PDCL (phosducin like)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 5082 |
| Gene name | Phosducin like |
| Gene symbol | PDCL |
| Synonyms (NCBI Gene) |
PhLP
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| Chromosome | 9 |
| Chromosome location | 9q33.2 |
| Summary | Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have |
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miRNA
miRNA information provided by mirtarbase database.
462
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q13371 | ||||||||||
| Protein name | Phosducin-like protein (PHLP) | ||||||||||
| Protein function | Acts as a positive regulator of hedgehog signaling and regulates ciliary function. ; [Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the | ||||||||||
| PDB | 8SFF , 8SG8 , 8SGC , 8SH9 , 8SHA , 8SHF , 8SHG , 8SHL , 8SHO , 8SHP , 8SHQ , 8SHT | ||||||||||
| Family and domains |
Pfam
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| Sequence | |||||||||||
| Sequence length | 301 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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