Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	5066
Gene name	Peptidylglycine alpha-amidating monooxygenase
Gene symbol	PAM
Synonyms (NCBI Gene)	PALPAM-1PHM
Chromosome	5
Chromosome location	5q21.1
Summary	This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PH

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miRTarBase ID	miRNA	Experiments	Reference
MIRT047841	hsa-miR-30c-5p	CLASH	23622248
MIRT046087	hsa-miR-125b-5p	CLASH	23622248
MIRT045767	hsa-miR-125a-5p	CLASH	23622248
MIRT440051	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440051	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1211930	hsa-miR-106a	CLIP-seq
MIRT1211931	hsa-miR-106b	CLIP-seq
MIRT1211932	hsa-miR-124	CLIP-seq
MIRT1211933	hsa-miR-1273d	CLIP-seq
MIRT1211934	hsa-miR-132	CLIP-seq
MIRT1211935	hsa-miR-15a	CLIP-seq
MIRT1211936	hsa-miR-15b	CLIP-seq
MIRT1211937	hsa-miR-16	CLIP-seq
MIRT1211938	hsa-miR-17	CLIP-seq
MIRT1211939	hsa-miR-195	CLIP-seq
MIRT1211940	hsa-miR-200b	CLIP-seq
MIRT1211941	hsa-miR-200c	CLIP-seq
MIRT1211942	hsa-miR-20a	CLIP-seq
MIRT1211943	hsa-miR-20b	CLIP-seq
MIRT1211944	hsa-miR-212	CLIP-seq
MIRT1211945	hsa-miR-302a	CLIP-seq
MIRT1211946	hsa-miR-302b	CLIP-seq
MIRT1211947	hsa-miR-302c	CLIP-seq
MIRT1211948	hsa-miR-302d	CLIP-seq
MIRT1211949	hsa-miR-302e	CLIP-seq
MIRT1211950	hsa-miR-3064-3p	CLIP-seq
MIRT1211951	hsa-miR-3128	CLIP-seq
MIRT1211952	hsa-miR-3153	CLIP-seq
MIRT1211953	hsa-miR-372	CLIP-seq
MIRT1211954	hsa-miR-373	CLIP-seq
MIRT1211955	hsa-miR-424	CLIP-seq
MIRT1211956	hsa-miR-4255	CLIP-seq
MIRT1211957	hsa-miR-429	CLIP-seq
MIRT1211958	hsa-miR-4438	CLIP-seq
MIRT1211959	hsa-miR-4524	CLIP-seq
MIRT1211960	hsa-miR-4668-5p	CLIP-seq
MIRT1211961	hsa-miR-4726-3p	CLIP-seq
MIRT1211962	hsa-miR-4753-3p	CLIP-seq
MIRT1211963	hsa-miR-4768-5p	CLIP-seq
MIRT1211964	hsa-miR-497	CLIP-seq
MIRT1211965	hsa-miR-503	CLIP-seq
MIRT1211966	hsa-miR-506	CLIP-seq
MIRT1211967	hsa-miR-519d	CLIP-seq
MIRT1211968	hsa-miR-520a-3p	CLIP-seq
MIRT1211969	hsa-miR-520b	CLIP-seq
MIRT1211970	hsa-miR-520c-3p	CLIP-seq
MIRT1211971	hsa-miR-520d-3p	CLIP-seq
MIRT1211972	hsa-miR-520e	CLIP-seq
MIRT1211973	hsa-miR-548an	CLIP-seq
MIRT1211974	hsa-miR-548c-3p	CLIP-seq
MIRT1211975	hsa-miR-646	CLIP-seq
MIRT1211976	hsa-miR-93	CLIP-seq
MIRT1211977	hsa-miR-3121-3p	CLIP-seq
MIRT1211978	hsa-miR-371-5p	CLIP-seq
MIRT1211979	hsa-miR-371b-5p	CLIP-seq
MIRT1211980	hsa-miR-3976	CLIP-seq
MIRT1211981	hsa-miR-4742-3p	CLIP-seq
MIRT1211982	hsa-miR-4795-3p	CLIP-seq
MIRT1211983	hsa-miR-548t	CLIP-seq
MIRT1211984	hsa-miR-606	CLIP-seq
MIRT1211932	hsa-miR-124	CLIP-seq
MIRT1552035	hsa-miR-4728-3p	CLIP-seq
MIRT1211966	hsa-miR-506	CLIP-seq
MIRT1211973	hsa-miR-548an	CLIP-seq
MIRT2060833	hsa-miR-1305	CLIP-seq
MIRT1211934	hsa-miR-132	CLIP-seq
MIRT2060834	hsa-miR-134	CLIP-seq
MIRT2060835	hsa-miR-205	CLIP-seq
MIRT1211944	hsa-miR-212	CLIP-seq
MIRT2060836	hsa-miR-30a	CLIP-seq
MIRT2060837	hsa-miR-30b	CLIP-seq
MIRT2060838	hsa-miR-30c	CLIP-seq
MIRT2060839	hsa-miR-30d	CLIP-seq
MIRT2060840	hsa-miR-30e	CLIP-seq
MIRT2060841	hsa-miR-3118	CLIP-seq
MIRT1211951	hsa-miR-3128	CLIP-seq
MIRT2060842	hsa-miR-3164	CLIP-seq
MIRT2060843	hsa-miR-3607-3p	CLIP-seq
MIRT2060844	hsa-miR-3686	CLIP-seq
MIRT2060845	hsa-miR-3907	CLIP-seq
MIRT2060846	hsa-miR-4317	CLIP-seq
MIRT2060847	hsa-miR-4318	CLIP-seq
MIRT2060848	hsa-miR-4693-5p	CLIP-seq
MIRT1211981	hsa-miR-4742-3p	CLIP-seq
MIRT1211982	hsa-miR-4795-3p	CLIP-seq
MIRT2060849	hsa-miR-892a	CLIP-seq
MIRT1211930	hsa-miR-106a	CLIP-seq
MIRT1211931	hsa-miR-106b	CLIP-seq
MIRT1211938	hsa-miR-17	CLIP-seq
MIRT1211942	hsa-miR-20a	CLIP-seq
MIRT1211943	hsa-miR-20b	CLIP-seq
MIRT1211967	hsa-miR-519d	CLIP-seq
MIRT1211976	hsa-miR-93	CLIP-seq
MIRT2392079	hsa-miR-1208	CLIP-seq
MIRT2392080	hsa-miR-4496	CLIP-seq
MIRT2392081	hsa-miR-651	CLIP-seq
MIRT2392079	hsa-miR-1208	CLIP-seq
MIRT2392080	hsa-miR-4496	CLIP-seq
MIRT2431874	hsa-miR-4786-3p	CLIP-seq
MIRT2431875	hsa-miR-548ad	CLIP-seq
MIRT2392081	hsa-miR-651	CLIP-seq
MIRT2687044	hsa-miR-330-3p	CLIP-seq
MIRT2687045	hsa-miR-4314	CLIP-seq
MIRT2687046	hsa-miR-4453	CLIP-seq
MIRT2687047	hsa-miR-4538	CLIP-seq
MIRT2687048	hsa-miR-4799-5p	CLIP-seq
MIRT2687049	hsa-miR-550b	CLIP-seq
MIRT2687050	hsa-miR-555	CLIP-seq
MIRT2687051	hsa-miR-888	CLIP-seq

Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001519	Process	Peptide amidation	IDA	2357221, 12699694
GO:0003824	Function	Catalytic activity	IEA
GO:0004497	Function	Monooxygenase activity	IEA
GO:0004504	Function	Peptidylglycine monooxygenase activity	IBA
GO:0004504	Function	Peptidylglycine monooxygenase activity	IDA	2357221, 12699694
GO:0004504	Function	Peptidylglycine monooxygenase activity	IEA
GO:0004598	Function	Peptidylamidoglycolate lyase activity	IDA	12699694
GO:0004598	Function	Peptidylamidoglycolate lyase activity	IEA
GO:0004598	Function	Peptidylamidoglycolate lyase activity	ISS
GO:0005507	Function	Copper ion binding	IEA
GO:0005507	Function	Copper ion binding	ISS
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0006518	Process	Peptide metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IDA	12699694
GO:0010043	Process	Response to zinc ion	IDA	12699694
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016715	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0030667	Component	Secretory granule membrane	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031418	Function	L-ascorbic acid binding	IEA
GO:0034599	Process	Cellular response to oxidative stress	IC	39880951
GO:0034599	Process	Cellular response to oxidative stress	IC	39880951
GO:0034599	Process	Cellular response to oxidative stress	IDA	39880951
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	39880951
GO:0046872	Function	Metal ion binding	IEA
GO:0062112	Process	Fatty acid primary amide biosynthetic process	ISS
GO:0070062	Component	Extracellular exosome	HDA	19199708, 23533145

MIM	HGNC	e!Ensembl
170270	8596	ENSG00000145730

P19021

Protein name

Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]

Protein function

Bifunctional enzyme that catalyzes amidation of the C-terminus of proteins (PubMed:12699694, PubMed:2357221). Alpha-amidation is present at the C-terminus of many endocrine hormones and neuropeptides and is required for their activity (PubMed:15

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01082	Cu2_monooxygen	59 → 175	Copper type II ascorbate-dependent monooxygenase, N-terminal domain	Domain
PF03712	Cu2_monoox_C	195 → 342	Copper type II ascorbate-dependent monooxygenase, C-terminal domain	Domain
PF01436	NHL	630 → 659	NHL repeat	Repeat
PF01436	NHL	683 → 711	NHL repeat	Repeat
PF01436	NHL	779 → 806	NHL repeat	Repeat

Sequence

MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALD
IRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWF
CDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKD
CSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHH
LGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATH
IGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHE
HHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESES
DLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQ
PPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSF
DSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALH
QVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFS
PSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVR
EIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFD
MPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMEN
KPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEH
KLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEE
YSAPLPALAPSSS

Sequence length

973

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Hepatocellular carcinoma	Benign; Likely benign	rs114014768	RCV005911638

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adrenocortical Hyperfunction	Associate	37388215
Bronchopulmonary Dysplasia	Associate	39988826
Burkitt Lymphoma	Associate	9689053
Carcinoma Hepatocellular	Associate	36177006
Congenital Abnormalities	Associate	8702008
Gigantism	Associate	37388215
Growth hormone excess	Associate	37388215
Growth Hormone Secreting Pituitary Adenoma	Associate	38075079
Hypertension	Associate	29162152
Insulin Resistance	Associate	29162152
Lung Neoplasms	Associate	8794407
Neoplasms	Associate	26848797, 8702008
Phenylketonurias	Associate	32107425, 34711827, 34914365, 35862031
Pituitary ACTH Hypersecretion	Associate	37388215, 38075079
Pituitary Neoplasms	Associate	37388215
Prolactinoma	Associate	38075079
Prostatitis	Associate	12949839
Pyruvate Carboxylase Deficiency Disease	Associate	12949839

PAM (peptidylglycine alpha-amidating monooxygenase)