Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	50636
Gene name	Anoctamin 7
Gene symbol	ANO7
Synonyms (NCBI Gene)	D-TMPPDTMPPIPCA-5IPCA5NGEPPCANAP5PCANAP5LTMEM16G
Chromosome	2
Chromosome location	2q37.3
Summary	This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different

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Show/Hide all (185)

miRTarBase ID	miRNA	Experiments	Reference
MIRT620898	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT620897	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT620896	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT620892	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT620891	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT620890	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT620889	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT620887	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT620886	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT620885	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620884	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620883	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT620898	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT620897	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT620896	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT649098	hsa-miR-5193	HITS-CLIP	23824327
MIRT620895	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620894	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620893	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT649097	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620892	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT620891	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT620890	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT620889	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT620888	hsa-miR-1976	HITS-CLIP	23824327
MIRT620887	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT620886	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT620885	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620884	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620883	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT620898	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT620897	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT620896	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT620895	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620894	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620893	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620892	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT620891	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT620890	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT620889	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT620888	hsa-miR-1976	HITS-CLIP	23824327
MIRT620887	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT620886	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT620885	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620884	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620883	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT620898	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT620897	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT620896	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT620895	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620894	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620893	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620892	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT620891	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT620890	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT620889	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT620888	hsa-miR-1976	HITS-CLIP	23824327
MIRT620887	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT620886	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT620885	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620884	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620883	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT620898	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT620897	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT620896	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT620892	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT620891	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT620890	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT620889	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT620887	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT620886	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT620885	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620884	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620883	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT620898	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT620897	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT620896	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT649098	hsa-miR-5193	HITS-CLIP	23824327
MIRT620895	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620894	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620893	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT649097	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT620892	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT620891	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT620890	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT620889	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT620888	hsa-miR-1976	HITS-CLIP	23824327
MIRT620887	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT620886	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT620885	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620884	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620883	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT620898	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT620897	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT620896	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT620895	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620894	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620893	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620892	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT620891	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT620890	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT620889	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT620888	hsa-miR-1976	HITS-CLIP	23824327
MIRT620887	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT620886	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT620885	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620884	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620883	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT620898	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT620897	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT620896	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT620895	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620894	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT620893	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT620892	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT620891	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT620890	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT620889	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT620888	hsa-miR-1976	HITS-CLIP	23824327
MIRT620887	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT620886	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT620885	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT620884	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620883	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT785859	hsa-miR-125a-3p	CLIP-seq
MIRT785860	hsa-miR-125a-5p	CLIP-seq
MIRT785861	hsa-miR-125b	CLIP-seq
MIRT785862	hsa-miR-3160-3p	CLIP-seq
MIRT785863	hsa-miR-3616-3p	CLIP-seq
MIRT785864	hsa-miR-4319	CLIP-seq
MIRT785865	hsa-miR-4712-3p	CLIP-seq
MIRT785866	hsa-miR-4721	CLIP-seq
MIRT785867	hsa-miR-4725-5p	CLIP-seq
MIRT785868	hsa-miR-504	CLIP-seq
MIRT785869	hsa-miR-544b	CLIP-seq
MIRT785870	hsa-miR-617	CLIP-seq
MIRT785871	hsa-miR-197	CLIP-seq
MIRT785872	hsa-miR-28-5p	CLIP-seq
MIRT785873	hsa-miR-3139	CLIP-seq
MIRT785874	hsa-miR-3192	CLIP-seq
MIRT785875	hsa-miR-4438	CLIP-seq
MIRT785876	hsa-miR-4487	CLIP-seq
MIRT785877	hsa-miR-4520a-3p	CLIP-seq
MIRT785878	hsa-miR-4520b-3p	CLIP-seq
MIRT785879	hsa-miR-4640-5p	CLIP-seq
MIRT785880	hsa-miR-4716-5p	CLIP-seq
MIRT785881	hsa-miR-4726-5p	CLIP-seq
MIRT785882	hsa-miR-4781-3p	CLIP-seq
MIRT785883	hsa-miR-5096	CLIP-seq
MIRT785884	hsa-miR-665	CLIP-seq
MIRT785885	hsa-miR-708	CLIP-seq
MIRT1931829	hsa-miR-1238	CLIP-seq
MIRT1931830	hsa-miR-1245b-3p	CLIP-seq
MIRT1931831	hsa-miR-3126-5p	CLIP-seq
MIRT1931832	hsa-miR-3145-5p	CLIP-seq
MIRT1931833	hsa-miR-3183	CLIP-seq
MIRT1931834	hsa-miR-3607-5p	CLIP-seq
MIRT1931835	hsa-miR-3663-3p	CLIP-seq
MIRT1931836	hsa-miR-3674	CLIP-seq
MIRT1931837	hsa-miR-377	CLIP-seq
MIRT1931838	hsa-miR-3913-3p	CLIP-seq
MIRT1931839	hsa-miR-4271	CLIP-seq
MIRT1931840	hsa-miR-4662a-5p	CLIP-seq
MIRT1931841	hsa-miR-4676-5p	CLIP-seq
MIRT1931842	hsa-miR-4691-5p	CLIP-seq
MIRT1931843	hsa-miR-4717-5p	CLIP-seq
MIRT1931844	hsa-miR-4723-3p	CLIP-seq
MIRT1931845	hsa-miR-4725-3p	CLIP-seq
MIRT1931846	hsa-miR-4733-5p	CLIP-seq
MIRT1931847	hsa-miR-575	CLIP-seq
MIRT1931839	hsa-miR-4271	CLIP-seq
MIRT2172314	hsa-miR-455-5p	CLIP-seq
MIRT2172315	hsa-miR-4690-5p	CLIP-seq
MIRT1931845	hsa-miR-4725-3p	CLIP-seq
MIRT2172316	hsa-miR-4742-5p	CLIP-seq
MIRT2172317	hsa-miR-625	CLIP-seq
MIRT2172318	hsa-miR-637	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IDA	21984732, 22075693
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IDA	22946059
GO:0005254	Function	Chloride channel activity	IBA
GO:0005254	Function	Chloride channel activity	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	22075693
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	14981236, 22946059
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006869	Process	Lipid transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:0046983	Function	Protein dimerization activity	IEA
GO:0061588	Process	Calcium activated phospholipid scrambling	IBA
GO:0070161	Component	Anchoring junction	IEA
GO:1902476	Process	Chloride transmembrane transport	IBA
GO:1902476	Process	Chloride transmembrane transport	IDA	22946059

MIM	HGNC	e!Ensembl
605096	31677	ENSG00000146205

Q6IWH7

Protein name

Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G)

Protein function

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693). May play a r

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16178	Anoct_dimer	105 → 332	Dimerisation domain of Ca+-activated chloride-channel, anoctamin	Family
PF04547	Anoctamin	335 → 886	Calcium-activated chloride channel	Family

Tissue specificity

TISSUE SPECIFICITY: Specifically expressed in epithelial cells of the prostate (at protein level). {ECO:0000269|PubMed:14981236, ECO:0000269|PubMed:15761874, ECO:0000269|PubMed:17308099}.

Sequence

MRMAATAWAGLQGPPLPTLCPAVRTGLYCRDQAHAERWAMTSETSSGSHCARSRMLRRRA
QEEDSTVLIDVSPPEAEKRGSYGSTAHASEPGGQQAAACRAGSPAKPRIADFVLVWEEDL
KLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVDQQDVQDGNTTVHYALLSASWAVLC
YYAEDLRLKLPLQELPNQASNWSAGLLAWLGIPNVLLEVVPDVPPEYYSCRFRVNKLPRF
LGSDNQDTFFTSTKRHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLHDGPFKT
PPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPA
AVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDH
GGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPRPQFAASAPMTAPNPI
TGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMAIVVSRSGNTLLAAW
ASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFVNFY
SSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEV
LIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQFGFVTI
FVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISN
AFLLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYS
QTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEVL
FGTNGTKDEQPEGSELSSHWTPFTVPKASQLQQ

Sequence length

933

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis		Stimuli-sensing channels

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cholangiocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROBLASTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	23955683	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	25803781	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Inhibit	33628598	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	18676855, 19495750, 23955683, 33628598, 37749167	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Associate	32599975	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Personality Disorders	Associate	30157291, 35043958	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	18676855, 19495750, 23955683, 30157291, 31570429, 32027096, 32176628, 33628598, 35043958, 37647111, 37749167	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Inhibit	36674564	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms Castration Resistant	Associate	31570429	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatitis	Associate	30157291	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Associate	31642198	★★★★★ ★☆☆☆☆ Found in Text Mining only

ANO7 (anoctamin 7)