Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5096
Gene name Gene Name - the full gene name approved by the HGNC.	Propionyl-CoA carboxylase subunit beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PCCB
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits.

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SNP ID	Visualize variation	Clinical significance	Consequence
rs77820367	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs111033542	C>T	Pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs121964959	C>A,T	Pathogenic-likely-pathogenic, likely-benign	Missense variant, synonymous variant, coding sequence variant, genic downstream transcript variant
rs121964960	G>A	Pathogenic-likely-pathogenic	Missense variant, coding sequence variant
rs121964961	A>G,T	Pathogenic-likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs145628302	A>G,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant, genic downstream transcript variant
rs150555106	G>A	Uncertain-significance, likely-benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs186031457	C>T	Pathogenic	Coding sequence variant, stop gained
rs186710233	C>A,T	Pathogenic	Coding sequence variant, genic downstream transcript variant, missense variant
rs199769617	T>A	Conflicting-interpretations-of-pathogenicity	Intron variant
rs202247817	G>T	Pathogenic	Coding sequence variant, stop gained
rs202247818	G>A	Pathogenic	Coding sequence variant, missense variant
rs202247819	G>C	Pathogenic	Coding sequence variant, missense variant
rs202247820	C>T	Pathogenic	Coding sequence variant, genic downstream transcript variant, stop gained
rs202247821	->CCC	Pathogenic	Coding sequence variant, genic downstream transcript variant, inframe insertion
rs202247822	T>C	Pathogenic	Coding sequence variant, genic downstream transcript variant, missense variant
rs202247823	A>G	Pathogenic, pathogenic-likely-pathogenic	Coding sequence variant, genic downstream transcript variant, missense variant
rs374722096	C>T	Pathogenic	Coding sequence variant, missense variant
rs397507445	GGGCATCATCCGGC>TAGAGCACAGGA	Pathogenic	Genic downstream transcript variant, coding sequence variant, frameshift variant
rs398123460	G>A	Pathogenic	Splice donor variant
rs398123462	T>A	Pathogenic	Initiator codon variant, missense variant
rs398123463	TT>AAC	Pathogenic	Coding sequence variant, stop gained
rs398123464	G>A	Pathogenic	Initiator codon variant, missense variant
rs572246667	C>A,T	Likely-pathogenic, pathogenic	Coding sequence variant, stop gained, synonymous variant
rs587776758	TT>-,TTT	Pathogenic	Genic downstream transcript variant, coding sequence variant, downstream transcript variant, frameshift variant
rs746102997	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs748393514	->C	Pathogenic	Coding sequence variant, frameshift variant
rs749908889	C>G,T	Pathogenic-likely-pathogenic	Stop gained, coding sequence variant, genic downstream transcript variant, missense variant
rs751538672	C>T	Pathogenic-likely-pathogenic	Coding sequence variant, genic downstream transcript variant, missense variant
rs752377212	A>G	Likely-pathogenic	Splice acceptor variant
rs753981900	C>T	Likely-pathogenic	Stop gained, coding sequence variant
rs754664563	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs755776820	TT>-	Pathogenic-likely-pathogenic	Frameshift variant, coding sequence variant
rs756414710	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs758309460	T>-	Pathogenic	Genic downstream transcript variant, frameshift variant, coding sequence variant
rs768935968	C>T	Pathogenic	Coding sequence variant, genic downstream transcript variant, stop gained
rs769521436	A>G	Pathogenic-likely-pathogenic	Coding sequence variant, genic downstream transcript variant, missense variant
rs769968548	->C,CC	Likely-pathogenic	Coding sequence variant, frameshift variant
rs774249198	C>A,G	Likely-pathogenic	Coding sequence variant, missense variant
rs777027944	G>A	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs777455573	->A	Likely-pathogenic	Coding sequence variant, frameshift variant
rs778742647	G>A	Conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, missense variant, coding sequence variant
rs781556055	A>C,G	Likely-benign, conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, coding sequence variant, synonymous variant
rs786200983	T>-,TT	Pathogenic	Frameshift variant, stop gained, coding sequence variant
rs794727092	G>C,T	Pathogenic, likely-pathogenic	Splice donor variant, genic downstream transcript variant
rs796052021	->G	Pathogenic, likely-pathogenic	Frameshift variant, coding sequence variant
rs796052022	A>-	Pathogenic	Splice acceptor variant
rs796052023	TGA>-	Likely-pathogenic	Inframe deletion, coding sequence variant
rs797044729	->AAGATCTGCAAA	Pathogenic	Inframe insertion, coding sequence variant
rs879253813	G>A,T	Conflicting-interpretations-of-pathogenicity	Intron variant
rs879253814	T>C	Pathogenic-likely-pathogenic	Splice donor variant
rs879253815	C>T	Pathogenic-likely-pathogenic	Missense variant, coding sequence variant
rs879253816	T>C	Pathogenic	Splice donor variant, genic downstream transcript variant
rs886044246	G>A	Pathogenic, likely-pathogenic	Splice acceptor variant
rs1021206121	A>C,G	Likely-pathogenic	Coding sequence variant, missense variant
rs1196443543	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs1249235758	CTTTCT>-	Pathogenic	Intron variant, genic downstream transcript variant, downstream transcript variant
rs1292452485	T>C,G	Likely-pathogenic	Missense variant, stop gained, coding sequence variant
rs1304714042	G>A	Pathogenic-likely-pathogenic	Missense variant, coding sequence variant
rs1317017233	G>A,T	Likely-pathogenic	Splice donor variant
rs1353971489	TTG>-	Pathogenic	Inframe deletion, coding sequence variant
rs1385850128	G>T	Pathogenic	Splice donor variant
rs1391142709	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1553774015	A>G	Likely-pathogenic	Splice acceptor variant
rs1553774018	G>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1553774884	G>-,GG,GGG	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1553777571	->GG	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1553777590	G>C	Likely-pathogenic	Splice donor variant
rs1553778912	G>A	Likely-pathogenic	Splice donor variant
rs1553778914	T>A,G	Likely-pathogenic	Splice donor variant
rs1553779458	G>C	Likely-pathogenic	Splice donor variant
rs1553780163	A>G	Likely-pathogenic	Splice acceptor variant
rs1553782747	A>C	Likely-pathogenic	Splice acceptor variant
rs1553782779	T>C	Likely-pathogenic	Splice donor variant
rs1553784569	->T	Likely-pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant
rs1553784684	A>C	Likely-pathogenic	Splice acceptor variant, genic downstream transcript variant
rs1553784721	TTGCAGT>-	Likely-pathogenic	Frameshift variant, genic downstream transcript variant, coding sequence variant
rs1553784921	G>T	Likely-pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant
rs1559995259	ACTAAATTGTCTGTGATGACATCACTGAGTGATCTTTGTTCCATTGTAGGGAAA>TGCTTTGCTTGCTTTGCTTTGCTTT	Pathogenic	Splice acceptor variant, intron variant, coding sequence variant
rs1576327011	A>G	Pathogenic	Intron variant
rs1576337935	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs1576360488	G>-	Pathogenic	Frameshift variant, coding sequence variant, genic downstream transcript variant
rs1576360539	G>A	Likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1576360934	C>T	Likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1576360976	C>T	Likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1576361811	->ATGT	Pathogenic	Frameshift variant, coding sequence variant, genic downstream transcript variant
rs1576397633	GCGC>CCT	Pathogenic	Frameshift variant, coding sequence variant
rs1576402832	T>C	Likely-pathogenic	Missense variant, coding sequence variant

Show/Hide all(206)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020658	hsa-miR-155-5p	Proteomics	18668040
MIRT029293	hsa-miR-26b-5p	Microarray	19088304
MIRT032255	hsa-let-7b-5p	Proteomics	18668040
MIRT043905	hsa-miR-378a-3p	CLASH	23622248
MIRT039868	hsa-miR-615-3p	CLASH	23622248
MIRT680722	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT680721	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT680720	hsa-miR-3174	HITS-CLIP	23706177
MIRT680719	hsa-miR-4257	HITS-CLIP	23706177
MIRT680718	hsa-miR-1827	HITS-CLIP	23706177
MIRT680717	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT680716	hsa-miR-6086	HITS-CLIP	23706177
MIRT680715	hsa-miR-4785	HITS-CLIP	23706177
MIRT680714	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT680713	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT680712	hsa-miR-3612	HITS-CLIP	23706177
MIRT680711	hsa-miR-650	HITS-CLIP	23706177
MIRT680710	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT680709	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT676348	hsa-miR-455-5p	HITS-CLIP	23824327
MIRT676347	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676346	hsa-miR-4324	HITS-CLIP	23824327
MIRT676345	hsa-miR-544b	HITS-CLIP	23824327
MIRT676344	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676343	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676342	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676341	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676340	hsa-miR-1976	HITS-CLIP	23824327
MIRT676339	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT676338	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT676337	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT676336	hsa-miR-612	HITS-CLIP	23824327
MIRT676335	hsa-miR-6860	HITS-CLIP	23824327
MIRT676334	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676333	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676332	hsa-miR-3945	HITS-CLIP	23824327
MIRT676331	hsa-miR-4253	HITS-CLIP	23824327
MIRT676330	hsa-miR-6862-5p	HITS-CLIP	23824327
MIRT676326	hsa-miR-1200	HITS-CLIP	23824327
MIRT676325	hsa-miR-4279	HITS-CLIP	23824327
MIRT676323	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT679008	hsa-miR-498	HITS-CLIP	23824327
MIRT676348	hsa-miR-455-5p	HITS-CLIP	23824327
MIRT676347	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676346	hsa-miR-4324	HITS-CLIP	23824327
MIRT676345	hsa-miR-544b	HITS-CLIP	23824327
MIRT676344	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676343	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676342	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676341	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676340	hsa-miR-1976	HITS-CLIP	23824327
MIRT676339	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT676338	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT676337	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT676336	hsa-miR-612	HITS-CLIP	23824327
MIRT676335	hsa-miR-6860	HITS-CLIP	23824327
MIRT676334	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676333	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676332	hsa-miR-3945	HITS-CLIP	23824327
MIRT676331	hsa-miR-4253	HITS-CLIP	23824327
MIRT676330	hsa-miR-6862-5p	HITS-CLIP	23824327
MIRT676329	hsa-miR-1271-3p	HITS-CLIP	23824327
MIRT676328	hsa-miR-550a-3-5p	HITS-CLIP	23824327
MIRT676327	hsa-miR-550a-5p	HITS-CLIP	23824327
MIRT676326	hsa-miR-1200	HITS-CLIP	23824327
MIRT676325	hsa-miR-4279	HITS-CLIP	23824327
MIRT676323	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT676324	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT676322	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT566490	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566490	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566489	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT566486	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT566488	hsa-miR-4311	PAR-CLIP	20371350
MIRT452644	hsa-miR-3714	PAR-CLIP	20371350
MIRT566487	hsa-miR-3910	PAR-CLIP	20371350
MIRT566486	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT566485	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT566484	hsa-miR-7161-3p	PAR-CLIP	20371350
MIRT566483	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT566482	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT452645	hsa-miR-548an	PAR-CLIP	23592263
MIRT452644	hsa-miR-3714	PAR-CLIP	23592263
MIRT452643	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT452642	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT452641	hsa-miR-940	PAR-CLIP	23592263
MIRT452640	hsa-miR-4790-3p	PAR-CLIP	23592263
MIRT452639	hsa-miR-3166	PAR-CLIP	23592263
MIRT452638	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT452637	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT452635	hsa-miR-5187-5p	PAR-CLIP	23592263
MIRT452636	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT452634	hsa-miR-1257	PAR-CLIP	23592263
MIRT452633	hsa-miR-6728-5p	PAR-CLIP	23592263
MIRT680718	hsa-miR-1827	PAR-CLIP	26701625
MIRT680722	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT680714	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT680720	hsa-miR-3174	PAR-CLIP	26701625
MIRT680712	hsa-miR-3612	PAR-CLIP	26701625
MIRT680717	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT680719	hsa-miR-4257	PAR-CLIP	26701625
MIRT680710	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT680715	hsa-miR-4785	PAR-CLIP	26701625
MIRT680716	hsa-miR-6086	PAR-CLIP	26701625
MIRT680713	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT680711	hsa-miR-650	PAR-CLIP	26701625
MIRT680721	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT680709	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT680722	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT680721	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT680720	hsa-miR-3174	HITS-CLIP	23706177
MIRT680719	hsa-miR-4257	HITS-CLIP	23706177
MIRT680718	hsa-miR-1827	HITS-CLIP	23706177
MIRT680717	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT680716	hsa-miR-6086	HITS-CLIP	23706177
MIRT680715	hsa-miR-4785	HITS-CLIP	23706177
MIRT680714	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT680713	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT680712	hsa-miR-3612	HITS-CLIP	23706177
MIRT680711	hsa-miR-650	HITS-CLIP	23706177
MIRT680710	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT680709	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT676348	hsa-miR-455-5p	HITS-CLIP	23824327
MIRT676347	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676346	hsa-miR-4324	HITS-CLIP	23824327
MIRT676345	hsa-miR-544b	HITS-CLIP	23824327
MIRT676344	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676343	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676342	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676341	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676340	hsa-miR-1976	HITS-CLIP	23824327
MIRT676339	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT676338	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT676337	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT676336	hsa-miR-612	HITS-CLIP	23824327
MIRT676335	hsa-miR-6860	HITS-CLIP	23824327
MIRT676334	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676333	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676332	hsa-miR-3945	HITS-CLIP	23824327
MIRT676331	hsa-miR-4253	HITS-CLIP	23824327
MIRT676330	hsa-miR-6862-5p	HITS-CLIP	23824327
MIRT676326	hsa-miR-1200	HITS-CLIP	23824327
MIRT676325	hsa-miR-4279	HITS-CLIP	23824327
MIRT676323	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT679008	hsa-miR-498	HITS-CLIP	23824327
MIRT676348	hsa-miR-455-5p	HITS-CLIP	23824327
MIRT676347	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676346	hsa-miR-4324	HITS-CLIP	23824327
MIRT676345	hsa-miR-544b	HITS-CLIP	23824327
MIRT676344	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676343	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676342	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676341	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676340	hsa-miR-1976	HITS-CLIP	23824327
MIRT676339	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT676338	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT676337	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT676336	hsa-miR-612	HITS-CLIP	23824327
MIRT676335	hsa-miR-6860	HITS-CLIP	23824327
MIRT676334	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676333	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676332	hsa-miR-3945	HITS-CLIP	23824327
MIRT676331	hsa-miR-4253	HITS-CLIP	23824327
MIRT676330	hsa-miR-6862-5p	HITS-CLIP	23824327
MIRT676329	hsa-miR-1271-3p	HITS-CLIP	23824327
MIRT676328	hsa-miR-550a-3-5p	HITS-CLIP	23824327
MIRT676327	hsa-miR-550a-5p	HITS-CLIP	23824327
MIRT676326	hsa-miR-1200	HITS-CLIP	23824327
MIRT676325	hsa-miR-4279	HITS-CLIP	23824327
MIRT676323	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT676324	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT676322	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT566490	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566490	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566489	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT566486	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT566488	hsa-miR-4311	PAR-CLIP	20371350
MIRT452644	hsa-miR-3714	PAR-CLIP	20371350
MIRT566487	hsa-miR-3910	PAR-CLIP	20371350
MIRT566486	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT566485	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT566484	hsa-miR-7161-3p	PAR-CLIP	20371350
MIRT566483	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT566482	hsa-miR-582-5p	PAR-CLIP	20371350
MIRT452645	hsa-miR-548an	PAR-CLIP	23592263
MIRT452644	hsa-miR-3714	PAR-CLIP	23592263
MIRT452643	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT452642	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT452641	hsa-miR-940	PAR-CLIP	23592263
MIRT452640	hsa-miR-4790-3p	PAR-CLIP	23592263
MIRT452639	hsa-miR-3166	PAR-CLIP	23592263
MIRT452638	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT452637	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT452635	hsa-miR-5187-5p	PAR-CLIP	23592263
MIRT452636	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT452634	hsa-miR-1257	PAR-CLIP	23592263
MIRT452633	hsa-miR-6728-5p	PAR-CLIP	23592263
MIRT1216559	hsa-miR-1324	CLIP-seq
MIRT1216560	hsa-miR-4645-3p	CLIP-seq
MIRT1216559	hsa-miR-1324	CLIP-seq
MIRT2290925	hsa-miR-4277	CLIP-seq
MIRT2290926	hsa-miR-433	CLIP-seq
MIRT1216560	hsa-miR-4645-3p	CLIP-seq
MIRT2290927	hsa-miR-4760-3p	CLIP-seq
MIRT2290928	hsa-miR-518a-5p	CLIP-seq
MIRT2290929	hsa-miR-527	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004658	Function	Propionyl-CoA carboxylase activity	IBA
GO:0004658	Function	Propionyl-CoA carboxylase activity	IDA	6765947
GO:0004658	Function	Propionyl-CoA carboxylase activity	IEA
GO:0005515	Function	Protein binding	IPI	20725044, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	8188292
GO:0005759	Component	Mitochondrial matrix	IDA	16023992
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	NAS	29033250
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006631	Process	Fatty acid metabolic process	NAS	29033250
GO:0009062	Process	Fatty acid catabolic process	IEA
GO:0009081	Process	Branched-chain amino acid metabolic process	NAS	29033250
GO:0016874	Function	Ligase activity	IEA
GO:0019626	Process	Short-chain fatty acid catabolic process	IC	6765947
GO:1902494	Component	Catalytic complex	IPI	20725044

MIM	HGNC	e!Ensembl
232050	8654	ENSG00000114054

Protein

UniProt ID

P05166

Protein name

Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)

Protein function

This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other

PDB

7YBU , 8XL3 , 8XL4 , 8XL5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01039	Carboxyl_trans	57 → 537	Carboxyl transferase domain	Family

Sequence

MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHK
RGKLTARERISLLLDPGSFVESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLVY
VFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIF
LRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPDVVKSVTNEDVT
QEELGGAKTHTTMSGVAHRAFENDVDALCNLRDFFNYLPLSSQDPAPVRECHDPSDRLVP
ELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPK
VASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFA
EATVPKVTVITRKAYGGAYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFKGHENVE
AAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKVQRPWRKHANIPL

Sequence length

539

Interactions

View interactions

	KEGG		Reactome
	Valine, leucine and isoleucine degradation Glyoxylate and dicarboxylate metabolism Propanoate metabolism Metabolic pathways Carbon metabolism		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Propionic acidemia	propionic acidemia	rs751538672, rs777027944, rs1553778912, rs121964961, rs1576337935, rs1553777590, rs398123464, rs1933813724, rs1553784721, rs879253816, rs1553779458, rs1576327011, rs1576360488, rs769968548, rs786200983 View all (68 more)	N/A

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Hypertension	Hypertension (confirmatory factor analysis Factor 12)	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Autism Spectrum Disorder	Associate	32490597
Cardiomyopathies	Associate	19238581
Genetic Diseases Inborn	Associate	27578510, 9683601
Methylmalonic acidemia	Associate	17966092
Mitochondrial Diseases	Associate	32490597
Propionic Acidemia	Associate	10353789, 10820128, 12757933, 15949719, 17966092, 19238581, 21125326, 24916042, 25046265, 31132581, 31916709, 32252659, 32822967, 33128956, 33183246 View all (7 more)
Propionic Acidemia	Inhibit	19238581, 26740382, 3687944, 6614005, 8023851

PCCB (propionyl-CoA carboxylase subunit beta)