Gene Gene information from NCBI Gene database.
Entrez ID 5037
Gene name Phosphatidylethanolamine binding protein 1
Gene symbol PEBP1
Synonyms (NCBI Gene)
HCNPHCNPppHEL-210HEL-S-34HEL-S-96PBPPEBPPEBP-1RKIP
Chromosome 12
Chromosome location 12q24.23
Summary This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The e
miRNA miRNA information provided by mirtarbase database.
500
miRTarBase ID miRNA Experiments Reference
MIRT007008 hsa-miR-224-5p Luciferase reporter assay 22809510
MIRT007008 hsa-miR-224-5p Luciferase reporter assay 22809510
MIRT019828 hsa-miR-375 Microarray 20215506
MIRT020686 hsa-miR-155-5p Proteomics 18668040
MIRT049454 hsa-miR-92a-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
AR Unknown 23095933
EZH2 Repression 22505648
SNAI1 Repression 18477483;19538137
SPI1 Activation 9334192
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0004867 Function Serine-type endopeptidase inhibitor activity IEA
GO:0005515 Function Protein binding IPI 17097642, 21831839, 30337686, 31980649, 32296183
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604591 8630 ENSG00000089220
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P30086
Protein name Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]
Protein function Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activato
PDB 1BD9 , 1BEH , 2L7W , 2QYQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01161 PBP 25 169 Phosphatidylethanolamine-binding protein Domain
Sequence
Sequence length 187
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants