OXT (oxytocin/neurophysin I prepropeptide)

Gene Gene information from NCBI Gene database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5020
Gene name Oxytocin/neurophysin I prepropeptide
Gene symbol OXT
Synonyms (NCBI Gene)
OTOT-NPIOXT-NPI
Chromosome 20
Chromosome location 20p13
Summary This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Togeth
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (3)
Transcription factor Regulation Reference
ESR1 Unknown 10411324
ESR2 Unknown 10411324
NR2C2 Unknown 17054912
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
63
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001975 Process Response to amphetamine IEA
GO:0002027 Process Regulation of heart rate IEA
GO:0002125 Process Maternal aggressive behavior IBA
GO:0002125 Process Maternal aggressive behavior IEA
GO:0005179 Function Hormone activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
167050 8528 ENSG00000101405
Protein Protein information from UniProt database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01178
Protein name Oxytocin-neurophysin 1 (OT-NPI) [Cleaved into: Oxytocin (Ocytocin); Neurophysin 1]
Protein function Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed:18174156).
PDB 7OFG , 7OTD , 7QVM , 7RYC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00220 Hormone_4 20 → 28 Neurohypophysial hormones, N-terminal Domain Family
PF00184 Hormone_5 39 → 116 Neurohypophysial hormones, C-terminal Domain Family
Sequence
Sequence length 125
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Oxytocin signaling pathway 		  Vasopressin-like receptors
G alpha (q) signalling events
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Neurodevelopmental disorder Uncertain significance rs1840123531 RCV001262143
Show/Hide Text Mining Associations (103)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 26406593
Adenomyosis Associate 33305666
Alopecia Associate 37863919
Alzheimer Disease Associate 31775875
Amyotrophic Lateral Sclerosis Associate 36495857
Anorexia Nervosa Associate 24523928
Anovulation Associate 37013781
Antisocial Personality Disorder Associate 27036876, 29927293
Anxiety Associate 22418012, 23413037, 25262417, 26615966, 27903255, 35462200
Anxiety Inhibit 26741286, 28371242, 29410310, 31252303