OSM (oncostatin M)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5008
Gene name Gene Name - the full gene name approved by the HGNC.
Oncostatin M
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
OSM
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q12.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that in
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT1206723 hsa-miR-1231 CLIP-seq
MIRT1206724 hsa-miR-1302 CLIP-seq
MIRT1206725 hsa-miR-193a-5p CLIP-seq
MIRT1206726 hsa-miR-3122 CLIP-seq
MIRT1206727 hsa-miR-3140-3p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
STAT3 Activation 10391682
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002675 Process Positive regulation of acute inflammatory response IC 8999038
GO:0005102 Function Signaling receptor binding IEA
GO:0005125 Function Cytokine activity IBA
GO:0005125 Function Cytokine activity IDA 8999038
GO:0005125 Function Cytokine activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
165095 8506 ENSG00000099985
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P13725
Protein name Oncostatin-M (OSM)
Protein function Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (he
PDB 1EVS , 8V29 , 8V2A
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01291 LIF_OSM 37 → 209 LIF / OSM family Domain
Sequence
Sequence length 252
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
JAK-STAT signaling pathway 		  Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Coronary artery disease Coronary artery disease N/A N/A GWAS
Myocardial Infarction Myocardial infarction N/A N/A GWAS
Show/Hide Text Mining Associations (85)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 10590238, 7657807, 8030759
Adenocarcinoma of Lung Inhibit 27486982
Adenocarcinoma of Lung Associate 40486872
AIDS related Kaposi sarcoma Associate 7657807
Amyotrophic Lateral Sclerosis Stimulate 40306441
Aortic Aneurysm Abdominal Associate 17321344
Arthritis Psoriatic Associate 16917497
Arthritis Rheumatoid Associate 10632674, 15146412, 17009243, 19565514, 19627579, 32561292
Asthma Stimulate 19916861
Astrocytoma Associate 11284716, 25246098