272	hsa-miR-4308	HITS-CLIP	23824327
MIRT641273	hsa-miR-4254	HITS-CLIP	23824327
MIRT641271	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT641270	hsa-miR-4786-5p	HITS-CLIP	23824327
MIRT641269	hsa-miR-139-3p	HITS-CLIP	23824327
MIRT530740	hsa-miR-7844-5p	PAR-CLIP	22012620
MIRT530739	hsa-miR-6856-3p	PAR-CLIP	22012620
MIRT530738	hsa-miR-3922-5p	PAR-CLIP	22012620
MIRT530737	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT530736	hsa-miR-5685	PAR-CLIP	22012620
MIRT530735	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT530734	hsa-miR-1260a	PAR-CLIP	22012620
MIRT530733	hsa-miR-1260b	PAR-CLIP	22012620
MIRT641278	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT641277	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT641276	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT641275	hsa-miR-4267	HITS-CLIP	23824327
MIRT641274	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT641272	hsa-miR-4308	HITS-CLIP	23824327
MIRT641273	hsa-miR-4254	HITS-CLIP	23824327
MIRT641271	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT641270	hsa-miR-4786-5p	HITS-CLIP	23824327
MIRT641269	hsa-miR-139-3p	HITS-CLIP	23824327
MIRT530740	hsa-miR-7844-5p	PAR-CLIP	22012620
MIRT530739	hsa-miR-6856-3p	PAR-CLIP	22012620
MIRT530738	hsa-miR-3922-5p	PAR-CLIP	22012620
MIRT530737	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT530736	hsa-miR-5685	PAR-CLIP	22012620
MIRT530735	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT530734	hsa-miR-1260a	PAR-CLIP	22012620
MIRT530733	hsa-miR-1260b	PAR-CLIP	22012620
MIRT1930103	hsa-miR-4292	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 29892012
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006046	Process	N-acetylglucosamine catabolic process	IBA	21873635
GO:0006048	Process	UDP-N-acetylglucosamine biosynthetic process	TAS
GO:0008448	Function	N-acetylglucosamine-6-phosphate deacetylase activity	IBA	21873635
GO:0008448	Function	N-acetylglucosamine-6-phosphate deacetylase activity	IDA	22692205
GO:0008448	Function	N-acetylglucosamine-6-phosphate deacetylase activity	TAS
GO:0019262	Process	N-acetylneuraminate catabolic process	IEA
GO:0019262	Process	N-acetylneuraminate catabolic process	TAS	22692205
GO:0046872	Function	Metal ion binding	IEA
GO:0047419	Function	N-acetylgalactosamine-6-phosphate deacetylase activity	IEA

Other IDs

• MIM: 620864
• HGNC: 24262
• e!Ensembl: ENSG00000162066

Protein

• UniProt ID: Q9Y303
• Protein name: N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) (EC 3.5.1.25) (Amidohydrolase domain-containing protein 2)
• Protein function: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5G
• PDB: 7NUT, 7NUU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01979	Amidohydro_1	62 → 401	Amidohydrolase family	Domain

• Sequence:

  MRGEQGAAGARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGG
  RILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCPTLVTSPPEVYHK
  VVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEAHLRSFEADAFQDLLATYGPLDN
  VRIVTLAPELGRSHEVIRALTARGICVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPF
  HHRDPGIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALG
  LGNGRHTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLH
  PAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADAARQ

• Sequence length: 409

Pathways

KEGG:

Amino sugar and nucleotide sugar metabolism
Metabolic pathways

Reactome:

Synthesis of UDP-N-acetyl-glucosamine

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208