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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q13219 |
| Protein name |
Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A) |
| Protein function |
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. { |
| PDB |
7UFG
, 7Y5N
, 7Y5Q
, 8A7D
, 8A7E
, 8D8O
, 8HGG
, 8HGH
|
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF13385 |
Laminin_G_3 |
100 → 269 |
|
Domain |
| PF05572 |
Peptidase_M43 |
499 → 660 |
Pregnancy-associated plasma protein-A |
Family |
| PF00084 |
Sushi |
1280 → 1342 |
Sushi repeat (SCR repeat) |
Domain |
| PF00084 |
Sushi |
1346 → 1412 |
Sushi repeat (SCR repeat) |
Domain |
| PF00084 |
Sushi |
1415 → 1471 |
Sushi repeat (SCR repeat) |
Domain |
|
| Tissue specificity |
TISSUE SPECIFICITY: High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myo |
| Sequence |
|
| Sequence length |
1627 |
| Interactions |
View interactions |