Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4897
Gene name	Neuronal cell adhesion molecule
Gene symbol	NRCAM
Synonyms (NCBI Gene)	NEDNMS
Chromosome	7
Chromosome location	7q31.1
Summary	Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved

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miRTarBase ID	miRNA	Experiments	Reference
MIRT037753	hsa-miR-708-5p	CLASH	23622248
MIRT450809	hsa-miR-4282	PAR-CLIP	22100165
MIRT450809	hsa-miR-4282	PAR-CLIP	22100165
MIRT1193797	hsa-miR-1179	CLIP-seq
MIRT1193798	hsa-miR-1279	CLIP-seq
MIRT1193799	hsa-miR-205	CLIP-seq
MIRT1193800	hsa-miR-23a	CLIP-seq
MIRT1193801	hsa-miR-23b	CLIP-seq
MIRT1193802	hsa-miR-23c	CLIP-seq
MIRT1193803	hsa-miR-2467-3p	CLIP-seq
MIRT1193804	hsa-miR-3125	CLIP-seq
MIRT1193805	hsa-miR-3152-5p	CLIP-seq
MIRT1193806	hsa-miR-3158-5p	CLIP-seq
MIRT1193807	hsa-miR-3545-3p	CLIP-seq
MIRT1193808	hsa-miR-3678-3p	CLIP-seq
MIRT1193809	hsa-miR-3713	CLIP-seq
MIRT1193810	hsa-miR-3916	CLIP-seq
MIRT1193811	hsa-miR-4491	CLIP-seq
MIRT1193812	hsa-miR-4657	CLIP-seq
MIRT1193813	hsa-miR-4704-3p	CLIP-seq
MIRT1193814	hsa-miR-4711-5p	CLIP-seq
MIRT1193815	hsa-miR-4774-3p	CLIP-seq
MIRT1193816	hsa-miR-486-5p	CLIP-seq
MIRT1193817	hsa-miR-1207-3p	CLIP-seq
MIRT1193818	hsa-miR-129-5p	CLIP-seq
MIRT1193819	hsa-miR-1296	CLIP-seq
MIRT1193820	hsa-miR-191	CLIP-seq
MIRT1193821	hsa-miR-2909	CLIP-seq
MIRT1193822	hsa-miR-302a	CLIP-seq
MIRT1193823	hsa-miR-302b	CLIP-seq
MIRT1193824	hsa-miR-302c	CLIP-seq
MIRT1193825	hsa-miR-302d	CLIP-seq
MIRT1193826	hsa-miR-302e	CLIP-seq
MIRT1193827	hsa-miR-372	CLIP-seq
MIRT1193828	hsa-miR-373	CLIP-seq
MIRT1193829	hsa-miR-4307	CLIP-seq
MIRT1193830	hsa-miR-4424	CLIP-seq
MIRT1193831	hsa-miR-4512	CLIP-seq
MIRT1193832	hsa-miR-4529-5p	CLIP-seq
MIRT1193833	hsa-miR-4718	CLIP-seq
MIRT1193834	hsa-miR-4760-3p	CLIP-seq
MIRT1193835	hsa-miR-520a-3p	CLIP-seq
MIRT1193836	hsa-miR-520b	CLIP-seq
MIRT1193837	hsa-miR-520c-3p	CLIP-seq
MIRT1193838	hsa-miR-520d-3p	CLIP-seq
MIRT1193839	hsa-miR-520e	CLIP-seq
MIRT1193840	hsa-miR-520f	CLIP-seq
MIRT1193841	hsa-miR-543	CLIP-seq
MIRT1193842	hsa-miR-570	CLIP-seq
MIRT1193843	hsa-miR-619	CLIP-seq
MIRT1193844	hsa-miR-651	CLIP-seq
MIRT1193817	hsa-miR-1207-3p	CLIP-seq
MIRT1193834	hsa-miR-4760-3p	CLIP-seq
MIRT2056214	hsa-miR-101	CLIP-seq
MIRT2056215	hsa-miR-1273d	CLIP-seq
MIRT2056216	hsa-miR-1284	CLIP-seq
MIRT2056217	hsa-miR-3065-5p	CLIP-seq
MIRT2056218	hsa-miR-3120-3p	CLIP-seq
MIRT1193814	hsa-miR-4711-5p	CLIP-seq
MIRT2056219	hsa-miR-4803	CLIP-seq
MIRT2056220	hsa-miR-577	CLIP-seq
MIRT2056221	hsa-miR-660	CLIP-seq
MIRT2284806	hsa-miR-132	CLIP-seq
MIRT2284807	hsa-miR-212	CLIP-seq
MIRT1193803	hsa-miR-2467-3p	CLIP-seq
MIRT2056218	hsa-miR-3120-3p	CLIP-seq
MIRT1193808	hsa-miR-3678-3p	CLIP-seq
MIRT2056218	hsa-miR-3120-3p	CLIP-seq
MIRT2284808	hsa-miR-3145-3p	CLIP-seq
MIRT2284809	hsa-miR-4703-3p	CLIP-seq
MIRT1193814	hsa-miR-4711-5p	CLIP-seq
MIRT2284810	hsa-miR-548g	CLIP-seq
MIRT2284811	hsa-miR-633	CLIP-seq
MIRT2582611	hsa-miR-3143	CLIP-seq
MIRT2582612	hsa-miR-526b	CLIP-seq
MIRT1193841	hsa-miR-543	CLIP-seq
MIRT1193842	hsa-miR-570	CLIP-seq
MIRT2582613	hsa-miR-802	CLIP-seq
MIRT2582611	hsa-miR-3143	CLIP-seq
MIRT2582612	hsa-miR-526b	CLIP-seq
MIRT1193841	hsa-miR-543	CLIP-seq
MIRT1193842	hsa-miR-570	CLIP-seq
MIRT2582613	hsa-miR-802	CLIP-seq

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Transcription factor	Regulation	Reference
CTNNB1	Unknown	17724465
LEF1	Activation	12183361

Show/Hide all (47)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEP	11866539
GO:0001764	Process	Neuron migration	NAS	11483367
GO:0005515	Function	Protein binding	IPI	23897819
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	8812479
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007409	Process	Axonogenesis	NAS	8812479
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0007413	Process	Axonal fasciculation	NAS	8812479
GO:0007416	Process	Synapse assembly	TAS	8812479
GO:0007417	Process	Central nervous system development	IEA
GO:0007417	Process	Central nervous system development	IMP	35108495
GO:0007417	Process	Central nervous system development	NAS	8812479
GO:0007420	Process	Brain development	IBA
GO:0008104	Process	Intracellular protein localization	IEA
GO:0009897	Component	External side of plasma membrane	NAS	8812479
GO:0010975	Process	Regulation of neuron projection development	IEA
GO:0016020	Component	Membrane	IEA
GO:0019227	Process	Neuronal action potential propagation	IEA
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	IEA
GO:0030506	Function	Ankyrin binding	IDA	14602817
GO:0030516	Process	Regulation of axon extension	NAS	8812479
GO:0031290	Process	Retinal ganglion cell axon guidance	IEA
GO:0034113	Process	Heterotypic cell-cell adhesion	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	NAS	8812479
GO:0043194	Component	Axon initial segment	ISS
GO:0045162	Process	Clustering of voltage-gated sodium channels	IDA	14602817
GO:0045162	Process	Clustering of voltage-gated sodium channels	IEA
GO:0045162	Process	Clustering of voltage-gated sodium channels	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	NAS	8812479
GO:0050808	Process	Synapse organization	IEA
GO:0086080	Function	Protein binding involved in heterotypic cell-cell adhesion	IEA
GO:0098609	Process	Cell-cell adhesion	IBA
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098609	Process	Cell-cell adhesion	NAS	8812479
GO:0098632	Function	Cell-cell adhesion mediator activity	IBA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099175	Process	Regulation of postsynapse organization	IEA

MIM	HGNC	e!Ensembl
601581	7994	ENSG00000091129

Q92823

Protein name

Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)

Protein function

Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts bet

PDB

1UEN , 1UEY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13927	Ig_3	45 → 127		Domain
PF07679	I-set	274 → 357	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	361 → 436		Domain
PF07679	I-set	454 → 542	Immunoglobulin I-set domain	Domain
PF07679	I-set	546 → 633	Immunoglobulin I-set domain	Domain
PF00041	fn3	648 → 733	Fibronectin type III domain	Domain
PF00041	fn3	748 → 833	Fibronectin type III domain	Domain
PF00041	fn3	847 → 940	Fibronectin type III domain	Domain
PF00041	fn3	953 → 1040	Fibronectin type III domain	Domain
PF00041	fn3	1068 → 1148	Fibronectin type III domain	Domain
PF13882	Bravo_FIGEY	1191 → 1280	Bravo-like intracellular region	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus. {ECO:0000269|PubMed:8812479}.

Sequence

MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDP
RENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGV
YQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFW
MDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVIS
VDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTP
IIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA
PYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFS
NVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFG
SPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL
EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDH
LVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLD
KSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFR
VMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGL
QYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHS
GEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIE
KKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKI
VNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNF
STRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAET
YANISWEYEGPEHVNFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAVG
DSGFVSSEDVFETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPV
KEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGE
GVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV

Sequence length

1304

Interactions

View interactions

	KEGG		Reactome
	Cell adhesion molecules		Neurofascin interactions

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Neurodevelopmental disorder with neuromuscular and skeletal abnormalities	Pathogenic; Likely pathogenic	rs2153275538, rs140770274, rs201033539, rs2062777274, rs772993703, rs2548032920	RCV002246516 RCV002246518 RCV002246519 RCV002246520 RCV002246521 RCV003221778
NRCAM-related disorder	Pathogenic; Likely pathogenic	rs2153275538, rs2153369022, rs1298979445, rs140770274, rs1413634373, rs575851831, rs201033539, rs2062777274, rs772993703	RCV001824181 RCV001824182 RCV001824183 RCV001824185 RCV001824186 RCV001824187 RCV001824190 RCV001824191 RCV001824192

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Familial cancer of breast	Uncertain significance	rs199867432	RCV005929059
High myopia	Uncertain significance	rs201534122	RCV000785731

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	24902845
Annular pancreas	Associate	37635636
Autistic Disorder	Associate	18664314
Autoimmune Diseases	Associate	35220890
Blood Coagulation Disorders Inherited	Associate	36606341
Breast Neoplasms	Associate	21281495
Carcinogenesis	Associate	31322225
Colorectal Neoplasms	Associate	21718388
COVID 19	Associate	33301474
Developmental Disabilities	Associate	36606341
Focal Nodular Hyperplasia	Associate	18602664
Graves Disease	Associate	35220890
Headache	Associate	36181733
Hepatic Adenomas Familial	Associate	18602664
Hereditary Breast and Ovarian Cancer Syndrome	Associate	21281495
Inflammation	Associate	33301474
Intellectual Disability	Associate	36606341
Neoplasm Metastasis	Stimulate	21718388
Neoplasms	Associate	15967107, 21718388
Neuroblastoma	Associate	36499391
Ovarian Neoplasms	Associate	20132413
Pancreatic Neoplasms	Associate	30397360
Peripheral Nervous System Diseases	Associate	36606341
Peritonitis	Stimulate	21718388
Polyneuropathies	Associate	36606341
Prostatic Neoplasms	Stimulate	31322225
Thyroid Cancer Papillary	Stimulate	17667921

NRCAM (neuronal cell adhesion molecule)