Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4904
Gene name Gene Name - the full gene name approved by the HGNC.
Y-box binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
YBX1
Synonyms (NCBI Gene) Gene synonyms aliases
BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007092 hsa-miR-137 Luciferase reporter assay 23178914
MIRT007092 hsa-miR-137 Luciferase reporter assay 23178914
MIRT022450 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT031527 hsa-miR-16-5p Proteomics 18668040
MIRT050595 hsa-miR-20a-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
TWIST1 Activation 21876555
TWIST1 Unknown 19318582
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000398 Process MRNA splicing, via spliceosome TAS
GO:0003676 Function Nucleic acid binding IBA 21873635
GO:0003677 Function DNA binding TAS 2977358, 3174636, 8188694
GO:0003690 Function Double-stranded DNA binding TAS 1738588
GO:0003723 Function RNA binding HDA 22658674, 22681889
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
154030 8014 ENSG00000065978
Protein
UniProt ID P67809
Protein name Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)
Protein function DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:3
PDB 1H95 , 5YTS , 5YTT , 5YTV , 5YTX , 6A6L , 6KTC , 6KUG , 6LMR , 6LMS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00313 CSD 59 128 Domain
Sequence
MSSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVL
GTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGA
EAANVTGP
GGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEG
QAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRG
YRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDG
KETKAADPPAENSSAPEAEQGGAE
Sequence length 324
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Noncanonical activation of NOTCH3
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
15703814
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
15703814
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 28077578
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
15703814
Associations from Text Mining
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 27463019
Acute Kidney Injury Associate 37058032
Adenocarcinoma Associate 31180040, 33934437
Adenocarcinoma of Lung Associate 33021972, 33144579
Amyotrophic Lateral Sclerosis Associate 31936368
Arrest of spermatogenesis Associate 33375868
Ataxia Telangiectasia Associate 28009354
Atherosclerosis Associate 18800033
Brain Neoplasms Associate 20398058
Breast Neoplasms Associate 16651443, 17875215, 18307537, 18925950, 19098458, 20079629, 20649952, 20844753, 21392397, 21466612, 21695211, 21968648, 22118625, 23178914, 24260353
View all (12 more)