Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4943
Gene name Gene Name - the full gene name approved by the HGNC.	TBC1 domain family member 25
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TBC1D25
Synonyms (NCBI Gene) Gene synonyms aliases	MG81, OATL1
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xp11.23
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031139	hsa-miR-19b-3p	Sequencing	20371350
MIRT036096	hsa-miR-1296-5p	CLASH	23622248
MIRT662792	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT662791	hsa-miR-873-5p	HITS-CLIP	23824327
MIRT662790	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT662789	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT662788	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT662787	hsa-miR-8055	HITS-CLIP	23824327
MIRT455150	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT455149	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT455148	hsa-miR-940	PAR-CLIP	23592263
MIRT455146	hsa-miR-1321	PAR-CLIP	23592263
MIRT455147	hsa-miR-4739	PAR-CLIP	23592263
MIRT455145	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT455144	hsa-miR-4514	PAR-CLIP	23592263
MIRT455143	hsa-miR-4692	PAR-CLIP	23592263
MIRT455142	hsa-miR-4270	PAR-CLIP	23592263
MIRT455141	hsa-miR-4441	PAR-CLIP	23592263
MIRT455140	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT455139	hsa-miR-4419a	PAR-CLIP	23592263
MIRT455138	hsa-miR-4510	PAR-CLIP	23592263
MIRT455137	hsa-miR-6127	PAR-CLIP	23592263
MIRT455136	hsa-miR-6129	PAR-CLIP	23592263
MIRT455135	hsa-miR-6130	PAR-CLIP	23592263
MIRT455134	hsa-miR-6133	PAR-CLIP	23592263
MIRT455133	hsa-miR-6134	PAR-CLIP	23592263
MIRT455132	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT455131	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT455130	hsa-miR-3689d	PAR-CLIP	23592263
MIRT455129	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT455128	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT455127	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT455126	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT455125	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT455124	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT455123	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT455122	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT455121	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT455120	hsa-miR-7704	PAR-CLIP	23592263
MIRT455119	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT455118	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT662792	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT662791	hsa-miR-873-5p	HITS-CLIP	23824327
MIRT662790	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT662789	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT662788	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT662787	hsa-miR-8055	HITS-CLIP	23824327
MIRT455150	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT455149	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT455148	hsa-miR-940	PAR-CLIP	23592263
MIRT455146	hsa-miR-1321	PAR-CLIP	23592263
MIRT455147	hsa-miR-4739	PAR-CLIP	23592263
MIRT455145	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT455144	hsa-miR-4514	PAR-CLIP	23592263
MIRT455143	hsa-miR-4692	PAR-CLIP	23592263
MIRT455142	hsa-miR-4270	PAR-CLIP	23592263
MIRT455141	hsa-miR-4441	PAR-CLIP	23592263
MIRT455140	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT455139	hsa-miR-4419a	PAR-CLIP	23592263
MIRT455138	hsa-miR-4510	PAR-CLIP	23592263
MIRT455137	hsa-miR-6127	PAR-CLIP	23592263
MIRT455136	hsa-miR-6129	PAR-CLIP	23592263
MIRT455135	hsa-miR-6130	PAR-CLIP	23592263
MIRT455134	hsa-miR-6133	PAR-CLIP	23592263
MIRT455133	hsa-miR-6134	PAR-CLIP	23592263
MIRT455132	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT455131	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT455130	hsa-miR-3689d	PAR-CLIP	23592263
MIRT455129	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT455128	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT455127	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT455126	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT455125	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT455124	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT455123	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT455122	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT455121	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT455120	hsa-miR-7704	PAR-CLIP	23592263
MIRT455119	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT455118	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT1412966	hsa-miR-1256	CLIP-seq
MIRT1412967	hsa-miR-183	CLIP-seq
MIRT1412968	hsa-miR-2355-5p	CLIP-seq
MIRT1412969	hsa-miR-28-5p	CLIP-seq
MIRT1412970	hsa-miR-297	CLIP-seq
MIRT1412971	hsa-miR-3139	CLIP-seq
MIRT1412972	hsa-miR-3140-5p	CLIP-seq
MIRT1412973	hsa-miR-3149	CLIP-seq
MIRT1412974	hsa-miR-330-3p	CLIP-seq
MIRT1412975	hsa-miR-4260	CLIP-seq
MIRT1412976	hsa-miR-4464	CLIP-seq
MIRT1412977	hsa-miR-4477b	CLIP-seq
MIRT1412978	hsa-miR-4504	CLIP-seq
MIRT1412979	hsa-miR-4675	CLIP-seq
MIRT1412980	hsa-miR-4685-5p	CLIP-seq
MIRT1412981	hsa-miR-4726-3p	CLIP-seq
MIRT1412982	hsa-miR-4741	CLIP-seq
MIRT1412983	hsa-miR-4748	CLIP-seq
MIRT1412984	hsa-miR-486-3p	CLIP-seq
MIRT1412985	hsa-miR-570	CLIP-seq
MIRT1412986	hsa-miR-635	CLIP-seq
MIRT1412987	hsa-miR-637	CLIP-seq
MIRT1412988	hsa-miR-708	CLIP-seq
MIRT2123974	hsa-miR-149	CLIP-seq
MIRT1412969	hsa-miR-28-5p	CLIP-seq
MIRT1412971	hsa-miR-3139	CLIP-seq
MIRT1412974	hsa-miR-330-3p	CLIP-seq
MIRT2123975	hsa-miR-3679-3p	CLIP-seq
MIRT1412978	hsa-miR-4504	CLIP-seq
MIRT2123976	hsa-miR-607	CLIP-seq
MIRT1412988	hsa-miR-708	CLIP-seq
MIRT2123977	hsa-miR-892b	CLIP-seq
MIRT2123975	hsa-miR-3679-3p	CLIP-seq
MIRT2123975	hsa-miR-3679-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005096	Function	GTPase activator activity	IDA	21383079
GO:0005515	Function	Protein binding	IPI	21383079, 22354992, 28514442, 32296183
GO:0005776	Component	Autophagosome	IBA	21873635
GO:0005776	Component	Autophagosome	IDA	21383079
GO:0005776	Component	Autophagosome	TAS
GO:0006886	Process	Intracellular protein transport	IBA	21873635
GO:0006914	Process	Autophagy	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0090630	Process	Activation of GTPase activity	IBA	21873635
GO:1901096	Process	Regulation of autophagosome maturation	IBA	21873635
GO:1901096	Process	Regulation of autophagosome maturation	IMP	21383079

MIM	HGNC	e!Ensembl
311240	8092	ENSG00000068354

Protein

UniProt ID

Q3MII6

Protein name

TBC1 domain family member 25

Protein function

Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00566	RabGAP-TBC	231 → 436	Rab-GTPase-TBC domain	Family

Sequence

MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI
TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL
RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV
QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY
LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHP
YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK
RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF
DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGST
FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS
EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV
PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL
RRARALFADYLQSEVWDSEEGAEATAAS

Sequence length

688

Interactions

View interactions

	Reactome
			TBC/RABGAPs

TBC1D25 (TBC1 domain family member 25)