Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4973
Gene name	Oxidized low density lipoprotein receptor 1
Gene symbol	OLR1
Synonyms (NCBI Gene)	CLEC8ALOX1LOXINSCARE1SLOX1
Chromosome	12
Chromosome location	12p13.2
Summary	This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. Thi

Show/Hide all (2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs11053646	C>G	Risk-factor	Missense variant, coding sequence variant, intron variant
rs12316150	A>T	Risk-factor	3 prime UTR variant

263

Show/Hide all (263)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020773	hsa-miR-155-5p	Western blot	21030878
MIRT027749	hsa-miR-98-5p	Microarray	19088304
MIRT031012	hsa-miR-21-5p	Microarray	18591254
MIRT708497	hsa-miR-4797-5p	HITS-CLIP	19536157
MIRT708496	hsa-miR-5586-3p	HITS-CLIP	19536157
MIRT708495	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT708494	hsa-miR-759	HITS-CLIP	19536157
MIRT708493	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT708492	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT708491	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT708490	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT708489	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT708488	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT708487	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT708486	hsa-miR-4469	HITS-CLIP	19536157
MIRT708485	hsa-miR-1285-3p	HITS-CLIP	19536157
MIRT708484	hsa-miR-3187-5p	HITS-CLIP	19536157
MIRT708483	hsa-miR-5189-5p	HITS-CLIP	19536157
MIRT708482	hsa-miR-612	HITS-CLIP	19536157
MIRT708481	hsa-miR-6860	HITS-CLIP	19536157
MIRT708480	hsa-miR-873-3p	HITS-CLIP	19536157
MIRT708479	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT708478	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT708477	hsa-miR-3672	HITS-CLIP	19536157
MIRT708476	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT682423	hsa-miR-4731-3p	HITS-CLIP	23706177
MIRT682422	hsa-miR-4801	HITS-CLIP	23706177
MIRT682421	hsa-miR-646	HITS-CLIP	23706177
MIRT682420	hsa-miR-4733-5p	HITS-CLIP	23706177
MIRT682419	hsa-miR-4719	HITS-CLIP	23706177
MIRT682418	hsa-miR-889-3p	HITS-CLIP	23706177
MIRT682417	hsa-miR-513a-5p	HITS-CLIP	23706177
MIRT682416	hsa-miR-27a-3p	HITS-CLIP	23706177
MIRT682415	hsa-miR-27b-3p	HITS-CLIP	23706177
MIRT682414	hsa-miR-2054	HITS-CLIP	23706177
MIRT682413	hsa-let-7c-3p	HITS-CLIP	23706177
MIRT682412	hsa-let-7a-2-3p	HITS-CLIP	23706177
MIRT682411	hsa-let-7g-3p	HITS-CLIP	23706177
MIRT682410	hsa-miR-493-5p	HITS-CLIP	23706177
MIRT661402	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT669848	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT669847	hsa-miR-1254	HITS-CLIP	23824327
MIRT669846	hsa-miR-3116	HITS-CLIP	23824327
MIRT669845	hsa-miR-661	HITS-CLIP	23824327
MIRT669844	hsa-miR-3180	HITS-CLIP	23824327
MIRT669843	hsa-miR-3180-3p	HITS-CLIP	23824327
MIRT669842	hsa-miR-3196	HITS-CLIP	23824327
MIRT669841	hsa-miR-6816-5p	HITS-CLIP	23824327
MIRT661399	hsa-miR-7977	HITS-CLIP	23824327
MIRT669840	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT669839	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT661398	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT661402	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT661401	hsa-miR-4284	HITS-CLIP	23824327
MIRT661400	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT661399	hsa-miR-7977	HITS-CLIP	23824327
MIRT661398	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT525602	hsa-miR-4698	HITS-CLIP	23824327
MIRT525601	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT525600	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT525599	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT525598	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT451717	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT525602	hsa-miR-4698	PAR-CLIP	22012620
MIRT525603	hsa-miR-186-3p	PAR-CLIP	22012620
MIRT525601	hsa-miR-3120-5p	PAR-CLIP	22012620
MIRT525600	hsa-miR-4711-3p	PAR-CLIP	22012620
MIRT525599	hsa-miR-6867-5p	PAR-CLIP	22012620
MIRT525598	hsa-miR-6888-3p	PAR-CLIP	22012620
MIRT451717	hsa-miR-574-5p	PAR-CLIP	22012620
MIRT451725	hsa-miR-590-3p	PAR-CLIP	23592263
MIRT451724	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT451723	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT451721	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT451722	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT451720	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT451718	hsa-miR-5194	PAR-CLIP	23592263
MIRT451719	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT451717	hsa-miR-574-5p	PAR-CLIP	23592263
MIRT451716	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT451714	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT451715	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT451713	hsa-miR-4271	PAR-CLIP	23592263
MIRT451712	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT451711	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT451710	hsa-miR-4316	PAR-CLIP	23592263
MIRT451709	hsa-miR-1294	PAR-CLIP	23592263
MIRT451708	hsa-miR-4266	PAR-CLIP	23592263
MIRT451707	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT451706	hsa-miR-651-5p	PAR-CLIP	23592263
MIRT451720	hsa-miR-1914-3p	RNA-seq	31722236
MIRT708482	hsa-miR-612	RNA-seq	31722236
MIRT708497	hsa-miR-4797-5p	HITS-CLIP	19536157
MIRT708496	hsa-miR-5586-3p	HITS-CLIP	19536157
MIRT708495	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT708494	hsa-miR-759	HITS-CLIP	19536157
MIRT708493	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT708492	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT708491	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT708490	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT708489	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT708488	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT708487	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT708486	hsa-miR-4469	HITS-CLIP	19536157
MIRT708485	hsa-miR-1285-3p	HITS-CLIP	19536157
MIRT708484	hsa-miR-3187-5p	HITS-CLIP	19536157
MIRT708483	hsa-miR-5189-5p	HITS-CLIP	19536157
MIRT708482	hsa-miR-612	HITS-CLIP	19536157
MIRT708481	hsa-miR-6860	HITS-CLIP	19536157
MIRT708480	hsa-miR-873-3p	HITS-CLIP	19536157
MIRT708479	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT708478	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT708477	hsa-miR-3672	HITS-CLIP	19536157
MIRT708476	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT682423	hsa-miR-4731-3p	HITS-CLIP	23706177
MIRT682422	hsa-miR-4801	HITS-CLIP	23706177
MIRT682421	hsa-miR-646	HITS-CLIP	23706177
MIRT682420	hsa-miR-4733-5p	HITS-CLIP	23706177
MIRT682419	hsa-miR-4719	HITS-CLIP	23706177
MIRT682418	hsa-miR-889-3p	HITS-CLIP	23706177
MIRT682417	hsa-miR-513a-5p	HITS-CLIP	23706177
MIRT682416	hsa-miR-27a-3p	HITS-CLIP	23706177
MIRT682415	hsa-miR-27b-3p	HITS-CLIP	23706177
MIRT682414	hsa-miR-2054	HITS-CLIP	23706177
MIRT682413	hsa-let-7c-3p	HITS-CLIP	23706177
MIRT682412	hsa-let-7a-2-3p	HITS-CLIP	23706177
MIRT682411	hsa-let-7g-3p	HITS-CLIP	23706177
MIRT682410	hsa-miR-493-5p	HITS-CLIP	23706177
MIRT661402	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT669848	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT669847	hsa-miR-1254	HITS-CLIP	23824327
MIRT669846	hsa-miR-3116	HITS-CLIP	23824327
MIRT669845	hsa-miR-661	HITS-CLIP	23824327
MIRT669844	hsa-miR-3180	HITS-CLIP	23824327
MIRT669843	hsa-miR-3180-3p	HITS-CLIP	23824327
MIRT669842	hsa-miR-3196	HITS-CLIP	23824327
MIRT669841	hsa-miR-6816-5p	HITS-CLIP	23824327
MIRT661399	hsa-miR-7977	HITS-CLIP	23824327
MIRT669840	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT669839	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT661398	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT661402	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT661401	hsa-miR-4284	HITS-CLIP	23824327
MIRT661400	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT661399	hsa-miR-7977	HITS-CLIP	23824327
MIRT661398	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT525602	hsa-miR-4698	HITS-CLIP	23824327
MIRT525601	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT525600	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT525599	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT525598	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT451717	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT525602	hsa-miR-4698	PAR-CLIP	22012620
MIRT525603	hsa-miR-186-3p	PAR-CLIP	22012620
MIRT525601	hsa-miR-3120-5p	PAR-CLIP	22012620
MIRT525600	hsa-miR-4711-3p	PAR-CLIP	22012620
MIRT525599	hsa-miR-6867-5p	PAR-CLIP	22012620
MIRT525598	hsa-miR-6888-3p	PAR-CLIP	22012620
MIRT451717	hsa-miR-574-5p	PAR-CLIP	22012620
MIRT451725	hsa-miR-590-3p	PAR-CLIP	23592263
MIRT451724	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT451723	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT451721	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT451722	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT451720	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT451718	hsa-miR-5194	PAR-CLIP	23592263
MIRT451719	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT451717	hsa-miR-574-5p	PAR-CLIP	23592263
MIRT451716	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT451714	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT451715	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT451713	hsa-miR-4271	PAR-CLIP	23592263
MIRT451712	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT451711	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT451710	hsa-miR-4316	PAR-CLIP	23592263
MIRT451709	hsa-miR-1294	PAR-CLIP	23592263
MIRT451708	hsa-miR-4266	PAR-CLIP	23592263
MIRT451707	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT451706	hsa-miR-651-5p	PAR-CLIP	23592263
MIRT1203335	hsa-miR-1253	CLIP-seq
MIRT1203336	hsa-miR-1283	CLIP-seq
MIRT1203337	hsa-miR-1293	CLIP-seq
MIRT1203338	hsa-miR-219-2-3p	CLIP-seq
MIRT1203339	hsa-miR-23a	CLIP-seq
MIRT1203340	hsa-miR-23b	CLIP-seq
MIRT1203341	hsa-miR-23c	CLIP-seq
MIRT1203342	hsa-miR-2964a-3p	CLIP-seq
MIRT1203343	hsa-miR-3065-5p	CLIP-seq
MIRT1203344	hsa-miR-320a	CLIP-seq
MIRT1203345	hsa-miR-320b	CLIP-seq
MIRT1203346	hsa-miR-320c	CLIP-seq
MIRT1203347	hsa-miR-320d	CLIP-seq
MIRT1203348	hsa-miR-3609	CLIP-seq
MIRT1203349	hsa-miR-3611	CLIP-seq
MIRT1203350	hsa-miR-3646	CLIP-seq
MIRT1203351	hsa-miR-3659	CLIP-seq
MIRT1203352	hsa-miR-3978	CLIP-seq
MIRT1203353	hsa-miR-4273	CLIP-seq
MIRT1203354	hsa-miR-4426	CLIP-seq
MIRT1203355	hsa-miR-4429	CLIP-seq
MIRT1203356	hsa-miR-4481	CLIP-seq
MIRT1203357	hsa-miR-4483	CLIP-seq
MIRT1203358	hsa-miR-4506	CLIP-seq
MIRT1203359	hsa-miR-4534	CLIP-seq
MIRT1203360	hsa-miR-4647	CLIP-seq
MIRT1203361	hsa-miR-4658	CLIP-seq
MIRT1203362	hsa-miR-4662b	CLIP-seq
MIRT1203363	hsa-miR-4677-5p	CLIP-seq
MIRT1203364	hsa-miR-4694-3p	CLIP-seq
MIRT1203365	hsa-miR-4709-3p	CLIP-seq
MIRT1203366	hsa-miR-4745-5p	CLIP-seq
MIRT1203367	hsa-miR-4758-5p	CLIP-seq
MIRT1203368	hsa-miR-4777-5p	CLIP-seq
MIRT1203369	hsa-miR-4786-3p	CLIP-seq
MIRT1203370	hsa-miR-491-3p	CLIP-seq
MIRT1203371	hsa-miR-495	CLIP-seq
MIRT1203372	hsa-miR-518a-5p	CLIP-seq
MIRT1203373	hsa-miR-518d-5p	CLIP-seq
MIRT1203374	hsa-miR-519b-5p	CLIP-seq
MIRT1203375	hsa-miR-519c-5p	CLIP-seq
MIRT1203376	hsa-miR-520c-5p	CLIP-seq
MIRT1203377	hsa-miR-520g	CLIP-seq
MIRT1203378	hsa-miR-520h	CLIP-seq
MIRT1203379	hsa-miR-522	CLIP-seq
MIRT1203380	hsa-miR-526a	CLIP-seq
MIRT1203381	hsa-miR-527	CLIP-seq
MIRT1203382	hsa-miR-548ah	CLIP-seq
MIRT1203383	hsa-miR-548m	CLIP-seq
MIRT1203384	hsa-miR-555	CLIP-seq
MIRT1203385	hsa-miR-579	CLIP-seq
MIRT1203386	hsa-miR-944	CLIP-seq
MIRT2058712	hsa-miR-1184	CLIP-seq
MIRT2058713	hsa-miR-1205	CLIP-seq
MIRT1203336	hsa-miR-1283	CLIP-seq
MIRT2058714	hsa-miR-186	CLIP-seq
MIRT2058715	hsa-miR-3158-5p	CLIP-seq
MIRT2058716	hsa-miR-3180-5p	CLIP-seq
MIRT1203350	hsa-miR-3646	CLIP-seq
MIRT2058717	hsa-miR-3662	CLIP-seq
MIRT1203354	hsa-miR-4426	CLIP-seq
MIRT2058718	hsa-miR-4504	CLIP-seq
MIRT1203359	hsa-miR-4534	CLIP-seq
MIRT2058719	hsa-miR-4536	CLIP-seq
MIRT1203360	hsa-miR-4647	CLIP-seq
MIRT1203362	hsa-miR-4662b	CLIP-seq
MIRT1203372	hsa-miR-518a-5p	CLIP-seq
MIRT2058720	hsa-miR-520a-5p	CLIP-seq
MIRT1203377	hsa-miR-520g	CLIP-seq
MIRT1203378	hsa-miR-520h	CLIP-seq
MIRT2058721	hsa-miR-525-5p	CLIP-seq
MIRT1203381	hsa-miR-527	CLIP-seq
MIRT2058722	hsa-miR-544	CLIP-seq
MIRT2058723	hsa-miR-548a-3p	CLIP-seq
MIRT2058724	hsa-miR-548e	CLIP-seq
MIRT2058725	hsa-miR-548f	CLIP-seq
MIRT1203354	hsa-miR-4426	CLIP-seq
MIRT1203359	hsa-miR-4534	CLIP-seq
MIRT1203360	hsa-miR-4647	CLIP-seq
MIRT1203362	hsa-miR-4662b	CLIP-seq
MIRT1203365	hsa-miR-4709-3p	CLIP-seq
MIRT2442425	hsa-miR-3121-3p	CLIP-seq
MIRT1203352	hsa-miR-3978	CLIP-seq
MIRT2442426	hsa-miR-548c-3p	CLIP-seq

Show/Hide all (3)

Transcription factor	Regulation	Reference
HR	Activation	20881612
NFKB1	Unknown	15001526
RELA	Unknown	15001526

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005041	Function	Low-density lipoprotein particle receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	24846140, 28514442, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9052782
GO:0006508	Process	Proteolysis	TAS	9052782
GO:0006954	Process	Inflammatory response	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007159	Process	Leukocyte cell-cell adhesion	IBA
GO:0008015	Process	Blood circulation	TAS	9052782
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9052782
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0042157	Process	Lipoprotein metabolic process	IBA
GO:0042802	Function	Identical protein binding	IPI	15939022, 19664054
GO:0043235	Component	Receptor complex	IBA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0045121	Component	Membrane raft	IEA
GO:0070821	Component	Tertiary granule membrane	TAS

MIM	HGNC	e!Ensembl
602601	8133	ENSG00000173391

P78380

Protein name

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized lo

Protein function

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation

PDB

1YPO , 1YPQ , 1YPU , 1YXJ , 1YXK , 3VLG , 6TL7 , 6TL9 , 6TLA , 7R8U , 7W5D , 7XMP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08391	Ly49	32 → 158	Ly49-like protein, N-terminal region	Family
PF00059	Lectin_C	161 → 266	Lectin C-type domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expre

Sequence

MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQL
SQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQ
MELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLL
KINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPS
GTCAYIQRGAVYAENCILAAFSICQKKANLRAQ

Sequence length

273

Interactions

View interactions

	KEGG		Reactome
	PPAR signaling pathway Phagosome Lipid and atherosclerosis		Cell surface interactions at the vascular wall Neutrophil degranulation

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Myocardial infarction, susceptibility to	Benign; risk factor	rs11053646, rs12316150	RCV001799590 RCV001799591
OLR1-related disorder	Benign; risk factor; Likely benign	rs11053646, rs146768121, rs184465084, rs375085053	RCV003974804 RCV003938917 RCV003909310 RCV003946830

Show/Hide Text Mining Associations (101)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Achalasia Addisonianism Alacrimia syndrome	Associate	15562935
Alzheimer Disease	Associate	12807963
Anemia Sickle Cell	Associate	27519944
Arthritis Rheumatoid	Associate	15529384
Arthritis Rheumatoid	Stimulate	24000379
Asthma	Associate	25335167
Atherosclerosis	Associate	10085242, 11728449, 15001526, 15010359, 15562935, 16173915, 16698017, 17420607, 18384690, 18390905, 18469066, 19667111, 20181930, 20385360, 20508287 View all (22 more)
Atrial Fibrillation	Associate	18375832
Brain Ischemia	Associate	31943892
Breast Neoplasms	Stimulate	30718451
Breast Neoplasms	Associate	31311202
Bronchiolitis Obliterans Syndrome	Associate	33932293
Cap Myopathy	Associate	36982155
Carcinogenesis	Associate	17167069, 37629087
Carcinoma Hepatocellular	Associate	29211299
Carcinoma Non Small Cell Lung	Associate	35449557
Carcinoma Renal Cell	Associate	15016631
Cardiomyopathy Dilated	Associate	37268658
Cardiovascular Diseases	Associate	19961348, 20181930, 21865331, 24776598, 25904137, 27527867, 27840386, 36982155
Carotid Artery Diseases	Stimulate	29330254
Carotid Stenosis	Associate	21257822, 29330254
Cerebral Infarction	Associate	24661313
Cerebrovascular Disorders	Associate	22619487
Chemical and Drug Induced Liver Injury	Associate	21865331
Colonic Neoplasms	Associate	35595808
Colorectal Neoplasms	Associate	17167069, 30368730, 31500382, 33675293, 35595808
Constriction Pathologic	Associate	15562935
Coronary Artery Disease	Associate	15562935, 19961348, 20023241, 22738689, 23391848, 26542080, 28601780, 29558038, 35795669
Coronary Disease	Associate	25904137, 28629174
COVID 19	Associate	33909917
Diabetes Mellitus	Stimulate	15001526, 18408244, 30894181
Diabetes Mellitus	Associate	21865331, 22863784, 24145224, 35705192
Diabetes Mellitus Type 2	Associate	15001526, 21423737, 36557031, 40071808
Diabetes Mellitus Type 2	Stimulate	18408244
Diabetes Mellitus Type 2	Inhibit	33317535
Diabetic Angiopathies	Associate	27519944
Diabetic Nephropathies	Associate	19218767
Drug Related Side Effects and Adverse Reactions	Inhibit	36982155
Dyslipidemias	Associate	30368730
Esophageal Neoplasms	Associate	34611296
Essential Hypertension	Associate	24480971
Glioma	Associate	37427890
Glomerulonephritis	Associate	32410835
Glomerulonephritis Membranous	Associate	19218767
Hepatitis B Chronic	Associate	33290259
Hypercholesterolemia	Associate	29558038
Hypertension	Associate	10085242, 24776598, 36982155
Hypertrophy Left Ventricular	Associate	24480971
Hypoxia	Associate	32824620
Hypoxia Brain	Inhibit	22791762
Hypoxia Brain	Stimulate	36910399
Inflammation	Associate	11728449, 22347434, 24068192, 24776598, 28601780, 30368730, 30718451, 32616761, 35269979
Inflammation	Stimulate	20385360, 23811604
Insulin Resistance	Associate	21865331
Intervertebral Disc Degeneration	Associate	28785062
Intervertebral Disc Displacement	Associate	28785062
Intracranial Arteriosclerosis	Associate	27840386
Ischemic Stroke	Stimulate	29330254
Leukemia Myeloid Acute	Associate	36212177
Lipid Metabolism Disorders	Associate	35449557
Liver Diseases	Associate	21865331
Lymphatic Metastasis	Associate	25566960, 35449557
Metabolic Syndrome	Associate	37629087
Myocardial Infarction	Associate	15562935, 18384690, 19961348, 26542080, 31928155
Myocardial Ischemia	Stimulate	30894181
Nasopharyngeal Carcinoma	Associate	33290259
Neoplasm Metastasis	Associate	35449557
Neoplasms	Associate	20385360, 28345638, 30718451, 32632664, 36982155, 37089448, 37629087
Neoplasms Vascular Tissue	Associate	24068192
Neuroblastoma	Associate	12807963
Non alcoholic Fatty Liver Disease	Associate	21865331, 26185381
Non ST Elevated Myocardial Infarction	Stimulate	21467660
Obesity	Stimulate	18388896
Obesity	Associate	19342029, 21423737, 36982155
Osteoarthritis	Associate	29039543, 32616761, 34833421
Pancreatic Neoplasms	Associate	31514732
Plaque Atherosclerotic	Associate	18469066, 25904137
Post Acute COVID 19 Syndrome	Associate	39391317
Pre Eclampsia	Associate	22791762, 24786389, 33725567
Preeclamptic toxemia	Inhibit	22791762
Preeclamptic toxemia	Associate	23275468
Prostatic Neoplasms	Associate	25566960, 36982155
Prostatic Neoplasms Castration Resistant	Associate	36982155
Pulmonary Embolism	Associate	22267767
Respiratory Distress Syndrome	Associate	33909917, 39684262
Rupture	Associate	25904137
Sepsis	Stimulate	39948564
Shock Septic	Associate	33909917
Shock Septic	Stimulate	39948564
Squamous Cell Carcinoma of Head and Neck	Associate	31698994, 34576110, 37089448, 37629087
ST Elevation Myocardial Infarction	Stimulate	21467660, 31928155
ST Elevation Myocardial Infarction	Associate	36910399
Stomach Neoplasms	Associate	24217965, 28345638
Stroke	Associate	21257822
Stroke	Stimulate	31943892
Subarachnoid Hemorrhage	Stimulate	31943892
Systemic Inflammatory Response Syndrome	Stimulate	39948564
Thrombosis	Associate	24661313
Urinary Bladder Neoplasms	Associate	33888644, 34329197, 35909123, 37988196
Vascular Diseases	Associate	10085242, 20203069, 22619487, 28345638, 32725144, 35269979
Ventricular Remodeling	Associate	24480971

OLR1 (oxidized low density lipoprotein receptor 1)