ARHGEF3 (Rho guanine nucleotide exchange factor 3)

Gene

• Entrez ID: 50650
• Gene name: Rho guanine nucleotide exchange factor 3
• Gene symbol: ARHGEF3
• Synonyms (NCBI Gene): GEF3, STA3, XPLN
• Chromosome: 3
• Chromosome location: 3p14.3
• Summary: Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000493	hsa-miR-138-5p	qRT-PCR, Luciferase reporter assay, Western blot	20232393
MIRT002512	hsa-miR-373-3p	Microarray	15685193
MIRT016803	hsa-miR-335-5p	Microarray	18185580
MIRT002512	hsa-miR-373-3p	Microarray;Other	15685193
MIRT039147	hsa-miR-769-5p	CLASH	23622248
MIRT497787	hsa-miR-5196-3p	PAR-CLIP	22291592
MIRT497786	hsa-miR-4793-5p	PAR-CLIP	22291592
MIRT497785	hsa-miR-889-3p	PAR-CLIP	22291592
MIRT497784	hsa-miR-450b-5p	PAR-CLIP	22291592
MIRT497783	hsa-miR-507	PAR-CLIP	22291592
MIRT497782	hsa-miR-557	PAR-CLIP	22291592
MIRT497781	hsa-miR-3680-3p	PAR-CLIP	22291592
MIRT441197	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT441196	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT441197	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT441196	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT497787	hsa-miR-5196-3p	PAR-CLIP	22291592
MIRT497786	hsa-miR-4793-5p	PAR-CLIP	22291592
MIRT497785	hsa-miR-889-3p	PAR-CLIP	22291592
MIRT497784	hsa-miR-450b-5p	PAR-CLIP	22291592
MIRT497783	hsa-miR-507	PAR-CLIP	22291592
MIRT497782	hsa-miR-557	PAR-CLIP	22291592
MIRT497781	hsa-miR-3680-3p	PAR-CLIP	22291592
MIRT795763	hsa-miR-4775	CLIP-seq
MIRT795764	hsa-miR-590-3p	CLIP-seq
MIRT795765	hsa-miR-103a	CLIP-seq
MIRT795766	hsa-miR-107	CLIP-seq
MIRT795767	hsa-miR-1184	CLIP-seq
MIRT795768	hsa-miR-1205	CLIP-seq
MIRT795769	hsa-miR-214	CLIP-seq
MIRT795770	hsa-miR-3120-5p	CLIP-seq
MIRT795771	hsa-miR-3158-5p	CLIP-seq
MIRT795772	hsa-miR-338-3p	CLIP-seq
MIRT795773	hsa-miR-346	CLIP-seq
MIRT795774	hsa-miR-3614-5p	CLIP-seq
MIRT795775	hsa-miR-3619-5p	CLIP-seq
MIRT795776	hsa-miR-4288	CLIP-seq
MIRT795777	hsa-miR-4530	CLIP-seq
MIRT795778	hsa-miR-4668-3p	CLIP-seq
MIRT795779	hsa-miR-632	CLIP-seq
MIRT795780	hsa-miR-657	CLIP-seq
MIRT795781	hsa-miR-761	CLIP-seq
MIRT795769	hsa-miR-214	CLIP-seq
MIRT795775	hsa-miR-3619-5p	CLIP-seq
MIRT1935032	hsa-miR-4477b	CLIP-seq
MIRT1935033	hsa-miR-4487	CLIP-seq
MIRT1935034	hsa-miR-4699-3p	CLIP-seq
MIRT1935035	hsa-miR-518a-5p	CLIP-seq
MIRT1935036	hsa-miR-527	CLIP-seq
MIRT1935037	hsa-miR-633	CLIP-seq
MIRT795780	hsa-miR-657	CLIP-seq
MIRT795781	hsa-miR-761	CLIP-seq
MIRT1935038	hsa-miR-935	CLIP-seq
MIRT2174815	hsa-miR-1	CLIP-seq
MIRT2174816	hsa-miR-101	CLIP-seq
MIRT2174817	hsa-miR-106a	CLIP-seq
MIRT2174818	hsa-miR-106b	CLIP-seq
MIRT2174819	hsa-miR-10a	CLIP-seq
MIRT2174820	hsa-miR-10b	CLIP-seq
MIRT2174821	hsa-miR-1183	CLIP-seq
MIRT2174822	hsa-miR-1245b-3p	CLIP-seq
MIRT2174823	hsa-miR-1324	CLIP-seq
MIRT2174824	hsa-miR-144	CLIP-seq
MIRT2174825	hsa-miR-1537	CLIP-seq
MIRT2174826	hsa-miR-17	CLIP-seq
MIRT2174827	hsa-miR-181a	CLIP-seq
MIRT2174828	hsa-miR-181b	CLIP-seq
MIRT2174829	hsa-miR-181c	CLIP-seq
MIRT2174830	hsa-miR-181d	CLIP-seq
MIRT2174831	hsa-miR-1909	CLIP-seq
MIRT2174832	hsa-miR-200b	CLIP-seq
MIRT2174833	hsa-miR-200c	CLIP-seq
MIRT2174834	hsa-miR-206	CLIP-seq
MIRT2174835	hsa-miR-20a	CLIP-seq
MIRT2174836	hsa-miR-20b	CLIP-seq
MIRT2174837	hsa-miR-2115	CLIP-seq
MIRT795769	hsa-miR-214	CLIP-seq
MIRT2174838	hsa-miR-300	CLIP-seq
MIRT2174839	hsa-miR-302a	CLIP-seq
MIRT2174840	hsa-miR-302b	CLIP-seq
MIRT2174841	hsa-miR-302c	CLIP-seq
MIRT2174842	hsa-miR-302d	CLIP-seq
MIRT2174843	hsa-miR-302e	CLIP-seq
MIRT2174844	hsa-miR-3064-3p	CLIP-seq
MIRT2174845	hsa-miR-3130-3p	CLIP-seq
MIRT2174846	hsa-miR-3153	CLIP-seq
MIRT2174847	hsa-miR-3157-3p	CLIP-seq
MIRT2174848	hsa-miR-3180-5p	CLIP-seq
MIRT2174849	hsa-miR-3182	CLIP-seq
MIRT2174850	hsa-miR-323b-3p	CLIP-seq
MIRT2174851	hsa-miR-34a	CLIP-seq
MIRT2174852	hsa-miR-34c-5p	CLIP-seq
MIRT2174853	hsa-miR-3607-3p	CLIP-seq
MIRT795774	hsa-miR-3614-5p	CLIP-seq
MIRT795775	hsa-miR-3619-5p	CLIP-seq
MIRT2174854	hsa-miR-3655	CLIP-seq
MIRT2174855	hsa-miR-3673	CLIP-seq
MIRT2174856	hsa-miR-372	CLIP-seq
MIRT2174857	hsa-miR-373	CLIP-seq
MIRT2174858	hsa-miR-377	CLIP-seq
MIRT2174859	hsa-miR-381	CLIP-seq
MIRT2174860	hsa-miR-3941	CLIP-seq
MIRT2174861	hsa-miR-3974	CLIP-seq
MIRT2174862	hsa-miR-4262	CLIP-seq
MIRT2174863	hsa-miR-4267	CLIP-seq
MIRT2174864	hsa-miR-4270	CLIP-seq
MIRT2174865	hsa-miR-429	CLIP-seq
MIRT2174866	hsa-miR-4300	CLIP-seq
MIRT2174867	hsa-miR-4307	CLIP-seq
MIRT2174868	hsa-miR-4325	CLIP-seq
MIRT2174869	hsa-miR-4326	CLIP-seq
MIRT2174870	hsa-miR-4426	CLIP-seq
MIRT2174871	hsa-miR-4441	CLIP-seq
MIRT2174872	hsa-miR-4463	CLIP-seq
MIRT1935032	hsa-miR-4477b	CLIP-seq
MIRT2174873	hsa-miR-449a	CLIP-seq
MIRT2174874	hsa-miR-449b	CLIP-seq
MIRT2174875	hsa-miR-451	CLIP-seq
MIRT2174876	hsa-miR-4527	CLIP-seq
MIRT2174877	hsa-miR-4528	CLIP-seq
MIRT2174878	hsa-miR-4640-5p	CLIP-seq
MIRT2174879	hsa-miR-4647	CLIP-seq
MIRT2174880	hsa-miR-4650-5p	CLIP-seq
MIRT2174881	hsa-miR-466	CLIP-seq
MIRT2174882	hsa-miR-4662b	CLIP-seq
MIRT2174883	hsa-miR-4666-3p	CLIP-seq
MIRT2174884	hsa-miR-4668-5p	CLIP-seq
MIRT2174885	hsa-miR-4672	CLIP-seq
MIRT1935034	hsa-miR-4699-3p	CLIP-seq
MIRT2174886	hsa-miR-4712-3p	CLIP-seq
MIRT2174887	hsa-miR-4715-3p	CLIP-seq
MIRT2174888	hsa-miR-4719	CLIP-seq
MIRT2174889	hsa-miR-4726-5p	CLIP-seq
MIRT2174890	hsa-miR-4733-5p	CLIP-seq
MIRT2174891	hsa-miR-4753-5p	CLIP-seq
MIRT2174892	hsa-miR-4789-5p	CLIP-seq
MIRT2174893	hsa-miR-4793-3p	CLIP-seq
MIRT2174894	hsa-miR-513b	CLIP-seq
MIRT2174895	hsa-miR-515-5p	CLIP-seq
MIRT2174896	hsa-miR-516a-3p	CLIP-seq
MIRT2174897	hsa-miR-519a	CLIP-seq
MIRT2174898	hsa-miR-519b-3p	CLIP-seq
MIRT2174899	hsa-miR-519c-3p	CLIP-seq
MIRT2174900	hsa-miR-519d	CLIP-seq
MIRT2174901	hsa-miR-520a-3p	CLIP-seq
MIRT2174902	hsa-miR-520a-5p	CLIP-seq
MIRT2174903	hsa-miR-520b	CLIP-seq
MIRT2174904	hsa-miR-520c-3p	CLIP-seq
MIRT2174905	hsa-miR-520d-3p	CLIP-seq
MIRT2174906	hsa-miR-520e	CLIP-seq
MIRT2174907	hsa-miR-520f	CLIP-seq
MIRT2174908	hsa-miR-525-5p	CLIP-seq
MIRT2174909	hsa-miR-543	CLIP-seq
MIRT2174910	hsa-miR-548l	CLIP-seq
MIRT2174911	hsa-miR-548m	CLIP-seq
MIRT2174912	hsa-miR-548n	CLIP-seq
MIRT2174913	hsa-miR-548t	CLIP-seq
MIRT2174914	hsa-miR-552	CLIP-seq
MIRT2174915	hsa-miR-561	CLIP-seq
MIRT2174916	hsa-miR-582-5p	CLIP-seq
MIRT2174917	hsa-miR-613	CLIP-seq
MIRT2174918	hsa-miR-621	CLIP-seq
MIRT2174919	hsa-miR-624	CLIP-seq
MIRT1935037	hsa-miR-633	CLIP-seq
MIRT2174920	hsa-miR-664	CLIP-seq
MIRT795781	hsa-miR-761	CLIP-seq
MIRT2174921	hsa-miR-889	CLIP-seq
MIRT2174922	hsa-miR-920	CLIP-seq
MIRT2174923	hsa-miR-93	CLIP-seq
MIRT1935038	hsa-miR-935	CLIP-seq
MIRT2174845	hsa-miR-3130-3p	CLIP-seq
MIRT2174861	hsa-miR-3974	CLIP-seq
MIRT2174868	hsa-miR-4325	CLIP-seq
MIRT1935032	hsa-miR-4477b	CLIP-seq
MIRT2174876	hsa-miR-4527	CLIP-seq
MIRT2174893	hsa-miR-4793-3p	CLIP-seq
MIRT2174816	hsa-miR-101	CLIP-seq
MIRT2174823	hsa-miR-1324	CLIP-seq
MIRT2174824	hsa-miR-144	CLIP-seq
MIRT2174851	hsa-miR-34a	CLIP-seq
MIRT2174852	hsa-miR-34c-5p	CLIP-seq
MIRT2174860	hsa-miR-3941	CLIP-seq
MIRT2174873	hsa-miR-449a	CLIP-seq
MIRT2174874	hsa-miR-449b	CLIP-seq
MIRT2174881	hsa-miR-466	CLIP-seq
MIRT2174885	hsa-miR-4672	CLIP-seq
MIRT2174916	hsa-miR-582-5p	CLIP-seq
MIRT1935038	hsa-miR-935	CLIP-seq
MIRT2174816	hsa-miR-101	CLIP-seq
MIRT2174821	hsa-miR-1183	CLIP-seq
MIRT2478169	hsa-miR-1243	CLIP-seq
MIRT2478170	hsa-miR-1255a	CLIP-seq
MIRT2478171	hsa-miR-1255b	CLIP-seq
MIRT2478172	hsa-miR-1291	CLIP-seq
MIRT2478173	hsa-miR-1305	CLIP-seq
MIRT2174823	hsa-miR-1324	CLIP-seq
MIRT2174824	hsa-miR-144	CLIP-seq
MIRT2174827	hsa-miR-181a	CLIP-seq
MIRT2174828	hsa-miR-181b	CLIP-seq
MIRT2174829	hsa-miR-181c	CLIP-seq
MIRT2174830	hsa-miR-181d	CLIP-seq
MIRT2478174	hsa-miR-1915	CLIP-seq
MIRT2174832	hsa-miR-200b	CLIP-seq
MIRT2174833	hsa-miR-200c	CLIP-seq
MIRT2478175	hsa-miR-2355-5p	CLIP-seq
MIRT2478176	hsa-miR-3121-5p	CLIP-seq
MIRT2478177	hsa-miR-3160-5p	CLIP-seq
MIRT2174849	hsa-miR-3182	CLIP-seq
MIRT2478178	hsa-miR-324-5p	CLIP-seq
MIRT2478179	hsa-miR-328	CLIP-seq
MIRT2174851	hsa-miR-34a	CLIP-seq
MIRT2174852	hsa-miR-34c-5p	CLIP-seq
MIRT2478180	hsa-miR-3614-3p	CLIP-seq
MIRT2478181	hsa-miR-374c	CLIP-seq
MIRT2174860	hsa-miR-3941	CLIP-seq
MIRT2174861	hsa-miR-3974	CLIP-seq
MIRT2174862	hsa-miR-4262	CLIP-seq
MIRT2174865	hsa-miR-429	CLIP-seq
MIRT2174867	hsa-miR-4307	CLIP-seq
MIRT2174868	hsa-miR-4325	CLIP-seq
MIRT2174870	hsa-miR-4426	CLIP-seq
MIRT1935032	hsa-miR-4477b	CLIP-seq
MIRT1935033	hsa-miR-4487	CLIP-seq
MIRT2174873	hsa-miR-449a	CLIP-seq
MIRT2174874	hsa-miR-449b	CLIP-seq
MIRT2174879	hsa-miR-4647	CLIP-seq
MIRT2478182	hsa-miR-4659a-5p	CLIP-seq
MIRT2478183	hsa-miR-4659b-5p	CLIP-seq
MIRT2174881	hsa-miR-466	CLIP-seq
MIRT2174882	hsa-miR-4662b	CLIP-seq
MIRT2478184	hsa-miR-4670-3p	CLIP-seq
MIRT2174885	hsa-miR-4672	CLIP-seq
MIRT2478185	hsa-miR-4684-3p	CLIP-seq
MIRT2478186	hsa-miR-4711-5p	CLIP-seq
MIRT2478187	hsa-miR-498	CLIP-seq
MIRT1935035	hsa-miR-518a-5p	CLIP-seq
MIRT1935036	hsa-miR-527	CLIP-seq
MIRT2174911	hsa-miR-548m	CLIP-seq
MIRT2478188	hsa-miR-548q	CLIP-seq
MIRT2174914	hsa-miR-552	CLIP-seq
MIRT2174916	hsa-miR-582-5p	CLIP-seq
MIRT2478189	hsa-miR-655	CLIP-seq
MIRT2478190	hsa-miR-676	CLIP-seq
MIRT2478191	hsa-miR-885-3p	CLIP-seq
MIRT1935038	hsa-miR-935	CLIP-seq
MIRT2174815	hsa-miR-1	CLIP-seq
MIRT2174816	hsa-miR-101	CLIP-seq
MIRT2174817	hsa-miR-106a	CLIP-seq
MIRT2174818	hsa-miR-106b	CLIP-seq
MIRT2174821	hsa-miR-1183	CLIP-seq
MIRT2478169	hsa-miR-1243	CLIP-seq
MIRT2478170	hsa-miR-1255a	CLIP-seq
MIRT2478171	hsa-miR-1255b	CLIP-seq
MIRT2478172	hsa-miR-1291	CLIP-seq
MIRT2478173	hsa-miR-1305	CLIP-seq
MIRT2174823	hsa-miR-1324	CLIP-seq
MIRT2174824	hsa-miR-144	CLIP-seq
MIRT2174826	hsa-miR-17	CLIP-seq
MIRT2174827	hsa-miR-181a	CLIP-seq
MIRT2174828	hsa-miR-181b	CLIP-seq
MIRT2174829	hsa-miR-181c	CLIP-seq
MIRT2174830	hsa-miR-181d	CLIP-seq
MIRT2478174	hsa-miR-1915	CLIP-seq
MIRT2174832	hsa-miR-200b	CLIP-seq
MIRT2174833	hsa-miR-200c	CLIP-seq
MIRT2174834	hsa-miR-206	CLIP-seq
MIRT2174835	hsa-miR-20a	CLIP-seq
MIRT2174836	hsa-miR-20b	CLIP-seq
MIRT2478175	hsa-miR-2355-5p	CLIP-seq
MIRT2174839	hsa-miR-302a	CLIP-seq
MIRT2174840	hsa-miR-302b	CLIP-seq
MIRT2174841	hsa-miR-302c	CLIP-seq
MIRT2174842	hsa-miR-302d	CLIP-seq
MIRT2174843	hsa-miR-302e	CLIP-seq
MIRT2478176	hsa-miR-3121-5p	CLIP-seq
MIRT2675320	hsa-miR-3156-5p	CLIP-seq
MIRT2478177	hsa-miR-3160-5p	CLIP-seq
MIRT2174849	hsa-miR-3182	CLIP-seq
MIRT2675321	hsa-miR-3190	CLIP-seq
MIRT2478178	hsa-miR-324-5p	CLIP-seq
MIRT2478179	hsa-miR-328	CLIP-seq
MIRT2174851	hsa-miR-34a	CLIP-seq
MIRT2174852	hsa-miR-34c-5p	CLIP-seq
MIRT2478180	hsa-miR-3614-3p	CLIP-seq
MIRT2174855	hsa-miR-3673	CLIP-seq
MIRT2174856	hsa-miR-372	CLIP-seq
MIRT2174857	hsa-miR-373	CLIP-seq
MIRT2478181	hsa-miR-374c	CLIP-seq
MIRT2174860	hsa-miR-3941	CLIP-seq
MIRT2174861	hsa-miR-3974	CLIP-seq
MIRT2174862	hsa-miR-4262	CLIP-seq
MIRT2174865	hsa-miR-429	CLIP-seq
MIRT2174867	hsa-miR-4307	CLIP-seq
MIRT2174868	hsa-miR-4325	CLIP-seq
MIRT2675322	hsa-miR-433	CLIP-seq
MIRT2174870	hsa-miR-4426	CLIP-seq
MIRT1935032	hsa-miR-4477b	CLIP-seq
MIRT1935033	hsa-miR-4487	CLIP-seq
MIRT2174873	hsa-miR-449a	CLIP-seq
MIRT2174874	hsa-miR-449b	CLIP-seq
MIRT2174879	hsa-miR-4647	CLIP-seq
MIRT2478182	hsa-miR-4659a-5p	CLIP-seq
MIRT2478183	hsa-miR-4659b-5p	CLIP-seq
MIRT2174881	hsa-miR-466	CLIP-seq
MIRT2174882	hsa-miR-4662b	CLIP-seq
MIRT2478184	hsa-miR-4670-3p	CLIP-seq
MIRT2174885	hsa-miR-4672	CLIP-seq
MIRT2478185	hsa-miR-4684-3p	CLIP-seq
MIRT2478186	hsa-miR-4711-5p	CLIP-seq
MIRT2174888	hsa-miR-4719	CLIP-seq
MIRT2478187	hsa-miR-498	CLIP-seq
MIRT2174894	hsa-miR-513b	CLIP-seq
MIRT2174895	hsa-miR-515-5p	CLIP-seq
MIRT1935035	hsa-miR-518a-5p	CLIP-seq
MIRT2174900	hsa-miR-519d	CLIP-seq
MIRT2174901	hsa-miR-520a-3p	CLIP-seq
MIRT2174903	hsa-miR-520b	CLIP-seq
MIRT2174904	hsa-miR-520c-3p	CLIP-seq
MIRT2174905	hsa-miR-520d-3p	CLIP-seq
MIRT2174906	hsa-miR-520e	CLIP-seq
MIRT2174907	hsa-miR-520f	CLIP-seq
MIRT1935036	hsa-miR-527	CLIP-seq
MIRT2174910	hsa-miR-548l	CLIP-seq
MIRT2174911	hsa-miR-548m	CLIP-seq
MIRT2174912	hsa-miR-548n	CLIP-seq
MIRT2478188	hsa-miR-548q	CLIP-seq
MIRT2174913	hsa-miR-548t	CLIP-seq
MIRT2174914	hsa-miR-552	CLIP-seq
MIRT2174916	hsa-miR-582-5p	CLIP-seq
MIRT2174917	hsa-miR-613	CLIP-seq
MIRT2478189	hsa-miR-655	CLIP-seq
MIRT2478190	hsa-miR-676	CLIP-seq
MIRT2478191	hsa-miR-885-3p	CLIP-seq
MIRT2174923	hsa-miR-93	CLIP-seq
MIRT1935038	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS	10873612
GO:0005515	Function	Protein binding	IPI	25416956, 29892012, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007266	Process	Rho protein signal transduction	TAS	10873612
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 612115
• HGNC: 683
• e!Ensembl: ENSG00000163947

Protein

• UniProt ID: Q9NR81
• Protein name: Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN)
• Protein function: Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	126 → 302	RhoGEF domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney. {ECO:0000269|PubMed:10873612, ECO:0000269|PubMed:12221096}.
• Sequence:

  MVAKDYPFYLTVKRANCSLELPPASGPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPL
  KRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKE
  IKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEEL
  LSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQR
  CLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAE
  INTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVI
  TRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKN
  GSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGE
  TKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV

• Sequence length: 526

Pathways

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events