Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5062
Gene name Gene Name - the full gene name approved by the HGNC.
P21 (RAC1) activated kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PAK2
Synonyms (NCBI Gene) Gene synonyms aliases
KNO2, PAK65, PAKgamma
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q29
Summary Summary of gene provided in NCBI Entrez Gene.
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 an
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020989 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT041405 hsa-miR-193b-3p CLASH 23622248
MIRT041157 hsa-miR-500a-3p CLASH 23622248
MIRT438618 hsa-miR-224-5p qRT-PCR 22989374
MIRT438618 hsa-miR-224-5p qRT-PCR 22989374
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0002223 Process Stimulatory C-type lectin receptor signaling pathway IEA
GO:0002223 Process Stimulatory C-type lectin receptor signaling pathway TAS
GO:0003300 Process Cardiac muscle hypertrophy IEA
GO:0003824 Function Catalytic activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605022 8591 ENSG00000180370
Protein
UniProt ID Q13177
Protein name Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Protein function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:1927359
PDB 3PCS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00786 PBD 73 131 P21-Rho-binding domain Domain
PF00069 Pkinase 249 500 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen. {ECO:0000269|PubMed:7744004}.
Sequence
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGT
EKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNP
QAVLDVLKFYD
SNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAP
PVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIV
SIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKE
LKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLH
ANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY
GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRC
LEMDVEKRGSAKELLQHPFL
KLAKPLSSLTPLIMAAKEAMKSNR
Sequence length 524
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Axon guidance
Focal adhesion
T cell receptor signaling pathway
Regulation of actin cytoskeleton
Pathogenic Escherichia coli infection
Human immunodeficiency virus 1 infection
Renal cell carcinoma
  Nef and signal transduction
Generation of second messenger molecules
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Atrial Fibrillation Atrial fibrillation N/A N/A GWAS
Knobloch Syndrome Knobloch syndrome 2 N/A N/A GenCC
Schizophrenia Schizophrenia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 17881449
Breast Neoplasms Associate 18411304, 19242610, 21555521, 29987050, 30964173, 31987914
Carcinoma Ductal Breast Associate 21555521
Carcinoma Non Small Cell Lung Associate 31587474
Carcinoma Ovarian Epithelial Associate 39350056
Carcinoma Renal Cell Associate 36152754
Carcinoma Squamous Cell Associate 23653450
Chromosome 3q29 Deletion Syndrome Stimulate 15918153
Death Associate 31681304
Diabetes Gestational Associate 34190178