Gene Gene information from NCBI Gene database.
Entrez ID 5036
Gene name Proliferation-associated 2G4
Gene symbol PA2G4
Synonyms (NCBI Gene)
EBP1HG4-1ITAF45p38-2G4
Chromosome 12
Chromosome location 12q13.2
Summary This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA process
miRNA miRNA information provided by mirtarbase database.
381
miRTarBase ID miRNA Experiments Reference
MIRT004018 hsa-miR-146a-5p MicroarrayqRT-PCRWestern blot 19944095
MIRT030585 hsa-miR-24-3p Microarray 19748357
MIRT031824 hsa-miR-16-5p Proteomics 18668040
MIRT052072 hsa-let-7b-5p CLASH 23622248
MIRT051631 hsa-let-7e-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IDA 15073182
GO:0003714 Function Transcription corepressor activity IDA 15073182
GO:0003723 Function RNA binding HDA 22658674
GO:0003723 Function RNA binding IEA
GO:0005515 Function Protein binding IPI 11268000, 15064750, 16254079, 16832058, 28514442, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602145 8550 ENSG00000170515
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UQ80
Protein name Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1)
Protein function May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription
PDB 2Q8K , 3J2I , 6CHT , 6LSR , 6SXO , 6WM8 , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 8K2C , 8XSX , 8XSY , 8XSZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00557 Peptidase_M24 19 295 Metallopeptidase family M24 Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. {E
Sequence
Sequence length 394
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation