Gene Gene information from NCBI Gene database.
Entrez ID 4904
Gene name Y-box binding protein 1
Gene symbol YBX1
Synonyms (NCBI Gene)
BP-8CBF-ACSDA2CSDBDBPBEFI-AMDR-NF1NSEP-1NSEP1YB-1YB1
Chromosome 1
Chromosome location 1p34.2
Summary This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation
miRNA miRNA information provided by mirtarbase database.
203
miRTarBase ID miRNA Experiments Reference
MIRT007092 hsa-miR-137 Luciferase reporter assay 23178914
MIRT007092 hsa-miR-137 Luciferase reporter assay 23178914
MIRT022450 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT031527 hsa-miR-16-5p Proteomics 18668040
MIRT050595 hsa-miR-20a-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
TWIST1 Activation 21876555
TWIST1 Unknown 19318582
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
64
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000932 Component P-body IEA
GO:0001701 Process In utero embryonic development IEA
GO:0003676 Function Nucleic acid binding IBA
GO:0003676 Function Nucleic acid binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
154030 8014 ENSG00000065978
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P67809
Protein name Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)
Protein function DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:3
PDB 1H95 , 5YTS , 5YTT , 5YTV , 5YTX , 6A6L , 6KTC , 6KUG , 6LMR , 6LMS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00313 CSD 59 128 Domain
Sequence
MSSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVL
GTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGA
EAANVTGP
GGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEG
QAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRG
YRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDG
KETKAADPPAENSSAPEAEQGGAE
Sequence length 324
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Noncanonical activation of NOTCH3
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
YBX1-related disorder Likely benign; Benign rs536995048, rs1190872059, rs148020196 RCV003912060
RCV003927048
RCV003971724
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 27463019
Acute Kidney Injury Associate 37058032
Adenocarcinoma Associate 31180040, 33934437
Adenocarcinoma of Lung Associate 33021972, 33144579
Amyotrophic Lateral Sclerosis Associate 31936368
Arrest of spermatogenesis Associate 33375868
Ataxia Telangiectasia Associate 28009354
Atherosclerosis Associate 18800033
Brain Neoplasms Associate 20398058
Breast Neoplasms Associate 16651443, 17875215, 18307537, 18925950, 19098458, 20079629, 20649952, 20844753, 21392397, 21466612, 21695211, 21968648, 22118625, 23178914, 24260353
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