Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5034
Gene name	Prolyl 4-hydroxylase subunit beta
Gene symbol	P4HB
Synonyms (NCBI Gene)	CLCRP1DSIERBA2LGITP4HbetaPDIPDIA1PHDBPO4DBPO4HBPROHB
Chromosome	17
Chromosome location	17q25.3
Summary	This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved

Show/Hide all (1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs786204843	T>C	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant

381

Show/Hide all (381)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003155	hsa-miR-210-3p	2DGEimmunoprecipitaionMass spectrometryMicroarrayqRT-PCRWestern blot	19826008
MIRT049210	hsa-miR-92a-3p	CLASH	23622248
MIRT047151	hsa-miR-183-5p	CLASH	23622248
MIRT042160	hsa-miR-484	CLASH	23622248
MIRT040772	hsa-miR-18a-3p	CLASH	23622248
MIRT040162	hsa-miR-615-3p	CLASH	23622248
MIRT053700	hsa-miR-188-5p	Microarray	22942087
MIRT684885	hsa-miR-548n	HITS-CLIP	23313552
MIRT684884	hsa-miR-514a-5p	HITS-CLIP	23313552
MIRT684883	hsa-miR-451b	HITS-CLIP	23313552
MIRT684882	hsa-miR-518c-5p	HITS-CLIP	23313552
MIRT684881	hsa-miR-4638-3p	HITS-CLIP	23313552
MIRT684880	hsa-miR-378a-3p	HITS-CLIP	23313552
MIRT684879	hsa-miR-378b	HITS-CLIP	23313552
MIRT684878	hsa-miR-378c	HITS-CLIP	23313552
MIRT684877	hsa-miR-378d	HITS-CLIP	23313552
MIRT684876	hsa-miR-378e	HITS-CLIP	23313552
MIRT684875	hsa-miR-378f	HITS-CLIP	23313552
MIRT684874	hsa-miR-378h	HITS-CLIP	23313552
MIRT684873	hsa-miR-378i	HITS-CLIP	23313552
MIRT684872	hsa-miR-422a	HITS-CLIP	23313552
MIRT684871	hsa-miR-6516-3p	HITS-CLIP	23313552
MIRT684870	hsa-miR-4520-3p	HITS-CLIP	23313552
MIRT684869	hsa-miR-3672	HITS-CLIP	23313552
MIRT684885	hsa-miR-548n	HITS-CLIP	23313552
MIRT684884	hsa-miR-514a-5p	HITS-CLIP	23313552
MIRT684883	hsa-miR-451b	HITS-CLIP	23313552
MIRT684882	hsa-miR-518c-5p	HITS-CLIP	23313552
MIRT684881	hsa-miR-4638-3p	HITS-CLIP	23313552
MIRT684880	hsa-miR-378a-3p	HITS-CLIP	23313552
MIRT684879	hsa-miR-378b	HITS-CLIP	23313552
MIRT684878	hsa-miR-378c	HITS-CLIP	23313552
MIRT684877	hsa-miR-378d	HITS-CLIP	23313552
MIRT684876	hsa-miR-378e	HITS-CLIP	23313552
MIRT684875	hsa-miR-378f	HITS-CLIP	23313552
MIRT684874	hsa-miR-378h	HITS-CLIP	23313552
MIRT684873	hsa-miR-378i	HITS-CLIP	23313552
MIRT684872	hsa-miR-422a	HITS-CLIP	23313552
MIRT684871	hsa-miR-6516-3p	HITS-CLIP	23313552
MIRT684870	hsa-miR-4520-3p	HITS-CLIP	23313552
MIRT684869	hsa-miR-3672	HITS-CLIP	23313552
MIRT003155	hsa-miR-210-3p	MicroarrayqRT-PCR	35816043
MIRT1209171	hsa-miR-1180	CLIP-seq
MIRT1209172	hsa-miR-1225-3p	CLIP-seq
MIRT1209173	hsa-miR-1233	CLIP-seq
MIRT1209174	hsa-miR-1252	CLIP-seq
MIRT1209175	hsa-miR-1254	CLIP-seq
MIRT1209176	hsa-miR-1270	CLIP-seq
MIRT1209177	hsa-miR-1273f	CLIP-seq
MIRT1209178	hsa-miR-1321	CLIP-seq
MIRT1209179	hsa-miR-1471	CLIP-seq
MIRT1209180	hsa-miR-1587	CLIP-seq
MIRT1209181	hsa-miR-1827	CLIP-seq
MIRT1209182	hsa-miR-204	CLIP-seq
MIRT1209183	hsa-miR-205	CLIP-seq
MIRT1209184	hsa-miR-211	CLIP-seq
MIRT1209185	hsa-miR-3116	CLIP-seq
MIRT1209186	hsa-miR-3121-3p	CLIP-seq
MIRT1209187	hsa-miR-3134	CLIP-seq
MIRT1209188	hsa-miR-3185	CLIP-seq
MIRT1209189	hsa-miR-3187-3p	CLIP-seq
MIRT1209190	hsa-miR-3189-3p	CLIP-seq
MIRT1209191	hsa-miR-338-3p	CLIP-seq
MIRT1209192	hsa-miR-3545-5p	CLIP-seq
MIRT1209193	hsa-miR-3611	CLIP-seq
MIRT1209194	hsa-miR-3612	CLIP-seq
MIRT1209195	hsa-miR-362-5p	CLIP-seq
MIRT1209196	hsa-miR-378	CLIP-seq
MIRT1209197	hsa-miR-3920	CLIP-seq
MIRT1209198	hsa-miR-3943	CLIP-seq
MIRT1209199	hsa-miR-3944-5p	CLIP-seq
MIRT1209200	hsa-miR-4254	CLIP-seq
MIRT1209201	hsa-miR-4261	CLIP-seq
MIRT1209202	hsa-miR-4286	CLIP-seq
MIRT1209203	hsa-miR-4290	CLIP-seq
MIRT1209204	hsa-miR-4323	CLIP-seq
MIRT1209205	hsa-miR-4417	CLIP-seq
MIRT1209206	hsa-miR-4419a	CLIP-seq
MIRT1209207	hsa-miR-4435	CLIP-seq
MIRT1209208	hsa-miR-4440	CLIP-seq
MIRT1209209	hsa-miR-4455	CLIP-seq
MIRT1209210	hsa-miR-4492	CLIP-seq
MIRT1209211	hsa-miR-4496	CLIP-seq
MIRT1209212	hsa-miR-4498	CLIP-seq
MIRT1209213	hsa-miR-4510	CLIP-seq
MIRT1209214	hsa-miR-4511	CLIP-seq
MIRT1209215	hsa-miR-4520a-3p	CLIP-seq
MIRT1209216	hsa-miR-4530	CLIP-seq
MIRT1209217	hsa-miR-4656	CLIP-seq
MIRT1209218	hsa-miR-4664-3p	CLIP-seq
MIRT1209219	hsa-miR-4667-3p	CLIP-seq
MIRT1209220	hsa-miR-4675	CLIP-seq
MIRT1209221	hsa-miR-4683	CLIP-seq
MIRT1209222	hsa-miR-4701-5p	CLIP-seq
MIRT1209223	hsa-miR-4728-5p	CLIP-seq
MIRT1209224	hsa-miR-4731-5p	CLIP-seq
MIRT1209225	hsa-miR-4733-3p	CLIP-seq
MIRT1209226	hsa-miR-4739	CLIP-seq
MIRT1209227	hsa-miR-4741	CLIP-seq
MIRT1209228	hsa-miR-4756-5p	CLIP-seq
MIRT1209229	hsa-miR-4758-3p	CLIP-seq
MIRT1209230	hsa-miR-498	CLIP-seq
MIRT1209231	hsa-miR-500b	CLIP-seq
MIRT1209232	hsa-miR-541	CLIP-seq
MIRT1209233	hsa-miR-548ac	CLIP-seq
MIRT1209234	hsa-miR-548d-3p	CLIP-seq
MIRT1209235	hsa-miR-548s	CLIP-seq
MIRT1209236	hsa-miR-548z	CLIP-seq
MIRT1209237	hsa-miR-588	CLIP-seq
MIRT1209238	hsa-miR-609	CLIP-seq
MIRT1209239	hsa-miR-620	CLIP-seq
MIRT1209240	hsa-miR-629	CLIP-seq
MIRT1209241	hsa-miR-650	CLIP-seq
MIRT1209242	hsa-miR-654-5p	CLIP-seq
MIRT1209243	hsa-miR-661	CLIP-seq
MIRT1209244	hsa-miR-670	CLIP-seq
MIRT1209245	hsa-miR-762	CLIP-seq
MIRT1209246	hsa-miR-766	CLIP-seq
MIRT1209247	hsa-miR-885-3p	CLIP-seq
MIRT1209248	hsa-miR-887	CLIP-seq
MIRT1209247	hsa-miR-885-3p	CLIP-seq
MIRT1209171	hsa-miR-1180	CLIP-seq
MIRT2060078	hsa-miR-1205	CLIP-seq
MIRT2060079	hsa-miR-1273	CLIP-seq
MIRT2060080	hsa-miR-1307	CLIP-seq
MIRT2060081	hsa-miR-136	CLIP-seq
MIRT2060082	hsa-miR-149	CLIP-seq
MIRT2060083	hsa-miR-1972	CLIP-seq
MIRT1209183	hsa-miR-205	CLIP-seq
MIRT2060084	hsa-miR-3064-5p	CLIP-seq
MIRT2060085	hsa-miR-3119	CLIP-seq
MIRT1209186	hsa-miR-3121-3p	CLIP-seq
MIRT1209188	hsa-miR-3185	CLIP-seq
MIRT1209189	hsa-miR-3187-3p	CLIP-seq
MIRT1209190	hsa-miR-3189-3p	CLIP-seq
MIRT1209191	hsa-miR-338-3p	CLIP-seq
MIRT1209192	hsa-miR-3545-5p	CLIP-seq
MIRT1209193	hsa-miR-3611	CLIP-seq
MIRT1209195	hsa-miR-362-5p	CLIP-seq
MIRT2060086	hsa-miR-383	CLIP-seq
MIRT1209197	hsa-miR-3920	CLIP-seq
MIRT2060087	hsa-miR-3926	CLIP-seq
MIRT1209198	hsa-miR-3943	CLIP-seq
MIRT1209199	hsa-miR-3944-5p	CLIP-seq
MIRT1209202	hsa-miR-4286	CLIP-seq
MIRT1209203	hsa-miR-4290	CLIP-seq
MIRT2060088	hsa-miR-4312	CLIP-seq
MIRT2060089	hsa-miR-4418	CLIP-seq
MIRT1209207	hsa-miR-4435	CLIP-seq
MIRT1209209	hsa-miR-4455	CLIP-seq
MIRT1209216	hsa-miR-4530	CLIP-seq
MIRT2060090	hsa-miR-4638-5p	CLIP-seq
MIRT1209218	hsa-miR-4664-3p	CLIP-seq
MIRT1209219	hsa-miR-4667-3p	CLIP-seq
MIRT1209222	hsa-miR-4701-5p	CLIP-seq
MIRT2060091	hsa-miR-4704-3p	CLIP-seq
MIRT2060092	hsa-miR-4717-5p	CLIP-seq
MIRT2060093	hsa-miR-4718	CLIP-seq
MIRT2060094	hsa-miR-4727-5p	CLIP-seq
MIRT1209224	hsa-miR-4731-5p	CLIP-seq
MIRT2060095	hsa-miR-4732-5p	CLIP-seq
MIRT2060096	hsa-miR-4772-5p	CLIP-seq
MIRT2060097	hsa-miR-4794	CLIP-seq
MIRT1209230	hsa-miR-498	CLIP-seq
MIRT1209231	hsa-miR-500b	CLIP-seq
MIRT2060098	hsa-miR-509-3-5p	CLIP-seq
MIRT2060099	hsa-miR-509-5p	CLIP-seq
MIRT1209235	hsa-miR-548s	CLIP-seq
MIRT1209237	hsa-miR-588	CLIP-seq
MIRT2060100	hsa-miR-597	CLIP-seq
MIRT1209238	hsa-miR-609	CLIP-seq
MIRT1209240	hsa-miR-629	CLIP-seq
MIRT2060101	hsa-miR-668	CLIP-seq
MIRT1209246	hsa-miR-766	CLIP-seq
MIRT1209247	hsa-miR-885-3p	CLIP-seq
MIRT2288452	hsa-miR-10a	CLIP-seq
MIRT2288453	hsa-miR-10b	CLIP-seq
MIRT1209171	hsa-miR-1180	CLIP-seq
MIRT2060078	hsa-miR-1205	CLIP-seq
MIRT2060079	hsa-miR-1273	CLIP-seq
MIRT2288454	hsa-miR-1305	CLIP-seq
MIRT1209178	hsa-miR-1321	CLIP-seq
MIRT2288455	hsa-miR-1470	CLIP-seq
MIRT1209179	hsa-miR-1471	CLIP-seq
MIRT2288456	hsa-miR-151-5p	CLIP-seq
MIRT2288457	hsa-miR-151b	CLIP-seq
MIRT1209181	hsa-miR-1827	CLIP-seq
MIRT2288458	hsa-miR-188-3p	CLIP-seq
MIRT1209183	hsa-miR-205	CLIP-seq
MIRT2288459	hsa-miR-2681	CLIP-seq
MIRT2288460	hsa-miR-2964a-5p	CLIP-seq
MIRT1209186	hsa-miR-3121-3p	CLIP-seq
MIRT1209187	hsa-miR-3134	CLIP-seq
MIRT1209188	hsa-miR-3185	CLIP-seq
MIRT1209189	hsa-miR-3187-3p	CLIP-seq
MIRT1209190	hsa-miR-3189-3p	CLIP-seq
MIRT1209192	hsa-miR-3545-5p	CLIP-seq
MIRT1209194	hsa-miR-3612	CLIP-seq
MIRT1209195	hsa-miR-362-5p	CLIP-seq
MIRT1209196	hsa-miR-378	CLIP-seq
MIRT2060086	hsa-miR-383	CLIP-seq
MIRT1209197	hsa-miR-3920	CLIP-seq
MIRT2060087	hsa-miR-3926	CLIP-seq
MIRT2288461	hsa-miR-3937	CLIP-seq
MIRT1209198	hsa-miR-3943	CLIP-seq
MIRT1209199	hsa-miR-3944-5p	CLIP-seq
MIRT1209202	hsa-miR-4286	CLIP-seq
MIRT1209203	hsa-miR-4290	CLIP-seq
MIRT2060089	hsa-miR-4418	CLIP-seq
MIRT1209206	hsa-miR-4419a	CLIP-seq
MIRT1209207	hsa-miR-4435	CLIP-seq
MIRT1209209	hsa-miR-4455	CLIP-seq
MIRT1209213	hsa-miR-4510	CLIP-seq
MIRT1209214	hsa-miR-4511	CLIP-seq
MIRT1209215	hsa-miR-4520a-3p	CLIP-seq
MIRT1209218	hsa-miR-4664-3p	CLIP-seq
MIRT1209219	hsa-miR-4667-3p	CLIP-seq
MIRT2288462	hsa-miR-4695-5p	CLIP-seq
MIRT1209222	hsa-miR-4701-5p	CLIP-seq
MIRT2060091	hsa-miR-4704-3p	CLIP-seq
MIRT2060093	hsa-miR-4718	CLIP-seq
MIRT1209223	hsa-miR-4728-5p	CLIP-seq
MIRT1209224	hsa-miR-4731-5p	CLIP-seq
MIRT2060095	hsa-miR-4732-5p	CLIP-seq
MIRT1209226	hsa-miR-4739	CLIP-seq
MIRT1209228	hsa-miR-4756-5p	CLIP-seq
MIRT2288463	hsa-miR-4761-5p	CLIP-seq
MIRT2288464	hsa-miR-4765	CLIP-seq
MIRT2060096	hsa-miR-4772-5p	CLIP-seq
MIRT1209230	hsa-miR-498	CLIP-seq
MIRT2288465	hsa-miR-499-3p	CLIP-seq
MIRT2288466	hsa-miR-499a-3p	CLIP-seq
MIRT1209231	hsa-miR-500b	CLIP-seq
MIRT2060098	hsa-miR-509-3-5p	CLIP-seq
MIRT2060099	hsa-miR-509-5p	CLIP-seq
MIRT2288467	hsa-miR-532-3p	CLIP-seq
MIRT2288468	hsa-miR-548k	CLIP-seq
MIRT1209235	hsa-miR-548s	CLIP-seq
MIRT1209237	hsa-miR-588	CLIP-seq
MIRT2288469	hsa-miR-591	CLIP-seq
MIRT2060100	hsa-miR-597	CLIP-seq
MIRT2288470	hsa-miR-602	CLIP-seq
MIRT1209238	hsa-miR-609	CLIP-seq
MIRT1209240	hsa-miR-629	CLIP-seq
MIRT1209241	hsa-miR-650	CLIP-seq
MIRT2060101	hsa-miR-668	CLIP-seq
MIRT1209244	hsa-miR-670	CLIP-seq
MIRT2288471	hsa-miR-873	CLIP-seq
MIRT1209247	hsa-miR-885-3p	CLIP-seq
MIRT1209171	hsa-miR-1180	CLIP-seq
MIRT2060078	hsa-miR-1205	CLIP-seq
MIRT2060079	hsa-miR-1273	CLIP-seq
MIRT2060081	hsa-miR-136	CLIP-seq
MIRT1209183	hsa-miR-205	CLIP-seq
MIRT1209189	hsa-miR-3187-3p	CLIP-seq
MIRT2439152	hsa-miR-335	CLIP-seq
MIRT2060086	hsa-miR-383	CLIP-seq
MIRT2060087	hsa-miR-3926	CLIP-seq
MIRT2288461	hsa-miR-3937	CLIP-seq
MIRT1209199	hsa-miR-3944-5p	CLIP-seq
MIRT1209203	hsa-miR-4290	CLIP-seq
MIRT2060089	hsa-miR-4418	CLIP-seq
MIRT1209207	hsa-miR-4435	CLIP-seq
MIRT1209209	hsa-miR-4455	CLIP-seq
MIRT2439153	hsa-miR-4661-3p	CLIP-seq
MIRT1209218	hsa-miR-4664-3p	CLIP-seq
MIRT1209219	hsa-miR-4667-3p	CLIP-seq
MIRT2439154	hsa-miR-4696	CLIP-seq
MIRT1209222	hsa-miR-4701-5p	CLIP-seq
MIRT2060091	hsa-miR-4704-3p	CLIP-seq
MIRT1209224	hsa-miR-4731-5p	CLIP-seq
MIRT2060096	hsa-miR-4772-5p	CLIP-seq
MIRT1209230	hsa-miR-498	CLIP-seq
MIRT2060098	hsa-miR-509-3-5p	CLIP-seq
MIRT2060099	hsa-miR-509-5p	CLIP-seq
MIRT1209235	hsa-miR-548s	CLIP-seq
MIRT1209237	hsa-miR-588	CLIP-seq
MIRT1209238	hsa-miR-609	CLIP-seq
MIRT1209240	hsa-miR-629	CLIP-seq
MIRT2060101	hsa-miR-668	CLIP-seq
MIRT1209244	hsa-miR-670	CLIP-seq
MIRT1209174	hsa-miR-1252	CLIP-seq
MIRT1209175	hsa-miR-1254	CLIP-seq
MIRT1209176	hsa-miR-1270	CLIP-seq
MIRT2060079	hsa-miR-1273	CLIP-seq
MIRT1209177	hsa-miR-1273f	CLIP-seq
MIRT2060081	hsa-miR-136	CLIP-seq
MIRT1209180	hsa-miR-1587	CLIP-seq
MIRT1209182	hsa-miR-204	CLIP-seq
MIRT1209184	hsa-miR-211	CLIP-seq
MIRT2288459	hsa-miR-2681	CLIP-seq
MIRT1209185	hsa-miR-3116	CLIP-seq
MIRT1209187	hsa-miR-3134	CLIP-seq
MIRT2439152	hsa-miR-335	CLIP-seq
MIRT2060086	hsa-miR-383	CLIP-seq
MIRT1209200	hsa-miR-4254	CLIP-seq
MIRT1209201	hsa-miR-4261	CLIP-seq
MIRT1209204	hsa-miR-4323	CLIP-seq
MIRT1209205	hsa-miR-4417	CLIP-seq
MIRT1209210	hsa-miR-4492	CLIP-seq
MIRT1209211	hsa-miR-4496	CLIP-seq
MIRT1209212	hsa-miR-4498	CLIP-seq
MIRT1209217	hsa-miR-4656	CLIP-seq
MIRT2439153	hsa-miR-4661-3p	CLIP-seq
MIRT1209220	hsa-miR-4675	CLIP-seq
MIRT1209221	hsa-miR-4683	CLIP-seq
MIRT2439154	hsa-miR-4696	CLIP-seq
MIRT2060091	hsa-miR-4704-3p	CLIP-seq
MIRT1209225	hsa-miR-4733-3p	CLIP-seq
MIRT1209227	hsa-miR-4741	CLIP-seq
MIRT1209229	hsa-miR-4758-3p	CLIP-seq
MIRT2060096	hsa-miR-4772-5p	CLIP-seq
MIRT2288465	hsa-miR-499-3p	CLIP-seq
MIRT2288466	hsa-miR-499a-3p	CLIP-seq
MIRT1209232	hsa-miR-541	CLIP-seq
MIRT1209233	hsa-miR-548ac	CLIP-seq
MIRT1209234	hsa-miR-548d-3p	CLIP-seq
MIRT2288468	hsa-miR-548k	CLIP-seq
MIRT1209236	hsa-miR-548z	CLIP-seq
MIRT1209239	hsa-miR-620	CLIP-seq
MIRT1209242	hsa-miR-654-5p	CLIP-seq
MIRT1209243	hsa-miR-661	CLIP-seq
MIRT1209245	hsa-miR-762	CLIP-seq
MIRT2288471	hsa-miR-873	CLIP-seq
MIRT1209248	hsa-miR-887	CLIP-seq
MIRT1209173	hsa-miR-1233	CLIP-seq
MIRT1209174	hsa-miR-1252	CLIP-seq
MIRT1209175	hsa-miR-1254	CLIP-seq
MIRT1209176	hsa-miR-1270	CLIP-seq
MIRT2060079	hsa-miR-1273	CLIP-seq
MIRT1209177	hsa-miR-1273f	CLIP-seq
MIRT2060081	hsa-miR-136	CLIP-seq
MIRT1209180	hsa-miR-1587	CLIP-seq
MIRT1209182	hsa-miR-204	CLIP-seq
MIRT1209184	hsa-miR-211	CLIP-seq
MIRT2288459	hsa-miR-2681	CLIP-seq
MIRT1209185	hsa-miR-3116	CLIP-seq
MIRT2687016	hsa-miR-3126-5p	CLIP-seq
MIRT1209187	hsa-miR-3134	CLIP-seq
MIRT2687017	hsa-miR-3179	CLIP-seq
MIRT2687018	hsa-miR-3202	CLIP-seq
MIRT2439152	hsa-miR-335	CLIP-seq
MIRT2060086	hsa-miR-383	CLIP-seq
MIRT1209200	hsa-miR-4254	CLIP-seq
MIRT1209201	hsa-miR-4261	CLIP-seq
MIRT2687019	hsa-miR-4271	CLIP-seq
MIRT1209204	hsa-miR-4323	CLIP-seq
MIRT1209205	hsa-miR-4417	CLIP-seq
MIRT1209206	hsa-miR-4419a	CLIP-seq
MIRT2687020	hsa-miR-4459	CLIP-seq
MIRT1209210	hsa-miR-4492	CLIP-seq
MIRT2687021	hsa-miR-4493	CLIP-seq
MIRT1209211	hsa-miR-4496	CLIP-seq
MIRT1209212	hsa-miR-4498	CLIP-seq
MIRT1209213	hsa-miR-4510	CLIP-seq
MIRT1209217	hsa-miR-4656	CLIP-seq
MIRT2439153	hsa-miR-4661-3p	CLIP-seq
MIRT1209220	hsa-miR-4675	CLIP-seq
MIRT1209221	hsa-miR-4683	CLIP-seq
MIRT2439154	hsa-miR-4696	CLIP-seq
MIRT2060091	hsa-miR-4704-3p	CLIP-seq
MIRT2687022	hsa-miR-4725-3p	CLIP-seq
MIRT1209225	hsa-miR-4733-3p	CLIP-seq
MIRT1209227	hsa-miR-4741	CLIP-seq
MIRT2687023	hsa-miR-4747-5p	CLIP-seq
MIRT1209229	hsa-miR-4758-3p	CLIP-seq
MIRT2060096	hsa-miR-4772-5p	CLIP-seq
MIRT2288465	hsa-miR-499-3p	CLIP-seq
MIRT2288466	hsa-miR-499a-3p	CLIP-seq
MIRT1209232	hsa-miR-541	CLIP-seq
MIRT1209233	hsa-miR-548ac	CLIP-seq
MIRT1209234	hsa-miR-548d-3p	CLIP-seq
MIRT2288468	hsa-miR-548k	CLIP-seq
MIRT1209236	hsa-miR-548z	CLIP-seq
MIRT1209239	hsa-miR-620	CLIP-seq
MIRT1209242	hsa-miR-654-5p	CLIP-seq
MIRT1209243	hsa-miR-661	CLIP-seq
MIRT1209245	hsa-miR-762	CLIP-seq
MIRT2687024	hsa-miR-765	CLIP-seq
MIRT2288471	hsa-miR-873	CLIP-seq
MIRT1209248	hsa-miR-887	CLIP-seq

Show/Hide all (63)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003756	Function	Protein disulfide isomerase activity	EXP	15720785
GO:0003756	Function	Protein disulfide isomerase activity	IBA
GO:0003756	Function	Protein disulfide isomerase activity	IDA	15225124, 21091435, 32149426
GO:0003756	Function	Protein disulfide isomerase activity	IEA
GO:0003756	Function	Protein disulfide isomerase activity	TAS	2846539
GO:0003779	Function	Actin binding	IPI	24415753
GO:0004656	Function	Procollagen-proline 4-dioxygenase activity	IDA	7753822
GO:0004656	Function	Procollagen-proline 4-dioxygenase activity	TAS	2846539
GO:0005178	Function	Integrin binding	IEA
GO:0005178	Function	Integrin binding	IPI	21670307
GO:0005515	Function	Protein binding	IPI	12095988, 16478722, 17055437, 19942855, 20802462, 21057456, 21670307, 23475612, 23861867, 24098548, 25108285, 26224785, 26370502, 30021884, 31992623, 32296183, 32812023, 32814053, 33961781, 35063084
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	32149426
GO:0005783	Component	Endoplasmic reticulum	IDA	12095988, 23152784, 23475612, 24415753
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	3034602
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IDA
GO:0005829	Component	Cytosol	IDA	24415753
GO:0005856	Component	Cytoskeleton	IDA	24415753
GO:0005886	Component	Plasma membrane	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006457	Process	Protein folding	IBA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IEA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IDA	21670307
GO:0009897	Component	External side of plasma membrane	IEA
GO:0015035	Function	Protein-disulfide reductase activity	EXP	21308844
GO:0015035	Function	Protein-disulfide reductase activity	IDA	16677074, 21670307
GO:0015035	Function	Protein-disulfide reductase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016222	Component	Procollagen-proline 4-dioxygenase complex	IDA	7753822
GO:0016853	Function	Isomerase activity	IEA
GO:0016972	Function	Thiol oxidase activity	IDA	21091435
GO:0018401	Process	Peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IDA	7753822
GO:0019899	Function	Enzyme binding	IEA
GO:0030027	Component	Lamellipodium	IDA	24415753
GO:0030070	Process	Insulin processing	IEA
GO:0030070	Process	Insulin processing	TAS
GO:0032991	Component	Protein-containing complex	IDA	24415753
GO:0034663	Component	Endoplasmic reticulum chaperone complex	IEA
GO:0034975	Process	Protein folding in endoplasmic reticulum	IDA	21091435
GO:0034975	Process	Protein folding in endoplasmic reticulum	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IBA
GO:0034976	Process	Response to endoplasmic reticulum stress	IMP	12095988
GO:0035722	Process	Interleukin-12-mediated signaling pathway	TAS
GO:0038155	Process	Interleukin-23-mediated signaling pathway	TAS
GO:0042470	Component	Melanosome	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045785	Process	Positive regulation of cell adhesion	IMP	24415753
GO:0046598	Process	Positive regulation of viral entry into host cell	IDA	21670307
GO:0046598	Process	Positive regulation of viral entry into host cell	IMP	21670307
GO:0046982	Function	Protein heterodimerization activity	IDA	23475612
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0071456	Process	Cellular response to hypoxia	IMP	12095988
GO:0098761	Process	Cellular response to interleukin-7	IEA
GO:1900026	Process	Positive regulation of substrate adhesion-dependent cell spreading	IMP	24415753
GO:1902175	Process	Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP	12095988
GO:2000406	Process	Positive regulation of T cell migration	IDA	21670307

MIM	HGNC	e!Ensembl
176790	8548	ENSG00000185624

P07237

Protein name

Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)

Protein function

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural m

PDB

1BJX , 1MEK , 1X5C , 2BJX , 2K18 , 3BJ5 , 3UEM , 4EKZ , 4EL1 , 4JU5 , 6I7S , 7ZSC , 8EOJ , 8GDY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00085	Thioredoxin	25 → 131	Thioredoxin	Domain
PF13848	Thioredoxin_6	161 → 345		Domain
PF00085	Thioredoxin	368 → 472	Thioredoxin	Domain

Sequence

MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALA
PEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGR
EADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAID
DIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEF
TEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQR
ILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQEL
PEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENI
VIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGD
DDDLEDLEEAEEPDMEEDDDQKAVKDEL

Sequence length

508

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum		Collagen biosynthesis and modifying enzymes Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Interleukin-12 signaling Interleukin-23 signaling

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Cole-Carpenter syndrome 1	Likely pathogenic; Pathogenic	rs2143371167, rs786204843	RCV001530199 RCV000169753

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cholangiocarcinoma	Uncertain significance	rs145146947	RCV005930449
Cole-Carpenter syndrome	Uncertain significance	rs2038725295	RCV001260283
Osteogenesis imperfecta	Uncertain significance	rs1158109159	RCV005626553
P4HB-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	rs138621837, rs376060719, rs759767318, rs145209834, rs201350121, rs1168761588, rs2509950922, rs2509951000, rs201834939, rs2509958020, rs201831951, rs145332986, rs144034161, rs142731141, rs151018460, rs752394154 View all (1 more)	RCV004754766 RCV003903533 RCV003971190 RCV003951217 RCV003936493 RCV003416870 RCV003397585 RCV003964197 RCV003941661 RCV003949220 RCV003955793 RCV003957934 RCV003920726 RCV003950768 RCV003970528 RCV003925817

Show/Hide Text Mining Associations (58)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abetalipoproteinemia	Associate	8939939
Adenocarcinoma	Associate	33120770
Adenocarcinoma of Lung	Associate	33120770, 35029906, 37880717
Alzheimer Disease	Associate	21130735, 24094038
Amyotrophic Lateral Sclerosis	Associate	25913742
Antiphospholipid Syndrome	Associate	18759277
Aortic Dissection	Associate	36819785
Azoospermia	Stimulate	39237030
Bone Diseases	Associate	29263160
Brain Neoplasms	Associate	29235250
Breast Neoplasms	Associate	16048908, 20005186, 33125139, 33637669, 35014681, 35301432
Carcinogenesis	Associate	32023222, 35014681
Carcinoma Pancreatic Ductal	Associate	38003657
Carcinoma Renal Cell	Associate	31640086, 32003756, 32830535, 33858375, 34620162, 35036081
Chromosome Disorders	Associate	2831713
Cole Carpenter syndrome	Associate	25683117, 29263160, 29384951
Colorectal Neoplasms	Associate	23004678, 30431122, 30760703, 36202782
Crohn Disease	Associate	24358121
Diabetes Mellitus Type 2	Associate	33161510
Diabetic Nephropathies	Associate	11703593, 39251943
Diabetic Nephropathies	Stimulate	33161510
Drug Related Side Effects and Adverse Reactions	Inhibit	29235250
Fibrosis	Associate	39251943
Fractures Bone	Associate	29263160
Glioblastoma	Associate	29235250, 30759340, 32830969, 35436915, 36927978
Glioma	Associate	21979894, 32023222
Glioma	Stimulate	29207176
Glycosuria Renal	Associate	32830535
Graves Ophthalmopathy	Stimulate	33934566
Hereditary Breast and Ovarian Cancer Syndrome	Associate	33125139
Hypoxia	Associate	29904245, 31467922, 35301432
Inflammation	Associate	33934566
Keratoconus	Associate	34478492
Leukemia	Associate	21471526
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	1629227
Leukemia Myeloid Acute	Associate	21471526
Lymphoma	Associate	26700650
Mitochondrial Diseases	Associate	32830535, 33125139
Mitochondrial Diseases	Stimulate	36202782
Multiple Sulfatase Deficiency Disease	Associate	18508857, 29972788
Neoplasm Metastasis	Associate	29904245, 31467922
Neoplasm Metastasis	Stimulate	36202782
Neoplasms	Associate	18359981, 22072120, 25228833, 27080849, 2831713, 29207176, 30760703, 32003756, 36202782, 37480146, 37880717
Neoplasms	Stimulate	34400417
Neoplasms	Inhibit	35014681
Neuroblastoma	Associate	23559015
Osteogenesis Imperfecta	Associate	30948499
Osteoporosis	Associate	18924182
Pemphigus and fogo selvagem	Stimulate	35632621
Prostatic Neoplasms	Associate	37270661, 37480146
Sclerosis	Associate	29263160
Squamous Cell Carcinoma of Head and Neck	Associate	20497865
Stomach Neoplasms	Associate	29904245, 31467922
Thromboembolism	Associate	34400417
Thrombosis	Associate	18759277, 34400417
Triple Negative Breast Neoplasms	Associate	33125139
Urinary Bladder Neoplasms	Associate	36562811, 37790935, 38299148
Urinary Bladder Neoplasms	Stimulate	37845668

P4HB (prolyl 4-hydroxylase subunit beta)