Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4953
Gene name Gene Name - the full gene name approved by the HGNC.
Ornithine decarboxylase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ODC1
Synonyms (NCBI Gene) Gene synonyms aliases
BABS, NEDBA, NEDBIA, ODC
Disease Acronyms (UniProt) Disease acronyms from UniProt database
BABS, NEDBA
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p25.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to o
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004127 hsa-miR-192-5p Microarray 16822819
MIRT051317 hsa-miR-15a-5p CLASH 23622248
MIRT048600 hsa-miR-100-5p CLASH 23622248
MIRT042942 hsa-miR-324-3p CLASH 23622248
MIRT041549 hsa-miR-193b-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
APC Repression 12112318
CREB1 Unknown 1356108
KLF4 Repression 12297499
MAX Activation 8262968
MLX Unknown 19960435
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004586 Function Ornithine decarboxylase activity IBA 21873635
GO:0004586 Function Ornithine decarboxylase activity IDA
GO:0004586 Function Ornithine decarboxylase activity ISS
GO:0004586 Function Ornithine decarboxylase activity TAS 2317811
GO:0005515 Function Protein binding IPI 25416956, 28514442, 29892012, 31515488, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
165640 8109 ENSG00000115758
Protein
UniProt ID P11926
Protein name Ornithine decarboxylase (ODC) (EC 4.1.1.17)
Protein function Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated
PDB 1D7K , 2ON3 , 2OO0 , 4ZGY , 5BWA , 7S3F , 7S3G , 7U6P , 7U6U , 9B8M , 9B8N
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00278 Orn_DAP_Arg_deC 40 387 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Domain
PF02784 Orn_Arg_deC_N 45 281 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Domain
Sequence
MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP
RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI
KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL
LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG
SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVA
SAFTLAVNIIAKKIVLKEQ
TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC
DGLDRIVERCDLPEMHVGDWMLFENMG
AYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF
QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV
Sequence length 461
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Arginine and proline metabolism
Glutathione metabolism
Metabolic pathways
Efferocytosis
  Regulation of ornithine decarboxylase (ODC)
Metabolism of polyamines
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 12810952
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
21930798
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
21930798
Developmental delay Global developmental delay rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291
View all (32 more)
30475435
Associations from Text Mining
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 34477286
Adenoma Associate 12810952, 18413818, 20798393, 21930798
Adenoma Inhibit 22648715
Adenomatous Polyposis Coli Stimulate 2487240
Alopecia Associate 33806076, 34282722
Alzheimer Disease Associate 35738259
Anxiety Associate 33806076
Atrial Fibrillation Associate 36226239
Bipolar Disorder Associate 31279243
Brain Diseases Associate 33806076