Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4883
Gene name Gene Name - the full gene name approved by the HGNC.
Natriuretic peptide receptor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NPR3
Synonyms (NCBI Gene) Gene synonyms aliases
ANP-C, ANPR-C, ANPRC, BOMOS, C5orf23, GUCY2B, NPR-C, NPRC
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of thi
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005159 hsa-miR-30a-5p pSILAC 18668040
MIRT001435 hsa-miR-16-5p pSILAC 18668040
MIRT017512 hsa-miR-335-5p Microarray 18185580
MIRT027551 hsa-miR-98-5p Microarray 19088304
MIRT005159 hsa-miR-30a-5p Proteomics;Other 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001501 Process Skeletal system development IEA
GO:0001501 Process Skeletal system development ISS
GO:0001525 Process Angiogenesis IEA
GO:0001974 Process Blood vessel remodeling IEA
GO:0002158 Process Osteoclast proliferation IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
108962 7945 ENSG00000113389
Protein
UniProt ID P17342
Protein name Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C)
Protein function Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB
PDB 1JDN , 1JDP , 1YK0 , 1YK1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01094 ANF_receptor 71 425 Receptor family ligand binding region Family
Sequence
Sequence length 541
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Hormone signaling  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Hypertension Hypertension, Hypertension (confirmatory factor analysis Factor 12), ICD10 O13: Gestational hypertension, High blood pressure / hypertension, Gestational hypertension, Hypertension (PheCode 401), Essential hypertension (PheCode 401.1) N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abdominal Injuries Associate 14981229
Alveolitis Extrinsic Allergic Associate 37800807
Atherosclerosis Associate 27101299
Atrial Fibrillation Inhibit 32431194
Breast Neoplasms Associate 33110086, 35558081, 37076508
Calcinosis Cutis Associate 29261789
Cardiomyopathy Dilated Associate 30032985
Cardiovascular Abnormalities Associate 30032985
Cardiovascular Diseases Associate 21909115, 29040610
Cardiovascular Diseases Inhibit 37101178