Gene Gene information from NCBI Gene database.
Entrez ID 5089
Gene name PBX homeobox 2
Gene symbol PBX2
Synonyms (NCBI Gene)
G17HOX12PBX2MHC
Chromosome 6
Chromosome location 6p21.32
Summary This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator
miRNA miRNA information provided by mirtarbase database.
421
miRTarBase ID miRNA Experiments Reference
MIRT049093 hsa-miR-92a-3p CLASH 23622248
MIRT048088 hsa-miR-197-3p CLASH 23622248
MIRT046804 hsa-miR-222-3p CLASH 23622248
MIRT045365 hsa-miR-185-5p CLASH 23622248
MIRT043641 hsa-miR-326 CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 12054735
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IEA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IDA 19356220
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
176311 8633 ENSG00000204304
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P40425
Protein name Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17)
Protein function Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03792 PBC 50 243 PBC domain Family
PF00046 Homeodomain 245 304 Homeodomain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed.
Sequence
MDERLLGPPPPGGGRGGLGLVSGEPGGPGEPPGGGDPGGGSGGVPGGRGKQDIGDILQQI
MTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRSSQEEEPVDPQLMRLDN
MLLAEGVAGPEKGGGSAAAAAAAAASGGGVSPDNSIEHSDYRSKLAQIRHIYHSELEKYE
QACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRKFSAIQMQLKQSTCEAVMILRSR
FLD
ARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRI
RYKK
NIGKFQEEANIYAVKTAVSVTQGGHSRTSSPTPPSSAGSGGSFNLSGSGDMFLGMP
GLNGDSYSASQVESLRHSMGPGGYGDNLGGGQMYSPREMRANGSWQEAVTPSSVTSPTEG
PGSVHSDTSN
Sequence length 430
Interactions View interactions