NRGN (neurogranin)

Gene

• Entrez ID: 4900
• Gene name: Neurogranin
• Gene symbol: NRGN
• Synonyms (NCBI Gene): RC3, hng
• Chromosome: 11
• Chromosome location: 11q24.2
• Summary: Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The ex

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT492851	hsa-miR-744-5p	PAR-CLIP	23592263
MIRT492850	hsa-miR-665	PAR-CLIP	23592263
MIRT492849	hsa-miR-3940-3p	PAR-CLIP	23592263
MIRT492848	hsa-miR-3141	PAR-CLIP	23592263
MIRT492847	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT492846	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT492845	hsa-miR-663a	PAR-CLIP	23592263
MIRT492844	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT492843	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT492841	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT492842	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT492840	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT492839	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT492838	hsa-miR-3180	PAR-CLIP	23592263
MIRT492837	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT492836	hsa-miR-3196	PAR-CLIP	23592263
MIRT492835	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT492834	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT492833	hsa-miR-5698	PAR-CLIP	23592263
MIRT492832	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT492831	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT492830	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT492829	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT492828	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT492843	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT492846	hsa-miR-1908-5p	PAR-CLIP	26701625
MIRT492848	hsa-miR-3141	PAR-CLIP	26701625
MIRT492849	hsa-miR-3940-3p	PAR-CLIP	26701625
MIRT492834	hsa-miR-4723-5p	PAR-CLIP	26701625
MIRT492841	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT492833	hsa-miR-5698	PAR-CLIP	26701625
MIRT492845	hsa-miR-663a	PAR-CLIP	26701625
MIRT492850	hsa-miR-665	PAR-CLIP	26701625
MIRT492842	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT492844	hsa-miR-6787-5p	PAR-CLIP	26701625
MIRT492830	hsa-miR-6795-5p	PAR-CLIP	26701625
MIRT492839	hsa-miR-6825-5p	PAR-CLIP	26701625
MIRT492847	hsa-miR-6840-3p	PAR-CLIP	26701625
MIRT492832	hsa-miR-6870-5p	PAR-CLIP	26701625
MIRT492840	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT492829	hsa-miR-6887-5p	PAR-CLIP	26701625
MIRT492831	hsa-miR-7111-5p	PAR-CLIP	26701625
MIRT734000	hsa-miR-4262	Luciferase reporter assay, qRT-PCR, Western blotting	32543324
MIRT492851	hsa-miR-744-5p	PAR-CLIP	23592263
MIRT492850	hsa-miR-665	PAR-CLIP	23592263
MIRT492849	hsa-miR-3940-3p	PAR-CLIP	23592263
MIRT492848	hsa-miR-3141	PAR-CLIP	23592263
MIRT492847	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT492846	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT492845	hsa-miR-663a	PAR-CLIP	23592263
MIRT492844	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT492843	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT492841	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT492842	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT492840	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT492839	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT492838	hsa-miR-3180	PAR-CLIP	23592263
MIRT492837	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT492836	hsa-miR-3196	PAR-CLIP	23592263
MIRT492835	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT492834	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT492833	hsa-miR-5698	PAR-CLIP	23592263
MIRT492832	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT492831	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT492830	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT492829	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT492828	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT1921275	hsa-miR-1908	CLIP-seq
MIRT1921276	hsa-miR-663	CLIP-seq
MIRT2056242	hsa-miR-122	CLIP-seq
MIRT2056243	hsa-miR-151-3p	CLIP-seq
MIRT2056244	hsa-miR-28-3p	CLIP-seq
MIRT2056245	hsa-miR-2909	CLIP-seq
MIRT2056246	hsa-miR-299-5p	CLIP-seq
MIRT2056247	hsa-miR-3144-5p	CLIP-seq
MIRT2056248	hsa-miR-3191	CLIP-seq
MIRT2056249	hsa-miR-342-5p	CLIP-seq
MIRT2056250	hsa-miR-3619-3p	CLIP-seq
MIRT2056251	hsa-miR-4418	CLIP-seq
MIRT2056252	hsa-miR-4463	CLIP-seq
MIRT2056253	hsa-miR-4499	CLIP-seq
MIRT2056254	hsa-miR-4651	CLIP-seq
MIRT2056255	hsa-miR-4652-5p	CLIP-seq
MIRT2056256	hsa-miR-4664-5p	CLIP-seq
MIRT2056257	hsa-miR-4704-3p	CLIP-seq
MIRT2056258	hsa-miR-4717-3p	CLIP-seq
MIRT2056259	hsa-miR-509-3-5p	CLIP-seq
MIRT2056260	hsa-miR-509-5p	CLIP-seq
MIRT2056261	hsa-miR-608	CLIP-seq
MIRT2284814	hsa-miR-1254	CLIP-seq
MIRT2284815	hsa-miR-1262	CLIP-seq
MIRT2056243	hsa-miR-151-3p	CLIP-seq
MIRT2056244	hsa-miR-28-3p	CLIP-seq
MIRT2284816	hsa-miR-3116	CLIP-seq
MIRT2284817	hsa-miR-3126-5p	CLIP-seq
MIRT2056247	hsa-miR-3144-5p	CLIP-seq
MIRT2284818	hsa-miR-3158-5p	CLIP-seq
MIRT2056248	hsa-miR-3191	CLIP-seq
MIRT2056250	hsa-miR-3619-3p	CLIP-seq
MIRT2284819	hsa-miR-4294	CLIP-seq
MIRT2056251	hsa-miR-4418	CLIP-seq
MIRT2284820	hsa-miR-4419a	CLIP-seq
MIRT2056252	hsa-miR-4463	CLIP-seq
MIRT2056253	hsa-miR-4499	CLIP-seq
MIRT2284821	hsa-miR-4510	CLIP-seq
MIRT2056255	hsa-miR-4652-5p	CLIP-seq
MIRT2284822	hsa-miR-4701-3p	CLIP-seq
MIRT2056257	hsa-miR-4704-3p	CLIP-seq
MIRT2284823	hsa-miR-4710	CLIP-seq
MIRT2056258	hsa-miR-4717-3p	CLIP-seq
MIRT2284824	hsa-miR-4763-5p	CLIP-seq
MIRT2056259	hsa-miR-509-3-5p	CLIP-seq
MIRT2056260	hsa-miR-509-5p	CLIP-seq
MIRT2284825	hsa-miR-596	CLIP-seq
MIRT2284826	hsa-miR-661	CLIP-seq
MIRT2391748	hsa-miR-4283	CLIP-seq
MIRT2391749	hsa-miR-4731-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005516	Function	Calmodulin binding	IEA
GO:0005516	Function	Calmodulin binding	TAS	10075657
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	TAS	10075657
GO:0007399	Process	Nervous system development	TAS	10075657
GO:0008306	Process	Associative learning	IEA
GO:0012510	Component	Trans-Golgi network transport vesicle membrane	IEA
GO:0021537	Process	Telencephalon development	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0044327	Component	Dendritic spine head	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0070300	Function	Phosphatidic acid binding	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099170	Process	Postsynaptic modulation of chemical synaptic transmission	IEA
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	IEA

Other IDs

• MIM: 602350
• HGNC: 8000
• e!Ensembl: ENSG00000154146

Protein

• UniProt ID: Q92686
• Protein name: Neurogranin (Ng) (RC3) [Cleaved into: NEUG(55-78)]
• Protein function: Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00612	IQ	27 → 47	IQ calmodulin-binding motif	Motif

• Tissue specificity: TISSUE SPECIFICITY: In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. {ECO:0000269|PubMed:9329454}.
• Sequence:

  MDCCTENACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARKKIKSGERGRKGPGPGG
  PGGAGVARGGAGGGPSGD

• Sequence length: 78

Pathways

Reactome:

Long-term potentiation