OXT (oxytocin/neurophysin I prepropeptide)

Gene
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5020
Gene name Gene Name - the full gene name approved by the HGNC.
Oxytocin/neurophysin I prepropeptide
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
OXT
Synonyms (NCBI Gene) Gene synonyms aliases
OT, OT-NPI, OXT-NPI
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20p13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Togeth
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
ESR1 Unknown 10411324
ESR2 Unknown 10411324
NR2C2 Unknown 17054912
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(55)
GO ID Ontology Definition Evidence Reference
GO:0001975 Process Response to amphetamine IEA
GO:0002027 Process Regulation of heart rate IEA
GO:0002125 Process Maternal aggressive behavior IEA
GO:0005184 Function Neuropeptide hormone activity IBA 21873635
GO:0005185 Function Neurohypophyseal hormone activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
167050 8528 ENSG00000101405
Protein
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P01178
Protein name Oxytocin-neurophysin 1 (OT-NPI) [Cleaved into: Oxytocin (Ocytocin); Neurophysin 1]
Protein function Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed:18174156).
PDB 7OFG , 7OTD , 7QVM , 7RYC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00220 Hormone_4 20 → 28 Neurohypophysial hormones, N-terminal Domain Family
PF00184 Hormone_5 39 → 116 Neurohypophysial hormones, C-terminal Domain Family
Sequence
Sequence length 125
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Oxytocin signaling pathway 		  Vasopressin-like receptors
G alpha (q) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (7)
Causal
Disease term Disease name dbSNP ID References
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)		 15288368, 18775368
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 8647655
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 8647655
Epilepsy Epilepsy, Tonic-Clonic, Familial, Epilepsy, Tonic-Clonic, Symptomatic rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670
View all (165 more)		 6407273, 4988877
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder 23846912, 23941164, 25025656, 24025838, 22088430, 19500216, 19515497, 21208749 ClinVar
Show/Hide Text Mining Associations (103)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 26406593
Adenomyosis Associate 33305666
Alopecia Associate 37863919
Alzheimer Disease Associate 31775875
Amyotrophic Lateral Sclerosis Associate 36495857
Anorexia Nervosa Associate 24523928
Anovulation Associate 37013781
Antisocial Personality Disorder Associate 27036876, 29927293
Anxiety Associate 22418012, 23413037, 25262417, 26615966, 27903255, 35462200
Anxiety Inhibit 26741286, 28371242, 29410310, 31252303