OAS3 (2'-5'-oligoadenylate synthetase 3)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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4940 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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2'-5'-oligoadenylate synthetase 3 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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OAS3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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p100, p100OAS |
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Chromosome
Chromosome number
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12 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12q24.13 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes an enzyme included in the 2`, 5` oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2`, 5` oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role i |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||||||||||||
| UniProt ID | Q9Y6K5 | |||||||||||||||||||||||||
| Protein name | 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) | |||||||||||||||||||||||||
| Protein function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene reg | |||||||||||||||||||||||||
| PDB | 4S3N | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Present at high level in placenta trophoblast. | |||||||||||||||||||||||||
| Sequence | ||||||||||||||||||||||||||
| Sequence length | 1087 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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