Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4887
Gene name Gene Name - the full gene name approved by the HGNC.	Neuropeptide Y receptor Y2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NPY2R
Synonyms (NCBI Gene) Gene synonyms aliases	NPY2-R
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q32.1

Show/Hide all(60)

miRTarBase ID	miRNA	Experiments	Reference
MIRT572391	hsa-miR-4803	PAR-CLIP	20371350
MIRT572390	hsa-miR-302f	PAR-CLIP	20371350
MIRT572391	hsa-miR-4803	PAR-CLIP	20371350
MIRT572390	hsa-miR-302f	PAR-CLIP	20371350
MIRT1191791	hsa-miR-1279	CLIP-seq
MIRT1191792	hsa-miR-1298	CLIP-seq
MIRT1191793	hsa-miR-203	CLIP-seq
MIRT1191794	hsa-miR-2054	CLIP-seq
MIRT1191795	hsa-miR-3064-3p	CLIP-seq
MIRT1191796	hsa-miR-3180-5p	CLIP-seq
MIRT1191797	hsa-miR-4270	CLIP-seq
MIRT1191798	hsa-miR-4441	CLIP-seq
MIRT1191799	hsa-miR-4517	CLIP-seq
MIRT1191800	hsa-miR-4699-3p	CLIP-seq
MIRT1191801	hsa-miR-4714-3p	CLIP-seq
MIRT1191802	hsa-miR-4760-3p	CLIP-seq
MIRT1191803	hsa-miR-503	CLIP-seq
MIRT1191804	hsa-miR-520a-5p	CLIP-seq
MIRT1191805	hsa-miR-520d-5p	CLIP-seq
MIRT1191806	hsa-miR-524-5p	CLIP-seq
MIRT1191807	hsa-miR-525-5p	CLIP-seq
MIRT1191808	hsa-miR-582-5p	CLIP-seq
MIRT1191809	hsa-miR-600	CLIP-seq
MIRT1191801	hsa-miR-4714-3p	CLIP-seq
MIRT1191801	hsa-miR-4714-3p	CLIP-seq
MIRT2055622	hsa-miR-145	CLIP-seq
MIRT1191793	hsa-miR-203	CLIP-seq
MIRT1191795	hsa-miR-3064-3p	CLIP-seq
MIRT2055623	hsa-miR-3161	CLIP-seq
MIRT2055624	hsa-miR-369-3p	CLIP-seq
MIRT2055625	hsa-miR-375	CLIP-seq
MIRT2055626	hsa-miR-3908	CLIP-seq
MIRT2055627	hsa-miR-4790-5p	CLIP-seq
MIRT2055628	hsa-miR-545	CLIP-seq
MIRT2055629	hsa-miR-944	CLIP-seq
MIRT1191793	hsa-miR-203	CLIP-seq
MIRT2284507	hsa-miR-3074-5p	CLIP-seq
MIRT1191796	hsa-miR-3180-5p	CLIP-seq
MIRT2284508	hsa-miR-4659a-3p	CLIP-seq
MIRT2284509	hsa-miR-4659b-3p	CLIP-seq
MIRT2284510	hsa-miR-513a-3p	CLIP-seq
MIRT1191804	hsa-miR-520a-5p	CLIP-seq
MIRT1191807	hsa-miR-525-5p	CLIP-seq
MIRT2055629	hsa-miR-944	CLIP-seq
MIRT1191793	hsa-miR-203	CLIP-seq
MIRT1191795	hsa-miR-3064-3p	CLIP-seq
MIRT2439067	hsa-miR-1297	CLIP-seq
MIRT2439068	hsa-miR-26a	CLIP-seq
MIRT2439069	hsa-miR-26b	CLIP-seq
MIRT2439070	hsa-miR-4465	CLIP-seq
MIRT2284508	hsa-miR-4659a-3p	CLIP-seq
MIRT2284509	hsa-miR-4659b-3p	CLIP-seq
MIRT2439071	hsa-miR-578	CLIP-seq
MIRT2686516	hsa-miR-129-5p	CLIP-seq
MIRT2686517	hsa-miR-3616-5p	CLIP-seq
MIRT2686518	hsa-miR-3647-5p	CLIP-seq
MIRT2686519	hsa-miR-4670-3p	CLIP-seq
MIRT2686520	hsa-miR-573	CLIP-seq
MIRT2686521	hsa-miR-586	CLIP-seq
MIRT2686522	hsa-miR-653	CLIP-seq

Show/Hide all(42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001601	Function	Peptide YY receptor activity	IEA
GO:0001662	Process	Behavioral fear response	IEA
GO:0002793	Process	Positive regulation of peptide secretion	IEA
GO:0003151	Process	Outflow tract morphogenesis	IMP	19593212
GO:0003214	Process	Cardiac left ventricle morphogenesis	IMP	19593212
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004983	Function	Neuropeptide Y receptor activity	IEA
GO:0004983	Function	Neuropeptide Y receptor activity	TAS	7559383
GO:0005246	Function	Calcium channel regulator activity	TAS	8132547
GO:0005515	Function	Protein binding	IPI	23597562, 32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7592910
GO:0005929	Component	Cilium	IDA	28154160
GO:0005929	Component	Cilium	IEA
GO:0005929	Component	Cilium	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	7559383
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0007263	Process	Nitric oxide mediated signal transduction	IEA
GO:0007626	Process	Locomotory behavior	TAS	9692752
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0016020	Component	Membrane	IEA
GO:0031645	Process	Negative regulation of nervous system process	IEA
GO:0033603	Process	Positive regulation of dopamine secretion	IEA
GO:0038023	Function	Signaling receptor activity	TAS	1321422
GO:0045987	Process	Positive regulation of smooth muscle contraction	IEA
GO:0046010	Process	Positive regulation of circadian sleep/wake cycle, non-REM sleep	IEA
GO:0050805	Process	Negative regulation of synaptic transmission	IEA
GO:0051048	Process	Negative regulation of secretion	IEA
GO:0051967	Process	Negative regulation of synaptic transmission, glutamatergic	IEA
GO:0090394	Process	Negative regulation of excitatory postsynaptic potential	IEA
GO:0097730	Component	Non-motile cilium	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099538	Process	Synaptic signaling via neuropeptide	IEA
GO:0141162	Process	Negative regulation of cAMP/PKA signal transduction	IEA
GO:2000252	Process	Negative regulation of feeding behavior	IEA

MIM	HGNC	e!Ensembl
162642	7957	ENSG00000185149

Protein

UniProt ID

P49146

Protein name

Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor)

Protein function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

PDB

7X9B , 7YON , 7YOO , 8K6N

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	67 → 325	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Sequence

MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI
ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK
KNLEVRKNSGPNDSFTEATNV

Sequence length

381

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		Peptide ligand-binding receptors G alpha (i) signalling events

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Myocardial Ischemia	Myocardial ischemia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alcoholism	Associate	18828811, 27584037
Anxiety	Associate	33531491
Behcet Syndrome	Associate	34975900
Cocaine Related Disorders	Associate	18828811
Depressive Disorder Major	Associate	27584037
Diabetes Mellitus	Inhibit	22029806
Diabetic Retinopathy	Associate	22427569
Hypertension	Associate	19593212
Hypertrophy Left Ventricular	Associate	19593212
Inflammation	Associate	34975900
Menopause Premature	Associate	29432556
Obesity	Associate	17235527, 20642810, 21818152, 26711810, 27584037, 33531491
Substance Withdrawal Syndrome	Associate	18828811
Vascular System Injuries	Associate	34975900

NPY2R (neuropeptide Y receptor Y2)