Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4893
Gene name Gene Name - the full gene name approved by the HGNC.
NRAS proto-oncogene, GTPase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NRAS
Synonyms (NCBI Gene) Gene synonyms aliases
ALPS4, CMNS, KRAS, N-ras, NCMS, NRAS1, NS6
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has i
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs11554290 T>A,C,G Pathogenic, likely-pathogenic Missense variant, coding sequence variant
rs121434595 C>A,G,T Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs121434596 C>A,G,T Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs121913237 C>A,G,T Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs121913248 C>G,T Likely-pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003836 hsa-let-7b-5p Immunohistochemistry, qRT-PCR 19966857
MIRT001854 hsa-let-7a-5p Luciferase reporter assay, Microarray 15766527
MIRT004531 hsa-let-7c-5p Microarray, Northern blot, qRT-PCR, Western blot 15766527
MIRT003903 hsa-miR-20a-5p Western blot 19110058
MIRT001854 hsa-let-7a-5p Western blot 19110058
Transcription factors
Transcription factor Regulation Reference
AR Repression 16281084
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0000165 Process MAPK cascade IEA
GO:0000165 Process MAPK cascade TAS
GO:0000166 Function Nucleotide binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164790 7989 ENSG00000213281
Protein
UniProt ID P01111
Protein name GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Protein function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
PDB 2N9C , 3CON , 5UHV , 6E6H , 6MPP , 6ULI , 6ULK , 6ULN , 6ULR , 6UON , 6WGH , 6ZIO , 6ZIR , 6ZIZ , 7F68 , 7OW3 , 7OW4 , 7OW5 , 7OW6 , 7PB2 , 8TBI , 8VM2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 5 165 Ras family Domain
Sequence
Sequence length 189
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Axon guidance
VEGF signaling pathway
Apelin signaling pathway
Gap junction
Signaling pathways regulating pluripotency of stem cells
C-type lectin receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Thermogenesis
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
GnRH secretion
AGE-RAGE signaling pathway in diabetic complications
Growth hormone synthesis, secretion and action
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Alcoholism
Hepatitis C
Hepatitis B
Human cytomegalovirus infection
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Colorectal cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Lipid and atherosclerosis
  Activation of RAS in B cells
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
RAS signaling downstream of NF1 loss-of-function variants
Paradoxical activation of RAF signaling by kinase inactive BRAF
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Estrogen-stimulated signaling through PRKCZ
RAS GTPase cycle mutants
Signaling downstream of RAS mutants
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
neoplasm Neoplasm rs121434596, rs121913250, rs121913237, rs11554290 N/A
Noonan Syndrome noonan syndrome 6, noonan syndrome 1, noonan syndrome, Noonan syndrome and Noonan-related syndrome rs267606921, rs121913250, rs121434595, rs121913237, rs267606920, rs11554290, rs869025573, rs397514553, rs121434596 N/A
acute myeloid leukemia Acute myeloid leukemia rs121434595 N/A
Autoimmune Lymphoproliferative Disorder Autoimmune lymphoproliferative syndrome type 4 rs121913237, rs121434596 N/A
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Costello Syndrome Costello syndrome N/A N/A GenCC
Noonan syndrome with multiple lentigines Noonan syndrome with multiple lentigines N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abdominal Neoplasms Associate 38254245
Aberrant Crypt Foci Associate 29222172
Acute erythroleukemia Associate 2200539
Adenocarcinoma Associate 23196793, 26317919, 26536055, 28097440, 28179590, 36788068
Adenocarcinoma Follicular Associate 24820091, 27264674, 31077238, 7951583
Adenocarcinoma Mucinous Associate 37296579
Adenocarcinoma of Lung Associate 22975805, 26098749, 26682952, 27151654, 31446140, 31532708, 35212617
Adenoma Associate 1452458, 27494611
Adenomatous Polyposis Coli Associate 28141798
Adrenocortical Carcinoma Associate 25078331