Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4928
Gene name Gene Name - the full gene name approved by the HGNC.	Nucleoporin 98 and 96 precursor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NUP98
Synonyms (NCBI Gene) Gene synonyms aliases	ADIR2, NUP196, NUP96, Nup98-96
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p15.4
Summary Summary of gene provided in NCBI Entrez Gene.	Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and e

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1057519323	T>C	Likely-pathogenic	Non coding transcript variant, genic downstream transcript variant, coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025511	hsa-miR-34a-5p	Proteomics	21566225
MIRT027735	hsa-miR-98-5p	Microarray	19088304
MIRT051267	hsa-miR-16-5p	CLASH	23622248
MIRT049913	hsa-miR-30a-3p	CLASH	23622248
MIRT045389	hsa-miR-149-5p	CLASH	23622248
MIRT040801	hsa-miR-18a-3p	CLASH	23622248
MIRT039534	hsa-miR-652-3p	CLASH	23622248
MIRT713837	hsa-miR-514a-5p	HITS-CLIP	19536157
MIRT713836	hsa-miR-4717-3p	HITS-CLIP	19536157
MIRT713835	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT713834	hsa-miR-326	HITS-CLIP	19536157
MIRT713833	hsa-miR-330-5p	HITS-CLIP	19536157
MIRT713832	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT713831	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT713830	hsa-miR-3192-5p	HITS-CLIP	19536157
MIRT713829	hsa-miR-619-5p	HITS-CLIP	19536157
MIRT713828	hsa-miR-6506-5p	HITS-CLIP	19536157
MIRT059114	hsa-miR-6827-5p	HITS-CLIP	19536157
MIRT713827	hsa-miR-6090	HITS-CLIP	19536157
MIRT713826	hsa-miR-4300	HITS-CLIP	19536157
MIRT713825	hsa-miR-5591-5p	HITS-CLIP	19536157
MIRT713824	hsa-miR-6726-5p	HITS-CLIP	19536157
MIRT713823	hsa-miR-920	HITS-CLIP	19536157
MIRT713822	hsa-miR-188-3p	HITS-CLIP	19536157
MIRT713821	hsa-miR-1260a	HITS-CLIP	19536157
MIRT713820	hsa-miR-1260b	HITS-CLIP	19536157
MIRT713819	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT713818	hsa-miR-4314	HITS-CLIP	19536157
MIRT687361	hsa-miR-21-3p	HITS-CLIP	23313552
MIRT687360	hsa-miR-3591-3p	HITS-CLIP	23313552
MIRT687359	hsa-miR-4687-5p	HITS-CLIP	23313552
MIRT687358	hsa-miR-6779-3p	HITS-CLIP	23313552
MIRT687357	hsa-miR-129-1-3p	HITS-CLIP	23313552
MIRT687356	hsa-miR-129-2-3p	HITS-CLIP	23313552
MIRT687355	hsa-miR-3651	HITS-CLIP	23313552
MIRT687354	hsa-miR-1226-3p	HITS-CLIP	23313552
MIRT687353	hsa-miR-3934-5p	HITS-CLIP	23313552
MIRT687352	hsa-miR-1279	HITS-CLIP	23313552
MIRT059110	hsa-miR-4726-3p	HITS-CLIP	23313552
MIRT687351	hsa-miR-4324	HITS-CLIP	23313552
MIRT687350	hsa-miR-18b-3p	HITS-CLIP	23313552
MIRT687349	hsa-miR-4529-5p	HITS-CLIP	23313552
MIRT687348	hsa-miR-663b	HITS-CLIP	23313552
MIRT687347	hsa-miR-644a	HITS-CLIP	23313552
MIRT687346	hsa-miR-6894-3p	HITS-CLIP	23313552
MIRT687345	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT687344	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT687343	hsa-miR-7108-5p	HITS-CLIP	23313552
MIRT440069	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440068	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440069	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT727051	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727050	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727048	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727049	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT440068	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT737172	hsa-miR-501-5p	RNA-seq, qRT-PCR	34148372
MIRT713837	hsa-miR-514a-5p	HITS-CLIP	19536157
MIRT713836	hsa-miR-4717-3p	HITS-CLIP	19536157
MIRT713835	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT713834	hsa-miR-326	HITS-CLIP	19536157
MIRT713833	hsa-miR-330-5p	HITS-CLIP	19536157
MIRT713832	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT713831	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT713830	hsa-miR-3192-5p	HITS-CLIP	19536157
MIRT713829	hsa-miR-619-5p	HITS-CLIP	19536157
MIRT713828	hsa-miR-6506-5p	HITS-CLIP	19536157
MIRT059114	hsa-miR-6827-5p	HITS-CLIP	19536157
MIRT713827	hsa-miR-6090	HITS-CLIP	19536157
MIRT713826	hsa-miR-4300	HITS-CLIP	19536157
MIRT713825	hsa-miR-5591-5p	HITS-CLIP	19536157
MIRT713824	hsa-miR-6726-5p	HITS-CLIP	19536157
MIRT713823	hsa-miR-920	HITS-CLIP	19536157
MIRT713822	hsa-miR-188-3p	HITS-CLIP	19536157
MIRT713821	hsa-miR-1260a	HITS-CLIP	19536157
MIRT713820	hsa-miR-1260b	HITS-CLIP	19536157
MIRT713819	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT713818	hsa-miR-4314	HITS-CLIP	19536157
MIRT687361	hsa-miR-21-3p	HITS-CLIP	23313552
MIRT687360	hsa-miR-3591-3p	HITS-CLIP	23313552
MIRT687359	hsa-miR-4687-5p	HITS-CLIP	23313552
MIRT687358	hsa-miR-6779-3p	HITS-CLIP	23313552
MIRT687357	hsa-miR-129-1-3p	HITS-CLIP	23313552
MIRT687356	hsa-miR-129-2-3p	HITS-CLIP	23313552
MIRT687355	hsa-miR-3651	HITS-CLIP	23313552
MIRT687354	hsa-miR-1226-3p	HITS-CLIP	23313552
MIRT687353	hsa-miR-3934-5p	HITS-CLIP	23313552
MIRT687352	hsa-miR-1279	HITS-CLIP	23313552
MIRT059110	hsa-miR-4726-3p	HITS-CLIP	23313552
MIRT687351	hsa-miR-4324	HITS-CLIP	23313552
MIRT687350	hsa-miR-18b-3p	HITS-CLIP	23313552
MIRT687349	hsa-miR-4529-5p	HITS-CLIP	23313552
MIRT687348	hsa-miR-663b	HITS-CLIP	23313552
MIRT687347	hsa-miR-644a	HITS-CLIP	23313552
MIRT687346	hsa-miR-6894-3p	HITS-CLIP	23313552
MIRT687345	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT687344	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT687343	hsa-miR-7108-5p	HITS-CLIP	23313552
MIRT1199897	hsa-let-7a	CLIP-seq
MIRT1199898	hsa-let-7b	CLIP-seq
MIRT1199899	hsa-let-7c	CLIP-seq
MIRT1199900	hsa-let-7d	CLIP-seq
MIRT1199901	hsa-let-7e	CLIP-seq
MIRT1199902	hsa-let-7f	CLIP-seq
MIRT1199903	hsa-let-7g	CLIP-seq
MIRT1199904	hsa-let-7i	CLIP-seq
MIRT1199905	hsa-miR-186	CLIP-seq
MIRT1199906	hsa-miR-196a	CLIP-seq
MIRT1199907	hsa-miR-196b	CLIP-seq
MIRT1199908	hsa-miR-214	CLIP-seq
MIRT1199909	hsa-miR-3125	CLIP-seq
MIRT1199910	hsa-miR-3133	CLIP-seq
MIRT1199911	hsa-miR-3148	CLIP-seq
MIRT1199912	hsa-miR-3605-5p	CLIP-seq
MIRT1199913	hsa-miR-3619-5p	CLIP-seq
MIRT1199914	hsa-miR-3688-3p	CLIP-seq
MIRT1199915	hsa-miR-3689d	CLIP-seq
MIRT1199916	hsa-miR-3714	CLIP-seq
MIRT1199917	hsa-miR-3916	CLIP-seq
MIRT1199918	hsa-miR-3927	CLIP-seq
MIRT1199919	hsa-miR-4291	CLIP-seq
MIRT1199920	hsa-miR-4451	CLIP-seq
MIRT1199921	hsa-miR-4458	CLIP-seq
MIRT1199922	hsa-miR-4484	CLIP-seq
MIRT1199923	hsa-miR-4500	CLIP-seq
MIRT1199924	hsa-miR-4699-3p	CLIP-seq
MIRT1199925	hsa-miR-4802-5p	CLIP-seq
MIRT1199926	hsa-miR-548aa	CLIP-seq
MIRT1199927	hsa-miR-548ac	CLIP-seq
MIRT1199928	hsa-miR-548an	CLIP-seq
MIRT1199929	hsa-miR-548d-3p	CLIP-seq
MIRT1199930	hsa-miR-548z	CLIP-seq
MIRT1199931	hsa-miR-601	CLIP-seq
MIRT1199932	hsa-miR-646	CLIP-seq
MIRT1199933	hsa-miR-761	CLIP-seq
MIRT1199934	hsa-miR-877	CLIP-seq
MIRT1199935	hsa-miR-922	CLIP-seq
MIRT1199936	hsa-miR-98	CLIP-seq
MIRT1199937	hsa-miR-320e	CLIP-seq
MIRT1199938	hsa-miR-3622b-5p	CLIP-seq
MIRT1199939	hsa-miR-4499	CLIP-seq
MIRT1199940	hsa-miR-451b	CLIP-seq
MIRT1199941	hsa-miR-4640-5p	CLIP-seq
MIRT1199942	hsa-miR-4642	CLIP-seq
MIRT1199943	hsa-miR-4696	CLIP-seq
MIRT1199944	hsa-miR-4726-5p	CLIP-seq
MIRT1199925	hsa-miR-4802-5p	CLIP-seq
MIRT1199945	hsa-miR-545	CLIP-seq
MIRT1199926	hsa-miR-548aa	CLIP-seq
MIRT1199946	hsa-miR-570	CLIP-seq
MIRT1199897	hsa-let-7a	CLIP-seq
MIRT1199898	hsa-let-7b	CLIP-seq
MIRT1199899	hsa-let-7c	CLIP-seq
MIRT1199900	hsa-let-7d	CLIP-seq
MIRT1199901	hsa-let-7e	CLIP-seq
MIRT1199902	hsa-let-7f	CLIP-seq
MIRT1199903	hsa-let-7g	CLIP-seq
MIRT1199904	hsa-let-7i	CLIP-seq
MIRT1199908	hsa-miR-214	CLIP-seq
MIRT1199909	hsa-miR-3125	CLIP-seq
MIRT1199947	hsa-miR-3149	CLIP-seq
MIRT1199912	hsa-miR-3605-5p	CLIP-seq
MIRT1199913	hsa-miR-3619-5p	CLIP-seq
MIRT1199917	hsa-miR-3916	CLIP-seq
MIRT1199918	hsa-miR-3927	CLIP-seq
MIRT1199919	hsa-miR-4291	CLIP-seq
MIRT1199920	hsa-miR-4451	CLIP-seq
MIRT1199921	hsa-miR-4458	CLIP-seq
MIRT1199923	hsa-miR-4500	CLIP-seq
MIRT1199948	hsa-miR-520d-5p	CLIP-seq
MIRT1199949	hsa-miR-524-5p	CLIP-seq
MIRT1199931	hsa-miR-601	CLIP-seq
MIRT1199932	hsa-miR-646	CLIP-seq
MIRT1199933	hsa-miR-761	CLIP-seq
MIRT1199934	hsa-miR-877	CLIP-seq
MIRT1199935	hsa-miR-922	CLIP-seq
MIRT1199936	hsa-miR-98	CLIP-seq
MIRT2057919	hsa-miR-1275	CLIP-seq
MIRT2057920	hsa-miR-4260	CLIP-seq
MIRT2057921	hsa-miR-4320	CLIP-seq
MIRT2057922	hsa-miR-4450	CLIP-seq
MIRT2057923	hsa-miR-4525	CLIP-seq
MIRT2057924	hsa-miR-4665-5p	CLIP-seq
MIRT2057925	hsa-miR-4723-5p	CLIP-seq
MIRT2057926	hsa-miR-4727-5p	CLIP-seq
MIRT2057927	hsa-miR-625	CLIP-seq
MIRT2057928	hsa-miR-9	CLIP-seq
MIRT2057919	hsa-miR-1275	CLIP-seq
MIRT2057920	hsa-miR-4260	CLIP-seq
MIRT2057921	hsa-miR-4320	CLIP-seq
MIRT2057922	hsa-miR-4450	CLIP-seq
MIRT2286241	hsa-miR-4501	CLIP-seq
MIRT2057923	hsa-miR-4525	CLIP-seq
MIRT2057924	hsa-miR-4665-5p	CLIP-seq
MIRT2057925	hsa-miR-4723-5p	CLIP-seq
MIRT2057926	hsa-miR-4727-5p	CLIP-seq
MIRT2057927	hsa-miR-625	CLIP-seq
MIRT2057928	hsa-miR-9	CLIP-seq
MIRT1199919	hsa-miR-4291	CLIP-seq
MIRT2057919	hsa-miR-1275	CLIP-seq
MIRT2057920	hsa-miR-4260	CLIP-seq
MIRT2057921	hsa-miR-4320	CLIP-seq
MIRT2057922	hsa-miR-4450	CLIP-seq
MIRT2057923	hsa-miR-4525	CLIP-seq
MIRT2057924	hsa-miR-4665-5p	CLIP-seq
MIRT2057925	hsa-miR-4723-5p	CLIP-seq
MIRT2057926	hsa-miR-4727-5p	CLIP-seq
MIRT2057927	hsa-miR-625	CLIP-seq
MIRT2057928	hsa-miR-9	CLIP-seq
MIRT2584160	hsa-miR-1206	CLIP-seq
MIRT2584161	hsa-miR-1226	CLIP-seq
MIRT2584162	hsa-miR-1244	CLIP-seq
MIRT2584163	hsa-miR-1260	CLIP-seq
MIRT2584164	hsa-miR-129-3p	CLIP-seq
MIRT2584165	hsa-miR-1321	CLIP-seq
MIRT2584166	hsa-miR-1913	CLIP-seq
MIRT1199908	hsa-miR-214	CLIP-seq
MIRT2584167	hsa-miR-3074-5p	CLIP-seq
MIRT2584168	hsa-miR-3128	CLIP-seq
MIRT2584169	hsa-miR-3146	CLIP-seq
MIRT2584170	hsa-miR-3180-5p	CLIP-seq
MIRT2584171	hsa-miR-3182	CLIP-seq
MIRT2584172	hsa-miR-3192	CLIP-seq
MIRT2584173	hsa-miR-324-3p	CLIP-seq
MIRT1199912	hsa-miR-3605-5p	CLIP-seq
MIRT1199913	hsa-miR-3619-5p	CLIP-seq
MIRT2584174	hsa-miR-3653	CLIP-seq
MIRT2584175	hsa-miR-3658	CLIP-seq
MIRT1199916	hsa-miR-3714	CLIP-seq
MIRT2584176	hsa-miR-4270	CLIP-seq
MIRT2584177	hsa-miR-4279	CLIP-seq
MIRT2584178	hsa-miR-4280	CLIP-seq
MIRT2584179	hsa-miR-4283	CLIP-seq
MIRT1199919	hsa-miR-4291	CLIP-seq
MIRT2584180	hsa-miR-4419a	CLIP-seq
MIRT2584181	hsa-miR-4441	CLIP-seq
MIRT2584182	hsa-miR-4477a	CLIP-seq
MIRT1199922	hsa-miR-4484	CLIP-seq
MIRT2584183	hsa-miR-4489	CLIP-seq
MIRT2286241	hsa-miR-4501	CLIP-seq
MIRT2584184	hsa-miR-4509	CLIP-seq
MIRT2584185	hsa-miR-4510	CLIP-seq
MIRT2584186	hsa-miR-4519	CLIP-seq
MIRT2584187	hsa-miR-4680-5p	CLIP-seq
MIRT2584188	hsa-miR-4694-5p	CLIP-seq
MIRT2584189	hsa-miR-4720-5p	CLIP-seq
MIRT2584190	hsa-miR-4728-5p	CLIP-seq
MIRT2584191	hsa-miR-4739	CLIP-seq
MIRT2584192	hsa-miR-4744	CLIP-seq
MIRT2584193	hsa-miR-4749-3p	CLIP-seq
MIRT2584194	hsa-miR-4756-5p	CLIP-seq
MIRT2584195	hsa-miR-4763-5p	CLIP-seq
MIRT2584196	hsa-miR-4799-3p	CLIP-seq
MIRT2584197	hsa-miR-490-5p	CLIP-seq
MIRT2584198	hsa-miR-520a-5p	CLIP-seq
MIRT2584199	hsa-miR-525-5p	CLIP-seq
MIRT1199926	hsa-miR-548aa	CLIP-seq
MIRT1199928	hsa-miR-548an	CLIP-seq
MIRT2584200	hsa-miR-548m	CLIP-seq
MIRT2584201	hsa-miR-548p	CLIP-seq
MIRT1199946	hsa-miR-570	CLIP-seq
MIRT2584202	hsa-miR-614	CLIP-seq
MIRT2584203	hsa-miR-618	CLIP-seq
MIRT2584204	hsa-miR-619	CLIP-seq
MIRT1199933	hsa-miR-761	CLIP-seq
MIRT2584205	hsa-miR-765	CLIP-seq
MIRT2584206	hsa-miR-873	CLIP-seq
MIRT2584207	hsa-miR-885-3p	CLIP-seq
MIRT2584208	hsa-miR-885-5p	CLIP-seq
MIRT1199935	hsa-miR-922	CLIP-seq
MIRT2584209	hsa-miR-938	CLIP-seq
MIRT2584210	hsa-miR-940	CLIP-seq
MIRT2584160	hsa-miR-1206	CLIP-seq
MIRT2584161	hsa-miR-1226	CLIP-seq
MIRT2584162	hsa-miR-1244	CLIP-seq
MIRT2584163	hsa-miR-1260	CLIP-seq
MIRT2584164	hsa-miR-129-3p	CLIP-seq
MIRT2584166	hsa-miR-1913	CLIP-seq
MIRT1199908	hsa-miR-214	CLIP-seq
MIRT2584167	hsa-miR-3074-5p	CLIP-seq
MIRT2584168	hsa-miR-3128	CLIP-seq
MIRT2584169	hsa-miR-3146	CLIP-seq
MIRT2584170	hsa-miR-3180-5p	CLIP-seq
MIRT2584171	hsa-miR-3182	CLIP-seq
MIRT2584172	hsa-miR-3192	CLIP-seq
MIRT2584173	hsa-miR-324-3p	CLIP-seq
MIRT1199912	hsa-miR-3605-5p	CLIP-seq
MIRT1199913	hsa-miR-3619-5p	CLIP-seq
MIRT2584174	hsa-miR-3653	CLIP-seq
MIRT2584175	hsa-miR-3658	CLIP-seq
MIRT1199916	hsa-miR-3714	CLIP-seq
MIRT2584177	hsa-miR-4279	CLIP-seq
MIRT2584178	hsa-miR-4280	CLIP-seq
MIRT2584179	hsa-miR-4283	CLIP-seq
MIRT1199919	hsa-miR-4291	CLIP-seq
MIRT2584182	hsa-miR-4477a	CLIP-seq
MIRT1199922	hsa-miR-4484	CLIP-seq
MIRT2584183	hsa-miR-4489	CLIP-seq
MIRT2286241	hsa-miR-4501	CLIP-seq
MIRT2584184	hsa-miR-4509	CLIP-seq
MIRT2584186	hsa-miR-4519	CLIP-seq
MIRT2584187	hsa-miR-4680-5p	CLIP-seq
MIRT2584188	hsa-miR-4694-5p	CLIP-seq
MIRT2584189	hsa-miR-4720-5p	CLIP-seq
MIRT2584192	hsa-miR-4744	CLIP-seq
MIRT2584193	hsa-miR-4749-3p	CLIP-seq
MIRT2584195	hsa-miR-4763-5p	CLIP-seq
MIRT2584196	hsa-miR-4799-3p	CLIP-seq
MIRT2584197	hsa-miR-490-5p	CLIP-seq
MIRT2584198	hsa-miR-520a-5p	CLIP-seq
MIRT2584199	hsa-miR-525-5p	CLIP-seq
MIRT1199926	hsa-miR-548aa	CLIP-seq
MIRT1199928	hsa-miR-548an	CLIP-seq
MIRT2584200	hsa-miR-548m	CLIP-seq
MIRT2584201	hsa-miR-548p	CLIP-seq
MIRT1199946	hsa-miR-570	CLIP-seq
MIRT2584202	hsa-miR-614	CLIP-seq
MIRT2584203	hsa-miR-618	CLIP-seq
MIRT2584204	hsa-miR-619	CLIP-seq
MIRT1199933	hsa-miR-761	CLIP-seq
MIRT2584205	hsa-miR-765	CLIP-seq
MIRT2584206	hsa-miR-873	CLIP-seq
MIRT2584207	hsa-miR-885-3p	CLIP-seq
MIRT2584208	hsa-miR-885-5p	CLIP-seq
MIRT1199935	hsa-miR-922	CLIP-seq
MIRT2584209	hsa-miR-938	CLIP-seq
MIRT2584210	hsa-miR-940	CLIP-seq

Show/Hide all(55)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000776	Component	Kinetochore	IDA	15146057
GO:0000973	Process	Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	IBA
GO:0003713	Function	Transcription coactivator activity	IMP	28221134
GO:0003723	Function	RNA binding	IBA
GO:0003729	Function	MRNA binding	IMP	28221134
GO:0005515	Function	Protein binding	IPI	9348540, 15146057, 17172455, 18832153, 20498086, 25562883, 28221134, 30543681, 32353859, 33060197, 33097660, 33765414, 33849972, 33961781, 35096974
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IDA	15146057, 28221134
GO:0005635	Component	Nuclear envelope	TAS
GO:0005643	Component	Nuclear pore	IDA	9348540, 12802065, 15229283
GO:0005643	Component	Nuclear pore	IEA
GO:0005643	Component	Nuclear pore	NAS	10087256
GO:0005654	Component	Nucleoplasm	IDA	28221134
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS	7736573
GO:0005829	Component	Cytosol	TAS
GO:0006405	Process	RNA export from nucleus	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006606	Process	Protein import into nucleus	IBA
GO:0006606	Process	Protein import into nucleus	IEA
GO:0006913	Process	Nucleocytoplasmic transport	IEA
GO:0006913	Process	Nucleocytoplasmic transport	TAS	9348540
GO:0006999	Process	Nuclear pore organization	NAS	9348540
GO:0008139	Function	Nuclear localization sequence binding	IBA
GO:0008139	Function	Nuclear localization sequence binding	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016604	Component	Nuclear body	IDA	28221134
GO:0016787	Function	Hydrolase activity	IEA
GO:0017056	Function	Structural constituent of nuclear pore	IBA
GO:0017056	Function	Structural constituent of nuclear pore	IEA
GO:0017056	Function	Structural constituent of nuclear pore	IMP	15229283
GO:0017056	Function	Structural constituent of nuclear pore	NAS	9348540
GO:0031080	Component	Nuclear pore outer ring	IDA	17360435
GO:0031080	Component	Nuclear pore outer ring	NAS	15146057
GO:0031965	Component	Nuclear membrane	IDA	11839768, 12802065, 15229283, 20407419
GO:0031965	Component	Nuclear membrane	IEA
GO:0034398	Process	Telomere tethering at nuclear periphery	IBA
GO:0034399	Component	Nuclear periphery	IDA	11839768, 15229283
GO:0034399	Component	Nuclear periphery	IEA
GO:0042277	Function	Peptide binding	IEA
GO:0042405	Component	Nuclear inclusion body	IDA	11839768
GO:0042405	Component	Nuclear inclusion body	IEA
GO:0044614	Component	Nuclear pore cytoplasmic filaments	IBA
GO:0044615	Component	Nuclear pore nuclear basket	IDA	11839768
GO:0044615	Component	Nuclear pore nuclear basket	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IMP	28221134
GO:0051028	Process	MRNA transport	IEA
GO:0051292	Process	Nuclear pore complex assembly	IMP	15229283
GO:0140693	Function	Molecular condensate scaffold activity	IDA	25562883
GO:1990841	Function	Promoter-specific chromatin binding	IMP	28221134
GO:1990904	Component	Ribonucleoprotein complex	IMP	28221134

MIM	HGNC	e!Ensembl
601021	8068	ENSG00000110713

Protein

UniProt ID

P52948

Protein name

Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]

Protein function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a rol

PDB

1KO6 , 2Q5X , 2Q5Y , 3MMY , 4OWR , 5A9Q , 6BZM , 7F60 , 7F90 , 7MNI , 7PEQ , 7Q64 , 7Q65 , 7Q66 , 7Q67 , 7VPG , 7VPH , 8CI8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04096	Nucleoporin2	738 → 885	Nucleoporin autopeptidase	Family
PF12110	Nup96	1332 → 1623	Nuclear protein 96	Domain

Sequence

MFNKSFGTPFGGGTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNNTGGLFGNSQTKPG
GLFGTSSFSQPATSTSTGFGFGTSTGTANTLFGTASTGTSLFSSQNNAFAQNKPTGFGNF
GTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVST
NISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQVGAGTTTGLFGSSPATSSATGL
FSSSTTNSGFAYGQNKTAFGTSTTGFGTNPGGLFGQQNQQTTSLFSKPFGQATTTQNTGF
SFGNTSTIGQPSTNTMGLFGVTQASQPGGLFGTATNTSTGTAFGTGTGLFGQTNTGFGAV
GSTLFGNNKLTTFGSSTTSAPSFGTTSGGLFGNKPTLTLGTNTNTSNFGFGTNTSGNSIF
GSKPAPGTLGTGLGAGFGTALGAGQASLFGNNQPKIGGPLGTGAFGAPGFNTTTATLGFG
APQAPVALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSDPKKKEERLKPTNPAA
QKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKL
VLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYT
NPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDRE
EIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGD
VNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSP
DRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTS
TKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLD
TMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKA
DTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAASLMNIP
STSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG
RSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEK
LSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDL
PEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEE
EVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLV
DWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTA
SISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYS
DRHYDLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEG
LWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAK
AVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERS
SLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKD
RLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAPHIGRLPMPEDYAMDE
LRSLTQSYLRELAVGSL

Sequence length

1817

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Hirschsprung Disease	Hirschsprung disease, susceptibility to, 1	rs1057519323	N/A

Show/Hide Text Mining Associations (44)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Altitude Sickness	Associate	32214168
Aneuploidy	Associate	24371226
Blast Crisis	Associate	10848835
Carcinogenesis	Associate	9166830
Carcinoma Renal Cell	Associate	27144525
Cell Transformation Viral	Associate	19696924, 32620764
Cerulean cataract	Associate	15721637, 19338047
Congenital Abnormalities	Stimulate	24371226
Diabetic Nephropathies	Associate	35482475
Down Syndrome	Associate	33832921
Emanuel syndrome	Associate	10848835, 11841413, 28776436, 9074407
Fibrosis	Associate	35482475
Hematologic Diseases	Associate	27389314
Hematologic Neoplasms	Associate	10830185, 12810632, 15721637, 30848074, 39892372
Hyperplasia	Stimulate	20805992
Inflammation	Associate	35482475
Isodicentric Chromosome 15 Syndrome	Stimulate	20558618
Leukemia	Associate	11369863, 11737860, 20233715, 20237156, 32620764, 32664447, 32868895, 37301844
Leukemia Biphenotypic Acute	Associate	33784031
Leukemia Lymphocytic Chronic B Cell	Associate	11841413
Leukemia Lymphoid	Associate	26004809
Leukemia Megakaryoblastic Acute	Associate	27114462
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	10848835, 11830496, 19338047
Leukemia Myeloid	Associate	11830496
Leukemia Myeloid Acute	Associate	10397741, 10477737, 10556215, 11493482, 11737860, 11830496, 11895789, 11986249, 15721637, 18603550, 19696924, 20237156, 20339440, 20484370, 20558618 View all (32 more)
Leukemia Myelomonocytic Acute	Associate	12542486
Leukemia Myelomonocytic Acute	Stimulate	21813447
Leukemia Myelomonocytic Juvenile	Associate	19338047, 32815876
Leukemia Promyelocytic Acute	Associate	20935257, 33019444, 34673934, 37387408
Leukemia T Cell	Associate	11841413
Myelodysplastic Myeloproliferative Diseases	Associate	27097363, 32815876
Myelodysplastic Syndromes	Associate	10556215, 10830185, 11830496, 26004809, 27389314, 35915143
Myeloproliferative Disorders	Associate	19338047
Myocarditis	Associate	28018858
Necrosis	Associate	32620764
Neoplasms	Associate	10556215, 11737860, 11841413, 12542486, 23541576, 36835439, 37019972, 9166830
Neuraminidase 1 deficiency	Associate	36815378
Personality Disorders	Associate	32868895
Philadelphia Chromosome	Associate	10848835
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	39892372
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	10929031, 11841413, 17233820, 26004809, 26684393, 31612466
Prostatic Neoplasms	Associate	36095024
Rothmund Thomson Syndrome	Associate	36835439
Triple Negative Breast Neoplasms	Associate	30935371

NUP98 (nucleoporin 98 and 96 precursor)