Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
50809
Gene name Gene Name - the full gene name approved by the HGNC.
Heterochromatin protein 1 binding protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HP1BP3
Synonyms (NCBI Gene) Gene synonyms aliases
HP1-BP74, HP1BP74
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.12
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT024041 hsa-miR-1-3p Proteomics 18668040
MIRT048364 hsa-miR-29b-3p CLASH 23622248
MIRT041380 hsa-miR-193b-3p CLASH 23622248
MIRT714373 hsa-miR-6757-3p HITS-CLIP 19536157
MIRT714372 hsa-miR-1228-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000786 Component Nucleosome IEA
GO:0003677 Function DNA binding IBA 21873635
GO:0003677 Function DNA binding IDA 20042602
GO:0005515 Function Protein binding IPI 20042602, 25416956
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616072 24973 ENSG00000127483
Protein
UniProt ID Q5SSJ5
Protein name Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74)
Protein function Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hy
PDB 2RQP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00538 Linker_histone 158 231 linker histone H1 and H5 family Domain
PF00538 Linker_histone 257 329 linker histone H1 and H5 family Domain
PF00538 Linker_histone 341 412 linker histone H1 and H5 family Domain
Sequence
MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRTVNSTRETPPKSKLAEG
EEEKPEPDISSEESVSTVEEQENETPPATSSEAEQPKGEPENEEKEENKSSEETKKDEKD
QSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASV
VAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVV
QKSRKTPQK
SRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQL
LKNALQRAVERGQLEQITGKGASGTFQLK
KSGEKPLLGGSLMEYAILSAIAAMNEPKTCS
TTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLC
FPYYPSPG
VLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGSKPA
PKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGK
GKSTMKKSFRVKK
Sequence length 553
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Mental depression Depression, Postpartum 23689534 ClinVar
Hypertension Hypertension GWAS
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 30221674
Glioma Associate 37115922
Neoplasms Associate 36761744
Urinary Bladder Neoplasms Associate 36761744