Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5055
Gene name Gene Name - the full gene name approved by the HGNC.	Serpin family B member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SERPINB2
Synonyms (NCBI Gene) Gene synonyms aliases	HsT1201, PAI, PAI-2, PAI2, PLANH2
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18q21.33-q22.1

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023021	hsa-miR-124-3p	Microarray	18668037
MIRT030054	hsa-miR-26b-5p	Microarray	19088304
MIRT1338685	hsa-miR-3132	CLIP-seq
MIRT1338686	hsa-miR-3591-5p	CLIP-seq
MIRT1338687	hsa-miR-4460	CLIP-seq
MIRT1338688	hsa-miR-4652-3p	CLIP-seq
MIRT1338689	hsa-miR-4727-3p	CLIP-seq
MIRT1338690	hsa-miR-4735-5p	CLIP-seq
MIRT1338691	hsa-miR-944	CLIP-seq
MIRT2620586	hsa-miR-296-3p	CLIP-seq
MIRT2620587	hsa-miR-298	CLIP-seq
MIRT1338685	hsa-miR-3132	CLIP-seq
MIRT2620588	hsa-miR-323b-5p	CLIP-seq
MIRT1338686	hsa-miR-3591-5p	CLIP-seq
MIRT2620589	hsa-miR-369-3p	CLIP-seq
MIRT2620590	hsa-miR-374a	CLIP-seq
MIRT2620591	hsa-miR-374b	CLIP-seq
MIRT2620592	hsa-miR-382	CLIP-seq
MIRT2620593	hsa-miR-3945	CLIP-seq
MIRT2620594	hsa-miR-4253	CLIP-seq
MIRT1338687	hsa-miR-4460	CLIP-seq
MIRT1338688	hsa-miR-4652-3p	CLIP-seq
MIRT2620595	hsa-miR-4694-3p	CLIP-seq
MIRT1338689	hsa-miR-4727-3p	CLIP-seq
MIRT1338690	hsa-miR-4735-5p	CLIP-seq
MIRT2620596	hsa-miR-4799-5p	CLIP-seq
MIRT2620597	hsa-miR-522	CLIP-seq
MIRT2620598	hsa-miR-633	CLIP-seq
MIRT1338691	hsa-miR-944	CLIP-seq
MIRT2620586	hsa-miR-296-3p	CLIP-seq
MIRT2620587	hsa-miR-298	CLIP-seq
MIRT1338685	hsa-miR-3132	CLIP-seq
MIRT2620588	hsa-miR-323b-5p	CLIP-seq
MIRT1338686	hsa-miR-3591-5p	CLIP-seq
MIRT2620589	hsa-miR-369-3p	CLIP-seq
MIRT2620590	hsa-miR-374a	CLIP-seq
MIRT2620591	hsa-miR-374b	CLIP-seq
MIRT2620592	hsa-miR-382	CLIP-seq
MIRT2620593	hsa-miR-3945	CLIP-seq
MIRT2620594	hsa-miR-4253	CLIP-seq
MIRT1338687	hsa-miR-4460	CLIP-seq
MIRT1338688	hsa-miR-4652-3p	CLIP-seq
MIRT2620595	hsa-miR-4694-3p	CLIP-seq
MIRT1338689	hsa-miR-4727-3p	CLIP-seq
MIRT1338690	hsa-miR-4735-5p	CLIP-seq
MIRT2620596	hsa-miR-4799-5p	CLIP-seq
MIRT2620597	hsa-miR-522	CLIP-seq
MIRT2620598	hsa-miR-633	CLIP-seq
MIRT1338691	hsa-miR-944	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
ZFP36	Unknown	12578825

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001533	Component	Cornified envelope	IEA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IBA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	TAS
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0042730	Process	Fibrinolysis	TAS
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	TAS	7499264

MIM	HGNC	e!Ensembl
173390	8584	ENSG00000197632

Protein

UniProt ID

P05120

Protein name

Plasminogen activator inhibitor 2 (PAI-2) (Monocyte Arg-serpin) (Placental plasminogen activator inhibitor) (Serpin B2) (Urokinase inhibitor)

Protein function

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

PDB

1BY7 , 1JRR , 2ARQ , 2ARR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00079	Serpin	6 → 415	Serpin (serine protease inhibitor)	Domain

Sequence

MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQF
NEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGN
YLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGK
IPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREK
LNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKM
AEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMV
DVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP

Sequence length

415

Interactions

View interactions

	KEGG		Reactome
	Complement and coagulation cascades		Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

SERPINB2 (serpin family B member 2)