Gene Gene information from NCBI Gene database.
Entrez ID 50999
Gene name Transmembrane p24 trafficking protein 5
Gene symbol TMED5
Synonyms (NCBI Gene)
CGI-100p24g2p28
Chromosome 1
Chromosome location 1p22.1
miRNA miRNA information provided by mirtarbase database.
947
miRTarBase ID miRNA Experiments Reference
MIRT019961 hsa-miR-375 Microarray 20215506
MIRT028593 hsa-miR-30a-5p Proteomics 18668040
MIRT029986 hsa-miR-26b-5p Microarray 19088304
MIRT032422 hsa-let-7b-5p Proteomics 18668040
MIRT046138 hsa-miR-30b-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 23455924, 32296183
GO:0005783 Component Endoplasmic reticulum IBA
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0005793 Component Endoplasmic reticulum-Golgi intermediate compartment IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616876 24251 ENSG00000117500
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y3A6
Protein name Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28)
Protein function Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicl
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01105 EMP24_GP25L 35 222 emp24/gp25L/p24 family/GOLD Domain
Sequence
Sequence length 229
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    WNT ligand biogenesis and trafficking
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinoma Hepatocellular Associate 36530030
★☆☆☆☆
Found in Text Mining only
Ovarian Neoplasms Associate 36657061
★☆☆☆☆
Found in Text Mining only
Uterine Cervical Neoplasms Associate 36530030
★☆☆☆☆
Found in Text Mining only