Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
494470
Gene name Gene Name - the full gene name approved by the HGNC.
Arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ARK2C
Synonyms (NCBI Gene) Gene synonyms aliases
ARKL2, RNF111L2, RNF165, lncAMPC
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT724359 hsa-miR-4682 HITS-CLIP 19536157
MIRT724358 hsa-miR-6857-3p HITS-CLIP 19536157
MIRT724357 hsa-miR-4740-5p HITS-CLIP 19536157
MIRT724356 hsa-miR-1288-3p HITS-CLIP 19536157
MIRT724355 hsa-miR-4515 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IEA
GO:0005515 Function Protein binding IPI 23610558
GO:0005634 Component Nucleus IBA 21873635
GO:0008045 Process Motor neuron axon guidance IBA 21873635
GO:0008270 Function Zinc ion binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein
UniProt ID Q6ZSG1
Protein name E3 ubiquitin-protein ligase ARK2C (EC 2.3.2.27) (RING finger protein 165) (RNF165)
Protein function E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated
PDB 5D0I , 5D0K , 5D0M , 5ULH , 5ULK , 7R70 , 7R71
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13639 zf-RING_2 292 335 Ring finger domain Domain
Sequence
MVLVHVGYLVLPVFGSVRNRGAPFQRSQHPHATSCRHFHLGPPQPQQLAPDFPLAHPVQS
QPGLSAHMAPAHQHSGALHQSLTPLPTLQFQDVTGPSFLPQALHQQYLLQQQLLEAQHRR
LVSHPRRSQERVSVHPHRLHPSFDFGQLQTPQPRYLAEGTDWDLSVDAGLSPAQFQVRPI
PQHYQHYLATPRMHHFPRNSSSTQMVVHEIRNYPYPQLHFLALQGLNPSRHTSAVRESYE
ELLQLEDRLGNVTRGAVQNTIERFTFPHKYKKRRPQDGKGKKDEGEESDTDEKCTICLSM
LEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICR
VDIETQLGADS
Sequence length 346
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
29274321
Multiple myeloma Multiple Myeloma rs11540652, rs78311289, rs121913482, rs397507340, rs121913343, rs121913240, rs121913529, rs730882018, rs1057517992, rs121913527, rs756183569, rs746646631, rs1574706907, rs372078034, rs745380962
View all (38 more)
29594489