Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5074
Gene name Gene Name - the full gene name approved by the HGNC.	Pro-apoptotic WT1 regulator
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PAWR
Synonyms (NCBI Gene) Gene synonyms aliases	PAR4, Par-4
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q21.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-medi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024766	hsa-miR-215-5p	Microarray	19074876
MIRT026315	hsa-miR-192-5p	Microarray	19074876
MIRT513790	hsa-miR-107	PAR-CLIP	20371350
MIRT513789	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT513788	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT513787	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT513786	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT513785	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT513784	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT513783	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT397728	hsa-miR-1179	PAR-CLIP	20371350
MIRT274980	hsa-miR-621	PAR-CLIP	20371350
MIRT513781	hsa-miR-7156-3p	PAR-CLIP	20371350
MIRT513782	hsa-miR-1301-3p	PAR-CLIP	20371350
MIRT513779	hsa-miR-5047	PAR-CLIP	20371350
MIRT513780	hsa-miR-218-5p	PAR-CLIP	20371350
MIRT067116	hsa-miR-8084	PAR-CLIP	20371350
MIRT566510	hsa-miR-8066	PAR-CLIP	20371350
MIRT566509	hsa-miR-5586-5p	PAR-CLIP	20371350
MIRT566508	hsa-miR-4307	PAR-CLIP	20371350
MIRT566507	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT566506	hsa-miR-488-5p	PAR-CLIP	20371350
MIRT566505	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT368584	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT561791	hsa-miR-4282	PAR-CLIP	20371350
MIRT561789	hsa-miR-3646	PAR-CLIP	20371350
MIRT561788	hsa-miR-1252-3p	PAR-CLIP	20371350
MIRT561787	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT561786	hsa-miR-4461	PAR-CLIP	20371350
MIRT566504	hsa-miR-1267	PAR-CLIP	20371350
MIRT561785	hsa-miR-496	PAR-CLIP	20371350
MIRT561785	hsa-miR-496	PAR-CLIP	20371350
MIRT561784	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT566503	hsa-miR-653-5p	PAR-CLIP	20371350
MIRT561804	hsa-miR-548n	PAR-CLIP	20371350
MIRT561803	hsa-miR-548l	PAR-CLIP	20371350
MIRT561802	hsa-miR-548ag	PAR-CLIP	20371350
MIRT561801	hsa-miR-548ai	PAR-CLIP	20371350
MIRT561800	hsa-miR-548ba	PAR-CLIP	20371350
MIRT561799	hsa-miR-570-5p	PAR-CLIP	20371350
MIRT561797	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT561798	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT561796	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT561795	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT561794	hsa-miR-493-3p	PAR-CLIP	20371350
MIRT561793	hsa-miR-7158-3p	PAR-CLIP	20371350
MIRT561792	hsa-miR-203b-3p	PAR-CLIP	20371350
MIRT561790	hsa-miR-3611	PAR-CLIP	20371350
MIRT561791	hsa-miR-4282	PAR-CLIP	20371350
MIRT561789	hsa-miR-3646	PAR-CLIP	20371350
MIRT561788	hsa-miR-1252-3p	PAR-CLIP	20371350
MIRT561787	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT561786	hsa-miR-4461	PAR-CLIP	20371350
MIRT561785	hsa-miR-496	PAR-CLIP	20371350
MIRT561785	hsa-miR-496	PAR-CLIP	20371350
MIRT561784	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT513790	hsa-miR-107	PAR-CLIP	21572407
MIRT513789	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT513788	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT513787	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT513786	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT513785	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT513784	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT513783	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT555837	hsa-miR-6512-5p	PAR-CLIP	21572407
MIRT397728	hsa-miR-1179	PAR-CLIP	21572407
MIRT555836	hsa-miR-591	PAR-CLIP	21572407
MIRT274980	hsa-miR-621	PAR-CLIP	21572407
MIRT513781	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT513782	hsa-miR-1301-3p	PAR-CLIP	21572407
MIRT513779	hsa-miR-5047	PAR-CLIP	21572407
MIRT513780	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT513790	hsa-miR-107	PAR-CLIP	21572407
MIRT513789	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT513788	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT513787	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT513786	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT513785	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT513784	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT513783	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT547194	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT274980	hsa-miR-621	PAR-CLIP	21572407
MIRT513781	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT513782	hsa-miR-1301-3p	PAR-CLIP	21572407
MIRT513779	hsa-miR-5047	PAR-CLIP	21572407
MIRT513780	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT513790	hsa-miR-107	PAR-CLIP	23446348
MIRT513789	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT513788	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT513787	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT513786	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT513785	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT513784	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT513783	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT274980	hsa-miR-621	PAR-CLIP	23446348
MIRT513781	hsa-miR-7156-3p	PAR-CLIP	23446348
MIRT513782	hsa-miR-1301-3p	PAR-CLIP	23446348
MIRT513779	hsa-miR-5047	PAR-CLIP	23446348
MIRT513780	hsa-miR-218-5p	PAR-CLIP	23446348
MIRT727012	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT727011	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT727009	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT727010	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT727008	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT733665	hsa-miR-498	Luciferase reporter assay, qRT-PCR, Western blotting	32767028
MIRT513790	hsa-miR-107	PAR-CLIP	20371350
MIRT513789	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT513788	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT513787	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT513786	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT513785	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT513784	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT513783	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT397728	hsa-miR-1179	PAR-CLIP	20371350
MIRT274980	hsa-miR-621	PAR-CLIP	20371350
MIRT513781	hsa-miR-7156-3p	PAR-CLIP	20371350
MIRT513782	hsa-miR-1301-3p	PAR-CLIP	20371350
MIRT513779	hsa-miR-5047	PAR-CLIP	20371350
MIRT513780	hsa-miR-218-5p	PAR-CLIP	20371350
MIRT067116	hsa-miR-8084	PAR-CLIP	20371350
MIRT566510	hsa-miR-8066	PAR-CLIP	20371350
MIRT566509	hsa-miR-5586-5p	PAR-CLIP	20371350
MIRT566508	hsa-miR-4307	PAR-CLIP	20371350
MIRT566507	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT566506	hsa-miR-488-5p	PAR-CLIP	20371350
MIRT566505	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT368584	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT561791	hsa-miR-4282	PAR-CLIP	20371350
MIRT561789	hsa-miR-3646	PAR-CLIP	20371350
MIRT561788	hsa-miR-1252-3p	PAR-CLIP	20371350
MIRT561787	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT561786	hsa-miR-4461	PAR-CLIP	20371350
MIRT566504	hsa-miR-1267	PAR-CLIP	20371350
MIRT561785	hsa-miR-496	PAR-CLIP	20371350
MIRT561785	hsa-miR-496	PAR-CLIP	20371350
MIRT561784	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT566503	hsa-miR-653-5p	PAR-CLIP	20371350
MIRT561804	hsa-miR-548n	PAR-CLIP	20371350
MIRT561803	hsa-miR-548l	PAR-CLIP	20371350
MIRT561802	hsa-miR-548ag	PAR-CLIP	20371350
MIRT561801	hsa-miR-548ai	PAR-CLIP	20371350
MIRT561800	hsa-miR-548ba	PAR-CLIP	20371350
MIRT561799	hsa-miR-570-5p	PAR-CLIP	20371350
MIRT561797	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT561798	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT561796	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT561795	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT561794	hsa-miR-493-3p	PAR-CLIP	20371350
MIRT561793	hsa-miR-7158-3p	PAR-CLIP	20371350
MIRT561792	hsa-miR-203b-3p	PAR-CLIP	20371350
MIRT561790	hsa-miR-3611	PAR-CLIP	20371350
MIRT561791	hsa-miR-4282	PAR-CLIP	20371350
MIRT561789	hsa-miR-3646	PAR-CLIP	20371350
MIRT561788	hsa-miR-1252-3p	PAR-CLIP	20371350
MIRT561787	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT561786	hsa-miR-4461	PAR-CLIP	20371350
MIRT561785	hsa-miR-496	PAR-CLIP	20371350
MIRT561785	hsa-miR-496	PAR-CLIP	20371350
MIRT561784	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT513790	hsa-miR-107	PAR-CLIP	21572407
MIRT513789	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT513788	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT513787	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT513786	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT513785	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT513784	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT513783	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT555837	hsa-miR-6512-5p	PAR-CLIP	21572407
MIRT397728	hsa-miR-1179	PAR-CLIP	21572407
MIRT555836	hsa-miR-591	PAR-CLIP	21572407
MIRT274980	hsa-miR-621	PAR-CLIP	21572407
MIRT513781	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT513782	hsa-miR-1301-3p	PAR-CLIP	21572407
MIRT513779	hsa-miR-5047	PAR-CLIP	21572407
MIRT513780	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT513790	hsa-miR-107	PAR-CLIP	21572407
MIRT513789	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT513788	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT513787	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT513786	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT513785	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT513784	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT513783	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT547194	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT274980	hsa-miR-621	PAR-CLIP	21572407
MIRT513781	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT513782	hsa-miR-1301-3p	PAR-CLIP	21572407
MIRT513779	hsa-miR-5047	PAR-CLIP	21572407
MIRT513780	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT513790	hsa-miR-107	PAR-CLIP	23446348
MIRT513789	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT513788	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT513787	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT513786	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT513785	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT513784	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT513783	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT274980	hsa-miR-621	PAR-CLIP	23446348
MIRT513781	hsa-miR-7156-3p	PAR-CLIP	23446348
MIRT513782	hsa-miR-1301-3p	PAR-CLIP	23446348
MIRT513779	hsa-miR-5047	PAR-CLIP	23446348
MIRT513780	hsa-miR-218-5p	PAR-CLIP	23446348
MIRT1215211	hsa-miR-103a	CLIP-seq
MIRT1215212	hsa-miR-1197	CLIP-seq
MIRT1215213	hsa-miR-1244	CLIP-seq
MIRT1215214	hsa-miR-1297	CLIP-seq
MIRT1215215	hsa-miR-1301	CLIP-seq
MIRT1215216	hsa-miR-181a	CLIP-seq
MIRT1215217	hsa-miR-181b	CLIP-seq
MIRT1215218	hsa-miR-181c	CLIP-seq
MIRT1215219	hsa-miR-181d	CLIP-seq
MIRT1215220	hsa-miR-199a-3p	CLIP-seq
MIRT1215221	hsa-miR-199b-3p	CLIP-seq
MIRT1215222	hsa-miR-218	CLIP-seq
MIRT1215223	hsa-miR-25	CLIP-seq
MIRT1215224	hsa-miR-26a	CLIP-seq
MIRT1215225	hsa-miR-26b	CLIP-seq
MIRT1215226	hsa-miR-30a	CLIP-seq
MIRT1215227	hsa-miR-30b	CLIP-seq
MIRT1215228	hsa-miR-30c	CLIP-seq
MIRT1215229	hsa-miR-30d	CLIP-seq
MIRT1215230	hsa-miR-30e	CLIP-seq
MIRT1215231	hsa-miR-3129-5p	CLIP-seq
MIRT1215232	hsa-miR-3143	CLIP-seq
MIRT1215233	hsa-miR-3163	CLIP-seq
MIRT1215234	hsa-miR-3164	CLIP-seq
MIRT1215235	hsa-miR-32	CLIP-seq
MIRT1215236	hsa-miR-3545-3p	CLIP-seq
MIRT1215237	hsa-miR-363	CLIP-seq
MIRT1215238	hsa-miR-367	CLIP-seq
MIRT1215239	hsa-miR-3924	CLIP-seq
MIRT1215240	hsa-miR-4262	CLIP-seq
MIRT1215241	hsa-miR-4465	CLIP-seq
MIRT1215242	hsa-miR-4495	CLIP-seq
MIRT1215243	hsa-miR-4645-3p	CLIP-seq
MIRT1215244	hsa-miR-4705	CLIP-seq
MIRT1215245	hsa-miR-4753-3p	CLIP-seq
MIRT1215246	hsa-miR-493	CLIP-seq
MIRT1215247	hsa-miR-513a-3p	CLIP-seq
MIRT1215248	hsa-miR-543	CLIP-seq
MIRT1215249	hsa-miR-548u	CLIP-seq
MIRT1215250	hsa-miR-577	CLIP-seq
MIRT1215251	hsa-miR-630	CLIP-seq
MIRT1215252	hsa-miR-92a	CLIP-seq
MIRT1215253	hsa-miR-92b	CLIP-seq
MIRT1215254	hsa-miR-936	CLIP-seq
MIRT1215213	hsa-miR-1244	CLIP-seq
MIRT1215220	hsa-miR-199a-3p	CLIP-seq
MIRT1215221	hsa-miR-199b-3p	CLIP-seq
MIRT1215226	hsa-miR-30a	CLIP-seq
MIRT1215227	hsa-miR-30b	CLIP-seq
MIRT1215228	hsa-miR-30c	CLIP-seq
MIRT1215229	hsa-miR-30d	CLIP-seq
MIRT1215230	hsa-miR-30e	CLIP-seq
MIRT1215231	hsa-miR-3129-5p	CLIP-seq
MIRT2061953	hsa-miR-3133	CLIP-seq
MIRT1215236	hsa-miR-3545-3p	CLIP-seq
MIRT1215239	hsa-miR-3924	CLIP-seq
MIRT2061954	hsa-miR-3978	CLIP-seq
MIRT1215242	hsa-miR-4495	CLIP-seq
MIRT1215243	hsa-miR-4645-3p	CLIP-seq
MIRT1215246	hsa-miR-493	CLIP-seq
MIRT1215249	hsa-miR-548u	CLIP-seq
MIRT1215254	hsa-miR-936	CLIP-seq
MIRT1215211	hsa-miR-103a	CLIP-seq
MIRT1215212	hsa-miR-1197	CLIP-seq
MIRT1215213	hsa-miR-1244	CLIP-seq
MIRT1215215	hsa-miR-1301	CLIP-seq
MIRT2290425	hsa-miR-134	CLIP-seq
MIRT2290426	hsa-miR-140-3p	CLIP-seq
MIRT1215216	hsa-miR-181a	CLIP-seq
MIRT1215217	hsa-miR-181b	CLIP-seq
MIRT1215218	hsa-miR-181c	CLIP-seq
MIRT1215219	hsa-miR-181d	CLIP-seq
MIRT1215220	hsa-miR-199a-3p	CLIP-seq
MIRT1215221	hsa-miR-199b-3p	CLIP-seq
MIRT1215222	hsa-miR-218	CLIP-seq
MIRT1215223	hsa-miR-25	CLIP-seq
MIRT1215226	hsa-miR-30a	CLIP-seq
MIRT1215227	hsa-miR-30b	CLIP-seq
MIRT1215228	hsa-miR-30c	CLIP-seq
MIRT1215229	hsa-miR-30d	CLIP-seq
MIRT1215230	hsa-miR-30e	CLIP-seq
MIRT2290427	hsa-miR-3118	CLIP-seq
MIRT1215231	hsa-miR-3129-5p	CLIP-seq
MIRT1215232	hsa-miR-3143	CLIP-seq
MIRT1215233	hsa-miR-3163	CLIP-seq
MIRT1215234	hsa-miR-3164	CLIP-seq
MIRT1215235	hsa-miR-32	CLIP-seq
MIRT2290428	hsa-miR-337-5p	CLIP-seq
MIRT1215236	hsa-miR-3545-3p	CLIP-seq
MIRT1215237	hsa-miR-363	CLIP-seq
MIRT1215238	hsa-miR-367	CLIP-seq
MIRT1215239	hsa-miR-3924	CLIP-seq
MIRT1215240	hsa-miR-4262	CLIP-seq
MIRT2290429	hsa-miR-4272	CLIP-seq
MIRT2290430	hsa-miR-4475	CLIP-seq
MIRT1215242	hsa-miR-4495	CLIP-seq
MIRT1215243	hsa-miR-4645-3p	CLIP-seq
MIRT1215244	hsa-miR-4705	CLIP-seq
MIRT1215245	hsa-miR-4753-3p	CLIP-seq
MIRT1215246	hsa-miR-493	CLIP-seq
MIRT1215247	hsa-miR-513a-3p	CLIP-seq
MIRT1215248	hsa-miR-543	CLIP-seq
MIRT2290431	hsa-miR-548aa	CLIP-seq
MIRT1215249	hsa-miR-548u	CLIP-seq
MIRT1215250	hsa-miR-577	CLIP-seq
MIRT1215252	hsa-miR-92a	CLIP-seq
MIRT1215253	hsa-miR-92b	CLIP-seq
MIRT1215254	hsa-miR-936	CLIP-seq
MIRT1215243	hsa-miR-4645-3p	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	IEA
GO:0003714	Function	Transcription corepressor activity	TAS	8943350
GO:0003779	Function	Actin binding	ISS
GO:0005515	Function	Protein binding	IPI	11755531, 16369487, 18660514, 19632185, 20561531, 25218743
GO:0005634	Component	Nucleus	IDA	14627703
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	14627703
GO:0005884	Component	Actin filament	ISS
GO:0005886	Component	Plasma membrane	IDA
GO:0006915	Process	Apoptotic process	ISS
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0019899	Function	Enzyme binding	IDA	15671026
GO:0030889	Process	Negative regulation of B cell proliferation	IEA
GO:0042130	Process	Negative regulation of T cell proliferation	IEA
GO:0042986	Process	Positive regulation of amyloid precursor protein biosynthetic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IBA	21873635
GO:0043065	Process	Positive regulation of apoptotic process	NAS	11585763
GO:0043522	Function	Leucine zipper domain binding	IPI	14627703
GO:0048147	Process	Negative regulation of fibroblast proliferation	IEA
GO:0050860	Process	Negative regulation of T cell receptor signaling pathway	IEA
GO:0051017	Process	Actin filament bundle assembly	ISS
GO:0097190	Process	Apoptotic signaling pathway	IEA
GO:1901300	Process	Positive regulation of hydrogen peroxide-mediated programmed cell death	IEA
GO:2000774	Process	Positive regulation of cellular senescence	IEA

MIM	HGNC	e!Ensembl
601936	8614	ENSG00000177425

Protein

UniProt ID

Q96IZ0

Protein name

PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4)

Protein function

Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the

PDB

2JK9

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. {ECO:0000269|PubMed:89433

Sequence

MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGT
PAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAA
PPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDD
EAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSR
YSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMI
GKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVVGQLTR

Sequence length

340

Interactions

View interactions

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Adenocarcinoma	Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular	rs121913530, rs886039394, rs121913474	15877079
Carcinoma	Carcinoma, Cribriform, Carcinoma, Granular Cell	rs121912654, rs555607708, rs786202962, rs1564055259	15877079
Endometrial carcinoma	Endometrial Carcinoma	rs34612342, rs587776667, rs587776701, rs63750955, rs587776706, rs121434629, rs80359605, rs121913530, rs104894365, rs79184941, rs121913478, rs63750781, rs193922343, rs267608094, rs267608077 View all (247 more)	15877079
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	15877079
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	18085546, 18281137

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Mental depression	Unipolar Depression, Major Depressive Disorder	20735158, 18085546	ClinVar
Coronary artery disease	Coronary artery disease		GWAS

Show/Hide Text Mining Associations (22)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	11278808
Alzheimer Disease	Stimulate	30518159
Breast Neoplasms	Associate	23760770, 26126114, 29330285, 31217499
Cap Myopathy	Associate	25803782
Carcinoma Renal Cell	Associate	37024613
Colorectal Neoplasms	Inhibit	20433755
Colorectal Neoplasms	Associate	27938501
Glioma	Associate	24523904, 32135176
Hypopharyngeal Neoplasms	Associate	24418097
Hypoxia	Associate	35251305
Leukemia	Associate	21526495, 26308964
Leukemia Lymphocytic Chronic B Cell	Associate	21526495
Leukemia Myeloid Acute	Associate	25331116
Neoplasms	Inhibit	15763985, 20433755, 21358824, 24418097, 24931006, 27830973, 30518159, 31217499, 32135176, 37024613
Neoplasms	Associate	16838325, 23760770, 24992930, 31177609
Neurodegenerative Diseases	Stimulate	30518159
Pancreatic Neoplasms	Associate	18427961, 27830973
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	23975424
Prostatic Neoplasms	Associate	18427961, 18922975, 21358824, 23661456, 23760770, 25803782
Prostatitis	Stimulate	21526495
Squamous Cell Carcinoma of Head and Neck	Associate	35886008
Wilms Tumor	Associate	8943350

PAWR (pro-apoptotic WT1 regulator)