PAEP (progestagen associated endometrial protein)

Gene Gene information from NCBI Gene database.
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 5047
Gene name Progestagen associated endometrial protein
Gene symbol PAEP
Synonyms (NCBI Gene)
GDGdAGdFGdSPAEGPEPPP14ZIF-1
Chromosome 9
Chromosome location 9q34.3
Summary This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromo
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
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Transcription factor Regulation Reference
GATA3 Activation 19483726
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 29892012, 31515488, 32296183
GO:0005576 Component Extracellular region IDA 3667877, 12672671
GO:0005576 Component Extracellular region IEA
GO:0006915 Process Apoptotic process IDA 18996219
GO:0032725 Process Positive regulation of granulocyte macrophage colony-stimulating factor production IDA 19945098
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
173310 8573 ENSG00000122133
Protein Protein information from UniProt database.
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P09466
Protein name Glycodelin (GD) (Placental protein 14) (PP14) (Pregnancy-associated endometrial alpha-2 globulin) (PAEG) (PEG) (Progestagen-associated endometrial protein) (Progesterone-associated endometrial protein) (Zona-binding inhibitory factor-1) (ZIF-1)
Protein function Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biologic
PDB 4R0B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 34 → 175 Lipocalin / cytosolic fatty-acid binding protein family Domain
Tissue specificity TISSUE SPECIFICITY: This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877). Glycodelin-A is expressed in amniotic fluid, endome
Sequence
Sequence length 180
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Ovarian serous cystadenocarcinoma Benign rs6537900 RCV005911757
Sarcoma Benign rs6537900 RCV005911756
Show/Hide Text Mining Associations (33)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Inhibit 18256018
Adenocarcinoma Associate 30535430
Breast Neoplasms Associate 16033096, 38358781
Brenner Tumor Associate 11437921
Carcinogenesis Associate 11459932
Carcinoma in Situ Associate 16033096
Carcinoma Non Small Cell Lung Associate 30535430, 38490536
Carcinoma Ovarian Epithelial Associate 16033096, 17649816, 23036050
Carcinoma Renal Cell Associate 35945780
Carcinoma Squamous Cell Stimulate 30535430