ATP4A (ATPase H+/K+ transporting subunit alpha)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
495
Gene name Gene Name - the full gene name approved by the HGNC.
ATPase H+/K+ transporting subunit alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ATP4A
Synonyms (NCBI Gene) Gene synonyms aliases
ATP6A
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.12
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT054640 hsa-miR-1289 Luciferase reporter assay, qRT-PCR, Western blot 24503769
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(14)
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IEA
GO:0005391 Function P-type sodium:potassium-exchanging ATPase activity IBA 21873635
GO:0005524 Function ATP binding IEA
GO:0005615 Component Extracellular space HDA 22664934
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
137216 819 ENSG00000105675
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P20648
Protein name Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
Protein function The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09040 H-K_ATPase_N 2 → 43 Gastric H+/K+-ATPase, N terminal domain Domain
PF00690 Cation_ATPase_N 54 → 122 Cation transporter/ATPase, N-terminus Domain
PF00122 E1-E2_ATPase 174 → 365 Family
PF13246 Cation_ATPase 437 → 532 Family
PF00689 Cation_ATPase_C 810 → 1020 Cation transporting ATPase, C-terminus Family
Tissue specificity TISSUE SPECIFICITY: Expressed in gastric parietal cells (at protein level). {ECO:0000269|PubMed:24188822}.
Sequence 
MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVA
ELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAA
ICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQA
TVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSP
ECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIE
HFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAK
RLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQ
TFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMG
YRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELP
LDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLV
SMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLR
VPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLG
AIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIF
DNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAES
DIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQ
WEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGF
FRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLG
VRCCPGSWWDQELYY
Sequence length 1035
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Oxidative phosphorylation
Metabolic pathways
Collecting duct acid secretion
Gastric acid secretion 		  Ion transport by P-type ATPases
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Gastric Neuroendocrine Tumor gastric neuroendocrine neoplasm, familial gastric type 1 neuroendocrine tumor GenCC
Intrahepatic Cholestasis Of Pregnancy Intrahepatic Cholestasis Of Pregnancy GWAS
Show/Hide Text Mining Associations (8)
Associations from Text Mining
Disease Name Relationship Type References
Achlorhydria Associate 17204545
Acidosis Associate 21653633
Anemia Sickle Cell Associate 25084696
Gastritis Inhibit 37962678
Gastritis Atrophic Associate 34944008
Neoplasms Associate 23317218
Spinocerebellar Ataxia 11 Associate 25084696
Stomach Neoplasms Inhibit 23317218, 33788653