Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4939
Gene name Gene Name - the full gene name approved by the HGNC.	2'-5'-oligoadenylate synthetase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	OAS2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.13
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2`-specific nucleotidyl transfer react

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019125	hsa-miR-335-5p	Microarray	18185580
MIRT021817	hsa-miR-132-3p	Microarray	17612493
MIRT025932	hsa-miR-7-5p	Microarray	17612493
MIRT446533	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446532	hsa-miR-1199-5p	PAR-CLIP	22100165
MIRT446531	hsa-miR-6751-3p	PAR-CLIP	22100165
MIRT446529	hsa-miR-4635	PAR-CLIP	22100165
MIRT446530	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446528	hsa-miR-2114-3p	PAR-CLIP	22100165
MIRT446527	hsa-miR-6823-3p	PAR-CLIP	22100165
MIRT446526	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446525	hsa-miR-4306	PAR-CLIP	22100165
MIRT446524	hsa-miR-4644	PAR-CLIP	22100165
MIRT446523	hsa-miR-5192	PAR-CLIP	22100165
MIRT446522	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446521	hsa-miR-573	PAR-CLIP	22100165
MIRT446519	hsa-miR-4531	PAR-CLIP	22100165
MIRT446520	hsa-miR-1270	PAR-CLIP	22100165
MIRT446518	hsa-miR-620	PAR-CLIP	22100165
MIRT446533	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446532	hsa-miR-1199-5p	PAR-CLIP	22100165
MIRT446531	hsa-miR-6751-3p	PAR-CLIP	22100165
MIRT446529	hsa-miR-4635	PAR-CLIP	22100165
MIRT446530	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446528	hsa-miR-2114-3p	PAR-CLIP	22100165
MIRT446527	hsa-miR-6823-3p	PAR-CLIP	22100165
MIRT446526	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446525	hsa-miR-4306	PAR-CLIP	22100165
MIRT446524	hsa-miR-4644	PAR-CLIP	22100165
MIRT446523	hsa-miR-5192	PAR-CLIP	22100165
MIRT446522	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446521	hsa-miR-573	PAR-CLIP	22100165
MIRT446519	hsa-miR-4531	PAR-CLIP	22100165
MIRT446520	hsa-miR-1270	PAR-CLIP	22100165
MIRT446518	hsa-miR-620	PAR-CLIP	22100165
MIRT446533	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446532	hsa-miR-1199-5p	PAR-CLIP	22100165
MIRT446531	hsa-miR-6751-3p	PAR-CLIP	22100165
MIRT446529	hsa-miR-4635	PAR-CLIP	22100165
MIRT446530	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446528	hsa-miR-2114-3p	PAR-CLIP	22100165
MIRT446527	hsa-miR-6823-3p	PAR-CLIP	22100165
MIRT446526	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446525	hsa-miR-4306	PAR-CLIP	22100165
MIRT446524	hsa-miR-4644	PAR-CLIP	22100165
MIRT446523	hsa-miR-5192	PAR-CLIP	22100165
MIRT446522	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446521	hsa-miR-573	PAR-CLIP	22100165
MIRT446519	hsa-miR-4531	PAR-CLIP	22100165
MIRT446520	hsa-miR-1270	PAR-CLIP	22100165
MIRT446518	hsa-miR-620	PAR-CLIP	22100165
MIRT446533	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446532	hsa-miR-1199-5p	PAR-CLIP	22100165
MIRT446531	hsa-miR-6751-3p	PAR-CLIP	22100165
MIRT446529	hsa-miR-4635	PAR-CLIP	22100165
MIRT446530	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446528	hsa-miR-2114-3p	PAR-CLIP	22100165
MIRT446527	hsa-miR-6823-3p	PAR-CLIP	22100165
MIRT446526	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446525	hsa-miR-4306	PAR-CLIP	22100165
MIRT446524	hsa-miR-4644	PAR-CLIP	22100165
MIRT446523	hsa-miR-5192	PAR-CLIP	22100165
MIRT446522	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446521	hsa-miR-573	PAR-CLIP	22100165
MIRT446519	hsa-miR-4531	PAR-CLIP	22100165
MIRT446520	hsa-miR-1270	PAR-CLIP	22100165
MIRT446518	hsa-miR-620	PAR-CLIP	22100165
MIRT756207	hsa-miR-580-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC), In situ hybridization	34516354
MIRT1200998	hsa-miR-1202	CLIP-seq
MIRT1200999	hsa-miR-142-3p	CLIP-seq
MIRT1201000	hsa-miR-2467-3p	CLIP-seq
MIRT1201001	hsa-miR-3158-5p	CLIP-seq
MIRT1201002	hsa-miR-3192	CLIP-seq
MIRT1201003	hsa-miR-323b-5p	CLIP-seq
MIRT1201004	hsa-miR-3614-5p	CLIP-seq
MIRT1201005	hsa-miR-3678-3p	CLIP-seq
MIRT1201006	hsa-miR-3972	CLIP-seq
MIRT1201007	hsa-miR-4278	CLIP-seq
MIRT1201008	hsa-miR-4291	CLIP-seq
MIRT1201009	hsa-miR-4314	CLIP-seq
MIRT1201010	hsa-miR-4419a	CLIP-seq
MIRT1201011	hsa-miR-4447	CLIP-seq
MIRT1201012	hsa-miR-4472	CLIP-seq
MIRT1201013	hsa-miR-4488	CLIP-seq
MIRT1201014	hsa-miR-4510	CLIP-seq
MIRT1201015	hsa-miR-4646-5p	CLIP-seq
MIRT1201016	hsa-miR-4697-5p	CLIP-seq
MIRT1201017	hsa-miR-4716-3p	CLIP-seq
MIRT1201018	hsa-miR-4721	CLIP-seq
MIRT1201019	hsa-miR-4727-3p	CLIP-seq
MIRT1201020	hsa-miR-4747-5p	CLIP-seq
MIRT1201021	hsa-miR-4763-5p	CLIP-seq
MIRT1201022	hsa-miR-4779	CLIP-seq
MIRT1201023	hsa-miR-545	CLIP-seq
MIRT1201024	hsa-miR-548ag	CLIP-seq
MIRT1201025	hsa-miR-548ai	CLIP-seq
MIRT1201026	hsa-miR-659	CLIP-seq
MIRT1201027	hsa-miR-668	CLIP-seq
MIRT1201028	hsa-miR-1	CLIP-seq
MIRT1201029	hsa-miR-106a	CLIP-seq
MIRT1201030	hsa-miR-106b	CLIP-seq
MIRT1201031	hsa-miR-1255a	CLIP-seq
MIRT1201032	hsa-miR-1255b	CLIP-seq
MIRT1201033	hsa-miR-142-5p	CLIP-seq
MIRT1201034	hsa-miR-17	CLIP-seq
MIRT1201035	hsa-miR-206	CLIP-seq
MIRT1201036	hsa-miR-20a	CLIP-seq
MIRT1201037	hsa-miR-20b	CLIP-seq
MIRT1201038	hsa-miR-2277-3p	CLIP-seq
MIRT1201039	hsa-miR-3120-3p	CLIP-seq
MIRT1201040	hsa-miR-346	CLIP-seq
MIRT1201041	hsa-miR-3609	CLIP-seq
MIRT1201042	hsa-miR-3647-3p	CLIP-seq
MIRT1201043	hsa-miR-3667-3p	CLIP-seq
MIRT1201044	hsa-miR-3673	CLIP-seq
MIRT1201045	hsa-miR-3675-5p	CLIP-seq
MIRT1201046	hsa-miR-3681	CLIP-seq
MIRT1201047	hsa-miR-3691-5p	CLIP-seq
MIRT1201048	hsa-miR-384	CLIP-seq
MIRT1201049	hsa-miR-4283	CLIP-seq
MIRT1201050	hsa-miR-4288	CLIP-seq
MIRT1201051	hsa-miR-4426	CLIP-seq
MIRT1201052	hsa-miR-4489	CLIP-seq
MIRT1201053	hsa-miR-4522	CLIP-seq
MIRT1201054	hsa-miR-4647	CLIP-seq
MIRT1201055	hsa-miR-4651	CLIP-seq
MIRT1201056	hsa-miR-4654	CLIP-seq
MIRT1201057	hsa-miR-4656	CLIP-seq
MIRT1201058	hsa-miR-4662b	CLIP-seq
MIRT1201059	hsa-miR-4764-5p	CLIP-seq
MIRT1201060	hsa-miR-4765	CLIP-seq
MIRT1201061	hsa-miR-4769-5p	CLIP-seq
MIRT1201062	hsa-miR-4796-3p	CLIP-seq
MIRT1201063	hsa-miR-498	CLIP-seq
MIRT1201064	hsa-miR-519d	CLIP-seq
MIRT1201065	hsa-miR-548ah	CLIP-seq
MIRT1201066	hsa-miR-608	CLIP-seq
MIRT1201067	hsa-miR-613	CLIP-seq
MIRT1201068	hsa-miR-632	CLIP-seq
MIRT1201069	hsa-miR-654-3p	CLIP-seq
MIRT1201070	hsa-miR-93	CLIP-seq
MIRT1556748	hsa-miR-488	CLIP-seq
MIRT2391842	hsa-miR-3170	CLIP-seq
MIRT2391843	hsa-miR-4705	CLIP-seq
MIRT1200998	hsa-miR-1202	CLIP-seq
MIRT2584433	hsa-miR-1229	CLIP-seq
MIRT1201031	hsa-miR-1255a	CLIP-seq
MIRT1201032	hsa-miR-1255b	CLIP-seq
MIRT2584434	hsa-miR-1262	CLIP-seq
MIRT2584435	hsa-miR-1265	CLIP-seq
MIRT2584436	hsa-miR-185	CLIP-seq
MIRT2584437	hsa-miR-219-1-3p	CLIP-seq
MIRT1201038	hsa-miR-2277-3p	CLIP-seq
MIRT1201000	hsa-miR-2467-3p	CLIP-seq
MIRT2584438	hsa-miR-296-3p	CLIP-seq
MIRT2584439	hsa-miR-3064-5p	CLIP-seq
MIRT2584440	hsa-miR-31	CLIP-seq
MIRT1201039	hsa-miR-3120-3p	CLIP-seq
MIRT2584441	hsa-miR-3125	CLIP-seq
MIRT2584442	hsa-miR-3158-3p	CLIP-seq
MIRT1201001	hsa-miR-3158-5p	CLIP-seq
MIRT2584443	hsa-miR-3168	CLIP-seq
MIRT2584444	hsa-miR-3173-3p	CLIP-seq
MIRT2584445	hsa-miR-3200-5p	CLIP-seq
MIRT2584446	hsa-miR-3605-5p	CLIP-seq
MIRT2584447	hsa-miR-3622b-5p	CLIP-seq
MIRT2584448	hsa-miR-3647-5p	CLIP-seq
MIRT2584449	hsa-miR-3652	CLIP-seq
MIRT1201005	hsa-miR-3678-3p	CLIP-seq
MIRT1201047	hsa-miR-3691-5p	CLIP-seq
MIRT2584450	hsa-miR-3714	CLIP-seq
MIRT2584451	hsa-miR-374a	CLIP-seq
MIRT2584452	hsa-miR-374b	CLIP-seq
MIRT2584453	hsa-miR-3916	CLIP-seq
MIRT1201006	hsa-miR-3972	CLIP-seq
MIRT1201008	hsa-miR-4291	CLIP-seq
MIRT2584454	hsa-miR-4303	CLIP-seq
MIRT1201010	hsa-miR-4419a	CLIP-seq
MIRT2584455	hsa-miR-4430	CLIP-seq
MIRT2584456	hsa-miR-4484	CLIP-seq
MIRT2584457	hsa-miR-4505	CLIP-seq
MIRT1201014	hsa-miR-4510	CLIP-seq
MIRT1201053	hsa-miR-4522	CLIP-seq
MIRT2584458	hsa-miR-4523	CLIP-seq
MIRT2584459	hsa-miR-4533	CLIP-seq
MIRT2584460	hsa-miR-4537	CLIP-seq
MIRT2584461	hsa-miR-4645-5p	CLIP-seq
MIRT2584462	hsa-miR-4673	CLIP-seq
MIRT2584463	hsa-miR-4696	CLIP-seq
MIRT2584464	hsa-miR-4700-3p	CLIP-seq
MIRT2584465	hsa-miR-4701-3p	CLIP-seq
MIRT2584466	hsa-miR-4708-3p	CLIP-seq
MIRT2584467	hsa-miR-4709-5p	CLIP-seq
MIRT2584468	hsa-miR-4720-5p	CLIP-seq
MIRT2584469	hsa-miR-4738-3p	CLIP-seq
MIRT1201020	hsa-miR-4747-5p	CLIP-seq
MIRT1201021	hsa-miR-4763-5p	CLIP-seq
MIRT2584470	hsa-miR-4792	CLIP-seq
MIRT2584471	hsa-miR-4797-5p	CLIP-seq
MIRT2584472	hsa-miR-4799-3p	CLIP-seq
MIRT1556748	hsa-miR-488	CLIP-seq
MIRT1201063	hsa-miR-498	CLIP-seq
MIRT1201023	hsa-miR-545	CLIP-seq
MIRT2584473	hsa-miR-548an	CLIP-seq
MIRT2584474	hsa-miR-549	CLIP-seq
MIRT2584475	hsa-miR-555	CLIP-seq
MIRT2584476	hsa-miR-571	CLIP-seq
MIRT2584477	hsa-miR-576-5p	CLIP-seq
MIRT2584478	hsa-miR-604	CLIP-seq
MIRT2584479	hsa-miR-647	CLIP-seq
MIRT1201069	hsa-miR-654-3p	CLIP-seq
MIRT2584480	hsa-miR-671-5p	CLIP-seq
MIRT2584481	hsa-miR-877	CLIP-seq
MIRT2584482	hsa-miR-924	CLIP-seq
MIRT2584483	hsa-miR-940	CLIP-seq
MIRT2584433	hsa-miR-1229	CLIP-seq
MIRT2584435	hsa-miR-1265	CLIP-seq
MIRT2584436	hsa-miR-185	CLIP-seq
MIRT2686755	hsa-miR-214	CLIP-seq
MIRT1201038	hsa-miR-2277-3p	CLIP-seq
MIRT1201000	hsa-miR-2467-3p	CLIP-seq
MIRT2584438	hsa-miR-296-3p	CLIP-seq
MIRT2584439	hsa-miR-3064-5p	CLIP-seq
MIRT2584440	hsa-miR-31	CLIP-seq
MIRT1201039	hsa-miR-3120-3p	CLIP-seq
MIRT2584441	hsa-miR-3125	CLIP-seq
MIRT1201001	hsa-miR-3158-5p	CLIP-seq
MIRT2584443	hsa-miR-3168	CLIP-seq
MIRT2584445	hsa-miR-3200-5p	CLIP-seq
MIRT2584446	hsa-miR-3605-5p	CLIP-seq
MIRT2686756	hsa-miR-3619-5p	CLIP-seq
MIRT2584448	hsa-miR-3647-5p	CLIP-seq
MIRT2584449	hsa-miR-3652	CLIP-seq
MIRT1201005	hsa-miR-3678-3p	CLIP-seq
MIRT2584450	hsa-miR-3714	CLIP-seq
MIRT2584451	hsa-miR-374a	CLIP-seq
MIRT2584452	hsa-miR-374b	CLIP-seq
MIRT2584453	hsa-miR-3916	CLIP-seq
MIRT1201008	hsa-miR-4291	CLIP-seq
MIRT2584454	hsa-miR-4303	CLIP-seq
MIRT1201010	hsa-miR-4419a	CLIP-seq
MIRT2584455	hsa-miR-4430	CLIP-seq
MIRT2584456	hsa-miR-4484	CLIP-seq
MIRT2584457	hsa-miR-4505	CLIP-seq
MIRT1201014	hsa-miR-4510	CLIP-seq
MIRT1201053	hsa-miR-4522	CLIP-seq
MIRT2584459	hsa-miR-4533	CLIP-seq
MIRT2584460	hsa-miR-4537	CLIP-seq
MIRT2584463	hsa-miR-4696	CLIP-seq
MIRT2584466	hsa-miR-4708-3p	CLIP-seq
MIRT2584467	hsa-miR-4709-5p	CLIP-seq
MIRT2584468	hsa-miR-4720-5p	CLIP-seq
MIRT2584469	hsa-miR-4738-3p	CLIP-seq
MIRT1201020	hsa-miR-4747-5p	CLIP-seq
MIRT1201021	hsa-miR-4763-5p	CLIP-seq
MIRT2584470	hsa-miR-4792	CLIP-seq
MIRT2584472	hsa-miR-4799-3p	CLIP-seq
MIRT1556748	hsa-miR-488	CLIP-seq
MIRT1201063	hsa-miR-498	CLIP-seq
MIRT1201023	hsa-miR-545	CLIP-seq
MIRT2584473	hsa-miR-548an	CLIP-seq
MIRT2584474	hsa-miR-549	CLIP-seq
MIRT2584475	hsa-miR-555	CLIP-seq
MIRT2584477	hsa-miR-576-5p	CLIP-seq
MIRT2686757	hsa-miR-592	CLIP-seq
MIRT2686758	hsa-miR-597	CLIP-seq
MIRT2584478	hsa-miR-604	CLIP-seq
MIRT2584479	hsa-miR-647	CLIP-seq
MIRT1201069	hsa-miR-654-3p	CLIP-seq
MIRT2686759	hsa-miR-761	CLIP-seq
MIRT2584481	hsa-miR-877	CLIP-seq
MIRT2686760	hsa-miR-922	CLIP-seq
MIRT2584482	hsa-miR-924	CLIP-seq
MIRT2584483	hsa-miR-940	CLIP-seq

Show/Hide all(50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001730	Function	2'-5'-oligoadenylate synthetase activity	IBA
GO:0001730	Function	2'-5'-oligoadenylate synthetase activity	IDA	9880569, 11682059
GO:0001730	Function	2'-5'-oligoadenylate synthetase activity	IEA
GO:0001730	Function	2'-5'-oligoadenylate synthetase activity	IMP	10464285
GO:0002376	Process	Immune system process	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0003725	Function	Double-stranded RNA binding	IDA	9880569
GO:0003725	Function	Double-stranded RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IMP	10464285
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	IMP	10464285
GO:0005654	Component	Nucleoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	19923450
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	2440675
GO:0006401	Process	RNA catabolic process	IEA
GO:0009615	Process	Response to virus	IEA
GO:0009615	Process	Response to virus	TAS	21142819
GO:0009617	Process	Response to bacterium	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	TAS	2440675
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0032728	Process	Positive regulation of interferon-beta production	IMP	30822544
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IMP	30822544
GO:0042742	Process	Defense response to bacterium	IMP	30822544
GO:0043231	Component	Intracellular membrane-bounded organelle	TAS	2440675
GO:0045071	Process	Negative regulation of viral genome replication	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	19923450
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051607	Process	Defense response to virus	IEA
GO:0051607	Process	Defense response to virus	ISS
GO:0060337	Process	Type I interferon-mediated signaling pathway	IBA
GO:0060337	Process	Type I interferon-mediated signaling pathway	IEA
GO:0060337	Process	Type I interferon-mediated signaling pathway	ISS
GO:0070106	Process	Interleukin-27-mediated signaling pathway	IBA
GO:0070106	Process	Interleukin-27-mediated signaling pathway	IDA	32270034
GO:0070106	Process	Interleukin-27-mediated signaling pathway	IEA
GO:0098542	Process	Defense response to other organism	IEA
GO:0140374	Process	Antiviral innate immune response	IBA
GO:1903487	Process	Regulation of lactation	IEA
GO:1903487	Process	Regulation of lactation	ISS

MIM	HGNC	e!Ensembl
603350	8087	ENSG00000111335

Protein

UniProt ID

P29728

Protein name

2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS)

Protein function

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10421	OAS1_C	154 → 338		Domain
PF01909	NTP_transf_2	373 → 471	Nucleotidyltransferase domain	Family
PF10421	OAS1_C	497 → 685		Domain

Sequence

MGNGESQLSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEPEQFPLVQGVAIG
GSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFEI
QKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIYRELKRSLDKTNASPGEFAVC
FTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKD
NFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPVILDPVDPTNN
VSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNK
CFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKGTALKTGSDADLVVFHNSLKS
YTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAPRVLSFSLKSKVLNESVSF
DVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLK
DLIRLVKHWYKECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVT
QYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTGDVGGGDRWCWHLLAKEA
KEWLSSPCFKDGTGNPIPPWKVPTMQTPGSCGARIHPIVNEMFSSRSHRILNNNSKRNF

Sequence length

719

Interactions

View interactions

	KEGG		Reactome
	NOD-like receptor signaling pathway Hepatitis C Measles Influenza A Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Adult asthma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (38)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acquired Immunodeficiency Syndrome	Associate	28050553
Arthritis Psoriatic	Associate	25809693
Arthritis Rheumatoid	Associate	27356888, 34079550
Breast Neoplasms	Associate	32560641
Celiac Disease	Associate	28934294
Colitis Ulcerative	Associate	36165492
Colonic Neoplasms	Associate	35593226
Colorectal Neoplasms	Associate	29703930, 30148861
Communicable Diseases	Associate	28427244
COVID 19	Associate	32599245, 33138195, 34730223, 34880855, 35027740, 35212764, 36072597, 36656015
Cytokine Release Syndrome	Associate	36538032
Depressive Disorder	Associate	31779701
Diabetes Mellitus	Associate	28427244
Diabetes Mellitus Type 2	Associate	28427244
Encephalitis Tick Borne	Associate	24594345
Fibrosis	Associate	28139728
Glioblastoma	Associate	36178522
Glioma	Associate	36007277
Hepatitis C Chronic	Associate	24594345
HIV Infections	Associate	28050553, 37209263
Inflammation	Associate	26419927, 36042612
Influenza Human	Associate	34367124
Influenza Human	Stimulate	39591472
Leukemia Myeloid Acute	Associate	34516354
Liver Cirrhosis	Associate	28139728
Liver Diseases	Associate	28139728
Lupus Erythematosus Systemic	Associate	24013589, 24434273, 27257790, 29257335, 34079550, 35967341
Lupus Erythematosus Systemic	Stimulate	32321151
Mouth Neoplasms	Associate	26595239
Neoplasm Invasiveness	Associate	30148861
Neoplasms	Associate	26595239
Papilloma Choroid Plexus	Associate	29703930
Prostatic Neoplasms	Associate	23272139
Psoriasis	Associate	27572959
Scleroderma Systemic	Associate	33253099
Squamous Cell Carcinoma of Head and Neck	Stimulate	27572959
Tarlov Cysts	Associate	30148861
Urinary Bladder Neoplasms	Associate	36162993

OAS2 (2'-5'-oligoadenylate synthetase 2)