Gene Gene information from NCBI Gene database.
Entrez ID 4883
Gene name Natriuretic peptide receptor 3
Gene symbol NPR3
Synonyms (NCBI Gene)
ANP-CANPR-CANPRCBOMOSC5orf23GUCY2BNPR-CNPRC
Chromosome 5
Chromosome location 5p13.3
Summary This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of thi
miRNA miRNA information provided by mirtarbase database.
527
miRTarBase ID miRNA Experiments Reference
MIRT005159 hsa-miR-30a-5p pSILAC 18668040
MIRT001435 hsa-miR-16-5p pSILAC 18668040
MIRT017512 hsa-miR-335-5p Microarray 18185580
MIRT027551 hsa-miR-98-5p Microarray 19088304
MIRT005159 hsa-miR-30a-5p Proteomics;Other 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0001501 Process Skeletal system development IEA
GO:0001501 Process Skeletal system development ISS
GO:0001525 Process Angiogenesis IEA
GO:0001974 Process Blood vessel remodeling IEA
GO:0002158 Process Osteoclast proliferation IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
108962 7945 ENSG00000113389
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P17342
Protein name Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C)
Protein function Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB
PDB 1JDN , 1JDP , 1YK0 , 1YK1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01094 ANF_receptor 71 425 Receptor family ligand binding region Family
Sequence
Sequence length 541
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Hormone signaling  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
18
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Boudin-Mortier syndrome Likely pathogenic; Pathogenic rs1433125500, rs753386861, rs1741953064, rs2111840582 RCV001707924
RCV001707925
RCV001707926
RCV001707927
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHAGAS CARDIOMYOPATHY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONGENITAL CONTRACTURAL ARACHNODACTYLY CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Abdominal Injuries Associate 14981229
★☆☆☆☆
Found in Text Mining only
Alveolitis Extrinsic Allergic Associate 37800807
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Associate 27101299
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Inhibit 32431194
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Associate 33110086, 35558081, 37076508
★☆☆☆☆
Found in Text Mining only
Calcinosis Cutis Associate 29261789
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Dilated Associate 30032985
★☆☆☆☆
Found in Text Mining only
Cardiovascular Abnormalities Associate 30032985
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Associate 21909115, 29040610
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Inhibit 37101178
★☆☆☆☆
Found in Text Mining only