Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4967
Gene name	Oxoglutarate dehydrogenase
Gene symbol	OGDH
Synonyms (NCBI Gene)	AKGDHE1kE1oHsOGDHKGD1OGDCOGDH-E1OGDH2OGDHD
Chromosome	7
Chromosome location	7p13
Summary	This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018112	hsa-miR-335-5p	Microarray	18185580
MIRT028586	hsa-miR-30a-5p	Proteomics	18668040
MIRT031751	hsa-miR-16-5p	Proteomics	18668040
MIRT044084	hsa-miR-361-5p	CLASH	23622248
MIRT701221	hsa-miR-4326	HITS-CLIP	23313552
MIRT701220	hsa-miR-552-5p	HITS-CLIP	23313552
MIRT701221	hsa-miR-4326	HITS-CLIP	23313552
MIRT701220	hsa-miR-552-5p	HITS-CLIP	23313552
MIRT1202594	hsa-miR-106a	CLIP-seq
MIRT1202595	hsa-miR-106b	CLIP-seq
MIRT1202596	hsa-miR-17	CLIP-seq
MIRT1202597	hsa-miR-20a	CLIP-seq
MIRT1202598	hsa-miR-20b	CLIP-seq
MIRT1202599	hsa-miR-302a	CLIP-seq
MIRT1202600	hsa-miR-302b	CLIP-seq
MIRT1202601	hsa-miR-302c	CLIP-seq
MIRT1202602	hsa-miR-302d	CLIP-seq
MIRT1202603	hsa-miR-302e	CLIP-seq
MIRT1202604	hsa-miR-3672	CLIP-seq
MIRT1202605	hsa-miR-372	CLIP-seq
MIRT1202606	hsa-miR-373	CLIP-seq
MIRT1202607	hsa-miR-4438	CLIP-seq
MIRT1202608	hsa-miR-4731-5p	CLIP-seq
MIRT1202609	hsa-miR-4797-5p	CLIP-seq
MIRT1202610	hsa-miR-5095	CLIP-seq
MIRT1202611	hsa-miR-512-3p	CLIP-seq
MIRT1202612	hsa-miR-519d	CLIP-seq
MIRT1202613	hsa-miR-520a-3p	CLIP-seq
MIRT1202614	hsa-miR-520b	CLIP-seq
MIRT1202615	hsa-miR-520c-3p	CLIP-seq
MIRT1202616	hsa-miR-520d-3p	CLIP-seq
MIRT1202617	hsa-miR-520e	CLIP-seq
MIRT1202618	hsa-miR-520g	CLIP-seq
MIRT1202619	hsa-miR-520h	CLIP-seq
MIRT1202620	hsa-miR-93	CLIP-seq
MIRT1202621	hsa-miR-1289	CLIP-seq
MIRT1202622	hsa-miR-3150a-3p	CLIP-seq
MIRT1202623	hsa-miR-3175	CLIP-seq
MIRT1202624	hsa-miR-3689d	CLIP-seq
MIRT1202625	hsa-miR-939	CLIP-seq
MIRT1202621	hsa-miR-1289	CLIP-seq
MIRT1202626	hsa-miR-136	CLIP-seq
MIRT1202627	hsa-miR-24	CLIP-seq
MIRT1202628	hsa-miR-3115	CLIP-seq
MIRT1202629	hsa-miR-3155	CLIP-seq
MIRT1202630	hsa-miR-3155b	CLIP-seq
MIRT1202624	hsa-miR-3689d	CLIP-seq
MIRT1202631	hsa-miR-382	CLIP-seq
MIRT1202632	hsa-miR-3940-5p	CLIP-seq
MIRT1202633	hsa-miR-4263	CLIP-seq
MIRT1202634	hsa-miR-4428	CLIP-seq
MIRT1202635	hsa-miR-4507	CLIP-seq
MIRT1202636	hsa-miR-4521	CLIP-seq
MIRT1202637	hsa-miR-4652-3p	CLIP-seq
MIRT1202638	hsa-miR-484	CLIP-seq
MIRT1202639	hsa-miR-518a-5p	CLIP-seq
MIRT1202640	hsa-miR-527	CLIP-seq
MIRT2058488	hsa-miR-1238	CLIP-seq
MIRT2058489	hsa-miR-1285	CLIP-seq
MIRT2058490	hsa-miR-151-5p	CLIP-seq
MIRT2058491	hsa-miR-1827	CLIP-seq
MIRT2058492	hsa-miR-1976	CLIP-seq
MIRT2058493	hsa-miR-214	CLIP-seq
MIRT2058494	hsa-miR-2277-3p	CLIP-seq
MIRT1202628	hsa-miR-3115	CLIP-seq
MIRT2058495	hsa-miR-3158-5p	CLIP-seq
MIRT2058496	hsa-miR-3187-5p	CLIP-seq
MIRT2058497	hsa-miR-339-5p	CLIP-seq
MIRT2058498	hsa-miR-3611	CLIP-seq
MIRT2058499	hsa-miR-3619-5p	CLIP-seq
MIRT2058500	hsa-miR-3650	CLIP-seq
MIRT2058501	hsa-miR-370	CLIP-seq
MIRT2058502	hsa-miR-3974	CLIP-seq
MIRT2058503	hsa-miR-4265	CLIP-seq
MIRT2058504	hsa-miR-4291	CLIP-seq
MIRT2058505	hsa-miR-4296	CLIP-seq
MIRT2058506	hsa-miR-4322	CLIP-seq
MIRT2058507	hsa-miR-4417	CLIP-seq
MIRT2058508	hsa-miR-4418	CLIP-seq
MIRT2058509	hsa-miR-4649-3p	CLIP-seq
MIRT2058510	hsa-miR-4691-5p	CLIP-seq
MIRT2058511	hsa-miR-4707-5p	CLIP-seq
MIRT1202608	hsa-miR-4731-5p	CLIP-seq
MIRT2058512	hsa-miR-493	CLIP-seq
MIRT2058513	hsa-miR-509-3-5p	CLIP-seq
MIRT2058514	hsa-miR-509-5p	CLIP-seq
MIRT2058515	hsa-miR-542-3p	CLIP-seq
MIRT2058516	hsa-miR-612	CLIP-seq
MIRT2058517	hsa-miR-644	CLIP-seq
MIRT2058518	hsa-miR-661	CLIP-seq
MIRT2058519	hsa-miR-663b	CLIP-seq
MIRT2058520	hsa-miR-761	CLIP-seq
MIRT2058521	hsa-miR-885-3p	CLIP-seq
MIRT2058522	hsa-miR-922	CLIP-seq
MIRT2286728	hsa-miR-1254	CLIP-seq
MIRT2286729	hsa-miR-1273g	CLIP-seq
MIRT1202621	hsa-miR-1289	CLIP-seq
MIRT2286730	hsa-miR-1343	CLIP-seq
MIRT2286731	hsa-miR-140-5p	CLIP-seq
MIRT2058490	hsa-miR-151-5p	CLIP-seq
MIRT2058491	hsa-miR-1827	CLIP-seq
MIRT2058494	hsa-miR-2277-3p	CLIP-seq
MIRT2286732	hsa-miR-296-5p	CLIP-seq
MIRT1202628	hsa-miR-3115	CLIP-seq
MIRT2286733	hsa-miR-3116	CLIP-seq
MIRT1202622	hsa-miR-3150a-3p	CLIP-seq
MIRT2286734	hsa-miR-3160-3p	CLIP-seq
MIRT2286735	hsa-miR-3170	CLIP-seq
MIRT1202623	hsa-miR-3175	CLIP-seq
MIRT2286736	hsa-miR-3183	CLIP-seq
MIRT2286737	hsa-miR-329	CLIP-seq
MIRT2286738	hsa-miR-342-5p	CLIP-seq
MIRT2286739	hsa-miR-361-3p	CLIP-seq
MIRT2286740	hsa-miR-362-3p	CLIP-seq
MIRT2058500	hsa-miR-3650	CLIP-seq
MIRT2286741	hsa-miR-3941	CLIP-seq
MIRT2286742	hsa-miR-4253	CLIP-seq
MIRT2058503	hsa-miR-4265	CLIP-seq
MIRT2058505	hsa-miR-4296	CLIP-seq
MIRT2058506	hsa-miR-4322	CLIP-seq
MIRT2058507	hsa-miR-4417	CLIP-seq
MIRT2286743	hsa-miR-4435	CLIP-seq
MIRT2286744	hsa-miR-4457	CLIP-seq
MIRT2286745	hsa-miR-4508	CLIP-seq
MIRT2058509	hsa-miR-4649-3p	CLIP-seq
MIRT2286746	hsa-miR-4664-5p	CLIP-seq
MIRT2286747	hsa-miR-4667-3p	CLIP-seq
MIRT2286748	hsa-miR-4723-3p	CLIP-seq
MIRT2286749	hsa-miR-4731-3p	CLIP-seq
MIRT2286750	hsa-miR-4749-3p	CLIP-seq
MIRT2286751	hsa-miR-4758-3p	CLIP-seq
MIRT2286752	hsa-miR-4786-3p	CLIP-seq
MIRT2286753	hsa-miR-4794	CLIP-seq
MIRT2286754	hsa-miR-4801	CLIP-seq
MIRT2286755	hsa-miR-491-5p	CLIP-seq
MIRT2286756	hsa-miR-516a-3p	CLIP-seq
MIRT2286757	hsa-miR-603	CLIP-seq
MIRT2286758	hsa-miR-635	CLIP-seq
MIRT2058519	hsa-miR-663b	CLIP-seq
MIRT2286759	hsa-miR-671-5p	CLIP-seq
MIRT2058521	hsa-miR-885-3p	CLIP-seq
MIRT1202625	hsa-miR-939	CLIP-seq
MIRT2391884	hsa-miR-122	CLIP-seq
MIRT2391885	hsa-miR-130a	CLIP-seq
MIRT2391886	hsa-miR-130b	CLIP-seq
MIRT2391887	hsa-miR-216a	CLIP-seq
MIRT2391888	hsa-miR-216b	CLIP-seq
MIRT2391889	hsa-miR-301a	CLIP-seq
MIRT2391890	hsa-miR-301b	CLIP-seq
MIRT2391891	hsa-miR-3135b	CLIP-seq
MIRT2391892	hsa-miR-3136-3p	CLIP-seq
MIRT2391893	hsa-miR-328	CLIP-seq
MIRT2391894	hsa-miR-3652	CLIP-seq
MIRT2391895	hsa-miR-3666	CLIP-seq
MIRT2391896	hsa-miR-4295	CLIP-seq
MIRT2391897	hsa-miR-4430	CLIP-seq
MIRT2391898	hsa-miR-454	CLIP-seq
MIRT2585035	hsa-miR-1202	CLIP-seq
MIRT2585036	hsa-miR-1227	CLIP-seq
MIRT2058488	hsa-miR-1238	CLIP-seq
MIRT2286728	hsa-miR-1254	CLIP-seq
MIRT2286729	hsa-miR-1273g	CLIP-seq
MIRT2585037	hsa-miR-127-5p	CLIP-seq
MIRT2058489	hsa-miR-1285	CLIP-seq
MIRT1202621	hsa-miR-1289	CLIP-seq
MIRT1202626	hsa-miR-136	CLIP-seq
MIRT2286731	hsa-miR-140-5p	CLIP-seq
MIRT2585038	hsa-miR-1913	CLIP-seq
MIRT2585039	hsa-miR-1972	CLIP-seq
MIRT2058492	hsa-miR-1976	CLIP-seq
MIRT2058493	hsa-miR-214	CLIP-seq
MIRT2585040	hsa-miR-22	CLIP-seq
MIRT2286732	hsa-miR-296-5p	CLIP-seq
MIRT2286733	hsa-miR-3116	CLIP-seq
MIRT2585041	hsa-miR-3120-3p	CLIP-seq
MIRT2585042	hsa-miR-3124-3p	CLIP-seq
MIRT2585043	hsa-miR-3148	CLIP-seq
MIRT1202622	hsa-miR-3150a-3p	CLIP-seq
MIRT2585044	hsa-miR-3151	CLIP-seq
MIRT2286734	hsa-miR-3160-3p	CLIP-seq
MIRT2286735	hsa-miR-3170	CLIP-seq
MIRT1202623	hsa-miR-3175	CLIP-seq
MIRT2058496	hsa-miR-3187-5p	CLIP-seq
MIRT2585045	hsa-miR-3194-5p	CLIP-seq
MIRT2585046	hsa-miR-324-3p	CLIP-seq
MIRT2286738	hsa-miR-342-5p	CLIP-seq
MIRT2058499	hsa-miR-3619-5p	CLIP-seq
MIRT2585047	hsa-miR-3664-5p	CLIP-seq
MIRT1202604	hsa-miR-3672	CLIP-seq
MIRT1202624	hsa-miR-3689d	CLIP-seq
MIRT2585048	hsa-miR-3690	CLIP-seq
MIRT2058501	hsa-miR-370	CLIP-seq
MIRT1202632	hsa-miR-3940-5p	CLIP-seq
MIRT2585049	hsa-miR-3972	CLIP-seq
MIRT2585050	hsa-miR-4254	CLIP-seq
MIRT2058503	hsa-miR-4265	CLIP-seq
MIRT2585051	hsa-miR-4277	CLIP-seq
MIRT2058504	hsa-miR-4291	CLIP-seq
MIRT2058505	hsa-miR-4296	CLIP-seq
MIRT2058506	hsa-miR-4322	CLIP-seq
MIRT2058507	hsa-miR-4417	CLIP-seq
MIRT1202634	hsa-miR-4428	CLIP-seq
MIRT2286743	hsa-miR-4435	CLIP-seq
MIRT2585052	hsa-miR-4437	CLIP-seq
MIRT2585053	hsa-miR-4447	CLIP-seq
MIRT2585054	hsa-miR-4456	CLIP-seq
MIRT2585055	hsa-miR-4459	CLIP-seq
MIRT2585056	hsa-miR-4463	CLIP-seq
MIRT2585057	hsa-miR-4472	CLIP-seq
MIRT2585058	hsa-miR-4474-3p	CLIP-seq
MIRT2585059	hsa-miR-4489	CLIP-seq
MIRT2585060	hsa-miR-4505	CLIP-seq
MIRT1202635	hsa-miR-4507	CLIP-seq
MIRT2585061	hsa-miR-4522	CLIP-seq
MIRT2585062	hsa-miR-4650-5p	CLIP-seq
MIRT1202637	hsa-miR-4652-3p	CLIP-seq
MIRT2585063	hsa-miR-4655-3p	CLIP-seq
MIRT2286746	hsa-miR-4664-5p	CLIP-seq
MIRT2585064	hsa-miR-4674	CLIP-seq
MIRT2058510	hsa-miR-4691-5p	CLIP-seq
MIRT2058511	hsa-miR-4707-5p	CLIP-seq
MIRT2585065	hsa-miR-4711-5p	CLIP-seq
MIRT2585066	hsa-miR-4722-3p	CLIP-seq
MIRT2585067	hsa-miR-4727-5p	CLIP-seq
MIRT1202608	hsa-miR-4731-5p	CLIP-seq
MIRT2585068	hsa-miR-4755-3p	CLIP-seq
MIRT2585069	hsa-miR-4769-3p	CLIP-seq
MIRT2585070	hsa-miR-4787-5p	CLIP-seq
MIRT2585071	hsa-miR-4793-5p	CLIP-seq
MIRT2585072	hsa-miR-486-3p	CLIP-seq
MIRT2286755	hsa-miR-491-5p	CLIP-seq
MIRT2585073	hsa-miR-541	CLIP-seq
MIRT2585074	hsa-miR-545	CLIP-seq
MIRT2585075	hsa-miR-548a-3p	CLIP-seq
MIRT2585076	hsa-miR-548ad	CLIP-seq
MIRT2585077	hsa-miR-548e	CLIP-seq
MIRT2585078	hsa-miR-548f	CLIP-seq
MIRT2058516	hsa-miR-612	CLIP-seq
MIRT2058517	hsa-miR-644	CLIP-seq
MIRT2585079	hsa-miR-654-5p	CLIP-seq
MIRT2058518	hsa-miR-661	CLIP-seq
MIRT2058519	hsa-miR-663b	CLIP-seq
MIRT2585080	hsa-miR-665	CLIP-seq
MIRT2058520	hsa-miR-761	CLIP-seq
MIRT2585081	hsa-miR-764	CLIP-seq
MIRT2585082	hsa-miR-767-3p	CLIP-seq
MIRT2585083	hsa-miR-875-3p	CLIP-seq
MIRT2058521	hsa-miR-885-3p	CLIP-seq
MIRT2058522	hsa-miR-922	CLIP-seq
MIRT2585084	hsa-miR-938	CLIP-seq
MIRT1202625	hsa-miR-939	CLIP-seq
MIRT2585035	hsa-miR-1202	CLIP-seq
MIRT2585036	hsa-miR-1227	CLIP-seq
MIRT2058488	hsa-miR-1238	CLIP-seq
MIRT2286728	hsa-miR-1254	CLIP-seq
MIRT2286729	hsa-miR-1273g	CLIP-seq
MIRT2585037	hsa-miR-127-5p	CLIP-seq
MIRT1202621	hsa-miR-1289	CLIP-seq
MIRT1202626	hsa-miR-136	CLIP-seq
MIRT2286731	hsa-miR-140-5p	CLIP-seq
MIRT2585038	hsa-miR-1913	CLIP-seq
MIRT2585039	hsa-miR-1972	CLIP-seq
MIRT2058492	hsa-miR-1976	CLIP-seq
MIRT2585040	hsa-miR-22	CLIP-seq
MIRT2286732	hsa-miR-296-5p	CLIP-seq
MIRT2286733	hsa-miR-3116	CLIP-seq
MIRT2585041	hsa-miR-3120-3p	CLIP-seq
MIRT2585042	hsa-miR-3124-3p	CLIP-seq
MIRT2585043	hsa-miR-3148	CLIP-seq
MIRT1202622	hsa-miR-3150a-3p	CLIP-seq
MIRT2286734	hsa-miR-3160-3p	CLIP-seq
MIRT2286735	hsa-miR-3170	CLIP-seq
MIRT1202623	hsa-miR-3175	CLIP-seq
MIRT2585045	hsa-miR-3194-5p	CLIP-seq
MIRT2585046	hsa-miR-324-3p	CLIP-seq
MIRT2286738	hsa-miR-342-5p	CLIP-seq
MIRT2585047	hsa-miR-3664-5p	CLIP-seq
MIRT1202604	hsa-miR-3672	CLIP-seq
MIRT1202624	hsa-miR-3689d	CLIP-seq
MIRT2585048	hsa-miR-3690	CLIP-seq
MIRT2058501	hsa-miR-370	CLIP-seq
MIRT1202632	hsa-miR-3940-5p	CLIP-seq
MIRT2585049	hsa-miR-3972	CLIP-seq
MIRT2585050	hsa-miR-4254	CLIP-seq
MIRT2058503	hsa-miR-4265	CLIP-seq
MIRT2585051	hsa-miR-4277	CLIP-seq
MIRT2058505	hsa-miR-4296	CLIP-seq
MIRT2058506	hsa-miR-4322	CLIP-seq
MIRT2058507	hsa-miR-4417	CLIP-seq
MIRT1202634	hsa-miR-4428	CLIP-seq
MIRT2286743	hsa-miR-4435	CLIP-seq
MIRT2585052	hsa-miR-4437	CLIP-seq
MIRT2585054	hsa-miR-4456	CLIP-seq
MIRT2585055	hsa-miR-4459	CLIP-seq
MIRT2585056	hsa-miR-4463	CLIP-seq
MIRT2585058	hsa-miR-4474-3p	CLIP-seq
MIRT2585059	hsa-miR-4489	CLIP-seq
MIRT2585060	hsa-miR-4505	CLIP-seq
MIRT1202635	hsa-miR-4507	CLIP-seq
MIRT2585061	hsa-miR-4522	CLIP-seq
MIRT2585062	hsa-miR-4650-5p	CLIP-seq
MIRT1202637	hsa-miR-4652-3p	CLIP-seq
MIRT2585063	hsa-miR-4655-3p	CLIP-seq
MIRT2286746	hsa-miR-4664-5p	CLIP-seq
MIRT2585064	hsa-miR-4674	CLIP-seq
MIRT2058510	hsa-miR-4691-5p	CLIP-seq
MIRT2686788	hsa-miR-4700-3p	CLIP-seq
MIRT2058511	hsa-miR-4707-5p	CLIP-seq
MIRT2585065	hsa-miR-4711-5p	CLIP-seq
MIRT2585066	hsa-miR-4722-3p	CLIP-seq
MIRT2585067	hsa-miR-4727-5p	CLIP-seq
MIRT1202608	hsa-miR-4731-5p	CLIP-seq
MIRT2585068	hsa-miR-4755-3p	CLIP-seq
MIRT2585069	hsa-miR-4769-3p	CLIP-seq
MIRT2585070	hsa-miR-4787-5p	CLIP-seq
MIRT2585071	hsa-miR-4793-5p	CLIP-seq
MIRT2286755	hsa-miR-491-5p	CLIP-seq
MIRT2585073	hsa-miR-541	CLIP-seq
MIRT2585074	hsa-miR-545	CLIP-seq
MIRT2585075	hsa-miR-548a-3p	CLIP-seq
MIRT2585076	hsa-miR-548ad	CLIP-seq
MIRT2585077	hsa-miR-548e	CLIP-seq
MIRT2585078	hsa-miR-548f	CLIP-seq
MIRT2585079	hsa-miR-654-5p	CLIP-seq
MIRT2058518	hsa-miR-661	CLIP-seq
MIRT2058519	hsa-miR-663b	CLIP-seq
MIRT2585080	hsa-miR-665	CLIP-seq
MIRT2585081	hsa-miR-764	CLIP-seq
MIRT2585082	hsa-miR-767-3p	CLIP-seq
MIRT2585083	hsa-miR-875-3p	CLIP-seq
MIRT2585084	hsa-miR-938	CLIP-seq
MIRT1202625	hsa-miR-939	CLIP-seq

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004591	Function	Oxoglutarate dehydrogenase (succinyl-transferring) activity	IBA
GO:0004591	Function	Oxoglutarate dehydrogenase (succinyl-transferring) activity	IDA	24495017, 29211711
GO:0004591	Function	Oxoglutarate dehydrogenase (succinyl-transferring) activity	IEA
GO:0004591	Function	Oxoglutarate dehydrogenase (succinyl-transferring) activity	ISS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IDA	29211711
GO:0005634	Component	Nucleus	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	29211711
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006091	Process	Generation of precursor metabolites and energy	ISS
GO:0006096	Process	Glycolytic process	IEA
GO:0006099	Process	Tricarboxylic acid cycle	IBA
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006103	Process	2-oxoglutarate metabolic process	IDA	24495017, 29211711
GO:0006103	Process	2-oxoglutarate metabolic process	IEA
GO:0006104	Process	Succinyl-CoA metabolic process	IDA	24495017, 29211711
GO:0006104	Process	Succinyl-CoA metabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016624	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA
GO:0016903	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors	IEA
GO:0019674	Process	NAD+ metabolic process	IEA
GO:0021695	Process	Cerebellar cortex development	IEA
GO:0021756	Process	Striatum development	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0021794	Process	Thalamus development	IEA
GO:0021860	Process	Pyramidal neuron development	IEA
GO:0022028	Process	Tangential migration from the subventricular zone to the olfactory bulb	IEA
GO:0030976	Function	Thiamine pyrophosphate binding	IDA	24495017
GO:0030976	Function	Thiamine pyrophosphate binding	IEA
GO:0031072	Function	Heat shock protein binding	IEA
GO:0031966	Component	Mitochondrial membrane	ISS
GO:0045252	Component	Oxoglutarate dehydrogenase complex	IBA
GO:0045252	Component	Oxoglutarate dehydrogenase complex	IDA	29211711
GO:0045252	Component	Oxoglutarate dehydrogenase complex	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051087	Function	Protein-folding chaperone binding	IEA
GO:0061034	Process	Olfactory bulb mitral cell layer development	IEA

MIM	HGNC	e!Ensembl
613022	8124	ENSG00000105953

Q02218

Protein name

2-oxoglutarate dehydrogenase complex component E1 (E1o) (HsOGDH) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehyd

Protein function

2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to s

PDB

3ERY , 7WGR , 8I0K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16078	2-oxogl_dehyd_N	47 → 87	2-oxoglutarate dehydrogenase N-terminus	Family
PF00676	E1_dh	256 → 582	Dehydrogenase E1 component	Family
PF02779	Transket_pyr	649 → 866	Transketolase, pyrimidine binding domain	Domain
PF16870	OxoGdeHyase_C	869 → 1014	2-oxoglutarate dehydrogenase C-terminal	Family

Sequence

MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEE
MYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNV
DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDES
DLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET
PGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSEN
GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR
VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV
YETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDP
EAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKY
AELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPR
SMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMA
FGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL
SEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLP
HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFH
VLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKR
LLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEH
KNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDVFK
NFS

Sequence length

1023

Interactions

View interactions

	KEGG		Reactome
	Citrate cycle (TCA cycle) Lipoic acid metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism		Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)

204

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Oxoglutaricaciduria	Pathogenic	rs2116163953, rs2484850454, rs2484805251, rs2116155540	RCV001806691 RCV003152437 RCV003152438 RCV003152439

Show/Hide Unknown Diseases (18)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign; Likely benign	rs147519663	RCV005910605
Clear cell carcinoma of kidney	Benign; Likely benign	rs147519663	RCV005910606
Colon adenocarcinoma	Benign; Likely benign	rs147519663	RCV005910600
Colorectal cancer	Benign; Likely benign	rs147519663	RCV005910607
Familial cancer of breast	Uncertain significance; Benign; Likely benign	rs375926612, rs147519663	RCV005922873 RCV005910599
Familial pancreatic carcinoma	Uncertain significance	rs375926612	RCV005922874
Gastric cancer	Benign; Likely benign	rs147519663	RCV005910609
Hepatocellular carcinoma	Benign; Likely benign	rs147519663	RCV005910602
Lung cancer	Benign; Likely benign	rs147519663	RCV005910613
Malignant tumor of esophagus	Benign; Likely benign	rs147519663	RCV005910603
Malignant tumor of urinary bladder	Benign; Likely benign	rs147519663	RCV005910601
Melanoma	Uncertain significance	rs375926612	RCV005922875
Nonpapillary renal cell carcinoma	Benign; Likely benign	rs147519663	RCV005910604
OGDH-related disorder	Likely benign; Benign; Conflicting classifications of pathogenicity	rs762293053, rs149447664, rs202133522, rs199871931, rs144282315, rs1379909736, rs771295157, rs375075849, rs57529168, rs34777281, rs41280648, rs112309751, rs2070606, rs61756583, rs2070607 View all (7 more)	RCV003963287 RCV003895963 RCV003923623 RCV003971112 RCV003961183 RCV003941942 RCV003937349 RCV003947376 RCV003969443 RCV003907938 RCV003918114 RCV003938028 RCV003980301 RCV003980302 RCV003983164 RCV003980303 RCV004757342 RCV003926141 RCV003936180 RCV003897952 RCV003895464 RCV003922921
Ovarian serous cystadenocarcinoma	Benign; Likely benign	rs147519663	RCV005910610
Sarcoma	Benign; Likely benign	rs147519663	RCV005910608
Thymoma	Benign; Likely benign	rs147519663	RCV005910611
Thyroid cancer, nonmedullary, 1	Benign; Likely benign	rs147519663	RCV005910612

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Coronary Syndrome	Stimulate	20226836
Alzheimer Disease	Inhibit	8020988
Barth Syndrome	Associate	30251684
Basal Ganglia Diseases	Associate	26637184
Bipolar Disorder	Associate	35821008
Carcinoma Renal Cell	Associate	33564363
Colorectal Neoplasms	Associate	28105922, 36879117
Demyelinating Diseases	Associate	26637184
Depressive Disorder Major	Associate	35821008
Glioblastoma	Associate	27027236
Hepatitis C	Associate	27769799
Neoplasms	Associate	27027236
Nerve Degeneration	Associate	23152800
Pyruvate Dehydrogenase Complex Deficiency Disease	Associate	24341803
Thyroid Carcinoma Anaplastic	Associate	26680454

OGDH (oxoglutarate dehydrogenase)