ORM1 (orosomucoid 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5004
Gene name Orosomucoid 1
Gene symbol ORM1
Synonyms (NCBI Gene)
A1AG1AGP-AAGP1HEL-S-153wORM
Chromosome 9
Chromosome location 9q32
Summary This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved
miRNA miRNA information provided by mirtarbase database.
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1)
miRTarBase ID miRNA Experiments Reference
MIRT734893 hsa-miR-362-3p Luciferase reporter assayWestern blottingqRT-PCR 33459949
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002682 Process Regulation of immune system process IEA
GO:0005515 Function Protein binding IPI 16272158, 28514442, 33961781
GO:0005576 Component Extracellular region HDA 27068509, 27559042
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region NAS 14718574
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
138600 8498 ENSG00000229314
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P02763
Protein name Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1)
Protein function Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating t
PDB 3KQ0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 40 → 180 Lipocalin / cytosolic fatty-acid binding protein family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
Sequence
Sequence length 201
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Platelet degranulation
Neutrophil degranulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
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Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
- no classification for the single variant rs1126801, rs17650 -
Show/Hide Text Mining Associations (51)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 34002800
Adenoma Liver Cell Associate 34963738
Alzheimer Disease Associate 40471493
Arthritis Rheumatoid Stimulate 26915672
Arthritis Rheumatoid Associate 35603148
Asthma Associate 20182505
Atherosclerosis Associate 24526693
Breast Neoplasms Stimulate 34654351
Breast Neoplasms Associate 35188865
Carcinogenesis Associate 35765957