Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5036
Gene name Gene Name - the full gene name approved by the HGNC.
Proliferation-associated 2G4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PA2G4
Synonyms (NCBI Gene) Gene synonyms aliases
EBP1, HG4-1, ITAF45, p38-2G4
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA process
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004018 hsa-miR-146a-5p Microarray, qRT-PCR, Western blot 19944095
MIRT030585 hsa-miR-24-3p Microarray 19748357
MIRT031824 hsa-miR-16-5p Proteomics 18668040
MIRT052072 hsa-let-7b-5p CLASH 23622248
MIRT051631 hsa-let-7e-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IDA 15073182
GO:0003714 Function Transcription corepressor activity IDA 15073182
GO:0003723 Function RNA binding HDA 22658674
GO:0003723 Function RNA binding IEA
GO:0005515 Function Protein binding IPI 11268000, 15064750, 16254079, 16832058, 28514442, 33961781
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602145 8550 ENSG00000170515
Protein
UniProt ID Q9UQ80
Protein name Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1)
Protein function May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription
PDB 2Q8K , 3J2I , 6CHT , 6LSR , 6SXO , 6WM8 , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 8K2C , 8XSX , 8XSY , 8XSZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00557 Peptidase_M24 19 295 Metallopeptidase family M24 Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. {E
Sequence
Sequence length 394
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Dermatitis Atopic dermatitis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Anodontia Associate 31828582
Autoimmune Diseases Stimulate 34113340
Breast Neoplasms Inhibit 18355957
Breast Neoplasms Associate 23361053
Carcinoma Adenoid Cystic Associate 23110497
Carcinoma Hepatocellular Associate 34257558
Carcinoma Non Small Cell Lung Associate 24998263
Carcinoma Pancreatic Ductal Associate 26088450
Colorectal Neoplasms Associate 20421926, 31828582, 37604903
Dermatitis Herpetiformis Associate 22991566