OSBP (oxysterol binding protein)

Gene

• Entrez ID: 5007
• Gene name: Oxysterol binding protein
• Gene symbol: OSBP
• Synonyms (NCBI Gene): OSBP1
• Chromosome: 11
• Chromosome location: 11q12.1
• Summary: Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1565117343	G>A	Pathogenic	Coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019139	hsa-miR-335-5p	Microarray	18185580
MIRT023205	hsa-miR-124-3p	Microarray	18668037
MIRT044025	hsa-miR-365a-3p	CLASH	23622248
MIRT041032	hsa-miR-505-3p	CLASH	23622248
MIRT490895	hsa-miR-6835-3p	PAR-CLIP	23592263
MIRT490894	hsa-miR-4422	PAR-CLIP	23592263
MIRT490893	hsa-miR-5680	PAR-CLIP	23592263
MIRT490892	hsa-miR-3154	PAR-CLIP	23592263
MIRT490891	hsa-miR-130a-3p	PAR-CLIP	23592263
MIRT490890	hsa-miR-130b-3p	PAR-CLIP	23592263
MIRT490889	hsa-miR-301a-3p	PAR-CLIP	23592263
MIRT490888	hsa-miR-301b-3p	PAR-CLIP	23592263
MIRT490887	hsa-miR-3666	PAR-CLIP	23592263
MIRT490886	hsa-miR-4295	PAR-CLIP	23592263
MIRT490885	hsa-miR-454-3p	PAR-CLIP	23592263
MIRT490884	hsa-miR-7852-3p	PAR-CLIP	23592263
MIRT490882	hsa-miR-4691-3p	PAR-CLIP	23592263
MIRT490883	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT490881	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT490880	hsa-miR-3179	PAR-CLIP	23592263
MIRT490879	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT490878	hsa-miR-6077	PAR-CLIP	23592263
MIRT490877	hsa-miR-6073	PAR-CLIP	23592263
MIRT490876	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT490875	hsa-miR-4671-3p	PAR-CLIP	23592263
MIRT490874	hsa-miR-3157-5p	PAR-CLIP	23592263
MIRT442512	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT442511	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT442510	hsa-miR-6873-5p	PAR-CLIP	22100165
MIRT442509	hsa-miR-6760-5p	PAR-CLIP	22100165
MIRT442507	hsa-miR-4419a	PAR-CLIP	22100165
MIRT442508	hsa-miR-4510	PAR-CLIP	22100165
MIRT442506	hsa-miR-6127	PAR-CLIP	22100165
MIRT442505	hsa-miR-6129	PAR-CLIP	22100165
MIRT442504	hsa-miR-6130	PAR-CLIP	22100165
MIRT442503	hsa-miR-6133	PAR-CLIP	22100165
MIRT442502	hsa-miR-2467-3p	PAR-CLIP	22100165
MIRT442501	hsa-miR-6878-5p	PAR-CLIP	22100165
MIRT490895	hsa-miR-6835-3p	PAR-CLIP	23592263
MIRT490894	hsa-miR-4422	PAR-CLIP	23592263
MIRT490893	hsa-miR-5680	PAR-CLIP	23592263
MIRT490892	hsa-miR-3154	PAR-CLIP	23592263
MIRT490891	hsa-miR-130a-3p	PAR-CLIP	23592263
MIRT490890	hsa-miR-130b-3p	PAR-CLIP	23592263
MIRT490889	hsa-miR-301a-3p	PAR-CLIP	23592263
MIRT490888	hsa-miR-301b-3p	PAR-CLIP	23592263
MIRT490887	hsa-miR-3666	PAR-CLIP	23592263
MIRT490886	hsa-miR-4295	PAR-CLIP	23592263
MIRT490885	hsa-miR-454-3p	PAR-CLIP	23592263
MIRT490884	hsa-miR-7852-3p	PAR-CLIP	23592263
MIRT490882	hsa-miR-4691-3p	PAR-CLIP	23592263
MIRT490883	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT490881	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT490880	hsa-miR-3179	PAR-CLIP	23592263
MIRT490879	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT490878	hsa-miR-6077	PAR-CLIP	23592263
MIRT490877	hsa-miR-6073	PAR-CLIP	23592263
MIRT490876	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT490875	hsa-miR-4671-3p	PAR-CLIP	23592263
MIRT490874	hsa-miR-3157-5p	PAR-CLIP	23592263
MIRT442512	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT442511	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT442510	hsa-miR-6873-5p	PAR-CLIP	22100165
MIRT442509	hsa-miR-6760-5p	PAR-CLIP	22100165
MIRT442507	hsa-miR-4419a	PAR-CLIP	22100165
MIRT442508	hsa-miR-4510	PAR-CLIP	22100165
MIRT442506	hsa-miR-6127	PAR-CLIP	22100165
MIRT442505	hsa-miR-6129	PAR-CLIP	22100165
MIRT442504	hsa-miR-6130	PAR-CLIP	22100165
MIRT442503	hsa-miR-6133	PAR-CLIP	22100165
MIRT442502	hsa-miR-2467-3p	PAR-CLIP	22100165
MIRT442501	hsa-miR-6878-5p	PAR-CLIP	22100165
MIRT1205886	hsa-miR-1200	CLIP-seq
MIRT1205887	hsa-miR-1229	CLIP-seq
MIRT1205888	hsa-miR-1236	CLIP-seq
MIRT1205889	hsa-miR-1244	CLIP-seq
MIRT1205890	hsa-miR-1252	CLIP-seq
MIRT1205891	hsa-miR-1256	CLIP-seq
MIRT1205892	hsa-miR-1266	CLIP-seq
MIRT1205893	hsa-miR-130a	CLIP-seq
MIRT1205894	hsa-miR-130b	CLIP-seq
MIRT1205895	hsa-miR-136	CLIP-seq
MIRT1205896	hsa-miR-1537	CLIP-seq
MIRT1205897	hsa-miR-2052	CLIP-seq
MIRT1205898	hsa-miR-2110	CLIP-seq
MIRT1205899	hsa-miR-2392	CLIP-seq
MIRT1205900	hsa-miR-301a	CLIP-seq
MIRT1205901	hsa-miR-301b	CLIP-seq
MIRT1205902	hsa-miR-3065-5p	CLIP-seq
MIRT1205903	hsa-miR-3138	CLIP-seq
MIRT1205904	hsa-miR-3140-5p	CLIP-seq
MIRT1205905	hsa-miR-3145-3p	CLIP-seq
MIRT1205906	hsa-miR-3150a-3p	CLIP-seq
MIRT1205907	hsa-miR-3153	CLIP-seq
MIRT1205908	hsa-miR-3185	CLIP-seq
MIRT1205909	hsa-miR-3202	CLIP-seq
MIRT1205910	hsa-miR-325	CLIP-seq
MIRT1205911	hsa-miR-3614-5p	CLIP-seq
MIRT1205912	hsa-miR-3664-3p	CLIP-seq
MIRT1205913	hsa-miR-370	CLIP-seq
MIRT1205914	hsa-miR-3920	CLIP-seq
MIRT1205915	hsa-miR-3936	CLIP-seq
MIRT1205916	hsa-miR-4259	CLIP-seq
MIRT1205917	hsa-miR-4270	CLIP-seq
MIRT1205918	hsa-miR-4271	CLIP-seq
MIRT1205919	hsa-miR-4292	CLIP-seq
MIRT1205920	hsa-miR-4308	CLIP-seq
MIRT1205921	hsa-miR-4321	CLIP-seq
MIRT1205922	hsa-miR-4425	CLIP-seq
MIRT1205923	hsa-miR-4441	CLIP-seq
MIRT1205924	hsa-miR-4476	CLIP-seq
MIRT1205925	hsa-miR-450b-3p	CLIP-seq
MIRT1205926	hsa-miR-4518	CLIP-seq
MIRT1205927	hsa-miR-4533	CLIP-seq
MIRT1205928	hsa-miR-454	CLIP-seq
MIRT1205929	hsa-miR-4668-5p	CLIP-seq
MIRT1205930	hsa-miR-4713-3p	CLIP-seq
MIRT1205931	hsa-miR-4715-5p	CLIP-seq
MIRT1205932	hsa-miR-4725-3p	CLIP-seq
MIRT1205933	hsa-miR-4778-3p	CLIP-seq
MIRT1205934	hsa-miR-4781-5p	CLIP-seq
MIRT1205935	hsa-miR-4786-3p	CLIP-seq
MIRT1205936	hsa-miR-4796-3p	CLIP-seq
MIRT1205937	hsa-miR-489	CLIP-seq
MIRT1205938	hsa-miR-509-3p	CLIP-seq
MIRT1205939	hsa-miR-513c	CLIP-seq
MIRT1205940	hsa-miR-514b-5p	CLIP-seq
MIRT1205941	hsa-miR-548p	CLIP-seq
MIRT1205942	hsa-miR-548t	CLIP-seq
MIRT1205943	hsa-miR-609	CLIP-seq
MIRT1205944	hsa-miR-638	CLIP-seq
MIRT1205945	hsa-miR-767-3p	CLIP-seq
MIRT1205946	hsa-miR-769-3p	CLIP-seq
MIRT1205947	hsa-miR-802	CLIP-seq
MIRT1205948	hsa-miR-885-5p	CLIP-seq
MIRT1205887	hsa-miR-1229	CLIP-seq
MIRT1205898	hsa-miR-2110	CLIP-seq
MIRT1205906	hsa-miR-3150a-3p	CLIP-seq
MIRT1205916	hsa-miR-4259	CLIP-seq
MIRT1205918	hsa-miR-4271	CLIP-seq
MIRT1205931	hsa-miR-4715-5p	CLIP-seq
MIRT1205932	hsa-miR-4725-3p	CLIP-seq
MIRT1205887	hsa-miR-1229	CLIP-seq
MIRT2059328	hsa-miR-135a	CLIP-seq
MIRT2059329	hsa-miR-135b	CLIP-seq
MIRT1205895	hsa-miR-136	CLIP-seq
MIRT1205897	hsa-miR-2052	CLIP-seq
MIRT2059330	hsa-miR-3121-5p	CLIP-seq
MIRT2059331	hsa-miR-3622a-3p	CLIP-seq
MIRT2059332	hsa-miR-3622b-3p	CLIP-seq
MIRT2059333	hsa-miR-3673	CLIP-seq
MIRT2059334	hsa-miR-4468	CLIP-seq
MIRT2059335	hsa-miR-4766-5p	CLIP-seq
MIRT2059336	hsa-miR-4787-3p	CLIP-seq
MIRT2059337	hsa-miR-516a-3p	CLIP-seq
MIRT1205948	hsa-miR-885-5p	CLIP-seq
MIRT2287624	hsa-miR-1	CLIP-seq
MIRT2287625	hsa-miR-1224-5p	CLIP-seq
MIRT2287626	hsa-miR-1227	CLIP-seq
MIRT1205887	hsa-miR-1229	CLIP-seq
MIRT2287627	hsa-miR-124	CLIP-seq
MIRT1205890	hsa-miR-1252	CLIP-seq
MIRT2287628	hsa-miR-1305	CLIP-seq
MIRT1205893	hsa-miR-130a	CLIP-seq
MIRT1205894	hsa-miR-130b	CLIP-seq
MIRT2059328	hsa-miR-135a	CLIP-seq
MIRT2059329	hsa-miR-135b	CLIP-seq
MIRT1205895	hsa-miR-136	CLIP-seq
MIRT2287629	hsa-miR-141	CLIP-seq
MIRT2287630	hsa-miR-150	CLIP-seq
MIRT1205896	hsa-miR-1537	CLIP-seq
MIRT2287631	hsa-miR-197	CLIP-seq
MIRT2287632	hsa-miR-200a	CLIP-seq
MIRT2287633	hsa-miR-206	CLIP-seq
MIRT1205898	hsa-miR-2110	CLIP-seq
MIRT2287634	hsa-miR-224	CLIP-seq
MIRT2287635	hsa-miR-2278	CLIP-seq
MIRT2287636	hsa-miR-2355-5p	CLIP-seq
MIRT2287637	hsa-miR-2467-5p	CLIP-seq
MIRT2287638	hsa-miR-29a	CLIP-seq
MIRT2287639	hsa-miR-29b	CLIP-seq
MIRT2287640	hsa-miR-29c	CLIP-seq
MIRT1205900	hsa-miR-301a	CLIP-seq
MIRT1205901	hsa-miR-301b	CLIP-seq
MIRT2287641	hsa-miR-3065-3p	CLIP-seq
MIRT2059330	hsa-miR-3121-5p	CLIP-seq
MIRT2287642	hsa-miR-3140-3p	CLIP-seq
MIRT1205905	hsa-miR-3145-3p	CLIP-seq
MIRT1205906	hsa-miR-3150a-3p	CLIP-seq
MIRT2287643	hsa-miR-3183	CLIP-seq
MIRT2287644	hsa-miR-3188	CLIP-seq
MIRT2287645	hsa-miR-3190	CLIP-seq
MIRT2287646	hsa-miR-335	CLIP-seq
MIRT1205911	hsa-miR-3614-5p	CLIP-seq
MIRT2287647	hsa-miR-3622a-5p	CLIP-seq
MIRT2287648	hsa-miR-365	CLIP-seq
MIRT2059333	hsa-miR-3673	CLIP-seq
MIRT2287649	hsa-miR-3677-3p	CLIP-seq
MIRT2287650	hsa-miR-3679-3p	CLIP-seq
MIRT2287651	hsa-miR-3687	CLIP-seq
MIRT2287652	hsa-miR-3691-5p	CLIP-seq
MIRT2287653	hsa-miR-3714	CLIP-seq
MIRT2287654	hsa-miR-3910	CLIP-seq
MIRT2287655	hsa-miR-3915	CLIP-seq
MIRT1205914	hsa-miR-3920	CLIP-seq
MIRT2287656	hsa-miR-3925-3p	CLIP-seq
MIRT2287657	hsa-miR-3928	CLIP-seq
MIRT2287658	hsa-miR-3973	CLIP-seq
MIRT2287659	hsa-miR-3975	CLIP-seq
MIRT1205916	hsa-miR-4259	CLIP-seq
MIRT2287660	hsa-miR-4266	CLIP-seq
MIRT1205918	hsa-miR-4271	CLIP-seq
MIRT2287661	hsa-miR-4287	CLIP-seq
MIRT2287662	hsa-miR-4318	CLIP-seq
MIRT1205921	hsa-miR-4321	CLIP-seq
MIRT2287663	hsa-miR-4328	CLIP-seq
MIRT2287664	hsa-miR-4423-3p	CLIP-seq
MIRT2287665	hsa-miR-4442	CLIP-seq
MIRT2059334	hsa-miR-4468	CLIP-seq
MIRT2287666	hsa-miR-4469	CLIP-seq
MIRT2287667	hsa-miR-4491	CLIP-seq
MIRT1205925	hsa-miR-450b-3p	CLIP-seq
MIRT1205928	hsa-miR-454	CLIP-seq
MIRT2287668	hsa-miR-4657	CLIP-seq
MIRT2287669	hsa-miR-4663	CLIP-seq
MIRT2287670	hsa-miR-4665-3p	CLIP-seq
MIRT2287671	hsa-miR-4685-3p	CLIP-seq
MIRT2287672	hsa-miR-4689	CLIP-seq
MIRT2287673	hsa-miR-4693-5p	CLIP-seq
MIRT2287674	hsa-miR-4698	CLIP-seq
MIRT2287675	hsa-miR-4705	CLIP-seq
MIRT1205930	hsa-miR-4713-3p	CLIP-seq
MIRT2287676	hsa-miR-4713-5p	CLIP-seq
MIRT1205931	hsa-miR-4715-5p	CLIP-seq
MIRT2287677	hsa-miR-4716-5p	CLIP-seq
MIRT2287678	hsa-miR-4723-3p	CLIP-seq
MIRT1205932	hsa-miR-4725-3p	CLIP-seq
MIRT2287679	hsa-miR-4728-5p	CLIP-seq
MIRT2287680	hsa-miR-4764-5p	CLIP-seq
MIRT2287681	hsa-miR-4765	CLIP-seq
MIRT1205934	hsa-miR-4781-5p	CLIP-seq
MIRT1205935	hsa-miR-4786-3p	CLIP-seq
MIRT2287682	hsa-miR-4790-3p	CLIP-seq
MIRT2287683	hsa-miR-483-3p	CLIP-seq
MIRT2287684	hsa-miR-485-5p	CLIP-seq
MIRT2287685	hsa-miR-498	CLIP-seq
MIRT2287686	hsa-miR-506	CLIP-seq
MIRT1205938	hsa-miR-509-3p	CLIP-seq
MIRT2059337	hsa-miR-516a-3p	CLIP-seq
MIRT2287687	hsa-miR-520g	CLIP-seq
MIRT2287688	hsa-miR-520h	CLIP-seq
MIRT2287689	hsa-miR-522	CLIP-seq
MIRT2287690	hsa-miR-532-3p	CLIP-seq
MIRT2287691	hsa-miR-548ae	CLIP-seq
MIRT2287692	hsa-miR-548aj	CLIP-seq
MIRT2287693	hsa-miR-548am	CLIP-seq
MIRT2287694	hsa-miR-548x	CLIP-seq
MIRT2287695	hsa-miR-556-5p	CLIP-seq
MIRT2287696	hsa-miR-579	CLIP-seq
MIRT2287697	hsa-miR-600	CLIP-seq
MIRT2287698	hsa-miR-613	CLIP-seq
MIRT2287699	hsa-miR-624	CLIP-seq
MIRT1205944	hsa-miR-638	CLIP-seq
MIRT2287700	hsa-miR-647	CLIP-seq
MIRT2287701	hsa-miR-668	CLIP-seq
MIRT1205946	hsa-miR-769-3p	CLIP-seq
MIRT1205948	hsa-miR-885-5p	CLIP-seq
MIRT2287702	hsa-miR-892a	CLIP-seq
MIRT1205887	hsa-miR-1229	CLIP-seq
MIRT2391938	hsa-miR-134	CLIP-seq
MIRT2287631	hsa-miR-197	CLIP-seq
MIRT1205897	hsa-miR-2052	CLIP-seq
MIRT1205898	hsa-miR-2110	CLIP-seq
MIRT2391939	hsa-miR-3118	CLIP-seq
MIRT1205906	hsa-miR-3150a-3p	CLIP-seq
MIRT2391940	hsa-miR-3164	CLIP-seq
MIRT2391941	hsa-miR-3607-5p	CLIP-seq
MIRT1205916	hsa-miR-4259	CLIP-seq
MIRT1205918	hsa-miR-4271	CLIP-seq
MIRT1205919	hsa-miR-4292	CLIP-seq
MIRT1205920	hsa-miR-4308	CLIP-seq
MIRT2391942	hsa-miR-4501	CLIP-seq
MIRT2287675	hsa-miR-4705	CLIP-seq
MIRT1205931	hsa-miR-4715-5p	CLIP-seq
MIRT1205932	hsa-miR-4725-3p	CLIP-seq
MIRT1205937	hsa-miR-489	CLIP-seq
MIRT2287627	hsa-miR-124	CLIP-seq
MIRT1205895	hsa-miR-136	CLIP-seq
MIRT2287629	hsa-miR-141	CLIP-seq
MIRT2585641	hsa-miR-185	CLIP-seq
MIRT2585642	hsa-miR-1913	CLIP-seq
MIRT2287632	hsa-miR-200a	CLIP-seq
MIRT2585643	hsa-miR-200b	CLIP-seq
MIRT2585644	hsa-miR-200c	CLIP-seq
MIRT2585645	hsa-miR-203	CLIP-seq
MIRT1205897	hsa-miR-2052	CLIP-seq
MIRT2585646	hsa-miR-216b	CLIP-seq
MIRT2585647	hsa-miR-217	CLIP-seq
MIRT2287635	hsa-miR-2278	CLIP-seq
MIRT2585648	hsa-miR-300	CLIP-seq
MIRT1205902	hsa-miR-3065-5p	CLIP-seq
MIRT1205905	hsa-miR-3145-3p	CLIP-seq
MIRT2287645	hsa-miR-3190	CLIP-seq
MIRT2585649	hsa-miR-324-3p	CLIP-seq
MIRT2287649	hsa-miR-3677-3p	CLIP-seq
MIRT2287652	hsa-miR-3691-5p	CLIP-seq
MIRT1205913	hsa-miR-370	CLIP-seq
MIRT2585650	hsa-miR-381	CLIP-seq
MIRT2585651	hsa-miR-3940-5p	CLIP-seq
MIRT2287661	hsa-miR-4287	CLIP-seq
MIRT2585652	hsa-miR-429	CLIP-seq
MIRT2585653	hsa-miR-4306	CLIP-seq
MIRT2585654	hsa-miR-4418	CLIP-seq
MIRT2585655	hsa-miR-4426	CLIP-seq
MIRT2585656	hsa-miR-4427	CLIP-seq
MIRT2585657	hsa-miR-4433	CLIP-seq
MIRT2287666	hsa-miR-4469	CLIP-seq
MIRT2585658	hsa-miR-4471	CLIP-seq
MIRT2585659	hsa-miR-4475	CLIP-seq
MIRT1205924	hsa-miR-4476	CLIP-seq
MIRT2585660	hsa-miR-4477b	CLIP-seq
MIRT2585661	hsa-miR-4488	CLIP-seq
MIRT2287667	hsa-miR-4491	CLIP-seq
MIRT2585662	hsa-miR-4507	CLIP-seq
MIRT2585663	hsa-miR-4534	CLIP-seq
MIRT2585664	hsa-miR-4641	CLIP-seq
MIRT2585665	hsa-miR-4644	CLIP-seq
MIRT2585666	hsa-miR-4647	CLIP-seq
MIRT2287668	hsa-miR-4657	CLIP-seq
MIRT2585667	hsa-miR-4662b	CLIP-seq
MIRT2287670	hsa-miR-4665-3p	CLIP-seq
MIRT2585668	hsa-miR-4680-3p	CLIP-seq
MIRT2287671	hsa-miR-4685-3p	CLIP-seq
MIRT2585669	hsa-miR-4694-3p	CLIP-seq
MIRT2585670	hsa-miR-4697-5p	CLIP-seq
MIRT2585671	hsa-miR-4714-5p	CLIP-seq
MIRT2585672	hsa-miR-4722-5p	CLIP-seq
MIRT2287680	hsa-miR-4764-5p	CLIP-seq
MIRT2585673	hsa-miR-486-3p	CLIP-seq
MIRT2585674	hsa-miR-495	CLIP-seq
MIRT2287686	hsa-miR-506	CLIP-seq
MIRT2585675	hsa-miR-509-3-5p	CLIP-seq
MIRT2585676	hsa-miR-509-5p	CLIP-seq
MIRT2585677	hsa-miR-511	CLIP-seq
MIRT2585678	hsa-miR-513b	CLIP-seq
MIRT1205939	hsa-miR-513c	CLIP-seq
MIRT1205940	hsa-miR-514b-5p	CLIP-seq
MIRT2287689	hsa-miR-522	CLIP-seq
MIRT2287697	hsa-miR-600	CLIP-seq
MIRT2585679	hsa-miR-617	CLIP-seq
MIRT2585680	hsa-miR-618	CLIP-seq
MIRT2287699	hsa-miR-624	CLIP-seq
MIRT2585681	hsa-miR-758	CLIP-seq
MIRT1205945	hsa-miR-767-3p	CLIP-seq
MIRT2287627	hsa-miR-124	CLIP-seq
MIRT2287629	hsa-miR-141	CLIP-seq
MIRT2585641	hsa-miR-185	CLIP-seq
MIRT2585642	hsa-miR-1913	CLIP-seq
MIRT2287632	hsa-miR-200a	CLIP-seq
MIRT2585645	hsa-miR-203	CLIP-seq
MIRT1205897	hsa-miR-2052	CLIP-seq
MIRT2585646	hsa-miR-216b	CLIP-seq
MIRT2287635	hsa-miR-2278	CLIP-seq
MIRT2585648	hsa-miR-300	CLIP-seq
MIRT2287645	hsa-miR-3190	CLIP-seq
MIRT2585649	hsa-miR-324-3p	CLIP-seq
MIRT2287649	hsa-miR-3677-3p	CLIP-seq
MIRT2287652	hsa-miR-3691-5p	CLIP-seq
MIRT1205913	hsa-miR-370	CLIP-seq
MIRT2585650	hsa-miR-381	CLIP-seq
MIRT2287661	hsa-miR-4287	CLIP-seq
MIRT2585653	hsa-miR-4306	CLIP-seq
MIRT2287663	hsa-miR-4328	CLIP-seq
MIRT2585655	hsa-miR-4426	CLIP-seq
MIRT2585657	hsa-miR-4433	CLIP-seq
MIRT2287666	hsa-miR-4469	CLIP-seq
MIRT1205924	hsa-miR-4476	CLIP-seq
MIRT2585661	hsa-miR-4488	CLIP-seq
MIRT2287667	hsa-miR-4491	CLIP-seq
MIRT2585663	hsa-miR-4534	CLIP-seq
MIRT2585664	hsa-miR-4641	CLIP-seq
MIRT2585665	hsa-miR-4644	CLIP-seq
MIRT2585666	hsa-miR-4647	CLIP-seq
MIRT2287668	hsa-miR-4657	CLIP-seq
MIRT2585667	hsa-miR-4662b	CLIP-seq
MIRT2287670	hsa-miR-4665-3p	CLIP-seq
MIRT2287671	hsa-miR-4685-3p	CLIP-seq
MIRT2585669	hsa-miR-4694-3p	CLIP-seq
MIRT2585670	hsa-miR-4697-5p	CLIP-seq
MIRT2287674	hsa-miR-4698	CLIP-seq
MIRT2585672	hsa-miR-4722-5p	CLIP-seq
MIRT2287680	hsa-miR-4764-5p	CLIP-seq
MIRT2585673	hsa-miR-486-3p	CLIP-seq
MIRT2585674	hsa-miR-495	CLIP-seq
MIRT2287686	hsa-miR-506	CLIP-seq
MIRT2585677	hsa-miR-511	CLIP-seq
MIRT2287689	hsa-miR-522	CLIP-seq
MIRT2287697	hsa-miR-600	CLIP-seq
MIRT2585679	hsa-miR-617	CLIP-seq
MIRT2287699	hsa-miR-624	CLIP-seq
MIRT1205945	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	24209621
GO:0005515	Function	Protein binding	IPI	21566117, 21988961, 24209621, 25036637, 25681634, 26496610, 28514442, 29547901, 29997244, 32814053
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	21988961
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005802	Component	Trans-Golgi network	IDA	29514919
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	24209621, 29514919
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006699	Process	Bile acid biosynthetic process	TAS
GO:0008142	Function	Oxysterol binding	TAS	1970801
GO:0015248	Function	Sterol transporter activity	IBA	21873635
GO:0015248	Function	Sterol transporter activity	TAS
GO:0015918	Process	Sterol transport	IDA	24209621
GO:0016020	Component	Membrane	IBA	21873635
GO:0016020	Component	Membrane	IDA	21988961
GO:0019904	Function	Protein domain specific binding	IPI	20178991
GO:0030054	Component	Cell junction	IDA
GO:0032367	Process	Intracellular cholesterol transport	IMP	29514919
GO:0032934	Function	Sterol binding	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	24209621
GO:0070273	Function	Phosphatidylinositol-4-phosphate binding	IDA	24209621
GO:0097038	Component	Perinuclear endoplasmic reticulum	IBA	21873635
GO:0120009	Process	Intermembrane lipid transfer	IEA
GO:0120015	Function	Sterol transfer activity	IDA	24209621

Other IDs

• MIM: 167040
• HGNC: 8503
• e!Ensembl: ENSG00000110048

Protein

• UniProt ID: P22059
• Protein name: Oxysterol-binding protein 1
• Protein function: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for
• PDB: 2RR3, 7V62
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	90 → 181	PH domain	Domain
  PF01237	Oxysterol_BP	418 → 793	Oxysterol-binding protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11278871}.
• Sequence:

  MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGP
  GAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYY
  RSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAK
  AKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLS
  ELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQ
  RIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFF
  DAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLW
  SIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFT
  VSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLR
  QEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDI
  VNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIG
  ENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPD
  QRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVT
  KELTHIYRGEYWECKEKQDWSSCPDIF

• Sequence length: 807

Pathways

Reactome:

Sphingolipid de novo biosynthesis
Synthesis of bile acids and bile salts

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208

Unknown
Disease term	Disease name	Evidence	References	Source
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Common Cold	Associate	30209171
Metabolic Syndrome	Associate	19325544
Motor Neuron Disease	Associate	20178991
Pulmonary Disease Chronic Obstructive	Associate	30209171