Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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50807
|
Gene name
Gene Name - the full gene name approved by the HGNC.
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ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ASAP1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P |
Chromosome
Chromosome number
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8 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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8q24.21-q24.22 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved |
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Arthritis |
Juvenile arthritis |
rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 |
19565504 |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
26198764 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Multiple Sclerosis |
Multiple Sclerosis |
|
|
GWAS |
Colorectal Cancer |
Colorectal Cancer |
In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. |
|
GWAS, CBGDA |
Progressive Supranuclear Palsy |
Progressive Supranuclear Palsy |
|
|
GWAS |
Dementia |
Dementia |
|
|
GWAS |
Alzheimer disease |
Alzheimer disease |
|
|
GWAS |
Astrocytoma |
Astrocytoma |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Breast Neoplasms |
Associate
|
17255943, 24621372, 32235890, 37762658 |
Carcinogenesis |
Associate
|
20187983 |
Carcinoma Hepatocellular |
Associate
|
36110251, 36550445 |
Carcinoma Non Small Cell Lung |
Associate
|
29364481 |
Carcinoma Ovarian Epithelial |
Associate
|
24427349, 27667152 |
Colorectal Neoplasms |
Associate
|
15750208 |
Glioblastoma |
Associate
|
32926734 |
Hepatoblastoma |
Associate
|
27910913 |
Intervertebral Disc Degeneration |
Associate
|
35069789 |
Lupus Erythematosus Systemic |
Inhibit
|
39473004 |
Neoplasm Metastasis |
Associate
|
24427349, 24621372, 31399545, 31591270 |
Neoplasm Metastasis |
Stimulate
|
29364481, 32235890 |
Neoplasms |
Associate
|
15750208, 17255943, 20187983, 24427349, 27667152, 30509302, 31399545, 31591270, 33639150, 36110251, 36758799, 36792578, 37762658 |
Neoplasms |
Inhibit
|
33576454 |
NOG Related Symphalangism Spectrum Disorder |
Associate
|
15750208 |
Ovarian Neoplasms |
Associate
|
24427349, 27667152, 36528667 |
Ovarian Neoplasms |
Inhibit
|
33576454 |
Squamous Cell Carcinoma of Head and Neck |
Associate
|
24621372 |
Stomach Neoplasms |
Associate
|
20187983, 33639150 |
Stomach Neoplasms |
Stimulate
|
36792578 |
Triple Negative Breast Neoplasms |
Associate
|
32235890 |
Tuberculosis |
Associate
|
25774636, 36249417 |
Tuberculosis |
Inhibit
|
25774636 |
Tuberculosis Pulmonary |
Associate
|
36249417 |
Urinary Bladder Neoplasms |
Associate
|
32535071 |
Vitamin D Deficiency |
Associate
|
15750208 |
|