OPCML (opioid binding protein/cell adhesion molecule like)

Gene

• Entrez ID: 4978
• Gene name: Opioid binding protein/cell adhesion molecule like
• Gene symbol: OPCML
• Synonyms (NCBI Gene): IGLON1, OBCAM, OPCM
• Chromosome: 11
• Chromosome location: 11q25
• Summary: This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an a

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs137852691	G>A,C	Pathogenic	Coding sequence variant, 5 prime UTR variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT551259	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT551258	hsa-miR-4307	PAR-CLIP	21572407
MIRT551257	hsa-miR-567	PAR-CLIP	21572407
MIRT551255	hsa-miR-8068	PAR-CLIP	21572407
MIRT551256	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT551254	hsa-miR-3924	PAR-CLIP	21572407
MIRT551253	hsa-miR-675-3p	PAR-CLIP	21572407
MIRT551252	hsa-miR-297	PAR-CLIP	21572407
MIRT551251	hsa-miR-3149	PAR-CLIP	21572407
MIRT551253	hsa-miR-675-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	33400243
MIRT551259	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT551258	hsa-miR-4307	PAR-CLIP	21572407
MIRT551257	hsa-miR-567	PAR-CLIP	21572407
MIRT551255	hsa-miR-8068	PAR-CLIP	21572407
MIRT551256	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT551254	hsa-miR-3924	PAR-CLIP	21572407
MIRT551253	hsa-miR-675-3p	PAR-CLIP	21572407
MIRT551252	hsa-miR-297	PAR-CLIP	21572407
MIRT551251	hsa-miR-3149	PAR-CLIP	21572407
MIRT1204104	hsa-miR-1237	CLIP-seq
MIRT1204105	hsa-miR-1297	CLIP-seq
MIRT1204106	hsa-miR-130a	CLIP-seq
MIRT1204107	hsa-miR-130b	CLIP-seq
MIRT1204108	hsa-miR-138	CLIP-seq
MIRT1204109	hsa-miR-149	CLIP-seq
MIRT1204110	hsa-miR-185	CLIP-seq
MIRT1204111	hsa-miR-19a	CLIP-seq
MIRT1204112	hsa-miR-19b	CLIP-seq
MIRT1204113	hsa-miR-205	CLIP-seq
MIRT1204114	hsa-miR-2052	CLIP-seq
MIRT1204115	hsa-miR-224	CLIP-seq
MIRT1204116	hsa-miR-2355-3p	CLIP-seq
MIRT1204117	hsa-miR-2467-3p	CLIP-seq
MIRT1204118	hsa-miR-26a	CLIP-seq
MIRT1204119	hsa-miR-26b	CLIP-seq
MIRT1204120	hsa-miR-27a	CLIP-seq
MIRT1204121	hsa-miR-27b	CLIP-seq
MIRT1204122	hsa-miR-301a	CLIP-seq
MIRT1204123	hsa-miR-301b	CLIP-seq
MIRT1204124	hsa-miR-3064-5p	CLIP-seq
MIRT1204125	hsa-miR-3117-5p	CLIP-seq
MIRT1204126	hsa-miR-3121-5p	CLIP-seq
MIRT1204127	hsa-miR-3122	CLIP-seq
MIRT1204128	hsa-miR-3125	CLIP-seq
MIRT1204129	hsa-miR-3129-3p	CLIP-seq
MIRT1204130	hsa-miR-3155	CLIP-seq
MIRT1204131	hsa-miR-3155b	CLIP-seq
MIRT1204132	hsa-miR-3161	CLIP-seq
MIRT1204133	hsa-miR-3179	CLIP-seq
MIRT1204134	hsa-miR-3189-3p	CLIP-seq
MIRT1204135	hsa-miR-3202	CLIP-seq
MIRT1204136	hsa-miR-320e	CLIP-seq
MIRT1204137	hsa-miR-346	CLIP-seq
MIRT1204138	hsa-miR-3591-5p	CLIP-seq
MIRT1204139	hsa-miR-362-5p	CLIP-seq
MIRT1204140	hsa-miR-3652	CLIP-seq
MIRT1204141	hsa-miR-3664-5p	CLIP-seq
MIRT1204142	hsa-miR-3666	CLIP-seq
MIRT1204143	hsa-miR-3913-5p	CLIP-seq
MIRT1204144	hsa-miR-3916	CLIP-seq
MIRT1204145	hsa-miR-4287	CLIP-seq
MIRT1204146	hsa-miR-4288	CLIP-seq
MIRT1204147	hsa-miR-4295	CLIP-seq
MIRT1204148	hsa-miR-4299	CLIP-seq
MIRT1204149	hsa-miR-4306	CLIP-seq
MIRT1204150	hsa-miR-4420	CLIP-seq
MIRT1204151	hsa-miR-4430	CLIP-seq
MIRT1204152	hsa-miR-4436b-3p	CLIP-seq
MIRT1204153	hsa-miR-4438	CLIP-seq
MIRT1204154	hsa-miR-4457	CLIP-seq
MIRT1204155	hsa-miR-4465	CLIP-seq
MIRT1204156	hsa-miR-4469	CLIP-seq
MIRT1204157	hsa-miR-448	CLIP-seq
MIRT1204158	hsa-miR-4487	CLIP-seq
MIRT1204159	hsa-miR-4496	CLIP-seq
MIRT1204160	hsa-miR-4505	CLIP-seq
MIRT1204161	hsa-miR-4533	CLIP-seq
MIRT1204162	hsa-miR-454	CLIP-seq
MIRT1204163	hsa-miR-4644	CLIP-seq
MIRT1204164	hsa-miR-4646-3p	CLIP-seq
MIRT1204165	hsa-miR-4660	CLIP-seq
MIRT1204166	hsa-miR-4670-3p	CLIP-seq
MIRT1204167	hsa-miR-4680-5p	CLIP-seq
MIRT1204168	hsa-miR-4685-3p	CLIP-seq
MIRT1204169	hsa-miR-4699-5p	CLIP-seq
MIRT1204170	hsa-miR-4709-3p	CLIP-seq
MIRT1204171	hsa-miR-4713-5p	CLIP-seq
MIRT1204172	hsa-miR-4716-3p	CLIP-seq
MIRT1204173	hsa-miR-4731-3p	CLIP-seq
MIRT1204174	hsa-miR-4747-5p	CLIP-seq
MIRT1204175	hsa-miR-4766-5p	CLIP-seq
MIRT1204176	hsa-miR-4775	CLIP-seq
MIRT1204177	hsa-miR-4780	CLIP-seq
MIRT1204178	hsa-miR-4794	CLIP-seq
MIRT1204179	hsa-miR-4801	CLIP-seq
MIRT1204180	hsa-miR-484	CLIP-seq
MIRT1204181	hsa-miR-488	CLIP-seq
MIRT1204182	hsa-miR-498	CLIP-seq
MIRT1204183	hsa-miR-500b	CLIP-seq
MIRT1204184	hsa-miR-501-5p	CLIP-seq
MIRT1204185	hsa-miR-513a-5p	CLIP-seq
MIRT1204186	hsa-miR-519a	CLIP-seq
MIRT1204187	hsa-miR-519b-3p	CLIP-seq
MIRT1204188	hsa-miR-519c-3p	CLIP-seq
MIRT1204189	hsa-miR-570	CLIP-seq
MIRT1204190	hsa-miR-586	CLIP-seq
MIRT1204191	hsa-miR-590-3p	CLIP-seq
MIRT1204192	hsa-miR-592	CLIP-seq
MIRT1204193	hsa-miR-597	CLIP-seq
MIRT1204194	hsa-miR-623	CLIP-seq
MIRT1204195	hsa-miR-632	CLIP-seq
MIRT1204196	hsa-miR-654-3p	CLIP-seq
MIRT1204197	hsa-miR-668	CLIP-seq
MIRT1204198	hsa-miR-676	CLIP-seq
MIRT1204199	hsa-miR-875-3p	CLIP-seq
MIRT1204200	hsa-miR-885-3p	CLIP-seq
MIRT1551947	hsa-miR-193a-5p	CLIP-seq
MIRT1551948	hsa-miR-4527	CLIP-seq
MIRT1551949	hsa-miR-4728-3p	CLIP-seq
MIRT1551950	hsa-miR-4731-5p	CLIP-seq
MIRT1204128	hsa-miR-3125	CLIP-seq
MIRT1920718	hsa-miR-34b	CLIP-seq
MIRT1920719	hsa-miR-3653	CLIP-seq
MIRT1920720	hsa-miR-3658	CLIP-seq
MIRT1204144	hsa-miR-3916	CLIP-seq
MIRT1920721	hsa-miR-4257	CLIP-seq
MIRT1204159	hsa-miR-4496	CLIP-seq
MIRT1920722	hsa-miR-4711-5p	CLIP-seq
MIRT1920723	hsa-miR-4738-3p	CLIP-seq
MIRT1920724	hsa-miR-548g	CLIP-seq
MIRT1920725	hsa-miR-646	CLIP-seq
MIRT1204128	hsa-miR-3125	CLIP-seq
MIRT1204144	hsa-miR-3916	CLIP-seq
MIRT1920721	hsa-miR-4257	CLIP-seq
MIRT1204159	hsa-miR-4496	CLIP-seq
MIRT1920722	hsa-miR-4711-5p	CLIP-seq
MIRT1920723	hsa-miR-4738-3p	CLIP-seq
MIRT1920724	hsa-miR-548g	CLIP-seq
MIRT1920725	hsa-miR-646	CLIP-seq
MIRT2058953	hsa-miR-642b	CLIP-seq
MIRT2058954	hsa-miR-1272	CLIP-seq
MIRT1204110	hsa-miR-185	CLIP-seq
MIRT1204117	hsa-miR-2467-3p	CLIP-seq
MIRT1204128	hsa-miR-3125	CLIP-seq
MIRT2058955	hsa-miR-3150b-3p	CLIP-seq
MIRT2058956	hsa-miR-3682-3p	CLIP-seq
MIRT1204144	hsa-miR-3916	CLIP-seq
MIRT1204149	hsa-miR-4306	CLIP-seq
MIRT1204163	hsa-miR-4644	CLIP-seq
MIRT2058957	hsa-miR-4689	CLIP-seq
MIRT1551950	hsa-miR-4731-5p	CLIP-seq
MIRT2058958	hsa-miR-4784	CLIP-seq
MIRT1204145	hsa-miR-4287	CLIP-seq
MIRT1204156	hsa-miR-4469	CLIP-seq
MIRT2287045	hsa-miR-4659a-3p	CLIP-seq
MIRT2287046	hsa-miR-4659b-3p	CLIP-seq
MIRT1204168	hsa-miR-4685-3p	CLIP-seq
MIRT2287047	hsa-miR-4762-5p	CLIP-seq
MIRT2287048	hsa-miR-4778-3p	CLIP-seq
MIRT2439144	hsa-miR-219-1-3p	CLIP-seq
MIRT2439145	hsa-miR-3545-3p	CLIP-seq
MIRT2439146	hsa-miR-4753-3p	CLIP-seq
MIRT2439147	hsa-miR-571	CLIP-seq
MIRT2439148	hsa-miR-942	CLIP-seq
MIRT2585271	hsa-miR-1178	CLIP-seq
MIRT1204104	hsa-miR-1237	CLIP-seq
MIRT2585272	hsa-miR-1273e	CLIP-seq
MIRT2585273	hsa-miR-2053	CLIP-seq
MIRT2585274	hsa-miR-223	CLIP-seq
MIRT1204115	hsa-miR-224	CLIP-seq
MIRT2585275	hsa-miR-302a	CLIP-seq
MIRT2585276	hsa-miR-302b	CLIP-seq
MIRT2585277	hsa-miR-302c	CLIP-seq
MIRT2585278	hsa-miR-302d	CLIP-seq
MIRT2585279	hsa-miR-302e	CLIP-seq
MIRT1204125	hsa-miR-3117-5p	CLIP-seq
MIRT2585280	hsa-miR-3152-3p	CLIP-seq
MIRT2585281	hsa-miR-3182	CLIP-seq
MIRT2585282	hsa-miR-3647-3p	CLIP-seq
MIRT2585283	hsa-miR-371b-3p	CLIP-seq
MIRT2585284	hsa-miR-372	CLIP-seq
MIRT2585285	hsa-miR-373	CLIP-seq
MIRT1204145	hsa-miR-4287	CLIP-seq
MIRT2585286	hsa-miR-4290	CLIP-seq
MIRT1204156	hsa-miR-4469	CLIP-seq
MIRT2585287	hsa-miR-4652-3p	CLIP-seq
MIRT1204168	hsa-miR-4685-3p	CLIP-seq
MIRT1204171	hsa-miR-4713-5p	CLIP-seq
MIRT2585288	hsa-miR-520a-3p	CLIP-seq
MIRT2585289	hsa-miR-520b	CLIP-seq
MIRT2585290	hsa-miR-520c-3p	CLIP-seq
MIRT2585291	hsa-miR-520d-3p	CLIP-seq
MIRT2585292	hsa-miR-520e	CLIP-seq
MIRT2585293	hsa-miR-520f	CLIP-seq
MIRT2585294	hsa-miR-569	CLIP-seq
MIRT2585295	hsa-miR-636	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	1333602
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	7721093
GO:0008038	Process	Neuron recognition	IEA
GO:0008038	Process	Neuron recognition	TAS	7891157
GO:0016020	Component	Membrane	IEA
GO:0098552	Component	Side of membrane	IEA

Other IDs

• MIM: 600632
• HGNC: 8143
• e!Ensembl: ENSG00000183715

Protein

• UniProt ID: Q14982
• Protein name: Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1)
• Protein function: Binds opioids in the presence of acidic lipids; probably involved in cell contact.
• PDB: 5UV6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	36 → 132	Immunoglobulin I-set domain	Domain
  PF13927	Ig_3	135 → 206		Domain
  PF07679	I-set	223 → 312	Immunoglobulin I-set domain	Domain

• Sequence:

  MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
  DRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTD
  NHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGF
  VSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKG
  ILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATN
  KLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHFFIKF

• Sequence length: 345

Pathways

Reactome:

Post-translational modification: synthesis of GPI-anchored proteins

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Ovarian neoplasm	Pathogenic	rs137852691	RCV000009546

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
OPCML-related disorder	Benign; Likely benign	rs113899050, rs145479085, rs145182728	RCV003979339 RCV003941754 RCV003942078 RCV003914404
Schizophrenia	Uncertain significance	rs2497352558	RCV002463509

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Associate	17967182
Adenocarcinoma in Situ	Associate	21731750
Adenocarcinoma of Lung	Associate	17967182, 21731750
Adenoma	Associate	27896617
Alzheimer Disease	Associate	39755674
Ascites	Associate	25966226
Biliary Tract Diseases	Associate	30832707
Breast Neoplasms	Associate	28775148
Carcinogenesis	Associate	23495067
Carcinoma Ovarian Epithelial	Associate	16115914, 25966226
Cholangiocarcinoma	Associate	30832707
Cholangiocarcinoma	Inhibit	34697068, 35478117
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	25625843
Coronary Artery Disease	Associate	23233742
Developmental Disabilities	Associate	23495067
Esophageal Squamous Cell Carcinoma	Associate	30880778
Hereditary Breast and Ovarian Cancer Syndrome	Inhibit	28775148
Lung Neoplasms	Associate	17967182
Lymphoma	Associate	18714356
Nasopharyngeal Carcinoma	Inhibit	18714356
Neoplasm Metastasis	Associate	17109515, 21731750
Neoplasms	Inhibit	16115914, 17109515, 18714356, 27384440, 28775148, 34697068, 35478117
Neoplasms	Associate	18616821, 23495067, 30880778, 31316070
Neoplasms Cystic Mucinous and Serous	Associate	25625843
Ovarian Neoplasms	Associate	16115914, 25625843, 27384440
Ovarian Neoplasms	Inhibit	28775148, 31316070
Periodontitis	Associate	34101221
Prostatic Neoplasms	Associate	26890304
Stomach Neoplasms	Associate	17109515