NPY1R (neuropeptide Y receptor Y1)

Gene

• Entrez ID: 4886
• Gene name: Neuropeptide Y receptor Y1
• Gene symbol: NPY1R
• Synonyms (NCBI Gene): NPY1-R, NPYR
• Chromosome: 4
• Chromosome location: 4q32.2
• Summary: This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast ago

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018353	hsa-miR-335-5p	Microarray	18185580
MIRT1191684	hsa-miR-101	CLIP-seq
MIRT1191685	hsa-miR-106a	CLIP-seq
MIRT1191686	hsa-miR-106b	CLIP-seq
MIRT1191687	hsa-miR-1184	CLIP-seq
MIRT1191688	hsa-miR-1193	CLIP-seq
MIRT1191689	hsa-miR-1205	CLIP-seq
MIRT1191690	hsa-miR-1249	CLIP-seq
MIRT1191691	hsa-miR-1264	CLIP-seq
MIRT1191692	hsa-miR-1298	CLIP-seq
MIRT1191693	hsa-miR-1323	CLIP-seq
MIRT1191694	hsa-miR-144	CLIP-seq
MIRT1191695	hsa-miR-148a	CLIP-seq
MIRT1191696	hsa-miR-148b	CLIP-seq
MIRT1191697	hsa-miR-152	CLIP-seq
MIRT1191698	hsa-miR-153	CLIP-seq
MIRT1191699	hsa-miR-17	CLIP-seq
MIRT1191700	hsa-miR-1911	CLIP-seq
MIRT1191701	hsa-miR-208a	CLIP-seq
MIRT1191702	hsa-miR-208b	CLIP-seq
MIRT1191703	hsa-miR-20a	CLIP-seq
MIRT1191704	hsa-miR-20b	CLIP-seq
MIRT1191705	hsa-miR-2113	CLIP-seq
MIRT1191706	hsa-miR-2116	CLIP-seq
MIRT1191707	hsa-miR-218	CLIP-seq
MIRT1191708	hsa-miR-223	CLIP-seq
MIRT1191709	hsa-miR-224	CLIP-seq
MIRT1191710	hsa-miR-2467-5p	CLIP-seq
MIRT1191711	hsa-miR-300	CLIP-seq
MIRT1191712	hsa-miR-3065-5p	CLIP-seq
MIRT1191713	hsa-miR-3140-3p	CLIP-seq
MIRT1191714	hsa-miR-3143	CLIP-seq
MIRT1191715	hsa-miR-3148	CLIP-seq
MIRT1191716	hsa-miR-3158-5p	CLIP-seq
MIRT1191717	hsa-miR-3163	CLIP-seq
MIRT1191718	hsa-miR-3180-5p	CLIP-seq
MIRT1191719	hsa-miR-3188	CLIP-seq
MIRT1191720	hsa-miR-323b-3p	CLIP-seq
MIRT1191721	hsa-miR-3609	CLIP-seq
MIRT1191722	hsa-miR-3619-3p	CLIP-seq
MIRT1191723	hsa-miR-3622a-5p	CLIP-seq
MIRT1191724	hsa-miR-3662	CLIP-seq
MIRT1191725	hsa-miR-3665	CLIP-seq
MIRT1191726	hsa-miR-3667-5p	CLIP-seq
MIRT1191727	hsa-miR-3682-5p	CLIP-seq
MIRT1191728	hsa-miR-3688-3p	CLIP-seq
MIRT1191729	hsa-miR-375	CLIP-seq
MIRT1191730	hsa-miR-377	CLIP-seq
MIRT1191731	hsa-miR-380	CLIP-seq
MIRT1191732	hsa-miR-381	CLIP-seq
MIRT1191733	hsa-miR-3912	CLIP-seq
MIRT1191734	hsa-miR-3975	CLIP-seq
MIRT1191735	hsa-miR-425	CLIP-seq
MIRT1191736	hsa-miR-4273	CLIP-seq
MIRT1191737	hsa-miR-4303	CLIP-seq
MIRT1191738	hsa-miR-431	CLIP-seq
MIRT1191739	hsa-miR-4328	CLIP-seq
MIRT1191740	hsa-miR-433	CLIP-seq
MIRT1191741	hsa-miR-4423-3p	CLIP-seq
MIRT1191742	hsa-miR-4446-5p	CLIP-seq
MIRT1191743	hsa-miR-448	CLIP-seq
MIRT1191744	hsa-miR-4497	CLIP-seq
MIRT1191745	hsa-miR-450b-5p	CLIP-seq
MIRT1191746	hsa-miR-452	CLIP-seq
MIRT1191747	hsa-miR-4633-5p	CLIP-seq
MIRT1191748	hsa-miR-4649-3p	CLIP-seq
MIRT1191749	hsa-miR-4666-3p	CLIP-seq
MIRT1191750	hsa-miR-4668-3p	CLIP-seq
MIRT1191751	hsa-miR-4676-3p	CLIP-seq
MIRT1191752	hsa-miR-4677-5p	CLIP-seq
MIRT1191753	hsa-miR-4686	CLIP-seq
MIRT1191754	hsa-miR-4704-3p	CLIP-seq
MIRT1191755	hsa-miR-4705	CLIP-seq
MIRT1191756	hsa-miR-4718	CLIP-seq
MIRT1191757	hsa-miR-4719	CLIP-seq
MIRT1191758	hsa-miR-4755-5p	CLIP-seq
MIRT1191759	hsa-miR-4789-5p	CLIP-seq
MIRT1191760	hsa-miR-4796-3p	CLIP-seq
MIRT1191761	hsa-miR-485-5p	CLIP-seq
MIRT1191762	hsa-miR-488	CLIP-seq
MIRT1191763	hsa-miR-491-3p	CLIP-seq
MIRT1191764	hsa-miR-507	CLIP-seq
MIRT1191765	hsa-miR-513a-3p	CLIP-seq
MIRT1191766	hsa-miR-513b	CLIP-seq
MIRT1191767	hsa-miR-515-5p	CLIP-seq
MIRT1191768	hsa-miR-519d	CLIP-seq
MIRT1191769	hsa-miR-520a-5p	CLIP-seq
MIRT1191770	hsa-miR-525-5p	CLIP-seq
MIRT1191771	hsa-miR-532-5p	CLIP-seq
MIRT1191772	hsa-miR-548ah	CLIP-seq
MIRT1191773	hsa-miR-548c-3p	CLIP-seq
MIRT1191774	hsa-miR-548n	CLIP-seq
MIRT1191775	hsa-miR-548o	CLIP-seq
MIRT1191776	hsa-miR-548t	CLIP-seq
MIRT1191777	hsa-miR-549	CLIP-seq
MIRT1191778	hsa-miR-557	CLIP-seq
MIRT1191779	hsa-miR-582-5p	CLIP-seq
MIRT1191780	hsa-miR-586	CLIP-seq
MIRT1191781	hsa-miR-599	CLIP-seq
MIRT1191782	hsa-miR-633	CLIP-seq
MIRT1191783	hsa-miR-636	CLIP-seq
MIRT1191784	hsa-miR-642b	CLIP-seq
MIRT1191785	hsa-miR-656	CLIP-seq
MIRT1191786	hsa-miR-657	CLIP-seq
MIRT1191787	hsa-miR-670	CLIP-seq
MIRT1191788	hsa-miR-93	CLIP-seq
MIRT1191789	hsa-miR-935	CLIP-seq
MIRT1191790	hsa-miR-944	CLIP-seq
MIRT1191687	hsa-miR-1184	CLIP-seq
MIRT1191688	hsa-miR-1193	CLIP-seq
MIRT1191689	hsa-miR-1205	CLIP-seq
MIRT2055569	hsa-miR-1207-5p	CLIP-seq
MIRT2055570	hsa-miR-1236	CLIP-seq
MIRT2055571	hsa-miR-1283	CLIP-seq
MIRT1191692	hsa-miR-1298	CLIP-seq
MIRT2055572	hsa-miR-132	CLIP-seq
MIRT2055573	hsa-miR-136	CLIP-seq
MIRT2055574	hsa-miR-141	CLIP-seq
MIRT1191695	hsa-miR-148a	CLIP-seq
MIRT1191696	hsa-miR-148b	CLIP-seq
MIRT1191697	hsa-miR-152	CLIP-seq
MIRT1191700	hsa-miR-1911	CLIP-seq
MIRT2055575	hsa-miR-1914	CLIP-seq
MIRT2055576	hsa-miR-200a	CLIP-seq
MIRT2055577	hsa-miR-200b	CLIP-seq
MIRT2055578	hsa-miR-200c	CLIP-seq
MIRT2055579	hsa-miR-2054	CLIP-seq
MIRT1191701	hsa-miR-208a	CLIP-seq
MIRT1191702	hsa-miR-208b	CLIP-seq
MIRT1191705	hsa-miR-2113	CLIP-seq
MIRT1191706	hsa-miR-2116	CLIP-seq
MIRT2055580	hsa-miR-212	CLIP-seq
MIRT2055581	hsa-miR-216b	CLIP-seq
MIRT1191708	hsa-miR-223	CLIP-seq
MIRT1191709	hsa-miR-224	CLIP-seq
MIRT1191711	hsa-miR-300	CLIP-seq
MIRT2055582	hsa-miR-3121-5p	CLIP-seq
MIRT1191715	hsa-miR-3148	CLIP-seq
MIRT1191716	hsa-miR-3158-5p	CLIP-seq
MIRT2055583	hsa-miR-3160-5p	CLIP-seq
MIRT2055584	hsa-miR-3189-3p	CLIP-seq
MIRT2055585	hsa-miR-3189-5p	CLIP-seq
MIRT2055586	hsa-miR-3200-3p	CLIP-seq
MIRT2055587	hsa-miR-3607-3p	CLIP-seq
MIRT2055588	hsa-miR-3616-5p	CLIP-seq
MIRT1191723	hsa-miR-3622a-5p	CLIP-seq
MIRT2055589	hsa-miR-3647-5p	CLIP-seq
MIRT1191724	hsa-miR-3662	CLIP-seq
MIRT1191727	hsa-miR-3682-5p	CLIP-seq
MIRT2055590	hsa-miR-3686	CLIP-seq
MIRT1191728	hsa-miR-3688-3p	CLIP-seq
MIRT2055591	hsa-miR-3689a-3p	CLIP-seq
MIRT2055592	hsa-miR-3689c	CLIP-seq
MIRT2055593	hsa-miR-369-3p	CLIP-seq
MIRT2055594	hsa-miR-374a	CLIP-seq
MIRT2055595	hsa-miR-374b	CLIP-seq
MIRT2055596	hsa-miR-374c	CLIP-seq
MIRT1191730	hsa-miR-377	CLIP-seq
MIRT1191731	hsa-miR-380	CLIP-seq
MIRT1191732	hsa-miR-381	CLIP-seq
MIRT1191733	hsa-miR-3912	CLIP-seq
MIRT1191736	hsa-miR-4273	CLIP-seq
MIRT2055597	hsa-miR-429	CLIP-seq
MIRT2055598	hsa-miR-4300	CLIP-seq
MIRT1191738	hsa-miR-431	CLIP-seq
MIRT1191739	hsa-miR-4328	CLIP-seq
MIRT1191741	hsa-miR-4423-3p	CLIP-seq
MIRT2055599	hsa-miR-4426	CLIP-seq
MIRT2055600	hsa-miR-4647	CLIP-seq
MIRT2055601	hsa-miR-4662b	CLIP-seq
MIRT1191749	hsa-miR-4666-3p	CLIP-seq
MIRT1191752	hsa-miR-4677-5p	CLIP-seq
MIRT1191753	hsa-miR-4686	CLIP-seq
MIRT2055602	hsa-miR-4694-3p	CLIP-seq
MIRT2055603	hsa-miR-4694-5p	CLIP-seq
MIRT1191754	hsa-miR-4704-3p	CLIP-seq
MIRT1191756	hsa-miR-4718	CLIP-seq
MIRT2055604	hsa-miR-4724-5p	CLIP-seq
MIRT2055605	hsa-miR-4729	CLIP-seq
MIRT2055606	hsa-miR-4736	CLIP-seq
MIRT2055607	hsa-miR-4742-3p	CLIP-seq
MIRT2055608	hsa-miR-4758-3p	CLIP-seq
MIRT2055609	hsa-miR-4763-3p	CLIP-seq
MIRT2055610	hsa-miR-4768-5p	CLIP-seq
MIRT2055611	hsa-miR-4773	CLIP-seq
MIRT1191759	hsa-miR-4789-5p	CLIP-seq
MIRT1191762	hsa-miR-488	CLIP-seq
MIRT2055612	hsa-miR-502-5p	CLIP-seq
MIRT1191767	hsa-miR-515-5p	CLIP-seq
MIRT1191771	hsa-miR-532-5p	CLIP-seq
MIRT1191773	hsa-miR-548c-3p	CLIP-seq
MIRT2055613	hsa-miR-558	CLIP-seq
MIRT2055614	hsa-miR-568	CLIP-seq
MIRT2055615	hsa-miR-573	CLIP-seq
MIRT1191779	hsa-miR-582-5p	CLIP-seq
MIRT2055616	hsa-miR-591	CLIP-seq
MIRT1191781	hsa-miR-599	CLIP-seq
MIRT2055617	hsa-miR-605	CLIP-seq
MIRT2055618	hsa-miR-622	CLIP-seq
MIRT1191782	hsa-miR-633	CLIP-seq
MIRT1191784	hsa-miR-642b	CLIP-seq
MIRT2055619	hsa-miR-654-3p	CLIP-seq
MIRT2055620	hsa-miR-655	CLIP-seq
MIRT2055621	hsa-miR-920	CLIP-seq
MIRT1191789	hsa-miR-935	CLIP-seq
MIRT2284504	hsa-miR-1231	CLIP-seq
MIRT2055571	hsa-miR-1283	CLIP-seq
MIRT1191692	hsa-miR-1298	CLIP-seq
MIRT1191695	hsa-miR-148a	CLIP-seq
MIRT1191696	hsa-miR-148b	CLIP-seq
MIRT1191697	hsa-miR-152	CLIP-seq
MIRT1191701	hsa-miR-208a	CLIP-seq
MIRT1191702	hsa-miR-208b	CLIP-seq
MIRT1191705	hsa-miR-2113	CLIP-seq
MIRT1191709	hsa-miR-224	CLIP-seq
MIRT2284505	hsa-miR-2392	CLIP-seq
MIRT1191710	hsa-miR-2467-5p	CLIP-seq
MIRT1191711	hsa-miR-300	CLIP-seq
MIRT1191712	hsa-miR-3065-5p	CLIP-seq
MIRT2284506	hsa-miR-3136-3p	CLIP-seq
MIRT1191714	hsa-miR-3143	CLIP-seq
MIRT1191715	hsa-miR-3148	CLIP-seq
MIRT1191719	hsa-miR-3188	CLIP-seq
MIRT1191723	hsa-miR-3622a-5p	CLIP-seq
MIRT1191724	hsa-miR-3662	CLIP-seq
MIRT1191728	hsa-miR-3688-3p	CLIP-seq
MIRT1191730	hsa-miR-377	CLIP-seq
MIRT1191732	hsa-miR-381	CLIP-seq
MIRT1191733	hsa-miR-3912	CLIP-seq
MIRT1191734	hsa-miR-3975	CLIP-seq
MIRT1191735	hsa-miR-425	CLIP-seq
MIRT1191737	hsa-miR-4303	CLIP-seq
MIRT1191740	hsa-miR-433	CLIP-seq
MIRT1191741	hsa-miR-4423-3p	CLIP-seq
MIRT1191747	hsa-miR-4633-5p	CLIP-seq
MIRT1191748	hsa-miR-4649-3p	CLIP-seq
MIRT1191749	hsa-miR-4666-3p	CLIP-seq
MIRT1191755	hsa-miR-4705	CLIP-seq
MIRT1191756	hsa-miR-4718	CLIP-seq
MIRT1191759	hsa-miR-4789-5p	CLIP-seq
MIRT1191761	hsa-miR-485-5p	CLIP-seq
MIRT1191763	hsa-miR-491-3p	CLIP-seq
MIRT1191767	hsa-miR-515-5p	CLIP-seq
MIRT1191777	hsa-miR-549	CLIP-seq
MIRT1191779	hsa-miR-582-5p	CLIP-seq
MIRT1191781	hsa-miR-599	CLIP-seq
MIRT1191784	hsa-miR-642b	CLIP-seq
MIRT2055619	hsa-miR-654-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001601	Function	Peptide YY receptor activity	IEA
GO:0001602	Function	Pancreatic polypeptide receptor activity	IEA
GO:0003151	Process	Outflow tract morphogenesis	IMP	19593212
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004983	Function	Neuropeptide Y receptor activity	IEA
GO:0004983	Function	Neuropeptide Y receptor activity	TAS	1317848
GO:0005515	Function	Protein binding	IPI	23597562
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	1317848
GO:0006006	Process	Glucose metabolic process	IEA
GO:0007154	Process	Cell communication	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	1317848
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	1321422
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0007631	Process	Feeding behavior	IEA
GO:0008188	Function	Neuropeptide receptor activity	IBA
GO:0008217	Process	Regulation of blood pressure	IEA
GO:0016020	Component	Membrane	IEA
GO:0019233	Process	Sensory perception of pain	IEA
GO:0023052	Process	Signaling	IEA
GO:0040014	Process	Regulation of multicellular organism growth	IEA
GO:0042923	Function	Neuropeptide binding	IBA
GO:0043005	Component	Neuron projection	IBA

Other IDs

• MIM: 162641
• HGNC: 7956
• e!Ensembl: ENSG00000164128

Protein

• UniProt ID: P25929
• Protein name: Neuropeptide Y receptor type 1 (NPY1-R)
• Protein function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
• PDB: 5ZBQ, 7VGX, 7X9A, 8K6M, 8K6O
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	57 → 320	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
  LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
  CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
  DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
  RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
  LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
  KTSLKQASPVAFKKINNNDDNEKI

• Sequence length: 384

Pathways

KEGG:

cAMP signaling pathway
Neuroactive ligand-receptor interaction
Regulation of lipolysis in adipocytes

Reactome:

Peptide ligand-binding receptors
G alpha (i) signalling events