Gene Gene information from NCBI Gene database.
Entrez ID 494470
Gene name Arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C
Gene symbol ARK2C
Synonyms (NCBI Gene)
ARKL2RNF111L2RNF165lncAMPC
Chromosome 18
Chromosome location 18q21.1
miRNA miRNA information provided by mirtarbase database.
305
miRTarBase ID miRNA Experiments Reference
MIRT724359 hsa-miR-4682 HITS-CLIP 19536157
MIRT724358 hsa-miR-6857-3p HITS-CLIP 19536157
MIRT724357 hsa-miR-4740-5p HITS-CLIP 19536157
MIRT724356 hsa-miR-1288-3p HITS-CLIP 19536157
MIRT724355 hsa-miR-4515 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IEA
GO:0005515 Function Protein binding IPI 23610558
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0007409 Process Axonogenesis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6ZSG1
Protein name E3 ubiquitin-protein ligase ARK2C (EC 2.3.2.27) (RING finger protein 165) (RNF165)
Protein function E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated
PDB 5D0I , 5D0K , 5D0M , 5ULH , 5ULK , 7R70 , 7R71
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13639 zf-RING_2 292 335 Ring finger domain Domain
Sequence
MVLVHVGYLVLPVFGSVRNRGAPFQRSQHPHATSCRHFHLGPPQPQQLAPDFPLAHPVQS
QPGLSAHMAPAHQHSGALHQSLTPLPTLQFQDVTGPSFLPQALHQQYLLQQQLLEAQHRR
LVSHPRRSQERVSVHPHRLHPSFDFGQLQTPQPRYLAEGTDWDLSVDAGLSPAQFQVRPI
PQHYQHYLATPRMHHFPRNSSSTQMVVHEIRNYPYPQLHFLALQGLNPSRHTSAVRESYE
ELLQLEDRLGNVTRGAVQNTIERFTFPHKYKKRRPQDGKGKKDEGEESDTDEKCTICLSM
LEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICR
VDIETQLGADS
Sequence length 346
Interactions View interactions