Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5036
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Proliferation-associated 2G4 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
PA2G4 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
EBP1, HG4-1, ITAF45, p38-2G4 |
Chromosome
Chromosome number
|
12 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
12q13.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA process |
UniProt ID |
Q9UQ80
|
Protein name |
Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) |
Protein function |
May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription |
PDB |
2Q8K
,
3J2I
,
6CHT
,
6LSR
,
6SXO
,
6WM8
,
6Z6L
,
6Z6M
,
6Z6N
,
6ZM7
,
6ZME
,
6ZMI
,
6ZMO
,
7BHP
,
8K2C
,
8XSX
,
8XSY
,
8XSZ
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00557
|
Peptidase_M24 |
19 → 295 |
Metallopeptidase family M24 |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. {E |
Sequence |
|
Sequence length |
394 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Gastric cancer |
Hereditary Diffuse Gastric Cancer |
rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208 View all (244 more) |
21364753 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Dermatitis |
Dermatitis |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Anodontia |
Associate
|
31828582 |
Autoimmune Diseases |
Stimulate
|
34113340 |
Breast Neoplasms |
Inhibit
|
18355957 |
Breast Neoplasms |
Associate
|
23361053 |
Carcinoma Adenoid Cystic |
Associate
|
23110497 |
Carcinoma Hepatocellular |
Associate
|
34257558 |
Carcinoma Non Small Cell Lung |
Associate
|
24998263 |
Carcinoma Pancreatic Ductal |
Associate
|
26088450 |
Colorectal Neoplasms |
Associate
|
20421926, 31828582, 37604903 |
Dermatitis Herpetiformis |
Associate
|
22991566 |
Diabetes Mellitus |
Associate
|
31362984 |
Diabetes Mellitus Type 1 |
Associate
|
35594935 |
Gallbladder Neoplasms |
Associate
|
31752867 |
Hepatitis B Chronic |
Associate
|
34113340 |
Inflammation |
Stimulate
|
34113340 |
Liver Failure |
Associate
|
34113340 |
Lymphatic Metastasis |
Inhibit
|
23110497 |
Lymphatic Metastasis |
Associate
|
26088450 |
Lymphatic Metastasis |
Stimulate
|
33605574 |
Metabolic Diseases |
Associate
|
31362984 |
Muscle Weakness |
Associate
|
28025995 |
Nasopharyngeal Carcinoma |
Associate
|
33605574, 36606322 |
Neoplasm Metastasis |
Inhibit
|
20048076, 23110497 |
Neoplasm Metastasis |
Stimulate
|
33605574 |
Neoplasms |
Associate
|
17641068, 23110497, 26081906, 26088450, 31828582, 33605574, 34257558, 36606322 |
Neoplasms |
Inhibit
|
26008146 |
Prostatic Neoplasms |
Associate
|
15583694, 21965718, 25876877 |
Prostatic Neoplasms |
Inhibit
|
20048076, 20159994 |
Prostatic Neoplasms Castration Resistant |
Associate
|
21965718 |
Pulmonary Disease Chronic Obstructive |
Associate
|
28025995 |
Sleep Apnea Obstructive |
Associate
|
35132330 |
Thyroid Cancer Papillary |
Associate
|
26008146 |
Thyroid Neoplasms |
Inhibit
|
26008146 |
Uterine Cervical Neoplasms |
Associate
|
26125746 |
|