Gene Gene information from NCBI Gene database.
Entrez ID 5082
Gene name Phosducin like
Gene symbol PDCL
Synonyms (NCBI Gene)
PhLP
Chromosome 9
Chromosome location 9q33.2
Summary Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have
miRNA miRNA information provided by mirtarbase database.
462
miRTarBase ID miRNA Experiments Reference
MIRT042501 hsa-miR-423-3p CLASH 23622248
MIRT622894 hsa-miR-1470 HITS-CLIP 23824327
MIRT622893 hsa-miR-4667-3p HITS-CLIP 23824327
MIRT622892 hsa-miR-6892-3p HITS-CLIP 23824327
MIRT622891 hsa-miR-2276-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21516116, 24375412, 25416956, 28514442, 29892012, 32296183, 32814053, 33961781
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA
GO:0005829 Component Cytosol TAS
GO:0005929 Component Cilium IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604421 8770 ENSG00000136940
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13371
Protein name Phosducin-like protein (PHLP)
Protein function Acts as a positive regulator of hedgehog signaling and regulates ciliary function. ; [Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the
PDB 8SFF , 8SG8 , 8SGC , 8SH9 , 8SHA , 8SHF , 8SHG , 8SHL , 8SHO , 8SHP , 8SHQ , 8SHT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02114 Phosducin 35 299 Phosducin Domain
Sequence
Sequence length 301
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Glioblastoma Associate 27571888
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 27571888
★☆☆☆☆
Found in Text Mining only